PL328228A1 - 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system - Google Patents

1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system

Info

Publication number: PL328228A1
Authority: PL; Poland
Prior art keywords: piperidines; indol; pyrazol; ethyl; nervous system
Prior art date: 1996-01-25

Application number

PL97328228A

Inventor

Henning Boettcher

Joachim Maerz

Gerd Bartoszyk

Hartmut Greiner

Juergen Harting

Christoph Seyfried

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-25

Filing date

1997-01-17

Publication date

1999-01-18

1997-01-17 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1999-01-18 Publication of PL328228A1 publication Critical patent/PL328228A1/en

Links

JVDQJXRWNLNSER-UHFFFAOYSA-N 3-[1-[2-(1h-pyrazol-5-yl)ethyl]piperidin-4-yl]-1h-indole Chemical class C1CC(C=2C3=CC=CC=C3NC=2)CCN1CCC1=CC=NN1 JVDQJXRWNLNSER-UHFFFAOYSA-N 0.000 title 1
210000003169 central nervous system Anatomy 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL97328228A 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system PL328228A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19602505A DE19602505A1 (en)	1996-01-25	1996-01-25	1- (pyrazol-4-indol-3-yl) piperidines
PCT/EP1997/000187 WO1997027186A1 (en)	1996-01-25	1997-01-17	1-pyrazol-3-yl-ethyl-4-indol-3-yl-piperidine used as medicine acting on the central nervous system

Publications (1)

Publication Number	Publication Date
PL328228A1 true PL328228A1 (en)	1999-01-18

Family

ID=7783568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL97328228A PL328228A1 (en)	1996-01-25	1997-01-17	1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system

Country Status (16)

Country	Link
EP (1)	EP0879234A1 (en)
JP (1)	JP2000503972A (en)
KR (1)	KR19990081970A (en)
CN (1)	CN1209807A (en)
AR (1)	AR005549A1 (en)
AU (1)	AU715785B2 (en)
BR (1)	BR9707467A (en)
CA (1)	CA2244136A1 (en)
CZ (1)	CZ231898A3 (en)
DE (1)	DE19602505A1 (en)
HU (1)	HUP9900980A2 (en)
NO (1)	NO983439L (en)
PL (1)	PL328228A1 (en)
SK (1)	SK99298A3 (en)
WO (1)	WO1997027186A1 (en)
ZA (1)	ZA97572B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2219385T3 (en) *	1999-09-09	2004-12-01	H. Lundbeck A/S	INDOLES REPLACED WITH 5-AMINOALQUILO AND 5-AMINOCARBONILO.
HK1045991B (en)	1999-11-10	2004-12-10	Takeda Pharmaceutical Company Limited	5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
HK1052509B (en)	2000-08-14	2007-09-07	Ortho-Mcneil Pharmaceutical, Inc.	Substituted pyrazoles
US7332494B2 (en)	2000-08-14	2008-02-19	Janssen Pharmaceutica, N.V.	Method for treating allergies using substituted pyrazoles
PL369674A1 (en) *	2001-11-14	2005-05-02	Merck Patent Gmbh	Pyrazole derivatives as psychopharmaceuticals
KR101009860B1 (en)	2005-10-11	2011-01-19	에프. 호프만-라 로슈 아게	Imidazo Benzodiazepines Derivatives
AU2006306497A1 (en) *	2005-10-24	2007-05-03	Janssen Pharmaceutica, N.V.	3-piperidin-4-yl-indole ORL-1 receptor modulators
TWI548630B (en)	2011-04-06	2016-09-11	Ｌｇ生命科學有限公司	1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid crystalline form and the producing method thereof
EP4218755A4 (en) *	2020-11-04	2024-03-27	Lg Chem, Ltd.	Method for preparing crystalline particles of 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylic acid, and pharmaceutical composition comprising same
IL326081A (en) *	2023-07-24	2026-03-01	Innovstone Therapeutics Ltd	Receptor agonist, and preparation method therefor and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2060816C3 (en) *	1970-12-10	1980-09-04	Merck Patent Gmbh, 6100 Darmstadt	4-Phenylpiperidine derivatives Process for their production and pharmaceutical preparations containing these compounds
DE2258033A1 (en) *	1972-11-27	1974-05-30	Merck Patent Gmbh	3-Heterocyclylalkyl-pyrazoles prodn. - by dehydrogenation or acid elimination from pyrazol(id)ines, useful as CNS depressants
GB8719167D0 (en) *	1987-08-13	1987-09-23	Glaxo Group Ltd	Chemical compounds
US5045550A (en) *	1990-09-20	1991-09-03	Warner-Lambert Co.	Substituted tetrahydropyridines as central nervous system agents
US5521196A (en) *	1994-10-05	1996-05-28	Eli Lilly And Company	5-HT1F agonists for the treatment of migraine

1996
- 1996-01-25 DE DE19602505A patent/DE19602505A1/en not_active Withdrawn
1997
- 1997-01-17 HU HU9900980A patent/HUP9900980A2/en unknown
- 1997-01-17 PL PL97328228A patent/PL328228A1/en unknown
- 1997-01-17 CZ CZ982318A patent/CZ231898A3/en unknown
- 1997-01-17 JP JP9526493A patent/JP2000503972A/en active Pending
- 1997-01-17 EP EP97901049A patent/EP0879234A1/en not_active Withdrawn
- 1997-01-17 BR BR9707467A patent/BR9707467A/en unknown
- 1997-01-17 CN CN97191852A patent/CN1209807A/en active Pending
- 1997-01-17 SK SK992-98A patent/SK99298A3/en unknown
- 1997-01-17 KR KR1019980705688A patent/KR19990081970A/en not_active Withdrawn
- 1997-01-17 WO PCT/EP1997/000187 patent/WO1997027186A1/en not_active Ceased
- 1997-01-17 CA CA002244136A patent/CA2244136A1/en not_active Abandoned
- 1997-01-17 AU AU14432/97A patent/AU715785B2/en not_active Ceased
- 1997-01-23 ZA ZA9700572A patent/ZA97572B/en unknown
- 1997-01-24 AR ARP970100297A patent/AR005549A1/en unknown
1998
- 1998-07-24 NO NO983439A patent/NO983439L/en unknown

Also Published As

Publication number	Publication date
ZA97572B (en)	1997-08-04
HUP9900980A2 (en)	1999-07-28
EP0879234A1 (en)	1998-11-25
WO1997027186A1 (en)	1997-07-31
AU715785B2 (en)	2000-02-10
KR19990081970A (en)	1999-11-15
BR9707467A (en)	1999-07-20
CA2244136A1 (en)	1997-07-31
JP2000503972A (en)	2000-04-04
SK99298A3 (en)	1999-01-11
AR005549A1 (en)	1999-06-23
CN1209807A (en)	1999-03-03
DE19602505A1 (en)	1997-07-31
AU1443297A (en)	1997-08-20
NO983439D0 (en)	1998-07-24
CZ231898A3 (en)	1998-10-14
NO983439L (en)	1998-09-25

Publication	Publication Date	Title
ZA979985B (en)	1998-05-07	N-substituted 2-cyanopyrrolidines.
HU9503402D0 (en)	1996-02-28	Neurokinin receptor antagonists
ZA977011B (en)	1998-02-06	Muscarinic antagonists.
ZA977969B (en)	1998-03-18	Reflux inhibitors.
GB9719141D0 (en)	1997-11-12	Stabilizer combination
HUP0000487A3 (en)	2001-04-28	Subsituted oximes derivatives useful as neurokinin antagonists
ZA97303B (en)	1997-07-17	Pyrido-fused thienyl- and furanyl-oxazolidinones
PL332593A1 (en)	1999-09-27	N-substituted azaheterocyclic compounds
CY2408B1 (en)	2004-09-10	Paroxetine controlled release compositions.
GB9605207D0 (en)	1996-05-15	Address block location
GB9605027D0 (en)	1996-05-08	Quinoxalinediones
HUP9904622A3 (en)	2001-07-30	1,4-di-sustituted piperidines as muscarinic antagonists
HUP0202034A3 (en)	2006-04-28	Heterocyclic substituted aminoazacycles useful as central nervous system agents
ZA985875B (en)	2000-01-10	Azetidines.
PL342732A1 (en)	2001-07-02	1-(heteroarylpropyl- or -prop-2-enyl)-4 benzylpiperidine as antagopnists nmda receptor
AP9600901A0 (en)	1997-01-31	Azetidines
AU2446297A (en)	1997-11-19	Substituted piperazines and piperidines as central nervous system agents
HRP970302B1 (en)	2004-10-31	Overvoltage sink
ZA972131B (en)	1997-09-15	Stabilizer combination.
PL328228A1 (en)	1999-01-18	1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system
IL129121A0 (en)	2000-02-17	N-substituted azaheterocyclic compounds
PL334569A1 (en)	2000-03-13	Substituted 4-(6-fluoro-(1h)-indol-3-yl)-1,2,3,6-tetrahydropyridine for treating the central nervous system
EP1017279A4 (en)	2002-07-31	Methods for regulating trka expression
AU4376997A (en)	1998-05-05	N-substituted azaheterocyclic compounds
HRP970094A2 (en)	1998-06-30	1,4-dihydropyridine compounds