PL3400017T3 - Ciągłe kompleksowanie aktywnych składników farmaceutycznych - Google Patents

Ciągłe kompleksowanie aktywnych składników farmaceutycznych

Info

Publication number
PL3400017T3
PL3400017T3 PL17707096T PL17707096T PL3400017T3 PL 3400017 T3 PL3400017 T3 PL 3400017T3 PL 17707096 T PL17707096 T PL 17707096T PL 17707096 T PL17707096 T PL 17707096T PL 3400017 T3 PL3400017 T3 PL 3400017T3
Authority
PL
Poland
Prior art keywords
active pharmaceutical
pharmaceutical ingredients
complexation
continuous
continuous complexation
Prior art date
Application number
PL17707096T
Other languages
English (en)
Inventor
Hugo LISBOA
Márcio TEMTEM
João VINCENTE
Filipa SANTOS
Original Assignee
Hovione Scientia Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Scientia Limited filed Critical Hovione Scientia Limited
Publication of PL3400017T3 publication Critical patent/PL3400017T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL17707096T 2016-01-28 2017-01-27 Ciągłe kompleksowanie aktywnych składników farmaceutycznych PL3400017T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT10911716A PT109117B (pt) 2016-01-28 2016-01-28 Complexação de ingredientes ativos farmacêuticos
PCT/GB2017/050210 WO2017129988A1 (en) 2016-01-28 2017-01-27 Continuous complexation of active pharmaceutical ingredients
EP17707096.8A EP3400017B1 (en) 2016-01-28 2017-01-27 Continuous complexation of active pharmaceutical ingredients

Publications (1)

Publication Number Publication Date
PL3400017T3 true PL3400017T3 (pl) 2020-07-13

Family

ID=58159103

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17707096T PL3400017T3 (pl) 2016-01-28 2017-01-27 Ciągłe kompleksowanie aktywnych składników farmaceutycznych

Country Status (12)

Country Link
US (1) US11759529B2 (pl)
EP (1) EP3400017B1 (pl)
JP (1) JP7038057B2 (pl)
CN (1) CN108778338B (pl)
AU (1) AU2017211520B2 (pl)
CA (1) CA3011820C (pl)
DK (1) DK3400017T3 (pl)
HU (1) HUE048601T2 (pl)
IL (1) IL260766B (pl)
PL (1) PL3400017T3 (pl)
PT (1) PT109117B (pl)
WO (1) WO2017129988A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT109117B (pt) 2016-01-28 2019-02-01 Hovione Farm Sa Complexação de ingredientes ativos farmacêuticos
UA127186C2 (uk) * 2017-09-18 2023-05-31 Феррінґ Інтернешнл Сентер С.А. Виготовлення фармацевтичного складу
US20190160005A1 (en) * 2017-11-24 2019-05-30 Biophore India Pharmaceuticals Pvt. Ltd. Method of Preparing Solid Dispersions of Active Pharmaceutical Ingredients
PT110585B (pt) * 2018-02-22 2021-04-22 Hovione Farmaciencia Sa Processo de produção contínua de partículas compreendendo secagem por atomização com preparação contínua da solução de atomização
CN115193496B (zh) * 2022-07-18 2024-02-27 南昌大学 一种微流道装置和该装置制备的高载油微胶囊及其方法
CN119015232A (zh) * 2024-08-23 2024-11-26 山东德州神牛药业有限公司 一种吡喹酮纳米粉和制备方法及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646131A (en) 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
GB9713149D0 (en) * 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
US6555139B2 (en) * 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US20020086061A1 (en) 1999-10-26 2002-07-04 Sharma Vinay K. Preparation of micron-size felodipine particles by microfluidization
DE10003493A1 (de) 2000-01-27 2001-08-09 Wacker Chemie Gmbh Verfahren zur Herstellung eines Koezym Q10-/y-Cyclodextrin Komplexes
US6884885B2 (en) 2000-12-21 2005-04-26 Cerestar Holding B.V. Production of cyclodextrin complexes
WO2002056883A1 (en) 2001-01-18 2002-07-25 Wockhardt Limited Preparation of micron-size felodipine particles by microfluidization
US20030091627A1 (en) 2001-10-31 2003-05-15 Vinay Sharma Rate-controlled delivery of macrolides
CN1813751A (zh) * 2005-11-24 2006-08-09 南京都药医药科技有限公司 一种伏立康唑注射剂及其制备方法
CN101172102B (zh) 2006-10-31 2010-09-01 沈阳市万嘉生物技术研究所 一种水溶性辅酶q10超分子组合物及制备方法
JP2008169379A (ja) 2006-12-11 2008-07-24 Japan Science & Technology Agency 包接化合物の製造方法
US7635773B2 (en) * 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
CN101507909A (zh) * 2009-02-25 2009-08-19 中国科学院过程工程研究所 一种利用微流控反应器组合合成分子印迹微球的方法
CN103690968A (zh) * 2013-11-21 2014-04-02 石药集团中奇制药技术(石家庄)有限公司 一种伏立康唑组合物及其制备方法
PT107433B (pt) 2014-01-28 2018-12-04 Hovione Farm S A Processo de redução e controlo do tamanho de partícula
NZ724756A (en) * 2014-04-04 2023-07-28 Ai Therapeutics Inc An inhalable rapamycin formulation for treating age-related conditions
PT109117B (pt) 2016-01-28 2019-02-01 Hovione Farm Sa Complexação de ingredientes ativos farmacêuticos

Also Published As

Publication number Publication date
AU2017211520A1 (en) 2018-08-16
PT109117A (pt) 2017-07-28
PT109117B (pt) 2019-02-01
IL260766B (en) 2020-11-30
HUE048601T2 (hu) 2020-07-28
US20190060486A1 (en) 2019-02-28
CN108778338B (zh) 2022-04-01
CN108778338A (zh) 2018-11-09
AU2017211520B2 (en) 2022-01-27
WO2017129988A1 (en) 2017-08-03
JP7038057B2 (ja) 2022-03-17
EP3400017A1 (en) 2018-11-14
CA3011820C (en) 2023-12-19
EP3400017B1 (en) 2020-02-19
JP2019507127A (ja) 2019-03-14
US11759529B2 (en) 2023-09-19
BR112018015481A2 (pt) 2018-12-18
CA3011820A1 (en) 2017-08-03
DK3400017T3 (da) 2020-05-18

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