PL3294762T3 - Konstrukty ekspresyjne i sposoby inżynierii genetycznej drożdży metylotroficznych - Google Patents
Konstrukty ekspresyjne i sposoby inżynierii genetycznej drożdży metylotroficznychInfo
- Publication number
- PL3294762T3 PL3294762T3 PL16793420T PL16793420T PL3294762T3 PL 3294762 T3 PL3294762 T3 PL 3294762T3 PL 16793420 T PL16793420 T PL 16793420T PL 16793420 T PL16793420 T PL 16793420T PL 3294762 T3 PL3294762 T3 PL 3294762T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- genetic engineering
- methylotrophic yeast
- expression structures
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/84—Pichia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562159899P | 2015-05-11 | 2015-05-11 | |
| US201562183074P | 2015-06-22 | 2015-06-22 | |
| US201562185921P | 2015-06-29 | 2015-06-29 | |
| US201562203052P | 2015-08-10 | 2015-08-10 | |
| US201562220366P | 2015-09-18 | 2015-09-18 | |
| US201562222388P | 2015-09-23 | 2015-09-23 | |
| US201562236506P | 2015-10-02 | 2015-10-02 | |
| US201662313491P | 2016-03-25 | 2016-03-25 | |
| PCT/US2016/031797 WO2016183163A1 (en) | 2015-05-11 | 2016-05-11 | Expression constructs and methods of genetically engineering methylotrophic yeast |
| EP16793420.7A EP3294762B1 (en) | 2015-05-11 | 2016-05-11 | Expression constructs and methods of genetically engineering methylotrophic yeast |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3294762T3 true PL3294762T3 (pl) | 2022-04-25 |
Family
ID=57249545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16793420T PL3294762T3 (pl) | 2015-05-11 | 2016-05-11 | Konstrukty ekspresyjne i sposoby inżynierii genetycznej drożdży metylotroficznych |
Country Status (21)
| Country | Link |
|---|---|
| US (6) | US10689656B2 (pl) |
| EP (3) | EP4624565A3 (pl) |
| JP (5) | JP6831797B2 (pl) |
| KR (4) | KR102504198B1 (pl) |
| CN (1) | CN107614516A (pl) |
| AU (4) | AU2016262494B2 (pl) |
| CA (1) | CA2985641A1 (pl) |
| CY (1) | CY1125979T1 (pl) |
| DK (1) | DK3294762T3 (pl) |
| ES (2) | ES3051659T3 (pl) |
| HR (1) | HRP20220299T1 (pl) |
| HU (1) | HUE058104T2 (pl) |
| LT (1) | LT3294762T (pl) |
| MX (3) | MX2017014469A (pl) |
| NZ (1) | NZ737094A (pl) |
| PL (1) | PL3294762T3 (pl) |
| PT (1) | PT3294762T (pl) |
| RS (1) | RS63099B1 (pl) |
| SI (1) | SI3294762T1 (pl) |
| SM (1) | SMT202200124T1 (pl) |
| WO (1) | WO2016183163A1 (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20220299T1 (hr) * | 2015-05-11 | 2022-05-13 | Impossible Foods Inc. | Ekspresijski konstrukti i postupci za genetsku modifikaciju metilotrofnog kvasca |
| WO2018132821A2 (en) * | 2017-01-13 | 2018-07-19 | Bolt Threads, Inc. | Elastomeric proteins |
| US20190359977A1 (en) * | 2017-01-25 | 2019-11-28 | Altius Institute For Biomedical Sciences | Methods and Platform of Designing Genetic Editing Tools |
| EP3684389A4 (en) | 2017-09-21 | 2021-06-16 | Dana Farber Cancer Institute, Inc. | Isolation, preservation, compositions and uses of extracts from justicia plants |
| US11051532B2 (en) | 2017-09-22 | 2021-07-06 | Impossible Foods Inc. | Methods for purifying protein |
| US10221403B1 (en) * | 2018-04-25 | 2019-03-05 | Life Rainbow Biotech Co., Ltd. | Method of preparing zearalenone hydrolase |
| CN108913732B (zh) * | 2018-07-31 | 2022-02-08 | 华东理工大学 | 一种莫纳可林j异源生产的方法及应用 |
| CN111286520B (zh) * | 2018-12-10 | 2021-05-07 | 上海凯赛生物技术股份有限公司 | 用于发酵生产l-赖氨酸的重组dna、菌株及其应用 |
| CN109749948A (zh) * | 2019-03-05 | 2019-05-14 | 天津科技大学 | 一种利用tef1启动子调控黏玉米谷氨酰胺转氨酶表达的重组毕赤酵母菌株及构建方法 |
| CN109929769B (zh) * | 2019-03-05 | 2021-07-23 | 天津科技大学 | 一种利用fld1启动子调控黏玉米谷氨酰胺转氨酶表达的重组毕赤酵母菌株及构建方法 |
| AU2020257270B2 (en) * | 2019-04-17 | 2026-01-15 | Impossible Foods Inc. | Materials and methods for protein production |
| WO2020219972A1 (en) | 2019-04-25 | 2020-10-29 | Impossible Foods Inc. | Strains and methods for production of heme-containing proteins |
| CN114761542A (zh) | 2019-11-27 | 2022-07-15 | 伊夫罗生物科学公司 | 用于培养血红蛋白依赖性细菌的方法和组合物 |
| EP4084629A4 (en) | 2019-12-31 | 2023-12-27 | Air Protein, Inc. | HIGH PROTEIN FOOD COMPOSITIONS |
| CN114929879A (zh) * | 2020-01-10 | 2022-08-19 | 尹特荣生物科技株式会社 | 一种利用大肠杆菌制备大豆豆血红蛋白的方法 |
| JP2023515676A (ja) | 2020-03-02 | 2023-04-13 | エア プロテイン,インコーポレイテッド | 構造化高タンパク質代用肉組成物 |
| US12011016B2 (en) | 2020-09-14 | 2024-06-18 | Impossible Foods Inc. | Protein methods and compositions |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| CA3191387A1 (en) | 2020-09-30 | 2022-04-07 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| WO2022072846A2 (en) | 2020-10-02 | 2022-04-07 | Impossible Foods Inc. | Transgenic plants with altered fatty acid profiles and upregulated heme biosynthesis |
| WO2022072833A2 (en) | 2020-10-02 | 2022-04-07 | Impossible Foods Inc. | Expression constructs and methods of genetically engineering cells |
| AU2021391607A1 (en) * | 2020-12-02 | 2023-06-29 | Planeat Foods Pte. Ltd. | Method of producing globin polypeptide recombinantly and meat substitute food product |
| US20240110168A1 (en) * | 2020-12-02 | 2024-04-04 | Genzyme Corporation | Polypeptide Having Beta-Hexosaminidase Activity, and Polynucleotides Coding for the Same |
| WO2022251166A2 (en) | 2021-05-25 | 2022-12-01 | Evelo Biosciences, Inc. | Bacterial compositions comprising soy hemoglobin |
| CA3231125A1 (en) | 2021-10-19 | 2023-04-27 | Joshua MARCH | Plant base/animal cell hybrid meat substitute |
| WO2023114395A1 (en) * | 2021-12-16 | 2023-06-22 | Impossible Foods Inc. | A genetic factor to increase expression of recombinant proteins |
| US11931687B2 (en) | 2022-02-15 | 2024-03-19 | Streamline Innovations, Inc. | Gas purification apparatus and method |
| KR102804540B1 (ko) | 2022-05-25 | 2025-05-07 | 한화솔루션 주식회사 | 야생형 효모 균주를 이용한 헴 고생산 방법 |
| US20250388947A1 (en) * | 2022-07-29 | 2025-12-25 | Nanjing Bestzyme Bio-Engineering Co., Ltd. | Chimeric transcriptional activator and use thereof |
| KR20240098834A (ko) | 2022-12-21 | 2024-06-28 | 한화솔루션 주식회사 | 고농도의 헴을 생산하는 효모 돌연변이 균주 및 이를 이용한 헴 고생산 방법 |
| CN116042621A (zh) * | 2023-01-06 | 2023-05-02 | 江南大学 | 一种酵母杂交启动子及其应用 |
| CN120769861A (zh) | 2023-02-08 | 2025-10-10 | 丹尼斯科美国公司 | 用于在丝状真菌细胞中生产异源球蛋白的组合物和方法 |
| KR20240162935A (ko) | 2023-05-09 | 2024-11-18 | 한화솔루션 주식회사 | 고농도의 헴을 생산하는 효모 돌연변이 균주 hs-y010 및 이를 이용한 헴 고생산 방법 |
| KR20240162936A (ko) | 2023-05-09 | 2024-11-18 | 한화솔루션 주식회사 | 고농도의 헴을 생산하는 효모 돌연변이 균주 hs-y007 및 이를 이용한 헴 고생산 방법 |
| CN121263531A (zh) * | 2023-06-06 | 2026-01-02 | 富士胶片株式会社 | 基因重组酵母、目标蛋白质的制造方法、试剂盒及基因重组酵母的制造方法 |
| WO2025247966A1 (en) * | 2024-05-29 | 2025-12-04 | Mybios Gmbh | Process for protein production in methylotrophic yeast host cell. |
| WO2025259480A2 (en) | 2024-06-12 | 2025-12-18 | Streamline Innovations Inc | Gas purification apparatus with eductor reduction unit and method |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4158065A (en) | 1977-12-16 | 1979-06-12 | Sugiyo Co., Ltd. | Crab meat substitute and method of preparing same |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| DK162399C (da) | 1986-01-28 | 1992-03-23 | Danisco | Fremgangsmaade til ekspression af gener i baelgplanteceller, dna-fragment, rekombineret dna-fragment samt plasmid til brug ved udoevelsen af fremgangsmaaden |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5753465A (en) | 1994-08-30 | 1998-05-19 | Carnegie Mellon University | Unmodified recombinant human adult hemoglobin production |
| US5538800A (en) | 1994-09-29 | 1996-07-23 | At&T Corp. | Magnetoresistive oxide material and articles comprising the material |
| FR2736930B1 (fr) | 1995-07-17 | 1997-09-19 | Biocem | Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines |
| US5824511A (en) | 1995-08-01 | 1998-10-20 | University Technology Corporation | Method for enhancing the production of hemoproteins |
| JP2001508758A (ja) | 1996-02-01 | 2001-07-03 | ノース・アメリカン・バクシーン・インコーポレイテッド | グループbナイセリア・メニンギチジス外膜(mb3)タンパク質の酵母からの発現およびワクチン |
| ATE265534T1 (de) | 1996-06-10 | 2004-05-15 | Novozymes Biotech Inc | Verfahren zur vermehrung der hemoproteinherstellung in filamentösen fungi |
| JP3794760B2 (ja) | 1996-07-30 | 2006-07-12 | 三井化学株式会社 | フィターゼ生産酵母 |
| US5959187A (en) | 1996-09-26 | 1999-09-28 | Bailey; James E. | Expression of oxygen-binding proteins in plants |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| CA2331772C (en) | 1998-06-26 | 2009-08-04 | The University Of Manitoba | Hemoglobins to maintain cell energy status |
| US7803765B2 (en) | 1999-05-05 | 2010-09-28 | Phylogica Limited | Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom |
| US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| AU2001266251A1 (en) | 2000-06-23 | 2002-01-02 | Syngenta Participations Ag | Promoters for regulation of plant gene expression |
| AU2001292749A1 (en) | 2000-09-18 | 2002-03-26 | Genencor International, Inc. | Twin-arginine translocation in bacillus |
| US8021695B2 (en) | 2002-02-15 | 2011-09-20 | Arch Personal Care Products, L.P. | Personal care composition containing leghemoglobin |
| CA2511186A1 (en) | 2002-12-23 | 2004-07-15 | Peter Geigenberger | Method for altering the content of reserve substances in plants |
| CA2525493C (en) | 2003-04-11 | 2018-10-30 | Ventria Bioscience | Human blood proteins expressed in oryza seeds |
| KR100660539B1 (ko) | 2004-07-29 | 2006-12-22 | 삼성전자주식회사 | 자기 기억 소자 및 그 형성 방법 |
| CN1308452C (zh) | 2004-09-14 | 2007-04-04 | 上海永业农科生物工程有限公司 | 一种含有改组乙醇氧化酶启动子的毕赤酵母植酸酶表达系统 |
| WO2006091094A2 (en) | 2005-01-12 | 2006-08-31 | Dsm Ip Assets B.V. | Hemoglobin overexpression in fungal fermentations |
| AT501955B1 (de) | 2005-02-23 | 2007-08-15 | Univ Graz Tech | Mutierte aox1-promotoren |
| WO2007025008A2 (en) | 2005-08-24 | 2007-03-01 | The Scripps Research Institute | Translation enhancer-element dependent vector systems |
| JP2007228956A (ja) | 2006-02-28 | 2007-09-13 | Suntory Ltd | 醸造用酵母由来の有用タンパク質同定方法 |
| JP2008017733A (ja) | 2006-07-11 | 2008-01-31 | Tokyo Univ Of Agriculture | 異種タンパク質の発現方法及び異種タンパク質の発現方法により得られたタンパク質 |
| JP2008017774A (ja) | 2006-07-13 | 2008-01-31 | Nipro Corp | ピキア酵母を用いた組換えヒトヘモグロビンの製造 |
| JP5558101B2 (ja) | 2006-11-01 | 2014-07-23 | シグマ・アリメントス・ソシエダ・アノニマ・デ・カピタル・バリアブレ | 肉代用食品およびこの調製方法 |
| JP5290997B2 (ja) * | 2007-01-26 | 2013-09-18 | ノボザイムス アクティーゼルスカブ | ピキアにおけるメタノール誘導性プロモーターからのメタノール非依存的誘導の方法 |
| WO2009009142A2 (en) | 2007-07-10 | 2009-01-15 | Monsanto Technology, Llc | Transgenic plants with enhanced agronomic traits |
| EP2058398A1 (en) * | 2007-11-09 | 2009-05-13 | Nipro Corporation | Production of recombinant human hemoglobin using pichia yeast |
| EP2300615A2 (en) | 2008-07-11 | 2011-03-30 | Novozymes A/S | Pichia pastoris das promoter variants |
| US20120156761A1 (en) | 2009-07-02 | 2012-06-21 | Verdezyne, Inc. | Biological methods for preparing adipic acid |
| WO2011006136A2 (en) | 2009-07-09 | 2011-01-13 | Verdezyne, Inc. | Engineered microorganisms with enhanced fermentation activity |
| WO2011079388A1 (en) | 2009-12-30 | 2011-07-07 | Iogen Energy Corporation | Modified yeast strains exhibiting enhanced fermentation of lignocellulosic hydrolysates |
| CN102190731B (zh) | 2010-03-09 | 2016-01-27 | 中国科学院上海生命科学研究院 | 用人工转录因子诱导产生多能干细胞 |
| US9085766B2 (en) | 2010-05-21 | 2015-07-21 | Cornell University | Methods of producing recombinant heme-binding proteins and uses thereof |
| CA2807270A1 (en) | 2010-08-02 | 2012-02-09 | Cellectis | Method for targeted genomic events in diatoms |
| WO2012083424A1 (en) | 2010-12-21 | 2012-06-28 | The University Of Western Ontario | Novel amino acid linker sequences for ligand immobilization |
| WO2012102171A1 (ja) | 2011-01-27 | 2012-08-02 | 株式会社カネカ | 形質転換用酵母およびタンパク質の製造方法 |
| WO2012177499A1 (en) | 2011-06-23 | 2012-12-27 | The Trustees Of Princeton University | Systems for induction of gene expression and protein depletion in yeast |
| US10039306B2 (en) | 2012-03-16 | 2018-08-07 | Impossible Foods Inc. | Methods and compositions for consumables |
| US20140220217A1 (en) | 2011-07-12 | 2014-08-07 | Maraxi, Inc. | Method and compositions for consumables |
| JP6650671B2 (ja) | 2011-07-12 | 2020-02-19 | インポッシブル フーズ インコーポレイテッド | 摂食可能品のための方法および組成物 |
| EP2565262A1 (en) | 2011-08-31 | 2013-03-06 | VTU Holding GmbH | Protein expression |
| JP6295512B2 (ja) | 2012-03-15 | 2018-03-20 | 株式会社豊田中央研究所 | 酵母における外来遺伝子の発現産物の生産方法、酵母における発現調節剤及びその利用 |
| WO2013158749A2 (en) | 2012-04-17 | 2013-10-24 | Gevo, Inc. | Engineered microorganisms with improved growth properties |
| CN102757976B (zh) * | 2012-07-12 | 2014-10-08 | 华东理工大学 | 消除甲醇诱导型启动子单一甲醇碳源依赖性的方法 |
| US9938326B2 (en) | 2012-09-19 | 2018-04-10 | Osaka University | Pneumococcal vaccine containing pneumococcal surface protein A |
| CA2897600C (en) | 2013-01-11 | 2023-10-17 | Impossible Foods Inc. | Methods and compositions for affecting the flavor and aroma profile of consumables |
| GB2566614B (en) | 2013-08-05 | 2019-08-14 | Agresearch Ltd | A method and control system for optimising the quality of meat |
| CN105745332A (zh) | 2013-09-11 | 2016-07-06 | 非凡食品有限公司 | 含有血红素的多肽的分泌 |
| KR102669270B1 (ko) * | 2014-03-31 | 2024-05-27 | 임파서블 푸즈 인크. | 재조합 효모 |
| WO2016089516A2 (en) | 2014-10-31 | 2016-06-09 | Board Of Regents, The University Of Texas System | Short exogenous promoter for high level expression in fungi |
| HRP20220299T1 (hr) | 2015-05-11 | 2022-05-13 | Impossible Foods Inc. | Ekspresijski konstrukti i postupci za genetsku modifikaciju metilotrofnog kvasca |
| EP3128006A1 (en) | 2015-08-06 | 2017-02-08 | Consejo Superior de Investigaciones Cientificas (CSIC) | Tools for multiprotein complex expression in pichia pastoris |
| US20190292555A1 (en) | 2016-12-02 | 2019-09-26 | Impossible Foods Inc. | Producing recombinant products in contained systems |
| US20190292217A1 (en) | 2016-12-02 | 2019-09-26 | Impossible Foods Inc. | Transgenic plants with upregulated heme biosynthesis |
| WO2019067558A1 (en) | 2017-09-28 | 2019-04-04 | Precision Fermentation, Inc. | METHODS, DEVICES AND COMPUTER PROGRAM PRODUCTS FOR YEAST PERFORMANCE MONITORING IN FERMENTATION SYSTEMS |
| RU2658758C1 (ru) | 2017-10-02 | 2018-06-22 | ООО "Лаборатория Ангиофарм" | Рекомбинантная плазмида для экспрессии в дрожжах Pichia pastoris гена химерного белка ангиогенина человека и штамм дрожжей Pichia pastoris - продуцент рекомбинантного химерного белка ангиогенина человека |
| US20200325484A1 (en) | 2019-04-12 | 2020-10-15 | Delin Liang | Enhancing gene expression by linking self-amplifying transcription factor with viral 2A-like peptide |
| AU2020257270B2 (en) | 2019-04-17 | 2026-01-15 | Impossible Foods Inc. | Materials and methods for protein production |
| WO2020219972A1 (en) | 2019-04-25 | 2020-10-29 | Impossible Foods Inc. | Strains and methods for production of heme-containing proteins |
| US20210062206A1 (en) | 2019-07-08 | 2021-03-04 | The Regents Of The University Of California | Synthetic transcription factors |
| WO2023114395A1 (en) | 2021-12-16 | 2023-06-22 | Impossible Foods Inc. | A genetic factor to increase expression of recombinant proteins |
-
2016
- 2016-05-11 HR HRP20220299TT patent/HRP20220299T1/hr unknown
- 2016-05-11 KR KR1020207026647A patent/KR102504198B1/ko active Active
- 2016-05-11 PT PT167934207T patent/PT3294762T/pt unknown
- 2016-05-11 ES ES22151183T patent/ES3051659T3/es active Active
- 2016-05-11 PL PL16793420T patent/PL3294762T3/pl unknown
- 2016-05-11 RS RS20220256A patent/RS63099B1/sr unknown
- 2016-05-11 CA CA2985641A patent/CA2985641A1/en active Pending
- 2016-05-11 DK DK16793420.7T patent/DK3294762T3/da active
- 2016-05-11 AU AU2016262494A patent/AU2016262494B2/en active Active
- 2016-05-11 JP JP2017558948A patent/JP6831797B2/ja active Active
- 2016-05-11 KR KR1020237006299A patent/KR102789173B1/ko active Active
- 2016-05-11 MX MX2017014469A patent/MX2017014469A/es unknown
- 2016-05-11 KR KR1020177033598A patent/KR102229968B1/ko active Active
- 2016-05-11 CN CN201680029580.4A patent/CN107614516A/zh active Pending
- 2016-05-11 WO PCT/US2016/031797 patent/WO2016183163A1/en not_active Ceased
- 2016-05-11 SM SM20220124T patent/SMT202200124T1/it unknown
- 2016-05-11 HU HUE16793420A patent/HUE058104T2/hu unknown
- 2016-05-11 EP EP25181056.0A patent/EP4624565A3/en active Pending
- 2016-05-11 ES ES16793420T patent/ES2908463T3/es active Active
- 2016-05-11 NZ NZ737094A patent/NZ737094A/en unknown
- 2016-05-11 KR KR1020257009989A patent/KR20250048145A/ko active Pending
- 2016-05-11 US US15/573,300 patent/US10689656B2/en active Active
- 2016-05-11 LT LTEPPCT/US2016/031797T patent/LT3294762T/lt unknown
- 2016-05-11 EP EP22151183.5A patent/EP4039695B1/en active Active
- 2016-05-11 EP EP16793420.7A patent/EP3294762B1/en active Active
- 2016-05-11 SI SI201631500T patent/SI3294762T1/sl unknown
-
2017
- 2017-08-16 US US15/678,891 patent/US9938327B2/en active Active
- 2017-08-16 US US15/678,342 patent/US10273492B2/en active Active
- 2017-11-10 MX MX2022006513A patent/MX2022006513A/es unknown
- 2017-11-10 MX MX2022013540A patent/MX2022013540A/es unknown
-
2018
- 2018-09-06 US US16/123,121 patent/US11319544B2/en active Active
-
2019
- 2019-10-17 AU AU2019250216A patent/AU2019250216B2/en active Active
-
2020
- 2020-02-03 JP JP2020016038A patent/JP7308160B2/ja active Active
-
2021
- 2021-09-30 JP JP2021161491A patent/JP2022025068A/ja active Pending
-
2022
- 2022-01-25 US US17/584,028 patent/US12084667B2/en active Active
- 2022-03-03 AU AU2022201465A patent/AU2022201465C1/en active Active
- 2022-03-04 CY CY20221100189T patent/CY1125979T1/el unknown
- 2022-11-04 JP JP2022177137A patent/JP7596344B2/ja active Active
-
2024
- 2024-07-29 US US18/786,876 patent/US20250051786A1/en active Pending
- 2024-09-13 JP JP2024158832A patent/JP2025003991A/ja active Pending
-
2025
- 2025-03-12 AU AU2025201786A patent/AU2025201786A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3294762T3 (pl) | Konstrukty ekspresyjne i sposoby inżynierii genetycznej drożdży metylotroficznych | |
| IL281638B1 (en) | Angiotensinogen (agt) irna compositions and methods of use thereof | |
| IL258692A (en) | Additive manufacturing system and method | |
| IL282048A (en) | Oxysterols and methods of use thereof | |
| IL256369A (en) | Novel crispr enzymes and systems | |
| IL257327B (en) | Nicotinamide mononucleotide derivatives and their uses | |
| IL253463A0 (en) | Binding-triggered transcriptional switches and methods of use thereof | |
| IL255269A (en) | Compositions of obeticholic acid and methods of use | |
| PL3353210T3 (pl) | Przeciwciała anty-TIGIT i sposoby stosowania | |
| PL3386534T3 (pl) | Kompozycje i sposoby internalizacji enzymów | |
| PL3291679T3 (pl) | Zmiana populacji drobnoustrojowych i modyfikowanie mikrobioty | |
| IL248740A0 (en) | Compositions for mosquito control and uses of same | |
| PL3167096T3 (pl) | Dwuetapowy sposób nanoszenia | |
| PL3394259T3 (pl) | Kompozycje i sposoby zmniejszania ekspresji tau | |
| EP3461890C0 (en) | TOTAL FERMENTATION OF OLIGOSACCHARIDES | |
| HUE056911T2 (hu) | Genetikai konstrukció | |
| PL3371206T3 (pl) | Sposoby wytwarzania postaci fukozylowanej i niefukozylowanej białka | |
| DK3274430T3 (da) | Mikroalgesammensætninger og deres anvendelser | |
| IL255228A0 (en) | Constructs targeting hpv16-e7 peptide/mhc complexes and uses thereof | |
| PL3277270T3 (pl) | Kompozycje i sposoby leczenia niedokrwistości | |
| IL256322B (en) | Improved formulations of deferasirox and methods of making the same | |
| DK3194564T3 (da) | Trichodermasammensætninger og anvendelsesfremgangsmåder | |
| KR20180084747A (ko) | Galgt2 유전자 치료 방법 및 물질 | |
| DK3283210T3 (da) | Fremgangsmåde | |
| DK3288379T3 (da) | Peptidsammensætninger og anvendelsesmåder |