PL3344747T3 - Wewnątrzkomórkowe dostarczanie biocząsteczek za pośrednictwem powierzchni z porami - Google Patents
Wewnątrzkomórkowe dostarczanie biocząsteczek za pośrednictwem powierzchni z poramiInfo
- Publication number
- PL3344747T3 PL3344747T3 PL16766432.5T PL16766432T PL3344747T3 PL 3344747 T3 PL3344747 T3 PL 3344747T3 PL 16766432 T PL16766432 T PL 16766432T PL 3344747 T3 PL3344747 T3 PL 3344747T3
- Authority
- PL
- Poland
- Prior art keywords
- biomolecules
- pores
- mediated
- intracellular delivery
- intracellular
- Prior art date
Links
- 230000003834 intracellular effect Effects 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 239000011148 porous material Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Mechanical Engineering (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562214820P | 2015-09-04 | 2015-09-04 | |
| US201662331363P | 2016-05-03 | 2016-05-03 | |
| PCT/US2016/050287 WO2017041050A1 (en) | 2015-09-04 | 2016-09-02 | Intracellular delivery of biomolecules mediated by a surface with pores |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3344747T3 true PL3344747T3 (pl) | 2023-06-19 |
Family
ID=56936529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16766432.5T PL3344747T3 (pl) | 2015-09-04 | 2016-09-02 | Wewnątrzkomórkowe dostarczanie biocząsteczek za pośrednictwem powierzchni z porami |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20190382796A1 (pl) |
| EP (1) | EP3344747B1 (pl) |
| JP (3) | JP7046795B2 (pl) |
| CN (1) | CN108138118B (pl) |
| ES (1) | ES2930017T3 (pl) |
| PL (1) | PL3344747T3 (pl) |
| WO (1) | WO2017041050A1 (pl) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2768942T (pt) | 2011-10-17 | 2020-01-21 | Massachusetts Inst Technology | Entrega intracelular |
| KR102243597B1 (ko) | 2013-08-16 | 2021-04-26 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포로의 선택적 물질 전달 |
| KR20170074235A (ko) | 2014-10-31 | 2017-06-29 | 메사추세츠 인스티튜트 오브 테크놀로지 | 면역 세포로의 생체분자의 전달 |
| CN107002089B (zh) | 2014-11-14 | 2021-09-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
| CN107250373A (zh) | 2015-01-12 | 2017-10-13 | 麻省理工学院 | 通过微流体递送实现的基因编辑 |
| AU2016289530B2 (en) | 2015-07-09 | 2021-05-06 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
| EP3344575B1 (en) | 2015-09-04 | 2020-04-15 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| CA3023092A1 (en) | 2016-05-03 | 2017-11-09 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| AU2017259988B2 (en) * | 2016-05-03 | 2023-04-27 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to induce tolerance |
| CN109844126A (zh) * | 2016-09-28 | 2019-06-04 | 诺华股份有限公司 | 基于多孔膜的大分子递送系统 |
| US11231347B2 (en) | 2016-11-29 | 2022-01-25 | S2 Genomics, Inc. | Method and apparatus for processing tissue samples |
| AU2018359015B2 (en) | 2017-11-02 | 2022-10-06 | Indee. Inc. | Intracellular delivery and method therefore |
| EP3728559A1 (en) | 2017-12-20 | 2020-10-28 | SQZ Biotechnologies Company | System for delivery of a payload into a cell |
| AU2019234549B2 (en) | 2018-03-12 | 2026-02-12 | Sqz Biotechnologies Company | Methods for treating HPV-associated diseases |
| US20240374654A2 (en) | 2018-03-12 | 2024-11-14 | Stemcell Technologies Canada Inc. | Intracellular delivery of biomolecules to modify immune response |
| EP3803324A4 (en) * | 2018-06-01 | 2023-02-22 | S2 Genomics, Inc. | Method and apparatus for processing tissue samples |
| US20210388390A1 (en) | 2018-10-04 | 2021-12-16 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to enhance antigen presenting cell function |
| WO2020154696A1 (en) | 2019-01-25 | 2020-07-30 | Sqz Biotechnologies Company | Anucleate cell-derived vaccines |
| CA3131701A1 (en) | 2019-02-28 | 2020-09-03 | Sqz Biotechnologies Company | Delivery of biomolecules to pbmcs to modify an immune response |
| KR20210149791A (ko) | 2019-04-08 | 2021-12-09 | 에스큐지 바이오테크놀로지스 컴퍼니 | 페이로드를 세포 내로 전달하기 위한 시스템에서 이용하기 위한 카트리지 |
| WO2020252215A1 (en) | 2019-06-12 | 2020-12-17 | Cellfe, Inc. | Methods and systems for cell labeling and imaging |
| IT201900009831A1 (it) * | 2019-06-21 | 2020-12-21 | Milano Politecnico | Eritrociti per la veicolazione di farmaci |
| CN110272810A (zh) * | 2019-07-01 | 2019-09-24 | 广州世赛生物科技有限公司 | 外源物质递送至真核细胞内的装置和方法及其应用 |
| EP4127195A4 (en) * | 2020-03-26 | 2024-12-11 | Agency for Science, Technology and Research | A method and system for introducing one or more exogenous substances into an immune cell |
| JP2023527690A (ja) | 2020-05-11 | 2023-06-30 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 改変ｐｂｍｃと免疫抱合体との併用療法 |
| KR20230058388A (ko) | 2020-07-29 | 2023-05-03 | 에스큐지 바이오테크놀로지스 컴퍼니 | 무핵 세포를 사용해 돌연변이체 ras에 대한 면역 반응을 자극하는 방법 |
| US20250255961A1 (en) | 2020-07-29 | 2025-08-14 | Stemcell Technologies Canada Inc. | Methods to stimulate immune responses to mutant ras using nucleated cells |
| CA3201944A1 (en) | 2020-11-18 | 2022-05-27 | Cellfe, Inc. | Methods and systems for mechanoporation-based payload delivery into biological cells |
| US12227729B2 (en) | 2020-12-24 | 2025-02-18 | Cellfe, Inc. | Methods and systems for high-throughput cell processing |
| EP4271407A1 (en) | 2020-12-29 | 2023-11-08 | SQZ Biotechnologies Company | Formulations of activating antigen carriers |
| EP4271711A1 (en) | 2020-12-29 | 2023-11-08 | SQZ Biotechnologies Company | Methods for treating cancers with modified pbmcs |
| US20220296691A1 (en) | 2020-12-29 | 2022-09-22 | Sqz Biotechnologies Company | Methods for treating cancer with activating antigen carriers |
| US12150982B2 (en) | 2020-12-29 | 2024-11-26 | Stemcell Technologies Canada Inc. | Formulations of PBMCs |
| US20240182851A1 (en) * | 2021-04-02 | 2024-06-06 | Sqz Biotechnologies Company | Reprogramming of cells and uses thereof |
| CA3218511A1 (en) | 2021-05-10 | 2022-11-17 | Sqz Biotechnologies Company | Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof |
| US20250327027A1 (en) | 2021-07-29 | 2025-10-23 | Stemcell Technologies Canada Inc. | Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery |
| EP4396329A4 (en) * | 2021-09-01 | 2025-07-30 | Visicell Medical Inc | MICROSPHERE-FACILITATED INTRACELLULAR DELIVERY AND RELATED METHODS AND DEVICES |
| JP2024545582A (ja) | 2021-11-11 | 2024-12-10 | ステムセル テクノロジーズ カナダ インコーポレイテッド | マイクロ流体送達による増強された腫瘍浸潤リンパ球を作製する方法 |
| WO2023133423A1 (en) | 2022-01-05 | 2023-07-13 | Sqz Biotechnologies Company | Modified hematopoietic stem cells and uses thereof |
| US20250163371A1 (en) | 2022-02-23 | 2025-05-22 | Stemcell Technologies Canada Inc. | Methods of producing glial cells and uses thereof |
| KR20250017224A (ko) | 2022-05-24 | 2025-02-04 | 스템셀 테크놀러지스 캐나다 인크. | 자가-증폭 rna를 사용한 세포의 리프로그래밍 |
| AU2023277543A1 (en) | 2022-05-27 | 2024-12-19 | Stemcell Technologies Canada Inc. | Cartridges and devices for use in a system for delivery of a payload into a cell |
| WO2024026490A1 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Polynucleotides encoding linked antigens and uses thereof |
| WO2024026491A2 (en) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Enhanced antigen presenting cell formulations |
| EP4561620A1 (en) | 2022-07-28 | 2025-06-04 | Stemcell Technologies Canada Inc. | Methods for treating cancer with enhanced antigen presenting cells |
| WO2024182430A2 (en) * | 2023-02-28 | 2024-09-06 | Portal Biotechnologies, Inc. | Membrane electro-mechanoporation devices and methods for transfecting cells |
| KR20250155562A (ko) * | 2023-02-28 | 2025-10-30 | 포털 바이오테크놀로지스, 인크. | 세포를 형질감염시키기 위한 막 기계천공 디바이스 및 방법 |
| WO2024182570A1 (en) * | 2023-02-28 | 2024-09-06 | VisiCELL Medical Inc. | Microsphere facilitated intracellular delivery and associated methods and devices |
| US20250186995A1 (en) * | 2023-12-11 | 2025-06-12 | Portal Biotechnologies, Inc. | High-throughput systems for intracellular delivery and components and uses thereof |
| US20250188401A1 (en) * | 2023-12-11 | 2025-06-12 | Portal Biotechnologies, Inc. | Silicon filters for cell mechanoporation |
| WO2025128569A1 (en) * | 2023-12-11 | 2025-06-19 | Portal Biotechnologies, Inc. | Cell mechanoporation cartridges and methods of use thereof |
| WO2025259199A1 (en) * | 2024-06-14 | 2025-12-18 | Singapore University Of Technology And Design | Method and device for intracellular delivery |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6045701A (en) * | 1994-10-17 | 2000-04-04 | Baxter International Inc. | Method of filtering a fluid suspension with a membrane having a particular coating |
| US7608425B2 (en) * | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
| DK2681306T3 (en) * | 2011-02-28 | 2019-04-23 | Harvard College | CELL CULTURE SYSTEM |
| PT2768942T (pt) | 2011-10-17 | 2020-01-21 | Massachusetts Inst Technology | Entrega intracelular |
| WO2015009688A1 (en) * | 2013-07-17 | 2015-01-22 | The Johns Hopkins University | Microfluidic chip for analysis of cell motility and methods for using same |
| KR102243597B1 (ko) | 2013-08-16 | 2021-04-26 | 메사추세츠 인스티튜트 오브 테크놀로지 | 세포로의 선택적 물질 전달 |
| US10039885B2 (en) * | 2015-02-09 | 2018-08-07 | Palo Alto Research Center Incorporated | System and method for enhancing particle delivery to biological tissue |
-
2016
- 2016-09-02 PL PL16766432.5T patent/PL3344747T3/pl unknown
- 2016-09-02 US US15/757,312 patent/US20190382796A1/en not_active Abandoned
- 2016-09-02 CN CN201680051309.0A patent/CN108138118B/zh active Active
- 2016-09-02 EP EP16766432.5A patent/EP3344747B1/en active Active
- 2016-09-02 JP JP2018512328A patent/JP7046795B2/ja active Active
- 2016-09-02 ES ES16766432T patent/ES2930017T3/es active Active
- 2016-09-02 WO PCT/US2016/050287 patent/WO2017041050A1/en not_active Ceased
-
2021
- 2021-10-25 JP JP2021173759A patent/JP2022023167A/ja active Pending
-
2023
- 2023-01-23 US US18/158,138 patent/US20230272427A1/en active Pending
-
2024
- 2024-03-28 JP JP2024053358A patent/JP2024079808A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP7046795B2 (ja) | 2022-04-04 |
| EP3344747B1 (en) | 2022-11-09 |
| US20230272427A1 (en) | 2023-08-31 |
| WO2017041050A1 (en) | 2017-03-09 |
| ES2930017T3 (es) | 2022-12-05 |
| JP2024079808A (ja) | 2024-06-11 |
| JP2022023167A (ja) | 2022-02-07 |
| CN108138118B (zh) | 2023-01-06 |
| US20190382796A1 (en) | 2019-12-19 |
| JP2018531592A (ja) | 2018-11-01 |
| EP3344747A1 (en) | 2018-07-11 |
| CN108138118A (zh) | 2018-06-08 |
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