PL3341367T3 - Skondensowane bicyklicznie związki heteroarylowe lub arylowe jako modulatory IRAK4 - Google Patents

Skondensowane bicyklicznie związki heteroarylowe lub arylowe jako modulatory IRAK4

Info

Publication number
PL3341367T3
PL3341367T3 PL16762869T PL16762869T PL3341367T3 PL 3341367 T3 PL3341367 T3 PL 3341367T3 PL 16762869 T PL16762869 T PL 16762869T PL 16762869 T PL16762869 T PL 16762869T PL 3341367 T3 PL3341367 T3 PL 3341367T3
Authority
PL
Poland
Prior art keywords
bicyclic
fused heteroaryl
aryl compounds
irak4
modulators
Prior art date
Application number
PL16762869T
Other languages
English (en)
Inventor
Katherine Lin Lee
Christophe Philippe ALLAIS
Christoph Martin Dehnhardt
Lori Krim Gavrin
Seungil Han
David Hepworth
Arthur Lee
Frank Eldridge Lovering
John Paul Mathias
Dafydd Rhys Owen
Nikolaos PAPAIOANNOU
Eddine Saiah
Joseph Walter Strohbach
John David TRZUPEK
Stephen Wayne Wright
Christoph Wolfgang ZAPF
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of PL3341367T3 publication Critical patent/PL3341367T3/pl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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PL16762869T 2015-08-27 2016-08-16 Skondensowane bicyklicznie związki heteroarylowe lub arylowe jako modulatory IRAK4 PL3341367T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562210573P 2015-08-27 2015-08-27
PCT/IB2016/054906 WO2017033093A1 (en) 2015-08-27 2016-08-16 Bicyclic-fused heteroaryl or aryl compounds as irak4 modulators
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