PL3415616T3 - Sposób odmładzania komórek - Google Patents

Sposób odmładzania komórek

Info

Publication number
PL3415616T3
PL3415616T3 PL18183987.9T PL18183987T PL3415616T3 PL 3415616 T3 PL3415616 T3 PL 3415616T3 PL 18183987 T PL18183987 T PL 18183987T PL 3415616 T3 PL3415616 T3 PL 3415616T3
Authority
PL
Poland
Prior art keywords
rejuvenation method
cell rejuvenation
cell
rejuvenation
Prior art date
Application number
PL18183987.9T
Other languages
English (en)
Inventor
Alexandre PRIEUR
Ollivier MILHAVET
Jean-Marc Lemaitre
Laure LAPASSET
Original Assignee
INSERM (Institut National de la Santé et de la Recherche Médicale)
Centre National De La Recherche Scientifique - Cnrs
Université De Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INSERM (Institut National de la Santé et de la Recherche Médicale), Centre National De La Recherche Scientifique - Cnrs, Université De Montpellier filed Critical INSERM (Institut National de la Santé et de la Recherche Médicale)
Publication of PL3415616T3 publication Critical patent/PL3415616T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/605—Nanog
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/606—Transcription factors c-Myc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/608—Lin28
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL18183987.9T 2011-04-08 2012-04-10 Sposób odmładzania komórek PL3415616T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11161771 2011-04-08

Publications (1)

Publication Number Publication Date
PL3415616T3 true PL3415616T3 (pl) 2024-10-14

Family

ID=45094314

Family Applications (2)

Application Number Title Priority Date Filing Date
PL12712670T PL2694642T3 (pl) 2011-04-08 2012-04-10 Sposób odmładzania komórek
PL18183987.9T PL3415616T3 (pl) 2011-04-08 2012-04-10 Sposób odmładzania komórek

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL12712670T PL2694642T3 (pl) 2011-04-08 2012-04-10 Sposób odmładzania komórek

Country Status (7)

Country Link
US (4) US9476031B2 (pl)
EP (3) EP4382171A3 (pl)
JP (3) JP6584776B2 (pl)
CN (1) CN103562376B (pl)
ES (2) ES2695550T3 (pl)
PL (2) PL2694642T3 (pl)
WO (1) WO2012136841A1 (pl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140051600A1 (en) * 2012-08-16 2014-02-20 Mandala Biosciences Llc SUPERCENTENARIAN INDUCED PLURIPOTENT STEM (sciPS) CELLS AND METHODS OF MAKING AND USING THEREOF
EP2986710A4 (en) * 2013-04-16 2016-11-09 Sloan Kettering Inst Cancer AGE-MODIFIED CELLS AND METHOD FOR PRODUCING AGED-MODIFIED CELLS
EP3204502B1 (en) 2014-10-06 2021-04-21 Memorial Sloan-Kettering Cancer Center Method to reduce oncogenic potential of induced pluripotent stem cells from aged donors
WO2016063192A1 (en) * 2014-10-21 2016-04-28 Consiglio Nazionale Delle Ricerche New methods and agents for cellular reprogramming
WO2016185481A2 (en) 2015-05-20 2016-11-24 Yeda Research And Development Co. Ltd. Method of targeting senescent cells
CN105061594B (zh) * 2015-07-16 2019-03-19 中国人民解放军第二军医大学 一种抗人Oct4单克隆抗体及其制备与应用
US20180245051A1 (en) * 2015-11-02 2018-08-30 Orig3N, Inc. Methods for generating induced pluripotent stem cells via cell cycle synchronization
EP3370744A4 (en) * 2015-11-02 2019-04-17 Orig3N, Inc. CELL CYCLE BLOCK FOR IMPROVING EFFICIENCY IN THE MANUFACTURE OF INDUCED PLURIPOTENTER STEM CELLS
WO2018148409A1 (en) * 2017-02-08 2018-08-16 Orig3N, Inc. Systems, methods, and apparatus for induced pluripotent stem cell isolation and combinatorial production
WO2019166702A1 (fr) 2018-02-28 2019-09-06 Hagalife Utilisation d'un procédé d'irradiation flash pour augmenter la longévité et/ou pour retarder les effets du vieillissement chez les mammifères
CN112154210A (zh) * 2018-03-13 2020-12-29 利兰斯坦福初级大学董事会 用于逆转细胞老化的瞬时细胞重编程
CN110628821B (zh) * 2018-06-25 2022-02-18 首都医科大学宣武医院 一种细胞模型及其制备方法、应用
JP7241483B2 (ja) * 2018-07-23 2023-03-17 株式会社ノエビア 皮膚用組成物
US12274733B2 (en) 2018-09-28 2025-04-15 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
EP3856226B1 (en) * 2018-09-28 2026-02-18 President and Fellows of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
EP3856260A1 (en) 2018-09-28 2021-08-04 President and Fellows of Harvard College Mutant reverse tetracycline transactivators for expression of genes
US20230091910A1 (en) * 2019-04-02 2023-03-23 Centagen, Inc. Engineered System of Stem Cell Rejuvenation to Treat Aging and Disease
GB201909975D0 (en) * 2019-07-11 2019-08-28 Babraham Inst Novel reprogramming method
IL275186A (en) 2020-06-07 2022-01-01 Yeda Res & Dev Human antibodies against grp94 and uses
MX2023003818A (es) * 2020-10-02 2023-06-14 Fate Therapeutics Inc Reprogramación, mantenimiento y conservación mejorados para células madre pluripotentes inducidas.
AU2021386370A1 (en) * 2020-11-24 2023-06-22 Lyell Immunopharma, Inc. Methods for making, compositions comprising, and methods of using rejuvenated t cells
WO2022135486A1 (zh) * 2020-12-22 2022-06-30 中国科学院动物研究所 鉴定和/或调节衰老的方法
WO2023288287A2 (en) * 2021-07-15 2023-01-19 Turn Biotechnologies, Inc. Synthetic, persistent rna constructs and methods of use for cell rejuvenation and for treatment
US20250288610A1 (en) * 2022-04-21 2025-09-18 Restoration Biologics Nutritional or Dietary Supplement to Enhance Regenerative Medicine Therapies
WO2024052434A1 (en) 2022-09-06 2024-03-14 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Engineering sox/oct heterodimerization to induce high-grade developmental reset
CN115607689A (zh) * 2022-10-13 2023-01-17 呈诺再生医学科技(北京)有限公司 Klf7基因在制备逆转细胞衰老的药物中的应用
US12252518B2 (en) 2023-01-06 2025-03-18 Life Biosciences, Inc. Methods of treating non-arteritic anterior ischemic optic neuropathy
CN119265241A (zh) * 2023-06-30 2025-01-07 深圳菁童生命科学有限公司 一种无相分离转录因子介导启始阶段重编程使细胞年轻化的方法
EP4744675A1 (en) * 2023-07-11 2026-05-20 Nanjing Reju Therapeutics Co Ltd COMPOSITION AND METHOD OF USE
WO2025166291A1 (en) * 2024-02-01 2025-08-07 Immorta Bio, Inc. Systemic means of dedifferentiation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1214443A4 (en) * 1999-09-07 2003-08-27 Advanced Cell Tech Inc RESTORATION OF THE TELOMER AND EXTENSION OF THE CELL LIFETIME IN CLONED ANIMALS FROM SENESCENT SOMATIC CELLS
CN101864392B (zh) 2005-12-13 2016-03-23 国立大学法人京都大学 核重新编程因子
AU2008297024B2 (en) * 2007-10-31 2014-08-28 Kyoto University Nuclear reprogramming method
JP2011516042A (ja) 2008-03-17 2011-05-26 へルムホルツ・ツェントルム・ミュンヘン−ドイチェス・フォルシュングスツェントルム・ヒューア・ゲズントハイト・ウント・ウムヴェルト（ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング） 部位特異的組み換えを用いて無ベクター誘導多能性幹（ｉＰＳ）細胞を作製するベクターおよびその方法
CN102159710B (zh) * 2008-07-16 2015-09-02 生物载体株式会社 使用染色体非整合型病毒载体制造经初始化的细胞的方法
WO2010042490A1 (en) 2008-10-06 2010-04-15 Boston Medical Center Corporation A single lentiviral vector system for induced pluripotent (ips) stem cells derivation
ES2900277T3 (es) * 2009-03-20 2022-03-16 Mesoblast Inc Producción de células pluripotentes reprogramadas
WO2011016588A1 (en) 2009-08-07 2011-02-10 Kyoto University Method of efficiently establishing induced pluripotent stem cells

Also Published As

Publication number Publication date
EP3415616B1 (en) 2024-05-22
JP2014511689A (ja) 2014-05-19
EP4382171A3 (en) 2024-10-09
US9476031B2 (en) 2016-10-25
US20200095556A1 (en) 2020-03-26
US20140056860A1 (en) 2014-02-27
US20180312813A1 (en) 2018-11-01
ES2695550T3 (es) 2019-01-09
US20160376560A1 (en) 2016-12-29
JP6584776B2 (ja) 2019-10-02
CN103562376B (zh) 2017-12-29
PL2694642T3 (pl) 2019-01-31
EP2694642A1 (en) 2014-02-12
EP3415616A1 (en) 2018-12-19
EP2694642B1 (en) 2018-08-15
JP7051748B2 (ja) 2022-04-11
JP2017140040A (ja) 2017-08-17
EP2694642B8 (en) 2018-10-17
JP2019151660A (ja) 2019-09-12
ES2991402T3 (es) 2024-12-03
EP4382171A2 (en) 2024-06-12
WO2012136841A1 (en) 2012-10-11
CN103562376A (zh) 2014-02-05
US11414649B2 (en) 2022-08-16

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