PL342468A1 - Streptomyces avermitilis gene controlling the ratio b2:b1 of avermerctins - Google Patents

Streptomyces avermitilis gene controlling the ratio b2:b1 of avermerctins

Info

Publication number
PL342468A1
PL342468A1 PL99342468A PL34246899A PL342468A1 PL 342468 A1 PL342468 A1 PL 342468A1 PL 99342468 A PL99342468 A PL 99342468A PL 34246899 A PL34246899 A PL 34246899A PL 342468 A1 PL342468 A1 PL 342468A1
Authority
PL
Poland
Prior art keywords
avermerctins
ratio
streptomyces avermitilis
gene controlling
avermitilis gene
Prior art date
Application number
PL99342468A
Other versions
PL194270B1 (en
Inventor
Kim Jonelle Stutzman-Engwall
Yoshihiro Katoh
Hamish Alastair Irvin Mcarthur
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PL342468A1 publication Critical patent/PL342468A1/en
Publication of PL194270B1 publication Critical patent/PL194270B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL99342468A 1998-02-13 1999-01-25 Streptomyces avermitilis gene controlling the ratio b2:b1 of avermerctins PL194270B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13
PCT/IB1999/000130 WO1999041389A1 (en) 1998-02-13 1999-01-25 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (2)

Publication Number Publication Date
PL342468A1 true PL342468A1 (en) 2001-06-04
PL194270B1 PL194270B1 (en) 2007-05-31

Family

ID=22120706

Family Applications (1)

Application Number Title Priority Date Filing Date
PL99342468A PL194270B1 (en) 1998-02-13 1999-01-25 Streptomyces avermitilis gene controlling the ratio b2:b1 of avermerctins

Country Status (32)

Country Link
EP (1) EP1053335A1 (en)
JP (2) JP2002503473A (en)
KR (3) KR20040099389A (en)
CN (2) CN1297485A (en)
AP (1) AP9901463A0 (en)
AR (1) AR018085A1 (en)
AU (1) AU752343C (en)
BG (1) BG64911B1 (en)
BR (1) BR9907893A (en)
CA (2) CA2521289A1 (en)
CO (1) CO5070698A1 (en)
DZ (1) DZ2720A1 (en)
EA (1) EA003905B1 (en)
GT (1) GT199900014A (en)
HN (1) HN1999000008A (en)
HR (1) HRP20000539A2 (en)
HU (1) HUP0100784A3 (en)
IL (2) IL137610A0 (en)
IS (1) IS5567A (en)
MA (1) MA24760A1 (en)
NO (1) NO20004044L (en)
NZ (2) NZ505676A (en)
OA (1) OA11449A (en)
PA (1) PA8467601A1 (en)
PE (1) PE20000352A1 (en)
PL (1) PL194270B1 (en)
SK (1) SK11722000A3 (en)
TN (1) TNSN99017A1 (en)
TW (1) TW585910B (en)
WO (1) WO1999041389A1 (en)
YU (1) YU50900A (en)
ZA (1) ZA991138B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL194270B1 (en) * 1998-02-13 2007-05-31 Pfizer Prod Inc Streptomyces avermitilis gene controlling the ratio b2:b1 of avermerctins
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
WO2001012821A1 (en) 1999-08-12 2001-02-22 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US7630836B2 (en) * 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
RS50813B (en) * 2002-02-12 2010-08-31 Pfizer Products Inc. STREPTOMYCES AVERMITILIS GEN DETERMINING RELATION B2: B1 AVERMECTIN
CN107338210B (en) * 2017-09-05 2021-08-17 天津科技大学 A kind of Streptomyces avermitilis synthetic medium and preparation method of fermentation broth thereof
CN111269296B (en) * 2020-03-06 2021-11-05 山东大学 nLsA protein, structural gene thereof and application thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (en) * 1976-04-19 1984-07-16 Merck & Co Inc SET TO MAKE NEW ANTIHELMINTICALLY EFFECTIVE ASSOCIATIONS BY CULTIVATING STREPTOMYCS AVERMITILIS
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (en) * 1987-01-23 1991-01-19 Pfizer
ATE89604T1 (en) * 1987-10-23 1993-06-15 Pfizer PROCESS FOR THE PREPARATION OF AGLYCONES OF AVERMECTIN AND CULTURES CONTAINING THEM.
JPH0747171B2 (en) * 1988-09-20 1995-05-24 株式会社東芝 Rolling mill setting method and device
DE69023036T2 (en) * 1989-03-31 1996-06-13 Merck & Co Inc Cloning of Streptomyces avermitilis genes for the biosynthesis of avermectin and method of using them.
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
JP2888586B2 (en) * 1990-03-05 1999-05-10 社団法人北里研究所 Microorganism for selective production of specific components of avermectin and its selective production method
FI942725A7 (en) * 1993-12-16 1995-06-17 Pfizer Genes encoding the branched-chain alpha-keto acid dehydrogenase complex from Streptomyces avermitilis
PL194270B1 (en) * 1998-02-13 2007-05-31 Pfizer Prod Inc Streptomyces avermitilis gene controlling the ratio b2:b1 of avermerctins

Also Published As

Publication number Publication date
AR018085A1 (en) 2001-10-31
AP9901463A0 (en) 1999-03-31
EA200000758A1 (en) 2001-04-23
KR100499214B1 (en) 2005-07-07
CA2521289A1 (en) 1999-08-19
HUP0100784A2 (en) 2001-06-28
OA11449A (en) 2003-12-03
KR20010052166A (en) 2001-06-25
IS5567A (en) 2000-07-20
DZ2720A1 (en) 2003-09-01
TNSN99017A1 (en) 2005-11-10
GT199900014A (en) 2000-07-25
CO5070698A1 (en) 2001-08-28
NO20004044D0 (en) 2000-08-11
HN1999000008A (en) 1999-10-29
ZA991138B (en) 2000-08-14
SK11722000A3 (en) 2001-04-09
AU752343B2 (en) 2002-09-19
TW585910B (en) 2004-05-01
PL194270B1 (en) 2007-05-31
KR20040099389A (en) 2004-11-26
IL183596A0 (en) 2007-09-20
AU752343C (en) 2005-11-03
NZ505676A (en) 2003-02-28
IL137610A0 (en) 2001-07-24
KR20040053390A (en) 2004-06-23
MA24760A1 (en) 1999-10-01
EP1053335A1 (en) 2000-11-22
BG104759A (en) 2001-04-30
HUP0100784A3 (en) 2004-10-28
NZ518657A (en) 2003-10-31
CN1297485A (en) 2001-05-30
BR9907893A (en) 2000-11-14
HRP20000539A2 (en) 2001-04-30
JP2004283174A (en) 2004-10-14
AU1887899A (en) 1999-08-30
JP2002503473A (en) 2002-02-05
JP4011036B2 (en) 2007-11-21
YU50900A (en) 2004-03-12
CA2320031A1 (en) 1999-08-19
PE20000352A1 (en) 2000-05-16
WO1999041389A1 (en) 1999-08-19
BG64911B1 (en) 2006-08-31
CN1521180A (en) 2004-08-18
EA003905B1 (en) 2003-10-30
NO20004044L (en) 2000-10-11
PA8467601A1 (en) 2000-09-29

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Legal Events

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LAPS Decisions on the lapse of the protection rights

Effective date: 20080125