PL3286300T3 - Izolacja bona fide komórek progenitorowych trzustki - Google Patents

Izolacja bona fide komórek progenitorowych trzustki

Info

Publication number
PL3286300T3
PL3286300T3 PL16721712T PL16721712T PL3286300T3 PL 3286300 T3 PL3286300 T3 PL 3286300T3 PL 16721712 T PL16721712 T PL 16721712T PL 16721712 T PL16721712 T PL 16721712T PL 3286300 T3 PL3286300 T3 PL 3286300T3
Authority
PL
Poland
Prior art keywords
isolation
progenitor cells
pancreatic progenitor
bona fide
fide pancreatic
Prior art date
Application number
PL16721712T
Other languages
English (en)
Inventor
Jacqueline Ameri
Henrik Semb
Original Assignee
University Of Copenhagen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Copenhagen filed Critical University Of Copenhagen
Publication of PL3286300T3 publication Critical patent/PL3286300T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/585—Integrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
PL16721712T 2015-04-24 2016-04-21 Izolacja bona fide komórek progenitorowych trzustki PL3286300T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15164999 2015-04-24
EP16721712.4A EP3286300B1 (en) 2015-04-24 2016-04-21 Isolation of bona fide pancreatic progenitor cells
PCT/EP2016/058920 WO2016170069A1 (en) 2015-04-24 2016-04-21 Isolation of bona fide pancreatic progenitor cells

Publications (1)

Publication Number Publication Date
PL3286300T3 true PL3286300T3 (pl) 2021-05-04

Family

ID=53016496

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16721712T PL3286300T3 (pl) 2015-04-24 2016-04-21 Izolacja bona fide komórek progenitorowych trzustki

Country Status (11)

Country Link
US (3) US10494608B2 (pl)
EP (2) EP3286300B1 (pl)
JP (1) JP6954711B2 (pl)
CN (1) CN107787363B (pl)
CA (1) CA2983764A1 (pl)
CY (1) CY1123677T1 (pl)
DK (1) DK3286300T3 (pl)
ES (1) ES2840076T3 (pl)
PL (1) PL3286300T3 (pl)
PT (1) PT3286300T (pl)
WO (1) WO2016170069A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3286300T (pt) 2015-04-24 2020-12-28 Univ Copenhagen Isolamento de células progenitoras pancreáticas genuínas
JP7145209B2 (ja) 2017-06-14 2022-09-30 ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト （ゲーエムベーハー） ヒト胚性幹細胞から誘導された内胚葉及び膵内胚葉細胞を精製するための方法
WO2019227198A1 (en) 2018-05-31 2019-12-05 University Health Network (Uhn) Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells
EP3856205A4 (en) * 2018-09-25 2022-06-15 The Regents of the University of California Production and enrichment of pancreatic endocrine progenitor cells
JP7389980B2 (ja) * 2018-12-06 2023-12-01 国立大学法人 琉球大学 ヒト膵臓組織特異的幹／前駆細胞の人工作製方法
WO2021051256A1 (en) 2019-09-17 2021-03-25 Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences Pancreatic pro-endocrine progenitor cells and use thereof
WO2021080642A1 (en) * 2019-10-21 2021-04-29 President And Fellows Of Harvard College Compositions and methods for enhancing differentiation of stem cell-derived beta cells

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002367091A1 (en) 2001-12-28 2003-07-15 Cellartis Ab A method for the establishment of a pluripotent human blastocyst-derived stem cell line
EP1498478A1 (en) * 2002-04-17 2005-01-19 Otsuka Pharmaceutical Co., Ltd. Method of forming pancreatic beta cells from mesenchymal cells
AU2003252164A1 (en) 2002-07-25 2004-02-16 The Board Of Trustees Of The Leland Stanford Junoir University Insulin-producing cell compositions and related methods
US20050196784A1 (en) * 2002-11-01 2005-09-08 Decode Genetics Ehf. Human Type II diabetes gene - Kv channel-interacting protein (KChIP1) located on chromosome 5
WO2005045001A2 (en) 2003-02-14 2005-05-19 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
JP4819697B2 (ja) 2003-12-23 2011-11-24 ヴィアサイト，インコーポレイテッド 胚体内胚葉
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
WO2005116073A2 (en) 2004-04-27 2005-12-08 Cythera, Inc. Pdx1 expressing endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20060153894A1 (en) 2004-06-30 2006-07-13 Ragae Ghabrial Multi-compartment delivery system
CA2613812A1 (en) 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
EP1860950B1 (en) 2005-03-04 2017-04-19 Lifescan, Inc. Adult pancreatic derived stromal cells
AU2006301549B2 (en) 2005-10-07 2013-02-14 Cellartis Ab A method for obtaining a xeno-free hBS cell line
DK2650359T3 (da) 2006-03-02 2022-06-13 Viacyte Inc Endokrine prekursorceller, pancreatiske hormon-udtrykkende celler og fremstillingsfremgangsmåder
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
WO2007127927A2 (en) 2006-04-28 2007-11-08 Lifescan, Inc. Differentiation of human embryonic stem cells
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2007130474A2 (en) * 2006-05-02 2007-11-15 Wisconsin Alumni Research Foundation Method of differentiating stem cells into cells of the endoderm and pancreatic lineage
AU2007277364B2 (en) 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
WO2008094597A2 (en) 2007-01-30 2008-08-07 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
ES2537578T3 (es) 2007-07-18 2015-06-09 Lifescan, Inc. Diferenciación de las células madre de embriones humanos
US9096832B2 (en) 2007-07-31 2015-08-04 Lifescan, Inc. Differentiation of human embryonic stem cells
WO2009083502A1 (en) 2007-12-28 2009-07-09 Novo Nordisk A/S Ddr1-mediated cell purification of pancreatic endocrine cells through their progenitors
EP2263083A1 (en) 2008-04-03 2010-12-22 Novo Nordisk A/S Dner-mediated cell purification of pancreatic endocrine pre-progenitor cells and their progeny
WO2009126927A2 (en) 2008-04-11 2009-10-15 Joslin Diabetes Center, Inc. Methods of generating insulin-producing cells
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
DK2283117T3 (da) 2008-04-21 2014-01-20 Viacyte Inc Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US20090280096A1 (en) * 2008-05-09 2009-11-12 Atsushi Kubo Pancreatic endocrine progenitor cells derived from pluripotent stem cells
TWI438275B (zh) 2008-06-11 2014-05-21 Healthbanks Biotech Co Ltd 促進幹細胞分化為胰島素製造細胞的方法
EP2356213B1 (en) 2008-11-04 2019-05-29 Viacyte, Inc. Stem cell aggregate suspension compositions and methods for differentiation thereof
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト，インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
DE102008063951A1 (de) 2008-12-19 2010-06-24 Leopold Kostal Gmbh & Co. Kg Winkelsensor
US8927274B2 (en) 2010-04-12 2015-01-06 Technion Research & Development Foundation Limited Populations of pancreatic progenitor cells and methods of isolating and using same
WO2012056997A1 (ja) 2010-10-28 2012-05-03 国立大学法人熊本大学 多能性幹細胞の分化誘導効率を改善するための方法及び培地
WO2012070014A2 (en) * 2010-11-26 2012-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells
RU2691027C2 (ru) 2011-12-05 2019-06-07 Фэктор Байосайенс Инк. Способы и препараты для трансфекции клеток
WO2013106844A2 (en) * 2012-01-13 2013-07-18 Oncocyte Corporation Methods and compositions for the treatment and diaginosis of pancreatic cancer
CN104411815B (zh) 2012-04-30 2017-11-28 大学健康网络 用于从hPSC生成胰腺祖细胞和功能性β细胞的方法和组合物
WO2013188138A1 (en) 2012-06-11 2013-12-19 The Regents Of The University Of California Inhibitors of hippo-yap signaling pathway
US20140030234A1 (en) 2012-07-12 2014-01-30 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating islet beta cell development
BR112015001435B1 (pt) 2012-08-06 2022-01-18 Brainstorm Cell Therapeutics Ltd Métodos para geração de células que secretam fator neurotrófico derivado do cérebro (bdnf), fator neurotrófico derivado da glia (gdnf), fator de crescimento de hepatócitos (hgf) e fator de crescimento endotelial vascular (vegf) em que as referidas células não secretam fator de crescimento do nervo(ngf)
WO2014127219A1 (en) 2013-02-14 2014-08-21 The Cleveland Clinic Foundation Methods for induction of cell fates from pluripotent cells
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
US20140329704A1 (en) * 2013-03-28 2014-11-06 President And Fellows Of Harvard College Markers for mature beta-cells and methods of using the same
KR102580225B1 (ko) 2013-06-11 2023-09-20 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 SC-β 세포 및 조성물 그리고 그 생성 방법
EP3143129A1 (en) 2014-05-14 2017-03-22 The University Court of The University of Aberdeen Methods of obtaining islet cells
US10865387B2 (en) 2014-05-14 2020-12-15 The University Court Of The University Of Aberdeen Regent Walk Methods of obtaining pancreatic endocrine cells
WO2016138464A1 (en) 2015-02-27 2016-09-01 Salk Institute For Biological Studies Reprogramming progenitor compositions and methods of use therefore
PT3286300T (pt) 2015-04-24 2020-12-28 Univ Copenhagen Isolamento de células progenitoras pancreáticas genuínas
WO2018159805A1 (ja) 2017-03-03 2018-09-07 国立大学法人京都大学 膵前駆細胞の製造方法
JP7145209B2 (ja) 2017-06-14 2022-09-30 ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト （ゲーエムベーハー） ヒト胚性幹細胞から誘導された内胚葉及び膵内胚葉細胞を精製するための方法
US20190128885A1 (en) 2017-07-25 2019-05-02 University Health Network Selection of pancreatic progenitors

Also Published As

Publication number Publication date
US20180127724A1 (en) 2018-05-10
EP3819372A3 (en) 2021-10-06
HK1248277A1 (zh) 2018-10-12
EP3286300B1 (en) 2020-10-21
PT3286300T (pt) 2020-12-28
CN107787363A (zh) 2018-03-09
US10494608B2 (en) 2019-12-03
JP2018512886A (ja) 2018-05-24
US20230227788A1 (en) 2023-07-20
US11613736B2 (en) 2023-03-28
CN107787363B (zh) 2021-06-25
WO2016170069A1 (en) 2016-10-27
JP6954711B2 (ja) 2021-10-27
US20200080062A1 (en) 2020-03-12
CY1123677T1 (el) 2022-03-24
EP3819372A2 (en) 2021-05-12
CA2983764A1 (en) 2016-10-27
DK3286300T3 (da) 2021-01-18
ES2840076T3 (es) 2021-07-06
EP3286300A1 (en) 2018-02-28

Similar Documents

Publication Publication Date Title
IL267378A (en) A system for creating a spray with pairs of electrodes
IL257026A (en) Solid state forms of eluxadoline
PT3286300T (pt) Isolamento de células progenitoras pancreáticas genuínas
IL259762B (en) Complement activity modulators
GB2536295B (en) Forming of battery components
PL3221873T3 (pl) System do zabezpieczenia transformatorów typu suchego
SI3154526T1 (sl) Trdne oblike sofosbuvira
IL285882A (en) Medicinal uses for l–4–chlorokynurenine
PL3250230T3 (pl) Modulatory aktywności dopełniacza
PT3334734T (pt) Forma c de avibactam sódico
IL265628A (en) Solid state forms of valbenazine
IL246979A0 (en) Crystalline forms of sofosbuvir
ZA201706282B (en) Solid forms of menaquinols
GB201522223D0 (en) Therapeutic T cells
PT3125867T (pt) Composição hiperosmolar de ácido hialurónico
GB201504459D0 (en) Isolation of DNA
GB2550525B (en) Forming of battery components
GB201408753D0 (en) Isolation of adipose derived cells
IL254666A0 (en) Crystalline forms of Aldecalcitol
GB201621464D0 (en) Set of panels
GB2534560B (en) Preparation of Composite Substrates
GB201511395D0 (en) St bernard of liverpool
IL249332A0 (en) Crystalline forms of sofosbuvir
TWM490651U (en) Improved structure of switch
GB201519795D0 (en) Construction of surfaces