PL329150A1 - Amidic derivatives and pharmaceutic composition containing such compounds - Google Patents

Amidic derivatives and pharmaceutic composition containing such compounds

Info

Publication number
PL329150A1
PL329150A1 PL98329150A PL32915098A PL329150A1 PL 329150 A1 PL329150 A1 PL 329150A1 PL 98329150 A PL98329150 A PL 98329150A PL 32915098 A PL32915098 A PL 32915098A PL 329150 A1 PL329150 A1 PL 329150A1
Authority
PL
Poland
Prior art keywords
compounds
composition containing
pharmaceutic composition
amidic derivatives
amidic
Prior art date
Application number
PL98329150A
Other versions
PL192411B1 (en
Inventor
Hirokazu Kubota
Yasuhiro Yonetoku
Keizou Sugasawa
Masashi Funatsu
Souichirou Kawazoe
Akira Toyoshima
Yoshinori Okamoto
Jun Ishikawa
Makoto Takeuchi
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of PL329150A1 publication Critical patent/PL329150A1/en
Publication of PL192411B1 publication Critical patent/PL192411B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL329150A 1997-10-13 1998-10-12 Amidic derivatives and pharmaceutic composition containing such compounds PL192411B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27909397 1997-10-13

Publications (2)

Publication Number Publication Date
PL329150A1 true PL329150A1 (en) 1999-04-26
PL192411B1 PL192411B1 (en) 2006-10-31

Family

ID=17606326

Family Applications (1)

Application Number Title Priority Date Filing Date
PL329150A PL192411B1 (en) 1997-10-13 1998-10-12 Amidic derivatives and pharmaceutic composition containing such compounds

Country Status (18)

Country Link
US (4) US6348480B1 (en)
EP (1) EP1024138B1 (en)
KR (1) KR100589868B1 (en)
CN (1) CN1107671C (en)
AR (1) AR016957A1 (en)
AT (1) ATE360618T1 (en)
AU (2) AU751139B2 (en)
BR (1) BR9803883A (en)
CA (1) CA2304979A1 (en)
DE (1) DE69837675T2 (en)
ES (1) ES2285784T3 (en)
HU (1) HUP9802310A1 (en)
NO (1) NO317417B1 (en)
PL (1) PL192411B1 (en)
PT (1) PT1024138E (en)
RU (1) RU2185381C2 (en)
TW (1) TW495498B (en)
WO (1) WO1999019303A1 (en)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
WO1999051580A1 (en) * 1998-04-08 1999-10-14 Abbott Laboratories Pyrazole inhibitors of cytokine production
WO1999062885A1 (en) * 1998-06-05 1999-12-09 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
CA2338804A1 (en) * 1998-07-28 2000-02-10 Smithkline Beecham Corporation Propenamides as ccr5 modulators
WO2000006550A1 (en) * 1998-07-31 2000-02-10 Nippon Soda Co., Ltd. Phenylazole compounds, process for producing the same and drugs for hyperlipemia
JP2001031509A (en) * 1999-07-15 2001-02-06 Nippon Bayer Agrochem Co Ltd Use of thienyl-pyrazoles as harmful organism controller
AU2001231143A1 (en) * 2000-01-27 2001-08-07 Cytovia, Inc. Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof
US6451820B1 (en) 2000-03-23 2002-09-17 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents
US6353007B1 (en) * 2000-07-13 2002-03-05 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents
EP1184457A1 (en) * 2000-09-05 2002-03-06 Warner-Lambert Company Identification of a capacitative calcium channel in antigen presenting cells and uses thereof
EP1186661A1 (en) * 2000-09-05 2002-03-13 Warner-Lambert Company Identification of the major capacitative calcium channel in antigen presenting cells and uses thereof
US7132546B2 (en) 2000-12-22 2006-11-07 Ishihara Sangyo Kaisha, Ltd. Aniline derivatives or salts thereof and cytokine production inhibitors containing the same
AU2002312348A1 (en) * 2001-06-06 2002-12-16 Agouron Pharmaceuticals, Inc. Non-peptide gnrh agents, pharmaceutical compositions and methods for their uses, and processes for preparing them
DE60222264T2 (en) 2001-06-29 2008-01-03 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield PHENYLPYRAZOL DERIVATIVES AS SEH INHIBITORS
GB0209715D0 (en) * 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
US7309710B2 (en) 2002-08-27 2007-12-18 Astellas Pharma Inc. Crystals
US20040077650A1 (en) * 2002-10-18 2004-04-22 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7790724B2 (en) * 2003-04-25 2010-09-07 Janssen Pharmaceutica N.V. c-fms kinase inhibitors
TWI376370B (en) * 2003-07-23 2012-11-11 Synta Pharmaceuticals Corp Compounds for inflammation and immune-related uses
MXPA06007326A (en) 2003-12-23 2007-01-26 Astex Therapeutics Ltd Pyrazole derivatives as protein kinase modulators.
PT1725544E (en) * 2004-03-09 2009-07-02 Boehringer Ingelheim Pharma 3-[4-heterocyclyl-1,2,3-triazol-1-yl]-n-aryl-benzamides as inhibitors of the cytokines production for the treatment of chronic inflammatory diseases
WO2005091752A2 (en) * 2004-03-25 2005-10-06 Synta Pharmaceuticals Corp. Acrylonitrile derivatives for inflammation and immune-related uses
TW200633990A (en) * 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
EP1875925A1 (en) * 2005-04-22 2008-01-09 Astellas Pharma Inc. Preventive or remedy for bowel disease
GB2427406A (en) * 2005-06-21 2006-12-27 Astex Technology Ltd Silicon-containing PKB/PKA kinase inhibitors
US8343953B2 (en) 2005-06-22 2013-01-01 Astex Therapeutics Limited Pharmaceutical compounds
WO2006136837A2 (en) 2005-06-23 2006-12-28 Astex Therapeutics Limited Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators
US7816535B2 (en) * 2006-01-25 2010-10-19 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
BRPI0708337A2 (en) 2006-02-28 2011-05-24 Helicon Therapeutics Inc therapeutic pipirazines as pde4 inhibitors
AU2013200480B2 (en) * 2006-02-28 2016-06-09 Dart Neuroscience (Cayman) Ltd. Therapeutic compounds
NZ570847A (en) 2006-02-28 2011-10-28 Helicon Therapeutics Inc Therapeutic compounds
US7803799B2 (en) * 2006-07-07 2010-09-28 National Health Research Institutes Selenophene compounds
EP2058309A4 (en) * 2006-08-04 2010-12-22 Takeda Pharmaceutical HETEROCYCLIC COMPOUND WITH FUSED CYCLES
MX2009002019A (en) * 2006-08-24 2009-03-09 Novartis Ag 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders.
BRPI0716239A2 (en) 2006-08-30 2013-08-13 Cellzome Ltd triazole derivatives as kinase inhibitors
TWI339205B (en) * 2006-10-02 2011-03-21 Nat Health Research Institutes Pyrazole compounds and pharmaceutical composition
TWI408136B (en) * 2006-10-02 2013-09-11 Nat Health Research Institutes Thiophene compound and its pharmaceutical composition
UY30892A1 (en) 2007-02-07 2008-09-02 Smithkline Beckman Corp AKT ACTIVITY INHIBITORS
NZ580195A (en) * 2007-03-05 2012-03-30 Univ Queensland Targeting crac for breast cancer therapy and/or diagnosis
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
KR101669432B1 (en) 2007-08-27 2016-10-26 다트 뉴로사이언스 (케이만) 엘티디. Therapeutic isoxazole compounds
GB0801888D0 (en) * 2008-02-01 2008-03-12 Isis Innovation Treatment of mast cell related disorders
DE102008014523A1 (en) * 2008-03-15 2009-09-17 Robert Bosch Gmbh heater
EP2565191B1 (en) * 2008-05-14 2014-10-08 Astellas Pharma Inc. 4-(Indol-7-ylcarbonylaminomethyl)cyclohexanecarboxylic acid derivatives as EP4 receptor antagonists useful for the treatment of chronic renal failure or diabetic nephropathy
JP2010030970A (en) * 2008-07-31 2010-02-12 Bayer Cropscience Ag Insecticidal benzenedicarboxamide derivative
TWI434686B (en) * 2008-11-03 2014-04-21 Nat Health Research Institutes Imidazol-4-one and imidazole-4-thione compounds
CN102405047B (en) * 2009-01-30 2014-07-09 葛兰素史密斯克莱有限责任公司 Crystalline n-{(1-s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
EP2421834A1 (en) 2009-04-24 2012-02-29 Glaxo Group Limited Pyrazole and triazole carboxamides as crac channel inhibitors
AR076373A1 (en) 2009-04-24 2011-06-08 Glaxo Group Ltd N-PIRAZOLIL CARBOXAMIDS AS CALCIUM CHANNEL INHIBITORS
WO2010126002A1 (en) * 2009-04-28 2010-11-04 塩野義製薬株式会社 Pharmaceutical product containing heterocyclic sulfonamide compound
WO2010144664A1 (en) * 2009-06-12 2010-12-16 Schering Corporation Thiophenes as glucagon receptor antagonists, compositions, and methods for their use
US8377970B2 (en) * 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
US8993612B2 (en) 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2563759B1 (en) * 2010-04-27 2022-04-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
JP6112486B2 (en) 2010-04-27 2017-04-12 カルシメディカ，インク． Compounds that regulate intracellular calcium
EP2609095A4 (en) 2010-08-27 2014-06-18 Calcimedica Inc Compounds that modulate intracellular calcium
EP2630127A1 (en) 2010-10-21 2013-08-28 Glaxo Group Limited Pyrazole compounds acting against allergic, inflammatory and immune disorders
US9156791B2 (en) 2010-10-21 2015-10-13 Glaxo Group Limited Pyrazole compounds acting against allergic, immune and inflammatory conditions
CA2834928C (en) * 2011-05-03 2017-10-17 Synta Pharmaceuticals Corp. Compounds for inflammation and immune-related uses
US20120316182A1 (en) 2011-06-10 2012-12-13 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059666A1 (en) * 2011-10-19 2013-04-25 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059677A1 (en) 2011-10-19 2013-04-25 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013164773A1 (en) * 2012-05-02 2013-11-07 Lupin Limited Substituted pyrazole compounds as crac modulators
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
AR094412A1 (en) 2013-01-10 2015-07-29 Gruenenthal Gmbh CARBOXAMIDS BASED ON PIRAZOLILO I
KR20150103752A (en) 2013-01-10 2015-09-11 그뤼넨탈 게엠베하 Pyrazolyl-based carboxamides ii as crac channel inhibitors
AU2014296278C1 (en) 2013-07-30 2023-02-02 Genevant Sciences Gmbh Block copolymers and their conjugates or complexes with oligonucleotides
AU2014365740A1 (en) * 2013-12-19 2016-05-26 Grünenthal GmbH Fluoromethyl-substituted pyrrole carboxamides iv
WO2015090603A1 (en) * 2013-12-19 2015-06-25 Grünenthal GmbH Fluoromethyl-substituted pyrrole carboxamides iii
CN104926801B (en) * 2014-03-22 2019-06-04 浙江大学 Substituted nitrogen heterocyclic derivatives, pharmaceutical compositions containing them and their application in antitumor
WO2015197187A1 (en) 2014-06-24 2015-12-30 Grünenthal GmbH Pyrazolyl-based carboxamides v
JP2018509387A (en) 2015-01-21 2018-04-05 フェーズアールエックス インコーポレイテッド Methods, compositions, and systems for delivering therapeutic and diagnostic agents to cells
EP3778595B1 (en) 2015-02-27 2021-08-25 Calcimedica, Inc. Pancreatitis treatment
CA2995094A1 (en) 2015-08-07 2017-02-16 Calcimedica, Inc. Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury
CN105503832B (en) * 2015-12-18 2018-03-27 浙江大学 Substituted pyrazolecarboxylic ring analog derivative and application thereof
EP3562510A4 (en) 2016-12-30 2021-01-06 Genevant Sciences GmbH BRANCHED PEG MOLECULES, ASSOCIATED COMPOSITIONS AND PROCESSES
WO2020053834A1 (en) 2018-09-14 2020-03-19 Rhizen Pharmaceuticals Sa Compositions comprising a crac inhibitor and a corticosteroid and methods of use thereof
CN111187204B (en) * 2020-01-13 2022-11-08 海利尔药业集团股份有限公司 Acetamiprid eutectic crystal and preparation method and application thereof
CA3169697A1 (en) * 2020-02-28 2021-09-02 Dominic Reynolds Thiophenyl derivatives useful for modulating nucleic acid splicing
JP2023528537A (en) 2020-03-20 2023-07-04 カルシメディカ，インク． Methods and compositions for treating acute lung injury and acute respiratory distress syndrome
CA3198798A1 (en) 2020-11-13 2022-05-19 Kenneth Stauderman Improved synthesis of crac channel inhibitors
WO2024126777A1 (en) * 2022-12-16 2024-06-20 Astrazeneca Ab Heteroaromatic compounds

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3401911A1 (en) * 1984-01-20 1985-08-01 A. Nattermann & Cie GmbH, 5000 Köln SUBSTITUTED 4,5-DIHYDRO-6-VINYL-3 (2H) -PYRIDAZINONE AND 6-VINYL-3 (2H) -PYRIDAZINONE AND METHOD FOR THE PRODUCTION THEREOF
GB8409986D0 (en) * 1984-04-17 1984-05-31 Beecham Group Plc Beta-lactam antibacterial agents
CA1292234C (en) * 1984-05-29 1991-11-19 Simon Fraser Campbell Heterocyclic-substituted quinolone inotropic agents
JPS6455557A (en) * 1987-08-26 1989-03-02 Fuji Photo Film Co Ltd Silver halide color photographic sensitive material
US5571821A (en) * 1993-05-20 1996-11-05 Texas Biotechnology Corporation Sulfonamides and derivatives thereof that modulate the activity of endothelin
JPH0419721Y2 (en) 1987-09-29 1992-05-06
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
JP2867450B2 (en) 1989-08-17 1999-03-08 吉富製薬株式会社 Alkylene bisamide compounds
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
FR2659655B1 (en) * 1990-03-19 1992-07-24 Union Pharma Scient Appl NOVEL ANGIOTENSIN II RECEPTOR ANTAGONIST OXYPYRAZOLE DERIVATIVES; THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE4126994A1 (en) * 1991-08-16 1993-02-18 Basf Ag (ALPHA) -ARYLACRYLIC ACID DERIVATIVES, THEIR PRODUCTION AND USE FOR CONTROLLING PLANTS AND MUSHROOMS
JP3141261B2 (en) 1992-10-22 2001-03-05 松下電工株式会社 Alarm indicator
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
JPH07225401A (en) * 1994-02-14 1995-08-22 Fuji Photo Film Co Ltd Nonlinear optical material
WO1995032963A1 (en) * 1994-06-01 1995-12-07 Yoshitomi Pharmaceutical Industries, Ltd. Thienylazole compound and thienotriazolodiazepine compound
GB9414139D0 (en) * 1994-07-13 1994-08-31 Smithkline Beecham Plc Novel compounds
KR970706242A (en) * 1994-10-04 1997-11-03 후지야마 아키라 Urea derivatives and their use as ACAT-inhibitors (Urea derivatives and their use as ACAT-inhibitors)
DK0808312T3 (en) * 1995-02-02 2001-02-12 Smithkline Beecham Plc Indole derivatives as a 5-HT receptor antagonist
WO1996031517A1 (en) * 1995-04-04 1996-10-10 E.I. Du Pont De Nemours And Company Herbicidal heteroaryl-substituted anilides
BR9606546A (en) 1995-08-02 1998-07-14 Uriach & Cia Sa J New carboxamides with fungicidal activity
JPH1072434A (en) * 1996-04-08 1998-03-17 Nissan Chem Ind Ltd 2, 4-substituted aniline derivative
AU6229298A (en) 1997-02-20 1998-09-09 Shionogi & Co., Ltd. Indole dicarboxylic acid derivatives
AU6320998A (en) * 1997-02-21 1998-09-09 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents
DE19708928A1 (en) * 1997-03-05 1998-09-10 Bayer Ag Substituted aromatic amino compounds
DE19744026A1 (en) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazole derivatives, their preparation and their use in medicinal products
AU751139B2 (en) * 1997-10-13 2002-08-08 Astellas Pharma Inc. Amide derivative
WO1999051580A1 (en) 1998-04-08 1999-10-14 Abbott Laboratories Pyrazole inhibitors of cytokine production
WO1999062885A1 (en) * 1998-06-05 1999-12-09 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
US6140509A (en) * 1998-06-26 2000-10-31 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof
US20010044445A1 (en) * 1999-04-08 2001-11-22 Bamaung Nwe Y. Azole inhibitors of cytokine production

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KR19990037018A (en) 1999-05-25
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US7285554B2 (en) 2007-10-23
HU9802310D0 (en) 1998-12-28
CN1107671C (en) 2003-05-07
DE69837675T2 (en) 2008-01-10
AU751139B2 (en) 2002-08-08
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BR9803883A (en) 2000-05-16
US20050234055A1 (en) 2005-10-20
US6348480B1 (en) 2002-02-19
US6958339B2 (en) 2005-10-25
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US20060264430A1 (en) 2006-11-23
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