PL336847A1 - Hiv protease inhibitor sulphate of improved absorption after oral administration and of improved bioavailability - Google Patents

Hiv protease inhibitor sulphate of improved absorption after oral administration and of improved bioavailability

Info

Publication number
PL336847A1
PL336847A1 PL98336847A PL33684798A PL336847A1 PL 336847 A1 PL336847 A1 PL 336847A1 PL 98336847 A PL98336847 A PL 98336847A PL 33684798 A PL33684798 A PL 33684798A PL 336847 A1 PL336847 A1 PL 336847A1
Authority
PL
Poland
Prior art keywords
improved
sulphate
oral administration
protease inhibitor
hiv protease
Prior art date
Application number
PL98336847A
Other languages
English (en)
Inventor
David Askin
R Scott Hoerrner
Robert M Purick
Paul Reider
Richard J Varsolona
Ralph P Volante
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9714320.0A external-priority patent/GB9714320D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PL336847A1 publication Critical patent/PL336847A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL98336847A 1997-05-29 1998-05-26 Hiv protease inhibitor sulphate of improved absorption after oral administration and of improved bioavailability PL336847A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4795097P 1997-05-29 1997-05-29
GBGB9714320.0A GB9714320D0 (en) 1997-07-07 1997-07-07 Hiv protease inhibitor

Publications (1)

Publication Number Publication Date
PL336847A1 true PL336847A1 (en) 2000-07-17

Family

ID=26311845

Family Applications (1)

Application Number Title Priority Date Filing Date
PL98336847A PL336847A1 (en) 1997-05-29 1998-05-26 Hiv protease inhibitor sulphate of improved absorption after oral administration and of improved bioavailability

Country Status (22)

Country Link
EP (1) EP0986554A1 (is)
JP (1) JP3267632B2 (is)
KR (1) KR20010013042A (is)
CN (1) CN1257497A (is)
AU (1) AU730245B2 (is)
BG (1) BG103923A (is)
BR (1) BR9809498A (is)
CA (1) CA2291086A1 (is)
EA (1) EA199901095A1 (is)
EE (1) EE9900543A (is)
HR (1) HRP980283A2 (is)
HU (1) HUP0004621A3 (is)
ID (1) ID23858A (is)
IL (1) IL132779A0 (is)
IS (1) IS5240A (is)
NO (1) NO995822L (is)
PE (1) PE75099A1 (is)
PL (1) PL336847A1 (is)
SK (1) SK163299A3 (is)
TR (1) TR199902816T2 (is)
TW (1) TW438799B (is)
WO (1) WO1998054178A1 (is)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001038332A1 (en) * 1999-11-24 2001-05-31 Merck & Co., Inc. Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides as hiv protease inhibitors
AU2001290743A1 (en) * 2000-09-14 2002-03-26 Ortho-Mcneil Pharmaceutical, Inc. Solid salt forms of n-(2-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)ethyl)-2-oxo-1-piperidineacetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT74681A (en) 1993-12-15 1997-01-28 Merck & Co Inc N-(2-hydroxy-1-indenyl)-2-phenylmethyl-4-hydroxy-5-(2-carboxamido-piperazinyl)-pentaneamide derivatives of hiv protease inhibitor activity and phrmaceutical compositions contining them

Also Published As

Publication number Publication date
ID23858A (id) 2000-05-25
TR199902816T2 (xx) 2000-02-21
CA2291086A1 (en) 1998-12-03
EA199901095A1 (ru) 2000-08-28
TW438799B (en) 2001-06-07
SK163299A3 (en) 2000-07-11
EP0986554A1 (en) 2000-03-22
IL132779A0 (en) 2001-03-19
IS5240A (is) 1999-11-09
EE9900543A (et) 2000-06-15
JP2000513747A (ja) 2000-10-17
JP3267632B2 (ja) 2002-03-18
KR20010013042A (ko) 2001-02-26
NO995822D0 (no) 1999-11-26
AU7595998A (en) 1998-12-30
NO995822L (no) 2000-01-28
HRP980283A2 (en) 1999-08-31
PE75099A1 (es) 1999-08-11
AU730245B2 (en) 2001-03-01
BG103923A (en) 2000-06-30
WO1998054178A1 (en) 1998-12-03
BR9809498A (pt) 2000-06-20
HUP0004621A2 (hu) 2002-03-28
HUP0004621A3 (en) 2002-04-29
CN1257497A (zh) 2000-06-21

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