PL3329775T3 - Sposoby syntezy związków diarylotiohydantoinowych i diarylohydantoinowych - Google Patents

Sposoby syntezy związków diarylotiohydantoinowych i diarylohydantoinowych

Info

Publication number
PL3329775T3
PL3329775T3 PL18153287T PL18153287T PL3329775T3 PL 3329775 T3 PL3329775 T3 PL 3329775T3 PL 18153287 T PL18153287 T PL 18153287T PL 18153287 T PL18153287 T PL 18153287T PL 3329775 T3 PL3329775 T3 PL 3329775T3
Authority
PL
Poland
Prior art keywords
diarylthiohydantoin
synthesis
processes
diarylhydantoin compounds
diarylhydantoin
Prior art date
Application number
PL18153287T
Other languages
English (en)
Inventor
Andrew Thompson
Carol Lamberson
Scott Greenfield
Rajendra Parasmal Jain
Remy Angelaud
Original Assignee
Medivation Prostate Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44507217&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3329775(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medivation Prostate Therapeutics Llc filed Critical Medivation Prostate Therapeutics Llc
Publication of PL3329775T3 publication Critical patent/PL3329775T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL18153287T 2010-02-24 2011-02-24 Sposoby syntezy związków diarylotiohydantoinowych i diarylohydantoinowych PL3329775T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30779610P 2010-02-24 2010-02-24
EP11748095.4A EP2538785B1 (en) 2010-02-24 2011-02-24 Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
EP18153287.0A EP3329775B1 (en) 2010-02-24 2011-02-24 Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
PCT/US2011/026135 WO2011106570A1 (en) 2010-02-24 2011-02-24 Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds

Publications (1)

Publication Number Publication Date
PL3329775T3 true PL3329775T3 (pl) 2021-11-08

Family

ID=44507217

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11748095T PL2538785T3 (pl) 2010-02-24 2011-02-24 Sposoby syntezy zwiazków diarylotiohydantoinowych i diarylohydantoinowych
PL18153287T PL3329775T3 (pl) 2010-02-24 2011-02-24 Sposoby syntezy związków diarylotiohydantoinowych i diarylohydantoinowych

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL11748095T PL2538785T3 (pl) 2010-02-24 2011-02-24 Sposoby syntezy zwiazków diarylotiohydantoinowych i diarylohydantoinowych

Country Status (17)

Country Link
US (1) US9174943B2 (pl)
EP (2) EP3329775B1 (pl)
JP (1) JP5718372B2 (pl)
KR (1) KR101514659B1 (pl)
CN (1) CN103108549B (pl)
BR (1) BR112012021406B1 (pl)
CA (1) CA2790924C (pl)
CY (2) CY1120207T1 (pl)
DK (2) DK3329775T3 (pl)
ES (2) ES2671343T3 (pl)
HU (2) HUE038637T2 (pl)
MX (1) MX2012009782A (pl)
PL (2) PL2538785T3 (pl)
PT (2) PT2538785T (pl)
RU (1) RU2554081C2 (pl)
SI (2) SI3329775T1 (pl)
WO (1) WO2011106570A1 (pl)

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* Cited by examiner, † Cited by third party
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CN109651256A (zh) * 2018-11-20 2019-04-19 上海健康医学院 一种式（viii）的恩杂鲁胺的制备方法
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CN112047888B (zh) * 2019-06-05 2024-08-02 安礼特（上海）医药科技有限公司 一种合成恩杂鲁胺的方法
CN111320552B (zh) * 2020-02-28 2023-10-27 江西科睿药业有限公司 一种恩扎卢胺中间体的制备方法
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CN117120436A (zh) * 2021-03-30 2023-11-24 苏州开拓药业股份有限公司 一种一步法合成乙内酰硫脲衍生物的方法
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CN115572264B (zh) * 2021-07-06 2025-12-05 山东新时代药业有限公司 一种恩杂鲁胺的制备方法
CN113698310B (zh) * 2021-08-20 2023-03-17 江西金丰药业有限公司 一种恩杂鲁胺双酯中间体的制备方法
CN114591246A (zh) * 2022-03-25 2022-06-07 重庆华邦制药有限公司 一种恩扎卢胺的纯化方法
CN114907439B (zh) * 2022-06-29 2023-07-21 云南中医药大学 一种抗癌化合物及其制药用途
CN115181043B (zh) * 2022-07-27 2024-05-07 爱斯特（成都）生物制药股份有限公司 一种连续流制备4-异硫氰基-2-(三氟甲基)苯甲腈的方法
CN115611765A (zh) * 2022-09-30 2023-01-17 重庆华邦胜凯制药有限公司 一种恩扎卢胺中间体的制备方法
CN115536634B (zh) * 2022-10-17 2024-06-11 上海博悦生物科技有限公司 一种阿帕他胺的合成方法
CN115724759B (zh) * 2022-11-23 2024-06-25 爱斯特（成都）生物制药股份有限公司 一种恩扎卢胺中间体的制备方法
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Also Published As

Publication number Publication date
KR20130027468A (ko) 2013-03-15
SI3329775T1 (sl) 2021-09-30
PT3329775T (pt) 2021-07-19
EP2538785A4 (en) 2013-10-30
CA2790924C (en) 2016-08-02
SI2538785T1 (en) 2018-05-31
CN103108549B (zh) 2015-09-09
ES2671343T3 (es) 2018-06-06
HUE055051T2 (hu) 2021-10-28
CY1120207T1 (el) 2018-12-12
MX2012009782A (es) 2012-11-29
JP5718372B2 (ja) 2015-05-13
PL2538785T3 (pl) 2018-08-31
KR101514659B1 (ko) 2015-04-23
US9174943B2 (en) 2015-11-03
EP3329775A1 (en) 2018-06-06
DK2538785T3 (en) 2018-05-22
CN103108549A (zh) 2013-05-15
PT2538785T (pt) 2018-05-09
CA2790924A1 (en) 2011-09-01
EP2538785A1 (en) 2013-01-02
WO2011106570A1 (en) 2011-09-01
US20130190507A1 (en) 2013-07-25
ES2880354T3 (es) 2021-11-24
EP2538785B1 (en) 2018-03-21
DK3329775T3 (da) 2021-07-26
CY1124334T1 (el) 2022-07-22
BR112012021406B1 (pt) 2021-08-10
BR112012021406A8 (pt) 2018-07-31
JP2013520519A (ja) 2013-06-06
RU2554081C2 (ru) 2015-06-27
EP3329775B1 (en) 2021-04-21
RU2012140454A (ru) 2014-03-27
BR112012021406A2 (pt) 2018-06-05
HUE038637T2 (hu) 2018-12-28

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