PL338510A1 - Benzyl compounds inhinbiting the adhesion of leucocytes occurring through the mediation of vla-4 - Google Patents

Benzyl compounds inhinbiting the adhesion of leucocytes occurring through the mediation of vla-4

Info

Publication number
PL338510A1
PL338510A1 PL98338510A PL33851098A PL338510A1 PL 338510 A1 PL338510 A1 PL 338510A1 PL 98338510 A PL98338510 A PL 98338510A PL 33851098 A PL33851098 A PL 33851098A PL 338510 A1 PL338510 A1 PL 338510A1
Authority
PL
Poland
Prior art keywords
inhinbiting
leucocytes
vla
mediation
adhesion
Prior art date
Application number
PL98338510A
Original Assignee
Elan Pharm Inc
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, American Home Prod filed Critical Elan Pharm Inc
Publication of PL338510A1 publication Critical patent/PL338510A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
PL98338510A 1997-07-31 1998-07-31 Benzyl compounds inhinbiting the adhesion of leucocytes occurring through the mediation of vla-4 PL338510A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90358597A 1997-07-31 1997-07-31

Publications (1)

Publication Number Publication Date
PL338510A1 true PL338510A1 (en) 2000-11-06

Family

ID=25417733

Family Applications (1)

Application Number Title Priority Date Filing Date
PL98338510A PL338510A1 (en) 1997-07-31 1998-07-31 Benzyl compounds inhinbiting the adhesion of leucocytes occurring through the mediation of vla-4

Country Status (12)

Country Link
EP (1) EP1001975A1 (en)
JP (1) JP2001512138A (en)
KR (1) KR20010022413A (en)
CN (1) CN1265675A (en)
AU (1) AU8585198A (en)
BR (1) BR9811573A (en)
CA (1) CA2291473A1 (en)
HU (1) HUP0002680A3 (en)
IL (1) IL133635A0 (en)
NO (1) NO20000414L (en)
PL (1) PL338510A1 (en)
WO (1) WO1999006436A1 (en)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903075B1 (en) 1997-05-29 2005-06-07 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
DE69820614T2 (en) * 1997-05-30 2004-09-30 Celltech Therapeutics Ltd., Slough ANTI-INFLAMMATORY TYROSINE DERIVATIVES
GB2365338B (en) * 1997-06-14 2002-04-03 Enzacta R & D Ltd Therapeutic systems
DK0991619T3 (en) 1997-06-23 2003-12-29 Tanabe Seiyaku Co Inhibitors of alpha 4-beta 1-mediated cell adhesion
US6939855B2 (en) 1997-07-31 2005-09-06 Elan Pharmaceuticals, Inc. Anti-inflammatory compositions and method
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en) 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6423688B1 (en) 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en) 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6197794B1 (en) * 1998-01-08 2001-03-06 Celltech Therapeutics Limited Phenylalanine derivatives
MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
ATE273273T1 (en) 1998-02-26 2004-08-15 Celltech Therapeutics Ltd PHENYLALANINE DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINS
US6521626B1 (en) * 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
GB9811969D0 (en) * 1998-06-03 1998-07-29 Celltech Therapeutics Ltd Chemical compounds
US6685617B1 (en) 1998-06-23 2004-02-03 Pharmacia & Upjohn Company Inhibitors of α4β1 mediated cell adhesion
GB9814414D0 (en) 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
US6339101B1 (en) * 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6333340B1 (en) * 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
GB9919776D0 (en) * 1998-08-31 1999-10-27 Zeneca Ltd Compoujnds
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
GB9821222D0 (en) 1998-09-30 1998-11-25 Celltech Therapeutics Ltd Chemical compounds
GB9825652D0 (en) 1998-11-23 1999-01-13 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6407066B1 (en) 1999-01-26 2002-06-18 Elan Pharmaceuticals, Inc. Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
JP2003517023A (en) * 1999-12-16 2003-05-20 バイオジェン インコーポレイテッド Method of treating ischemic or hemorrhagic damage of the central nervous system with an anti-α4 integrin antagonist
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
EA004673B1 (en) 1999-12-28 2004-06-24 Пфайзер Продактс Инк. Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
DE60130910T2 (en) 2000-04-17 2008-07-10 Ucb Pharma, S.A. ENAMINE DERIVATIVES AS CELL ADHESION MOLECULES
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
JP2004502762A (en) 2000-07-07 2004-01-29 セルテック　アール　アンド　ディ　リミテッド Squaric acid derivatives as integrin antagonists containing bicyclic heteroaromatic rings
JP2004505110A (en) 2000-08-02 2004-02-19 セルテック　アール　アンド　ディ　リミテッド 3-position substituted isoquinolin-1-yl derivative
MY129000A (en) 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
JP2005022976A (en) * 2001-07-18 2005-01-27 Ajinomoto Co Inc Carboxylic acid derivative
MY140707A (en) 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
ES2360882T3 (en) * 2002-03-28 2011-06-10 Merck Serono Sa DERIVATIVES OF THIAZOLIDINE CARBOXAMIDE AS MODULATORS OF PROSTAGLANDINA F. RECEIVER
UY28170A1 (en) * 2003-01-24 2004-07-30 Elan Pharm Inc PREPARATION AND TREATMENT FOR DEMIELINIZING DISEASES AND PARALYSIS THROUGH THE APPLICATION OF REMIELINIZING AGENTS.
ES2390057T3 (en) * 2004-04-20 2012-11-06 Amgen Inc. Arylsulfonylamides and uses as hydroxysteroid dehydrogenase
ATE546430T1 (en) * 2004-06-29 2012-03-15 Aventis Pharma Inc FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF
EP2510941A3 (en) 2007-02-20 2013-01-23 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
BRPI0911652A2 (en) 2008-04-11 2015-08-04 Merrimack Pharmaceuticals Inc Human serum albumin binders and their conjugates
EA201291065A1 (en) 2010-04-16 2013-03-29 Байоджен Айдек Ма Инк. ANTIBODIES AGAINST VLA-4
CN102675244B (en) * 2011-03-16 2016-03-30 中国人民解放军军事医学科学院毒物药物研究所 Thiazine amide derivatives and in the purposes preparing neurodegenerative disease medicine
US20170002077A1 (en) 2014-03-13 2017-01-05 Prothena Biosciences Limited Combination treatment for multiple sclerosis
JP7457661B2 (en) 2018-06-04 2024-03-28 バイオジェン・エムエイ・インコーポレイテッド Anti-VLA-4 antibodies with reduced effector function
KR102630416B1 (en) 2018-10-30 2024-02-01 길리애드 사이언시즈, 인코포레이티드 Quinoline derivatives as alpha4beta7 integrin inhibitors
ES3013256T3 (en) 2018-10-30 2025-04-11 Gilead Sciences Inc Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
AU2019373242B2 (en) 2018-10-30 2023-07-13 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
CN114222730B (en) 2019-08-14 2024-09-10 吉利德科学公司 Compounds for inhibiting α4β7 integrin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04154732A (en) * 1990-10-18 1992-05-27 Nippon Kayaku Co Ltd Optical resolution method
WO1995015973A1 (en) * 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors

Also Published As

Publication number Publication date
HUP0002680A3 (en) 2001-12-28
CA2291473A1 (en) 1999-02-11
NO20000414D0 (en) 2000-01-27
CN1265675A (en) 2000-09-06
JP2001512138A (en) 2001-08-21
KR20010022413A (en) 2001-03-15
NO20000414L (en) 2000-03-28
BR9811573A (en) 2000-09-19
IL133635A0 (en) 2001-04-30
WO1999006436A1 (en) 1999-02-11
HUP0002680A2 (en) 2001-07-30
AU8585198A (en) 1999-02-22
EP1001975A1 (en) 2000-05-24

Similar Documents

Publication Publication Date Title
PL338521A1 (en) Carbamyloxylic compounds inhibiting adhesion of leucocytes occurring through the mediation of vla-4
PL338506A1 (en) Compounds inhibiting adhesion of leucocytes occuring through the mediation of vla-4
PL338554A1 (en) Dipeptidic compounds inhibiting adhesion of leucocytes occurring through the mediation of vla-4
PL338423A1 (en) Compounds of substituted phenylamine type capable to inhibit adhesion of leucocytes through the mediation of vla-4
PL338457A1 (en) Sulphonylated dipeptidic compounds capable to inhibit adhesion of leucocytes through the mediation of vla-4
PL338373A1 (en) Dipeptide and its affinite compounds inhibiting adhesion of leucocytes occurring through mediation of vla-4
IL127563A0 (en) Cell adhesion inhibiting compounds
PL338413A1 (en) Compound of 4-amino phenylalanine type inhibiting adhesion of leucocytes through the meditation of vla-4
IL133635A0 (en) Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4
GB9805214D0 (en) Cell adhesion
GB9720922D0 (en) Adhesives
ZA966292B (en) Adhesive fastening arrangement.
TW299073U (en) Battery assembly
ZA984088B (en) Antithrombotic compound.
GB2341180A9 (en) Compounds on the basis of polyalkyl-1-oxa diazaspirodecane compounds
EP1028947B8 (en) H3 receptor ligands of the phenyl-alkyl-imidazoles type
GB9711118D0 (en) Compound
AUPO691897A0 (en) New compound
GB9515173D0 (en) The fighting flex
GB9706377D0 (en) Novel compound
AUPO973297A0 (en) New compound
AU8546598A (en) Cartridge
HU9700260V0 (en) Arrangement for commercial over the telephone
AU6507998A (en) Distributed telephony management
GB9716429D0 (en) The other option