PL337606A1 - Derivatives of erythromycin 9-oxime - Google Patents

Derivatives of erythromycin 9-oxime

Info

Publication number: PL337606A1
Authority: PL; Poland
Prior art keywords: erythromycin; oxime; derivatives
Prior art date: 1997-06-11

Application number

PL98337606A

Inventor

Young-Jin Wu

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-11

Filing date

1998-05-15

Publication date

2000-08-28

1998-05-15 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2000-08-28 Publication of PL337606A1 publication Critical patent/PL337606A1/en

Links

KYTWXIARANQMCA-PGYIPVOXSA-N (3r,4s,5s,6r,7r,9r,10z,11s,12r,13s,14r)-6-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-10-hydroxyimino-4-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradec Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N\O)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 KYTWXIARANQMCA-PGYIPVOXSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

PL98337606A 1997-06-11 1998-05-15 Derivatives of erythromycin 9-oxime PL337606A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4934997P	1997-06-11	1997-06-11
PCT/IB1998/000741 WO1998056800A1 (en)	1997-06-11	1998-05-15	9-oxime erythromycin derivatives

Publications (1)

Publication Number	Publication Date
PL337606A1 true PL337606A1 (en)	2000-08-28

Family

ID=21959341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL98337606A PL337606A1 (en)	1997-06-11	1998-05-15	Derivatives of erythromycin 9-oxime

Country Status (31)

Country	Link
EP (1)	EP0988308A1 (en)
JP (1)	JP2000513026A (en)
KR (1)	KR20010013660A (en)
CN (1)	CN1259135A (en)
AP (1)	AP9801253A0 (en)
AR (1)	AR012244A1 (en)
AU (1)	AU7226798A (en)
BG (1)	BG103947A (en)
BR (1)	BR9810021A (en)
CA (1)	CA2293335A1 (en)
CO (1)	CO4940506A1 (en)
CZ (1)	CZ9904388A3 (en)
EA (1)	EA199901016A1 (en)
GT (1)	GT199800074A (en)
HN (1)	HN1998000073A (en)
HR (1)	HRP980316A2 (en)
HU (1)	HUP0002252A3 (en)
ID (1)	ID24529A (en)
IL (1)	IL132767A0 (en)
IS (1)	IS5251A (en)
MA (1)	MA26505A1 (en)
NO (1)	NO996108L (en)
OA (1)	OA11225A (en)
PA (1)	PA8451801A1 (en)
PE (1)	PE79899A1 (en)
PL (1)	PL337606A1 (en)
TN (1)	TNSN98083A1 (en)
TR (1)	TR199902995T2 (en)
TW (1)	TW448174B (en)
WO (1)	WO1998056800A1 (en)
ZA (1)	ZA985018B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HN1998000159A (en) *	1997-10-29	1999-02-09	Monsanto Co	DERIVATIVES OF 9- AMINO - 3 CETO ERITROMICINA
AU5299499A (en)	1998-09-22	2000-04-10	Pfizer Products Inc.	Carbamate and carbazate ketolide antibiotics
FR2786188B1 (en) *	1998-11-24	2002-10-31	Hoechst Marion Roussel Inc	NOVEL ERYTHROMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
US6258785B1 (en)	1998-12-02	2001-07-10	Pfizer Inc.	Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
EP1298138B1 (en) *	1998-12-10	2006-11-02	Pfizer Products Inc.	Carbamate and Carbazate Ketolide Antibiotics
US6284732B1 (en) *	1998-12-18	2001-09-04	Bio-Rad Laboratories, Inc.	Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
US6395710B1 (en) *	1999-04-16	2002-05-28	Kosan Biosciences, Inc.	Macrolide antiinfective agents
IL145739A0 (en)	1999-05-24	2002-07-25	Pfizer Prod Inc	13-methyl-erythromycin derivatives
ATE250076T1 (en) *	1999-06-07	2003-10-15	Abbott Lab	6-O-CARBAMAT KETOLIDE DERIVATIVES
ID27331A (en) *	1999-09-29	2001-03-29	Pfizer Prod Inc	MAKING ANTIBIOTIC-ANTIBIOTIC KETOLIDA CARBAMATE
EP1114826A3 (en) *	1999-12-29	2001-10-31	Pfizer Products Inc.	Novel antibacterial and prokinetic macrolides
EP1439186A3 (en) *	1999-12-29	2004-11-03	Pfizer Products Inc.	Intermediates for novel antibacterial and prokinetic macrolides
US6946446B2 (en)	2000-02-24	2005-09-20	Abbott Laboratories	Anti-infective agents useful against multidrug-resistant strains of bacteria
US6403776B1 (en)	2000-07-05	2002-06-11	Pfizer Inc.	Synthesis of carbamate ketolide antibiotics
WO2003090761A1 (en) *	2002-04-25	2003-11-06	Abbott Laboratories	9-oxime macrolide antibacterials
AR043050A1 (en)	2002-09-26	2005-07-13	Rib X Pharmaceuticals Inc	BIFunctional HETEROCICLICAL COMPOUNDS AND METHODS TO PREPARE AND USE THE SAME
EP1638549A4 (en) *	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	NEW ANTIBACTERIAL AGENTS
EP2716647A3 (en)	2004-02-27	2014-08-20	Rib-X Pharmaceuticals, Inc.	Macrocyclic compounds and methods of making and using the same
CA2703475A1 (en)	2007-10-25	2009-04-30	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
US8796232B2 (en)	2008-10-24	2014-08-05	Cempra Pharmaceuticals, Inc.	Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
JP5914335B2 (en)	2009-09-10	2016-05-11	センプラファーマシューティカルズ，インコーポレイテッド	Method for treating malaria, tuberculosis and MAC disease
CN102146085B (en) *	2010-02-09	2014-03-26	北京理工大学	9-oxime-ether ketolide derivative, and preparation method and medical composite thereof
CN103080122A (en)	2010-03-22	2013-05-01	森普拉制药公司	Crystalline forms of macrolides and their uses
WO2011146829A1 (en)	2010-05-20	2011-11-24	Cempra Pharmaceuticals, Inc.	Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (en)	2010-09-10	2016-12-14	センプラファーマシューティカルズ，インコーポレイテッド	Hydrogen bond forming fluoroketolides for disease treatment
CN104470527B (en)	2012-03-27	2019-05-28	森普拉制药公司	Parenteral formulations for administration of macrolide antibiotics
RU2015138796A (en)	2013-03-14	2017-04-19	Семпра Фармасьютикалс, Инк.	METHODS AND COMPOSITIONS FOR TREATMENT OF RESPIRATORY DISEASES
WO2014145210A1 (en)	2013-03-15	2014-09-18	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
FR2718450B1 (en) *	1994-04-08	1997-01-10	Roussel Uclaf	New erythromycin derivatives, their preparation process and their use as drugs.

1998
- 1998-05-15 CN CN98805848A patent/CN1259135A/en active Pending
- 1998-05-15 EP EP98919394A patent/EP0988308A1/en not_active Withdrawn
- 1998-05-15 JP JP11501928A patent/JP2000513026A/en active Pending
- 1998-05-15 KR KR1019997011672A patent/KR20010013660A/en not_active Ceased
- 1998-05-15 BR BR9810021-1A patent/BR9810021A/en not_active IP Right Cessation
- 1998-05-15 WO PCT/IB1998/000741 patent/WO1998056800A1/en not_active Ceased
- 1998-05-15 AU AU72267/98A patent/AU7226798A/en not_active Abandoned
- 1998-05-15 CA CA002293335A patent/CA2293335A1/en not_active Abandoned
- 1998-05-15 EA EA199901016A patent/EA199901016A1/en unknown
- 1998-05-15 HU HU0002252A patent/HUP0002252A3/en unknown
- 1998-05-15 ID IDW991570A patent/ID24529A/en unknown
- 1998-05-15 IL IL13276798A patent/IL132767A0/en unknown
- 1998-05-15 PL PL98337606A patent/PL337606A1/en unknown
- 1998-05-15 CZ CZ19994388A patent/CZ9904388A3/en unknown
- 1998-05-15 TR TR1999/02995T patent/TR199902995T2/en unknown
- 1998-05-19 HN HN1998000073A patent/HN1998000073A/en unknown
- 1998-05-21 PA PA19988451801A patent/PA8451801A1/en unknown
- 1998-06-04 AP APAP/P/1998/001253A patent/AP9801253A0/en unknown
- 1998-06-05 GT GT199800074A patent/GT199800074A/en unknown
- 1998-06-08 PE PE1998000470A patent/PE79899A1/en not_active Application Discontinuation
- 1998-06-08 TW TW087109086A patent/TW448174B/en active
- 1998-06-09 AR ARP980102703A patent/AR012244A1/en unknown
- 1998-06-10 TN TNTNSN98083A patent/TNSN98083A1/en unknown
- 1998-06-10 MA MA25105A patent/MA26505A1/en unknown
- 1998-06-10 ZA ZA9805018A patent/ZA985018B/en unknown
- 1998-06-11 CO CO98033538A patent/CO4940506A1/en unknown
- 1998-06-11 HR HR60/049,349A patent/HRP980316A2/en not_active Application Discontinuation
1999
- 1999-11-16 IS IS5251A patent/IS5251A/en unknown
- 1999-12-03 OA OA9900269A patent/OA11225A/en unknown
- 1999-12-03 BG BG103947A patent/BG103947A/en unknown
- 1999-12-10 NO NO996108A patent/NO996108L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20010013660A (en)	2001-02-26
HUP0002252A3 (en)	2002-01-28
GT199800074A (en)	1999-11-27
WO1998056800A1 (en)	1998-12-17
NO996108D0 (en)	1999-12-10
HUP0002252A2 (en)	2000-12-28
EA199901016A1 (en)	2000-06-26
BG103947A (en)	2000-07-31
TR199902995T2 (en)	2000-02-21
HRP980316A2 (en)	1999-04-30
HN1998000073A (en)	1999-01-08
ZA985018B (en)	1999-12-10
AP9801253A0 (en)	1999-12-04
CZ9904388A3 (en)	2002-10-16
EP0988308A1 (en)	2000-03-29
AR012244A1 (en)	2000-09-27
PE79899A1 (en)	1999-08-25
IS5251A (en)	1999-11-16
IL132767A0 (en)	2001-03-19
BR9810021A (en)	2000-09-19
AU7226798A (en)	1998-12-30
JP2000513026A (en)	2000-10-03
PA8451801A1 (en)	2000-05-24
TW448174B (en)	2001-08-01
MA26505A1 (en)	2004-12-20
CN1259135A (en)	2000-07-05
OA11225A (en)	2003-07-17
ID24529A (en)	2000-07-20
TNSN98083A1 (en)	2005-03-15
NO996108L (en)	2000-02-10
CO4940506A1 (en)	2000-07-24
CA2293335A1 (en)	1998-12-17

Publication	Publication Date	Title
IL132767A0 (en)	2001-03-19	9-Oxime erythromycin derivatives
HUP0001518A3 (en)	2001-11-28	Tricyclic erythromycin derivatives
PL341647A1 (en)	2001-04-23	Novel derivatives of erythromycin
AU9277698A (en)	1999-05-17	9-amino-3-keto erythromycin derivatives
PL348333A1 (en)	2002-05-20	Macrolides
IL137024A0 (en)	2001-06-14	Novel macrolides
IL142628A0 (en)	2002-03-10	Novel macrolide antibiotics
PL340290A1 (en)	2001-01-29	2-halogeno-6-0-substituted derivatives of ketolide
PL339137A1 (en)	2000-12-04	6,9-bridged derivatives of erythromycin
PL340253A1 (en)	2001-01-29	6,11-bridged derivatives of erythromycin
PL324346A1 (en)	1998-05-25	Macrolides
ZA985655B (en)	1998-12-30	Crystalline macrolides
NZ513998A (en)	2001-09-28	Erythromycin derivatives
AU8925398A (en)	1999-03-22	3-descladinose 6-o-substituded erythromycin derivatives
AU6932098A (en)	1998-12-08	Erythromycin derivatives
IL115312A0 (en)	1995-12-31	Antibiotic macrolides
AU1504899A (en)	1999-06-28	Erythromycin derivatives
PL337066A1 (en)	2000-07-31	Polycyclic derivatives of erythromycin
GB9700702D0 (en)	1997-03-05	Erythromycin derivatives
ZA951845B (en)	1996-03-15	Acid-stabile erythromycin derivatives
HK1031384A (en)	2001-06-15	3-descladinose 6-o-substituted erythromycin derivatives
ZA989845B (en)	1999-04-29	2-halo-6-O-substituted ketolide derivatives
SI1027362T1 (en)	2005-12-31	2-halo-6-o-substituted ketolide derivatives
AU3634397A (en)	1998-02-10	Erythromycin derivatives
PL319678A1 (en)	1998-10-26	Method of biosynthesising erythromycin c