PL328228A1 - 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system - Google Patents
1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous systemInfo
- Publication number
- PL328228A1 PL328228A1 PL97328228A PL32822897A PL328228A1 PL 328228 A1 PL328228 A1 PL 328228A1 PL 97328228 A PL97328228 A PL 97328228A PL 32822897 A PL32822897 A PL 32822897A PL 328228 A1 PL328228 A1 PL 328228A1
- Authority
- PL
- Poland
- Prior art keywords
- piperidines
- indol
- pyrazol
- ethyl
- nervous system
- Prior art date
Links
- JVDQJXRWNLNSER-UHFFFAOYSA-N 3-[1-[2-(1h-pyrazol-5-yl)ethyl]piperidin-4-yl]-1h-indole Chemical class C1CC(C=2C3=CC=CC=C3NC=2)CCN1CCC1=CC=NN1 JVDQJXRWNLNSER-UHFFFAOYSA-N 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19602505A DE19602505A1 (en) | 1996-01-25 | 1996-01-25 | 1- (pyrazol-4-indol-3-yl) piperidines |
| PCT/EP1997/000187 WO1997027186A1 (en) | 1996-01-25 | 1997-01-17 | 1-pyrazol-3-yl-ethyl-4-indol-3-yl-piperidine used as medicine acting on the central nervous system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL328228A1 true PL328228A1 (en) | 1999-01-18 |
Family
ID=7783568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL97328228A PL328228A1 (en) | 1996-01-25 | 1997-01-17 | 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0879234A1 (en) |
| JP (1) | JP2000503972A (en) |
| KR (1) | KR19990081970A (en) |
| CN (1) | CN1209807A (en) |
| AR (1) | AR005549A1 (en) |
| AU (1) | AU715785B2 (en) |
| BR (1) | BR9707467A (en) |
| CA (1) | CA2244136A1 (en) |
| CZ (1) | CZ231898A3 (en) |
| DE (1) | DE19602505A1 (en) |
| HU (1) | HUP9900980A2 (en) |
| NO (1) | NO983439L (en) |
| PL (1) | PL328228A1 (en) |
| SK (1) | SK99298A3 (en) |
| WO (1) | WO1997027186A1 (en) |
| ZA (1) | ZA97572B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1214312B1 (en) * | 1999-09-09 | 2004-04-14 | H. Lundbeck A/S | 5-aminoalkyl and 5-aminocarbonyl substituted indoles |
| ES2225252T3 (en) | 1999-11-10 | 2005-03-16 | Takeda Chemical Industries, Ltd. | 5-MEMBER N-HETEROCICLIC COMPOUNDS WITH HYPOGLUCEMIC AND HYPOLIPIDEMIC ACTIVITY. |
| AU2001281255B2 (en) | 2000-08-14 | 2006-07-20 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
| US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
| JP2005511625A (en) * | 2001-11-14 | 2005-04-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Pyrazole derivatives as psychotropic drugs |
| ATE477255T1 (en) | 2005-10-11 | 2010-08-15 | Hoffmann La Roche | IMIDAZOBENZDIAZEPINE DERIVATIVES |
| WO2007050381A2 (en) * | 2005-10-24 | 2007-05-03 | Janssen Pharmaceutica, N.V. | 3-piperidin-4-yl-indole orl-1 receptor modulators |
| TWI548630B (en) | 2011-04-06 | 2016-09-11 | Ｌｇ生命科學有限公司 | 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid crystalline form and the producing method thereof |
| MX2023004835A (en) * | 2020-11-04 | 2023-05-10 | Lg Chemical Ltd | Method for preparing crystalline particles of 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylic acid, and pharmaceutical composition comprising same. |
| AU2024298630A1 (en) * | 2023-07-24 | 2026-02-05 | Innovstone Therapeutics Limited | 5-ht2a receptor agonist, and preparation method therefor and use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2060816C3 (en) * | 1970-12-10 | 1980-09-04 | Merck Patent Gmbh, 6100 Darmstadt | 4-Phenylpiperidine derivatives Process for their production and pharmaceutical preparations containing these compounds |
| DE2258033A1 (en) * | 1972-11-27 | 1974-05-30 | Merck Patent Gmbh | 3-Heterocyclylalkyl-pyrazoles prodn. - by dehydrogenation or acid elimination from pyrazol(id)ines, useful as CNS depressants |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| US5045550A (en) * | 1990-09-20 | 1991-09-03 | Warner-Lambert Co. | Substituted tetrahydropyridines as central nervous system agents |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
-
1996
- 1996-01-25 DE DE19602505A patent/DE19602505A1/en not_active Withdrawn
-
1997
- 1997-01-17 CZ CZ982318A patent/CZ231898A3/en unknown
- 1997-01-17 PL PL97328228A patent/PL328228A1/en unknown
- 1997-01-17 EP EP97901049A patent/EP0879234A1/en not_active Withdrawn
- 1997-01-17 BR BR9707467A patent/BR9707467A/en unknown
- 1997-01-17 SK SK992-98A patent/SK99298A3/en unknown
- 1997-01-17 WO PCT/EP1997/000187 patent/WO1997027186A1/en not_active Ceased
- 1997-01-17 AU AU14432/97A patent/AU715785B2/en not_active Ceased
- 1997-01-17 CN CN97191852A patent/CN1209807A/en active Pending
- 1997-01-17 HU HU9900980A patent/HUP9900980A2/en unknown
- 1997-01-17 CA CA002244136A patent/CA2244136A1/en not_active Abandoned
- 1997-01-17 KR KR1019980705688A patent/KR19990081970A/en not_active Withdrawn
- 1997-01-17 JP JP9526493A patent/JP2000503972A/en active Pending
- 1997-01-23 ZA ZA9700572A patent/ZA97572B/en unknown
- 1997-01-24 AR ARP970100297A patent/AR005549A1/en unknown
-
1998
- 1998-07-24 NO NO983439A patent/NO983439L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK99298A3 (en) | 1999-01-11 |
| CA2244136A1 (en) | 1997-07-31 |
| NO983439D0 (en) | 1998-07-24 |
| WO1997027186A1 (en) | 1997-07-31 |
| DE19602505A1 (en) | 1997-07-31 |
| CN1209807A (en) | 1999-03-03 |
| KR19990081970A (en) | 1999-11-15 |
| BR9707467A (en) | 1999-07-20 |
| EP0879234A1 (en) | 1998-11-25 |
| HUP9900980A2 (en) | 1999-07-28 |
| CZ231898A3 (en) | 1998-10-14 |
| ZA97572B (en) | 1997-08-04 |
| AU1443297A (en) | 1997-08-20 |
| AR005549A1 (en) | 1999-06-23 |
| NO983439L (en) | 1998-09-25 |
| JP2000503972A (en) | 2000-04-04 |
| AU715785B2 (en) | 2000-02-10 |
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