PL3383851T3 - Pochodne dekstrorfanu o stłumionej nerwowej aktywności ośrodkowej - Google Patents

Pochodne dekstrorfanu o stłumionej nerwowej aktywności ośrodkowej

Info

Publication number
PL3383851T3
PL3383851T3 PL16805448T PL16805448T PL3383851T3 PL 3383851 T3 PL3383851 T3 PL 3383851T3 PL 16805448 T PL16805448 T PL 16805448T PL 16805448 T PL16805448 T PL 16805448T PL 3383851 T3 PL3383851 T3 PL 3383851T3
Authority
PL
Poland
Prior art keywords
dextrorphan
derivatives
central nervous
nervous activity
suppressed
Prior art date
Application number
PL16805448T
Other languages
English (en)
Inventor
Eckhard Lammert
Alena WELTERS
Silke OTTER
Jan Marquard
Thomas Meissner
Diran HEREBIAN
Ertan MAYATEPEK
Original Assignee
Heinrich-Heine-Universität Düsseldorf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heinrich-Heine-Universität Düsseldorf filed Critical Heinrich-Heine-Universität Düsseldorf
Publication of PL3383851T3 publication Critical patent/PL3383851T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/28Morphinans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL16805448T 2015-12-03 2016-12-02 Pochodne dekstrorfanu o stłumionej nerwowej aktywności ośrodkowej PL3383851T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15197832 2015-12-03
PCT/EP2016/079645 WO2017093519A1 (en) 2015-12-03 2016-12-02 Dextrorphan-derivatives with suppressed central nervous activity
EP16805448.4A EP3383851B1 (en) 2015-12-03 2016-12-02 Dextrorphan-derivatives with suppressed central nervous activity

Publications (1)

Publication Number Publication Date
PL3383851T3 true PL3383851T3 (pl) 2022-01-10

Family

ID=54782566

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16805448T PL3383851T3 (pl) 2015-12-03 2016-12-02 Pochodne dekstrorfanu o stłumionej nerwowej aktywności ośrodkowej

Country Status (6)

Country Link
US (1) US10464904B2 (pl)
EP (1) EP3383851B1 (pl)
CA (1) CA3037766C (pl)
ES (1) ES2894324T3 (pl)
PL (1) PL3383851T3 (pl)
WO (1) WO2017093519A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107652236A (zh) * 2017-11-14 2018-02-02 江苏宝众宝达药业有限公司 一种右美沙芬杂质17‑甲基吗啡喃‑3‑醇对映异构体的制备方法
WO2022235576A1 (en) * 2021-05-03 2022-11-10 Wang Michael Z Methods and compositions for treating depression
CA3255072A1 (en) 2022-03-31 2023-10-05 Taros Chemicals Gmbh & Co. Kg SYNTHESIS OF MORPHINANES WITH REDUCED HERG ACTIVITY AND MOP BONDING
WO2025165207A1 (ko) * 2024-02-02 2025-08-07 단국대학교 천안캠퍼스 산학협력단 덱스트로메토르판을 유효성분으로 포함하는 신경 질환 예방 또는 치료용 약학 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6089474A (ja) * 1983-10-20 1985-05-20 Toyo Pharma- Kk モルフイナン誘導体,その製造方法,及び該化合物を含有する抗腫瘍剤
WO2008097924A2 (en) 2007-02-05 2008-08-14 Avanir Pharmaceuticals Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders
US20120122848A1 (en) * 2009-07-29 2012-05-17 Green Cross Corporation (+)-3-hydroxymorphinan derivatives as neuroprotectants
CN102906099A (zh) * 2010-05-13 2013-01-30 株式会社绿十字 作为神经保护剂的基于(+)-3-羟基吗啡喃的多环衍生物
WO2013029762A1 (en) * 2011-08-26 2013-03-07 Heinrich-Heine-Universität Düsseldorf Morphinan-derivatives for treating diabetes and related disorders
US10766864B2 (en) * 2015-05-08 2020-09-08 Nektar Therapeutics Morphinan derivatives for the treatment of neuropathic pain

Also Published As

Publication number Publication date
EP3383851B1 (en) 2021-07-14
ES2894324T3 (es) 2022-02-14
US20180362469A1 (en) 2018-12-20
WO2017093519A1 (en) 2017-06-08
CA3037766A1 (en) 2017-06-08
EP3383851A1 (en) 2018-10-10
CA3037766C (en) 2023-09-26
US10464904B2 (en) 2019-11-05

Similar Documents

Publication Publication Date Title
ZA201704562B (en) Picolinamides with fungicidal activity
ZA201802081B (en) Measuring multiple carriers under discontinuous activity
IL256625A (en) Antibodies to cd40 with increased agonistic activity
IL250320B (en) Compounds active toward bromodomains
GB2530726B (en) Distributed single sign-on
IL247935A0 (en) Automatic injector with shock reduction elements
GB2537441B (en) Needle assemblies
GB201407288D0 (en) Activity monitors
PL3292145T3 (pl) Mutanty fc ze zmodyfikowaną aktywnością funkcjonalną
IL249511A0 (en) Novel p450-bm3 variants with enhanced activity
GB2538043B (en) Activity monitor
IL256441B (en) New p450–bm3 variants with enhanced activity
ZA201705537B (en) Compounds with anti-tumoral activity
PL3383851T3 (pl) Pochodne dekstrorfanu o stłumionej nerwowej aktywności ośrodkowej
EP3279323A4 (en) Amadoriase having improved specific activity
GB201510359D0 (en) Incubator
IL257971A (en) Materials with combined activity
GB201519799D0 (en) Catalysts
GB201517650D0 (en) Catalysts
GB201505556D0 (en) Catalysts
PT3355744T (pt) Cama com fundo melhorado
GB201517648D0 (en) Catalysts
PL3070078T3 (pl) Niesymetryczne bisakrydyny o działaniu przeciwnowotworowym i ich zastosowania
ZA201705324B (en) Carbon activity analyser
GB201510017D0 (en) Activity assay