PL3391890T3 - Preparaty dożylnego roztworu pozakonazolu stabilizowane podstawioną beta-cyklodekstryną - Google Patents

Preparaty dożylnego roztworu pozakonazolu stabilizowane podstawioną beta-cyklodekstryną

Info

Publication number
PL3391890T3
PL3391890T3 PL18171672T PL18171672T PL3391890T3 PL 3391890 T3 PL3391890 T3 PL 3391890T3 PL 18171672 T PL18171672 T PL 18171672T PL 18171672 T PL18171672 T PL 18171672T PL 3391890 T3 PL3391890 T3 PL 3391890T3
Authority
PL
Poland
Prior art keywords
cyclodextrin
intravenous solution
solution formulations
substituted beta
formulations stabilized
Prior art date
Application number
PL18171672T
Other languages
English (en)
Inventor
Susan K. Heimbecher
David Monteith
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45441500&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3391890(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of PL3391890T3 publication Critical patent/PL3391890T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A—HUMAN NECESSITIES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
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    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • AIDS & HIV (AREA)
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  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
PL18171672T 2010-06-29 2011-06-24 Preparaty dożylnego roztworu pozakonazolu stabilizowane podstawioną beta-cyklodekstryną PL3391890T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35970110P 2010-06-29 2010-06-29
EP18171672.1A EP3391890B1 (en) 2010-06-29 2011-06-24 Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin
EP11804061.7A EP2588116A4 (en) 2010-06-29 2011-06-24 BY SUBSTITUTED BETA-CYCLODEXTRIN STABILIZED INTRAVENOUS POSACONAZOLE SOLUTION FORMULATIONS
PCT/US2011/041715 WO2012005973A1 (en) 2010-06-29 2011-06-24 Posaconazole intravenous solution formulations stabilized by substituted beta-cyclodextrin

Publications (1)

Publication Number Publication Date
PL3391890T3 true PL3391890T3 (pl) 2021-12-20

Family

ID=45441500

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18171672T PL3391890T3 (pl) 2010-06-29 2011-06-24 Preparaty dożylnego roztworu pozakonazolu stabilizowane podstawioną beta-cyklodekstryną

Country Status (20)

Country Link
US (2) US9023790B2 (pl)
EP (3) EP3960185A1 (pl)
JP (1) JP6008849B2 (pl)
KR (1) KR101834024B1 (pl)
CN (2) CN107049935A (pl)
AU (1) AU2011276680B2 (pl)
BR (1) BR112012033077B8 (pl)
CA (1) CA2802929C (pl)
CY (1) CY1124690T1 (pl)
DK (1) DK3391890T3 (pl)
ES (1) ES2893444T3 (pl)
HR (1) HRP20211686T1 (pl)
HU (1) HUE056581T2 (pl)
LT (1) LT3391890T (pl)
MX (2) MX338685B (pl)
PL (1) PL3391890T3 (pl)
PT (1) PT3391890T (pl)
RS (1) RS62583B1 (pl)
SI (1) SI3391890T1 (pl)
WO (1) WO2012005973A1 (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090175810A1 (en) 2008-01-03 2009-07-09 Gareth Winckle Compositions and methods for treating diseases of the nail
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
HRP20211686T1 (hr) 2010-06-29 2022-03-04 Merck Sharp & Dohme Corp. Formulacije intravenozne otopine sa posakonazolom, stabilizirane supstituiranim beta-ciklodekstrinom
US8039494B1 (en) 2010-07-08 2011-10-18 Dow Pharmaceutical Sciences, Inc. Compositions and methods for treating diseases of the nail
EP4083075A1 (en) 2012-02-15 2022-11-02 CyDex Pharmaceuticals, Inc. Manufacturing process for cyclodextrin derivatives
MX363386B (es) 2013-10-03 2019-03-20 Dow Pharmaceutical Sciences Formulaciones de efinaconazol estabilizadas.
CN104546724A (zh) * 2013-10-12 2015-04-29 博瑞生物医药技术(苏州)有限公司 一种抗真菌药的固体分散体
CN105848719A (zh) 2013-11-22 2016-08-10 道尔医药科学公司 抗感染的方法、组合物和装置
CN105879041A (zh) * 2014-11-14 2016-08-24 北京赛林泰医药技术有限公司 一种泊沙康唑口服液及其制备方法
EP3220954A4 (en) * 2014-11-19 2018-06-27 Gufic Biosciences Limited Process for preparation of parenteral formulation of anidulafungin
CN104473871B (zh) * 2014-11-28 2017-03-08 济南康和医药科技有限公司 一种泊沙康唑脂肪乳注射液及其制备方法
CN106265534A (zh) * 2015-05-25 2017-01-04 江苏正大丰海制药有限公司 一种泊沙康唑冻干粉针剂的制备方法
CN106511262A (zh) * 2015-09-11 2017-03-22 上海美悦生物科技发展有限公司 一种泊沙康唑口服溶液剂及其制备方法
WO2017133632A1 (zh) 2016-02-04 2017-08-10 武汉朗来科技发展有限公司 泊沙康唑衍生物、其药物组合物和用途
AU2017361875A1 (en) 2016-11-18 2019-06-06 Aicuris Gmbh & Co. Kg Novel formulations of amidine substituted beta-lactam compounds on the basis of modified cyclodextrins and acidifying agents, their preparation and use as antimicrobial pharmaceutical compositions
EP3781209B1 (en) 2018-04-16 2023-08-30 Merck Patent GmbH Viscosity reduction of highly concentrated protein formulations
CN110711174A (zh) * 2018-07-11 2020-01-21 郑州泰丰制药有限公司 一种泊沙康唑注射液中间体溶液配制方法
TR201820816A2 (tr) * 2018-12-28 2020-07-21 Polifarma Ilac Sanayi Ve Ticaret Anonim Sirketi Si̇klodekstri̇n ve şeker i̇çeren stabi̇l enjekte edi̇lebi̇li̇r posakonazol formülasyonlari
WO2021245703A2 (en) * 2020-06-06 2021-12-09 Inventia Healthcare Limited Stable liquid compositions of posaconazole
CN115429748A (zh) * 2021-06-02 2022-12-06 江苏奥赛康药业有限公司 一种泊沙康唑注射液的制备方法
WO2023148763A1 (en) * 2022-02-01 2023-08-10 Cipla Limited Injectable pharmaceutical compositions of azole antifungal agents

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5257985A (en) 1989-12-04 1993-11-02 Richard Puhl Multi-chamber intravenous bag apparatus
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5661151A (en) 1993-12-21 1997-08-26 Schering Corporation Tetrahydrofuran antifungals
ZA9410142B (en) 1993-12-21 1996-05-02 Schering Corp Tetrahydrofuran antifungals
US5703079A (en) 1993-12-21 1997-12-30 Schering Corporation Tetrahydrofuran antifungals
US5834472A (en) 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
US5972381A (en) 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
GB9713149D0 (en) 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
US6713481B1 (en) 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
US20030099674A1 (en) * 2001-08-11 2003-05-29 Chen Andrew X. Lyophilized injectable formulations containing paclitaxel or other taxoid drugs
AU2003234087B2 (en) 2002-04-30 2008-04-17 Otsuka Pharmaceutical Factory, Inc. Multiple-chamber medical container and bag for enclosing same
CA2528493C (en) * 2003-06-06 2009-01-20 Sankyo Company Limited Medicinal composition containing triazole compound
PE20060291A1 (es) * 2004-05-28 2006-04-14 Schering Corp Composiciones farmaceuticas inyectables de posaconazol con particulas estabilizadas
US20060009469A1 (en) * 2004-05-28 2006-01-12 Leonore Witchey-Lakshmanan Particulate-stabilized injectable pharmacutical compositions of posaconazole
US20060160823A1 (en) 2004-05-28 2006-07-20 Leonore Witchey-Lakshmanan Particulate-stabilized injectable pharmaceutical compositions of Posaconazole
ES2320360T3 (es) * 2004-08-13 2009-05-21 Schering-Plough Ltd. Formulacion farmaceutica que comprende un antibiotico, un triazol y un corticosteroide.
WO2006098345A1 (ja) 2005-03-15 2006-09-21 Ajinomoto Co., Inc. 薬剤移送具
US20070082870A1 (en) * 2005-10-11 2007-04-12 Buchanan Charles M Pharmaceutical formulations of cyclodextrins and antifungal azole compounds
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
CN101442987A (zh) * 2005-12-14 2009-05-27 扎尔斯制药公司 喷雾制剂和皮肤给药方法
BRPI0712130A2 (pt) * 2006-05-30 2012-01-17 Elan Pharma Int Ltd formulações de posaconazol em nanopartìculas
PT2061458E (pt) * 2006-09-15 2015-03-11 Univ Minnesota Composições de topiramato e métodos para a sua utilização
EP2125014A2 (en) 2007-01-16 2009-12-02 Enzon Pharmaceuticals, Inc. Posaconazole polymer conjugates and methods of treatment using posaconazole and polymer conjugates thereof
WO2009018069A2 (en) 2007-07-30 2009-02-05 Cydex Pharmaceuticals, Inc Mixtures of cyclodextrin derivatives
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
WO2010011821A2 (en) * 2008-07-24 2010-01-28 Theravance, Inc. Dual-acting antihypertensive agents
HRP20211686T1 (hr) 2010-06-29 2022-03-04 Merck Sharp & Dohme Corp. Formulacije intravenozne otopine sa posakonazolom, stabilizirane supstituiranim beta-ciklodekstrinom

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