PL3277272T3 - Sposoby stratyfikacji pacjentów do leczenia agonistami receptora kwasu retinowego - Google Patents

Sposoby stratyfikacji pacjentów do leczenia agonistami receptora kwasu retinowego

Info

Publication number: PL3277272T3
Authority: PL; Poland
Prior art keywords: stratification; patients; treatment; methods; receptor agonists
Prior art date: 2015-03-31

Application number

PL16774191T

Other languages

English (en)

Inventor

Mei Wei CHEN

Cindy COLLINS

Matthew Lucas EATON

Matthew G. Guenther

Nan KE

Jeremy LOPEZ

Michael R. Mckeown

David A. Orlando

Original Assignee

Syros Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-03-31

Filing date

2016-03-31

Publication date

2022-01-24

2016-03-31 Application filed by Syros Pharmaceuticals, Inc. filed Critical Syros Pharmaceuticals, Inc.

2022-01-24 Publication of PL3277272T3 publication Critical patent/PL3277272T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Pathology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
General Engineering & Computer Science (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL16774191T 2015-03-31 2016-03-31 Sposoby stratyfikacji pacjentów do leczenia agonistami receptora kwasu retinowego PL3277272T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201562140999P	2015-03-31	2015-03-31
US201562268203P	2015-12-16	2015-12-16
EP16774191.7A EP3277272B1 (en)	2015-03-31	2016-03-31	Methods of stratifying patients for treatment with retinoic acid receptor-agonists
PCT/US2016/025256 WO2016161107A1 (en)	2015-03-31	2016-03-31	METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-α AGONISTS

Publications (1)

Publication Number	Publication Date
PL3277272T3 true PL3277272T3 (pl)	2022-01-24

Family

ID=57006493

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL16774191T PL3277272T3 (pl)	2015-03-31	2016-03-31	Sposoby stratyfikacji pacjentów do leczenia agonistami receptora kwasu retinowego

Country Status (14)

Country	Link
US (5)	US9845508B2 (pl)
EP (2)	EP3967305A1 (pl)
JP (4)	JP6952604B2 (pl)
KR (1)	KR20170132248A (pl)
CN (2)	CN116059365A (pl)
AU (3)	AU2016243702B2 (pl)
BR (3)	BR122023024813A2 (pl)
CA (1)	CA2981518C (pl)
ES (1)	ES2901792T3 (pl)
HU (1)	HUE057325T2 (pl)
IL (3)	IL309066A (pl)
MX (2)	MX391949B (pl)
PL (1)	PL3277272T3 (pl)
WO (1)	WO2016161107A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2969031A4 (en)	2013-03-15	2017-03-08	Avisenna Cosmetics LLC	Topical compositions for reducing aging effects
PL3277272T3 (pl) *	2015-03-31	2022-01-24	Syros Pharmaceuticals, Inc.	Sposoby stratyfikacji pacjentów do leczenia agonistami receptora kwasu retinowego
WO2017177167A1 (en) *	2016-04-08	2017-10-12	Syros Pharmaceuticals, Inc.	Rara agonists for the treatment of aml and mds
US9868994B2 (en)	2016-04-08	2018-01-16	Syros Pharmaceuticals, Inc.	Methods of stratifying patients for treatment with retinoic acid receptor-α agonists
WO2018067946A1 (en) *	2016-10-06	2018-04-12	Syros Pharmaceuticals, Inc.	Methods of treating patients with a retinoic acid receptor-alpha agonist and an anti-cd38 antibody
WO2018136961A1 (en) *	2017-01-23	2018-07-26	Syros Pharmaceuticals Inc.	METHODS OF TREATING PATIENTS WITH A RETINOIC ACID RECEPTOR-α AGONIST AND AN ANTI-CD38 ANTIBODY
JP2019043865A (ja) *	2017-08-31	2019-03-22	ひまわり製薬株式会社	ざ瘡様疾患を治療又は予防するための皮膚外用組成物
WO2020069187A1 (en) *	2018-09-28	2020-04-02	The Children's Medical Center Corporation	Combination therapy for acute myeloid leukemia
JP2023542273A (ja) *	2020-08-06	2023-10-06	サイロスファーマシューティカルズ，インコーポレイテッド	Ａｍｌを処置するための治療、ならびにｒａｒａアゴニスト、低メチル化剤、およびｂｃｌ－２阻害剤の使用
CN112390731B (zh) *	2020-11-16	2022-11-25	成都大学	一种具有多靶点的维甲酸类衍生物及其制备方法与应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3580134D1 (de)	1984-07-07	1990-11-22	Shudo Koichi Prof Dr Chem	Benzoesaeurederivate.
US5089509A (en)	1988-09-15	1992-02-18	Allergan, Inc.	Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
JP2752630B2 (ja)	1988-03-29	1998-05-18	大鵬薬品工業株式会社	新規安息香酸誘導体及びその製造方法
WO1992016660A1 (en)	1991-03-22	1992-10-01	Sloan-Kettering Institute For Cancer Research	Methods for detection and treatment of cancer
US5759785A (en)	1992-05-14	1998-06-02	Baylor College Of Medicine	Method of identifying hormone antagonists and agonists
US5455265A (en)	1993-02-11	1995-10-03	Allergan, Inc.	Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5824685A (en)	1995-02-01	1998-10-20	The Johns Hopkins University School Of Medicine	Method of preventing proliferation of retinal pigment epithelium by retinoic acid receptor agonists
FR2739777B1 (fr)	1995-10-11	1997-11-14	Cird Galderma	Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose
US5675024A (en)	1995-11-22	1997-10-07	Allergan	Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US5965606A (en)	1995-12-29	1999-10-12	Allergan Sales, Inc.	Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity
CN1255396C (zh)	1996-03-18	2006-05-10	卫材株式会社	含有稠环的羧酸衍生物
DE69739909D1 (de)	1996-03-26	2010-07-29	Michael S Kopreski	Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden
US5919970A (en)	1997-04-24	1999-07-06	Allergan Sales, Inc.	Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
EP1025857A4 (en)	1997-10-22	2003-11-12	Eisai Co Ltd	RETINOIC ACID AGONISTS, PREVENTIVE AND THERAPEUTIC AGENTS FOR NEPHRITES
CA2702148C (en)	1999-01-06	2014-03-04	Genenews Inc.	Method of profiling gene expression in a human subject having an infectious disease
TWI281911B (en)	2000-04-04	2007-06-01	Allergan Inc	Treatment of tumors with RARalpha selective retinoid compounds in combination with other anti-tumor agents
WO2003025171A2 (en) *	2001-09-17	2003-03-27	Angiogene Inc.	Modulation of retinoic acid receptor gene expression and therapeutic uses thereof
JP5113038B2 (ja)	2006-03-23	2013-01-09	テムリック株式会社	癌治療用キットおよび癌治療用医薬組成物
US8768629B2 (en)	2009-02-11	2014-07-01	Caris Mpi, Inc.	Molecular profiling of tumors
EP2143428B1 (en)	2007-03-30	2015-11-04	TMRC Co., Ltd.	Tamibarotene capsule preparation
UA103319C2 (en)	2008-05-06	2013-10-10	Глаксосмитклайн Ллк	Thiazole- and oxazole-benzene sulfonamide compounds
US20100099084A1 (en)	2008-10-17	2010-04-22	Maher Albitar	Detection of npm1 nucleic acid in acellular body fluids
WO2011097712A1 (en) *	2010-02-11	2011-08-18	The Royal Institution For The Advancement Of Learning/Mcgill University	Hybrid molecule having mixed retinoic acid receptor agonism and histone deacetylase inhibitory properties
KR102083046B1 (ko) *	2012-06-07	2020-02-28	칠드런＇스 하스피틀 로스 앤젤레스	레티노이드 작용제를 이용하여 호중구감소증을 치료하기 위한 방법
US20140296218A1 (en)	2012-10-25	2014-10-02	Whitehead Institute For Biomedical Research	Super-enhancers and methods of use thereof
EP2912178B1 (en)	2012-10-25	2020-06-17	Whitehead Institute For Biomedical Research	Super-enhancers and methods of use thereof
CN105229175A (zh)	2013-03-15	2016-01-06	雅培分子公司	用于扩增和测定rna融合基因变体的方法、区分它们的方法以及有关的引物、探针和试剂盒
EP3021866A4 (en)	2013-07-15	2017-02-22	The Board of Trustees of the Leland Stanford Junior University	Medical uses of cd38 agonists
WO2015085172A2 (en)	2013-12-06	2015-06-11	Celgene Corporation	Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
WO2015101618A1 (en)	2013-12-30	2015-07-09	INSERM (Institut National de la Santé et de la Recherche Médicale)	Combination of an arsenic compound and at least one retinoid for treating acute myeloid leukemia
EP3267969A1 (en)	2015-03-09	2018-01-17	King's College London	Combination therapy with rar alpha agonists for enhancing th1 response
PL3277272T3 (pl)	2015-03-31	2022-01-24	Syros Pharmaceuticals, Inc.	Sposoby stratyfikacji pacjentów do leczenia agonistami receptora kwasu retinowego
EP3380086B1 (en)	2015-11-25	2021-10-13	IO Therapeutics, Inc.	Cyp26-resistant rar-alpha selective agonists in the treatment of cancer
WO2017177167A1 (en)	2016-04-08	2017-10-12	Syros Pharmaceuticals, Inc.	Rara agonists for the treatment of aml and mds
US9868994B2 (en)	2016-04-08	2018-01-16	Syros Pharmaceuticals, Inc.	Methods of stratifying patients for treatment with retinoic acid receptor-α agonists
WO2018067946A1 (en)	2016-10-06	2018-04-12	Syros Pharmaceuticals, Inc.	Methods of treating patients with a retinoic acid receptor-alpha agonist and an anti-cd38 antibody
WO2018136961A1 (en)	2017-01-23	2018-07-26	Syros Pharmaceuticals Inc.	METHODS OF TREATING PATIENTS WITH A RETINOIC ACID RECEPTOR-α AGONIST AND AN ANTI-CD38 ANTIBODY

2016
- 2016-03-31 PL PL16774191T patent/PL3277272T3/pl unknown
- 2016-03-31 IL IL309066A patent/IL309066A/en unknown
- 2016-03-31 MX MX2017012470A patent/MX391949B/es unknown
- 2016-03-31 CN CN202210785569.8A patent/CN116059365A/zh active Pending
- 2016-03-31 BR BR122023024813-9A patent/BR122023024813A2/pt not_active Application Discontinuation
- 2016-03-31 HU HUE16774191A patent/HUE057325T2/hu unknown
- 2016-03-31 BR BR112017020745-1A patent/BR112017020745A2/en not_active Application Discontinuation
- 2016-03-31 JP JP2017552074A patent/JP6952604B2/ja active Active
- 2016-03-31 ES ES16774191T patent/ES2901792T3/es active Active
- 2016-03-31 BR BR122023024814-7A patent/BR122023024814A2/pt unknown
- 2016-03-31 WO PCT/US2016/025256 patent/WO2016161107A1/en not_active Ceased
- 2016-03-31 AU AU2016243702A patent/AU2016243702B2/en not_active Ceased
- 2016-03-31 IL IL254697A patent/IL254697B/en unknown
- 2016-03-31 EP EP21188938.1A patent/EP3967305A1/en not_active Withdrawn
- 2016-03-31 CA CA2981518A patent/CA2981518C/en active Active
- 2016-03-31 KR KR1020177030920A patent/KR20170132248A/ko not_active Ceased
- 2016-03-31 IL IL294449A patent/IL294449B2/en unknown
- 2016-03-31 EP EP16774191.7A patent/EP3277272B1/en active Active
- 2016-03-31 CN CN201680028129.0A patent/CN107613969B/zh not_active Expired - Fee Related
- 2016-06-02 US US15/172,045 patent/US9845508B2/en not_active Expired - Fee Related
2017
- 2017-09-28 MX MX2022005020A patent/MX2022005020A/es unknown
- 2017-10-31 US US15/799,519 patent/US10167518B2/en active Active
2018
- 2018-02-20 US US15/899,629 patent/US10697025B2/en active Active
2020
- 2020-05-08 US US16/870,370 patent/US11447831B2/en active Active
- 2020-08-28 JP JP2020144363A patent/JP2020203911A/ja not_active Withdrawn
2022
- 2022-01-06 AU AU2022200059A patent/AU2022200059B2/en not_active Ceased
- 2022-07-22 US US17/871,584 patent/US20230042181A1/en not_active Abandoned
- 2022-10-11 JP JP2022163053A patent/JP2022185101A/ja not_active Withdrawn
2024
- 2024-03-26 JP JP2024049322A patent/JP2024081713A/ja active Pending
- 2024-08-23 AU AU2024216311A patent/AU2024216311A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2901792T3 (es)	2022-03-23
AU2024216311A1 (en)	2024-09-12
US20160355888A1 (en)	2016-12-08
CA2981518C (en)	2024-06-25
WO2016161107A1 (en)	2016-10-06
MX2017012470A (es)	2018-03-23
US11447831B2 (en)	2022-09-20
BR112017020745A2 (en)	2018-07-17
AU2016243702B2 (en)	2021-10-07
JP2022185101A (ja)	2022-12-13
JP2018514517A (ja)	2018-06-07
BR122023024814A2 (pt)	2024-02-20
IL309066A (en)	2024-02-01
IL294449A (en)	2022-09-01
KR20170132248A (ko)	2017-12-01
IL294449B2 (en)	2024-05-01
US20230042181A1 (en)	2023-02-09
EP3277272B1 (en)	2021-08-04
MX2022005020A (es)	2022-05-16
CN107613969A (zh)	2018-01-19
US10697025B2 (en)	2020-06-30
CN107613969B (zh)	2022-07-22
IL254697A0 (en)	2017-11-30
US20180087115A1 (en)	2018-03-29
JP2024081713A (ja)	2024-06-18
US20180187271A1 (en)	2018-07-05
MX391949B (es)	2025-03-21
CN116059365A (zh)	2023-05-05
EP3277272A4 (en)	2018-09-26
IL254697B (en)	2022-08-01
AU2022200059B2 (en)	2024-05-23
US10167518B2 (en)	2019-01-01
JP2020203911A (ja)	2020-12-24
HUE057325T2 (hu)	2022-04-28
US20200392583A1 (en)	2020-12-17
EP3967305A1 (en)	2022-03-16
RU2017134582A (ru)	2019-04-04
AU2022200059A1 (en)	2022-02-03
RU2017134582A3 (pl)	2019-12-13
EP3277272A1 (en)	2018-02-07
AU2016243702A1 (en)	2017-10-26
IL294449B1 (en)	2024-01-01
JP6952604B2 (ja)	2021-10-20
CA2981518A1 (en)	2016-10-06
BR122023024813A2 (pt)	2024-02-20
US9845508B2 (en)	2017-12-19

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