PL3315610T3 - Sposób wytwarzania fukozylowanych oligosacharydów - Google Patents

Sposób wytwarzania fukozylowanych oligosacharydów

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Publication number
PL3315610T3
PL3315610T3 PL16196486T PL16196486T PL3315610T3 PL 3315610 T3 PL3315610 T3 PL 3315610T3 PL 16196486 T PL16196486 T PL 16196486T PL 16196486 T PL16196486 T PL 16196486T PL 3315610 T3 PL3315610 T3 PL 3315610T3
Authority
PL
Poland
Prior art keywords
production
fucosylated oligosaccharides
fucosylated
oligosaccharides
Prior art date
Application number
PL16196486T
Other languages
English (en)
Inventor
Stefan Jennewein
Dirk Wartenberg
Katja Parschat
Original Assignee
Jennewein Biotechnologie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57256077&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3315610(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jennewein Biotechnologie Gmbh filed Critical Jennewein Biotechnologie Gmbh
Publication of PL3315610T3 publication Critical patent/PL3315610T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01271—GDP-L-fucose synthase (1.1.1.271)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01065—3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (2.4.1.65), i.e. alpha-1-3 fucosyltransferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01011—6-Phosphofructokinase (2.7.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07013—Mannose-1-phosphate guanylyltransferase (2.7.7.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03011—Fructose-bisphosphatase (3.1.3.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02013—Fructose-bisphosphate aldolase (4.1.2.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01047—GDP-mannose 4,6-dehydratase (4.2.1.47), i.e. GMD
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02008—Phosphomannomutase (5.4.2.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01152—4-Galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase (2.4.1.152)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
PL16196486T 2016-10-29 2016-10-29 Sposób wytwarzania fukozylowanych oligosacharydów PL3315610T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16196486.1A EP3315610B1 (en) 2016-10-29 2016-10-29 Process for the production of fucosylated oligosaccharides

Publications (1)

Publication Number Publication Date
PL3315610T3 true PL3315610T3 (pl) 2021-06-14

Family

ID=57256077

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16196486T PL3315610T3 (pl) 2016-10-29 2016-10-29 Sposób wytwarzania fukozylowanych oligosacharydów

Country Status (14)

Country Link
US (2) US11898185B2 (pl)
EP (2) EP3315610B1 (pl)
JP (2) JP2019531752A (pl)
KR (1) KR102554781B1 (pl)
CN (1) CN109790559A (pl)
AU (1) AU2017351657B2 (pl)
DK (1) DK3315610T3 (pl)
ES (1) ES2856749T3 (pl)
MX (1) MX389743B (pl)
PH (1) PH12019550056A1 (pl)
PL (1) PL3315610T3 (pl)
SG (1) SG11201903024YA (pl)
TW (1) TWI799395B (pl)
WO (1) WO2018077892A1 (pl)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3315610T3 (da) 2016-10-29 2021-03-08 Jennewein Biotechnologie Gmbh Fremgangsmåde til fremstilling af fucosylerede oligosaccharider
PL3375291T3 (pl) * 2017-03-17 2022-11-28 Chr. Hansen HMO GmbH Sposób hamowania izomeryzacji sacharydu redukującego po obróbce termicznej
EP3613858B1 (en) * 2017-04-21 2024-03-13 Seoul National University R&DB Foundation Method for producing 3'-fucosyllactose using corynebacterium glutamicum
WO2019222391A1 (en) * 2018-05-15 2019-11-21 The Board Of Trustees Of The University Of Illinois Engineered microorganisms for production of 2' fucosyllactose and l-fucose
CA3104645A1 (en) * 2018-07-27 2020-01-30 Global Bioenergies Method for producing fructose-6-phosphate from dihydroxyacetone phosphate and glyceraldehyde-3-phosphate
EP3620510B1 (en) 2018-09-06 2023-11-01 Chr. Hansen HMO GmbH Fermentative production of oligosaccharides by total fermentation utilizing a mixed feedstock
CN109402158B (zh) * 2018-09-14 2022-01-11 江苏大学 一种产岩藻糖基乳糖的重组表达质粒载体、代谢工程菌及生产方法
EP3861123A4 (en) * 2018-10-02 2022-08-10 Zimitech, Inc. USE OF SUBSTRATE IMPORTERS FOR EXPORT OF OLIGOSACCHARIDS
US20220002773A1 (en) * 2018-12-18 2022-01-06 Inbiose N.V. Production of 3-fucosyllactose and lactose converting alpha-1,3-fucosyltransferase enzymes
CA3125806A1 (en) 2019-01-10 2020-07-16 Expres2Ion Biotechnologies Aps Glyco-engineered immunization antigens
CN109749976B (zh) * 2019-01-30 2022-04-01 光明乳业股份有限公司 一种高效合成鸟苷二磷酸岩藻糖的重组枯草芽孢杆菌及其构建方法与应用
CN110172486A (zh) * 2019-05-14 2019-08-27 天津科技大学 一种合成2’-岩藻糖基乳糖的方法
JP2022541287A (ja) * 2019-07-19 2022-09-22 インバイオス エン．フェー． 宿主細胞におけるフコシルラクトースの産生
KR102154256B1 (ko) * 2019-07-30 2020-09-10 서울대학교산학협력단 코리네박테리움 글루타미쿰을 이용한 3'-푸코실락토오스의 생산방법
KR102268092B1 (ko) * 2019-09-02 2021-06-25 서울대학교산학협력단 코리네박테리움 글루타미쿰에 푸코실락토오스 수송체 도입과 gdp-l-푸코오스 생합성 경로의 최적화를 통한 2'-푸코실락토오스 생산 증대
KR20220066904A (ko) 2019-09-24 2022-05-24 프롤랙타 바이오사이언스, 인코포레이티드 염증 및 면역 질환의 치료용 조성물 및 방법
JP6917434B2 (ja) * 2019-10-25 2021-08-11 長瀬産業株式会社 好気性菌の代謝酵素破壊株およびその培養法
CN110804577B (zh) * 2019-11-28 2021-05-28 江南大学 一种高效生产2’-岩藻糖基乳糖的重组菌的构建方法及其应用
WO2021125245A1 (ja) * 2019-12-16 2021-06-24 協和発酵バイオ株式会社 改変されたラクトースパーミアーゼを有する微生物及びラクトース含有オリゴ糖の製造法
WO2021122708A1 (en) * 2019-12-17 2021-06-24 Inbiose N.V. Lactose converting alpha-1,2-fucosyltransferase enzymes
EP4093747A1 (en) * 2020-01-23 2022-11-30 Glycom A/S Hmo production
JP2023511523A (ja) 2020-01-23 2023-03-20 グリコム・アクティーゼルスカブ Ｈｍｏの産生
US20230193335A1 (en) * 2020-01-23 2023-06-22 Glycom A/S Hmo production
BR112022014420A2 (pt) 2020-01-23 2022-09-27 Glycom As Produção de hmo
US20220396817A1 (en) * 2020-02-14 2022-12-15 Inbiose N.V. Production of glycosylated product in host cells
WO2021181349A1 (en) 2020-03-12 2021-09-16 Glycom A/S Crystallization of 2'-fl
CN111471637A (zh) * 2020-05-08 2020-07-31 江苏华燕集团有限公司 2`-岩藻糖基乳糖高产菌株及其制备方法和用途
CN111575220B (zh) * 2020-05-25 2023-06-02 江南大学 合成2’-岩藻糖基乳糖的重组大肠杆菌及其构建方法与应用
CN111549013A (zh) * 2020-06-09 2020-08-18 中国科学院天津工业生物技术研究所 一种atp依赖的甘露糖激酶及其在岩藻基乳糖合成中的应用
EP3929300A1 (en) * 2020-06-26 2021-12-29 Chr. Hansen HMO GmbH Improved export of oligosaccharides from bacterial cells
EP4192944A1 (en) * 2020-08-10 2023-06-14 Inbiose N.V. Production of oligosaccharide mixtures by a cell
JP2023537608A (ja) 2020-08-14 2023-09-04 プロラクタ バイオサイエンス，インコーポレイテッド 細菌療法で使用するためのヒトミルクオリゴ糖組成物
CN114438001B (zh) * 2020-11-05 2022-11-15 中国科学院上海高等研究院 生产3-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法和应用
CN112625987B (zh) * 2020-12-21 2023-01-06 南通励成生物工程有限公司 一种同时生产2`-岩藻糖基乳糖和d-阿洛酮糖的方法
CN112574936A (zh) * 2020-12-21 2021-03-30 中国科学院合肥物质科学研究院 一种重组大肠杆菌及其构建方法与应用
DK180952B1 (en) 2020-12-22 2022-08-10 Glycom As A dfl-producing strain
CN112662604B (zh) * 2020-12-29 2023-10-20 量子高科(广东)生物有限公司 一种合成3-岩藻糖基乳糖的重组大肠杆菌及其构建方法
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