PL3340796T4 - Sondy do obrazowania białka huntingtyny - Google Patents

Sondy do obrazowania białka huntingtyny

Info

Publication number
PL3340796T4
PL3340796T4 PL16842715T PL16842715T PL3340796T4 PL 3340796 T4 PL3340796 T4 PL 3340796T4 PL 16842715 T PL16842715 T PL 16842715T PL 16842715 T PL16842715 T PL 16842715T PL 3340796 T4 PL3340796 T4 PL 3340796T4
Authority
PL
Poland
Prior art keywords
probes
huntingtin protein
imaging
imaging huntingtin
protein
Prior art date
Application number
PL16842715T
Other languages
English (en)
Other versions
PL3340796T3 (pl
Inventor
Celia Dominguez
John Wityak
Jonathan Bard
Christopher John Brown
Michael Edward PRIME
Peter David Johnson
Thomas Martin Krulle
Daniel CLARK-FREW
Duane HIGGINS
Matthew Robert MILLS
Richard Waldron Marston
Samuel COE
Samantha Louise Jones GREEN
Sarah HAYES
Original Assignee
Chdi Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation, Inc. filed Critical Chdi Foundation, Inc.
Publication of PL3340796T4 publication Critical patent/PL3340796T4/pl
Publication of PL3340796T3 publication Critical patent/PL3340796T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nuclear Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL16842715T 2015-08-28 2016-08-26 Sondy do obrazowania białka huntingtyny PL3340796T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562211118P 2015-08-28 2015-08-28
EP16842715.1A EP3340796B1 (en) 2015-08-28 2016-08-26 Probes for imaging huntingtin protein
PCT/US2016/049112 WO2017040336A1 (en) 2015-08-28 2016-08-26 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
PL3340796T4 true PL3340796T4 (pl) 2022-02-21
PL3340796T3 PL3340796T3 (pl) 2022-02-21

Family

ID=58103449

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16842715T PL3340796T3 (pl) 2015-08-28 2016-08-26 Sondy do obrazowania białka huntingtyny

Country Status (18)

Country Link
US (3) US10137211B2 (pl)
EP (1) EP3340796B1 (pl)
JP (1) JP6944929B2 (pl)
CN (1) CN108135172B (pl)
AU (1) AU2016315648B2 (pl)
BR (1) BR112018003331B1 (pl)
CA (1) CA2995847C (pl)
DK (1) DK3340796T3 (pl)
ES (1) ES2885053T3 (pl)
HR (1) HRP20211156T1 (pl)
HU (1) HUE056509T2 (pl)
IL (1) IL257537B (pl)
MX (1) MX382156B (pl)
PL (1) PL3340796T3 (pl)
PT (1) PT3340796T (pl)
RU (1) RU2721419C2 (pl)
SI (1) SI3340796T1 (pl)
WO (1) WO2017040336A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20211778T1 (hr) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
SG11201701578YA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
SG11201701580XA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
PL3197277T3 (pl) 2014-08-29 2022-04-04 Chdi Foundation, Inc. Sondy do obrazowania molekularnego białka huntingtyny
CA2995847C (en) 2015-08-28 2024-05-28 Chdi Foundation, Inc. Probes for imaging huntingtin protein
WO2019157128A1 (en) 2018-02-08 2019-08-15 Phraxis Inc. End to end anastomotic connector
EP3749225A4 (en) * 2018-02-08 2021-11-17 Phraxis Inc. ONE-PIECE ANASTOMOTIC CONNECTOR
WO2020176424A1 (en) 2019-02-25 2020-09-03 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
IL298941A (en) * 2020-06-11 2023-02-01 Chdi Foundation Inc Heterocyclic compounds and imaging agents for the imaging of huntingtin protein
MX2023011888A (es) * 2021-04-08 2023-12-06 Chdi Foundation Inc Compuestos de isoindolinona y agentes de formación de imágenes para la obtencion de imágenes de la proteína huntingtina.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2126636T3 (es) 1992-05-19 1999-04-01 Adir Derivados del bencimidazol con actividad antidiabetica y antiagregante plaquetaria.
JP2000351782A (ja) * 1999-04-06 2000-12-19 Yamanouchi Pharmaceut Co Ltd メタボトロピックグルタメート受容体作用薬及び新規チアゾロベンゾイミダゾール誘導体
AU2241400A (en) * 1999-04-06 2000-10-12 Yamanouchi Pharmaceutical Co., Ltd. Novel thiazolobenzoimidazole derivative
UY27003A1 (es) 2000-11-06 2002-07-31 Schering Ag Productos radiofarmacéuticos para el diagnóstico de la enfermedad de alzheimer
WO2005048953A2 (en) * 2003-11-13 2005-06-02 Ambit Biosciences Corporation Amide derivatives as kinase modulators
TW201018678A (en) * 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
FR2919610B1 (fr) * 2007-08-02 2009-10-16 Sanofi Aventis Sa Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique
WO2010011964A2 (en) * 2008-07-24 2010-01-28 Siemens Medical Solutions Usa, Inc. Imaging agents useful for identifying ad pathology
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
CN102438660A (zh) 2009-03-23 2012-05-02 美国西门子医疗解决公司 用于检测神经障碍的显像剂
HK1210732A1 (en) 2012-07-11 2016-05-06 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US9902702B2 (en) * 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
PL3197277T3 (pl) 2014-08-29 2022-04-04 Chdi Foundation, Inc. Sondy do obrazowania molekularnego białka huntingtyny
HRP20211778T1 (hr) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
SG11201701580XA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
SG11201701578YA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
CA2995847C (en) 2015-08-28 2024-05-28 Chdi Foundation, Inc. Probes for imaging huntingtin protein

Also Published As

Publication number Publication date
MX2018002338A (es) 2018-07-06
DK3340796T3 (da) 2021-07-26
US10137211B2 (en) 2018-11-27
US10765764B2 (en) 2020-09-08
US20210060187A1 (en) 2021-03-04
PT3340796T (pt) 2021-07-28
CA2995847C (en) 2024-05-28
IL257537B (en) 2020-08-31
RU2721419C2 (ru) 2020-05-19
HRP20211156T1 (hr) 2021-12-24
HUE056509T2 (hu) 2022-02-28
RU2018110055A3 (pl) 2019-10-28
JP6944929B2 (ja) 2021-10-06
US20190167821A1 (en) 2019-06-06
MX382156B (es) 2025-03-13
CN108135172B (zh) 2021-03-30
AU2016315648A1 (en) 2018-03-29
EP3340796A4 (en) 2019-05-15
RU2018110055A (ru) 2019-09-30
US11344637B2 (en) 2022-05-31
CA2995847A1 (en) 2017-03-09
CN108135172A (zh) 2018-06-08
US20170056535A1 (en) 2017-03-02
SI3340796T1 (sl) 2022-02-28
PL3340796T3 (pl) 2022-02-21
AU2016315648B2 (en) 2021-04-01
EP3340796B1 (en) 2021-04-21
WO2017040336A1 (en) 2017-03-09
ES2885053T3 (es) 2021-12-13
EP3340796A1 (en) 2018-07-04
JP2018531897A (ja) 2018-11-01
IL257537A (en) 2018-04-30
BR112018003331B1 (pt) 2022-05-10
BR112018003331A2 (pt) 2018-11-06

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