PL3438096T3 - Sposób wytwarzania 1-(arylometylo)chinazolino-2,4(1H,3H)-dionu - Google Patents

Sposób wytwarzania 1-(arylometylo)chinazolino-2,4(1H,3H)-dionu

Info

Publication number
PL3438096T3
PL3438096T3 PL17773281T PL17773281T PL3438096T3 PL 3438096 T3 PL3438096 T3 PL 3438096T3 PL 17773281 T PL17773281 T PL 17773281T PL 17773281 T PL17773281 T PL 17773281T PL 3438096 T3 PL3438096 T3 PL 3438096T3
Authority
PL
Poland
Prior art keywords
arylmethyl
quinazoline
dione
manufacturing process
manufacturing
Prior art date
Application number
PL17773281T
Other languages
English (en)
Inventor
Suixiong Cai
Ping Huang
Original Assignee
Impact Therapeutics, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Impact Therapeutics, Inc filed Critical Impact Therapeutics, Inc
Publication of PL3438096T3 publication Critical patent/PL3438096T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL17773281T 2016-04-01 2017-03-31 Sposób wytwarzania 1-(arylometylo)chinazolino-2,4(1H,3H)-dionu PL3438096T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610202881 2016-04-01
EP17773281.5A EP3438096B1 (en) 2016-04-01 2017-03-31 Manufacturing process for 1-(arylmethyl) quinazoline-2,4 (1h, 3h)-dione
PCT/CN2017/078913 WO2017167251A1 (zh) 2016-04-01 2017-03-31 1-(芳基甲基)喹唑啉-2,4(1h,3h)-二酮的制备工艺

Publications (1)

Publication Number Publication Date
PL3438096T3 true PL3438096T3 (pl) 2021-05-17

Family

ID=59963547

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17773281T PL3438096T3 (pl) 2016-04-01 2017-03-31 Sposób wytwarzania 1-(arylometylo)chinazolino-2,4(1H,3H)-dionu

Country Status (13)

Country Link
US (1) US10562889B2 (pl)
EP (1) EP3438096B1 (pl)
CN (1) CN109153652B (pl)
CY (1) CY1123898T1 (pl)
DK (1) DK3438096T3 (pl)
ES (1) ES2859460T3 (pl)
HR (1) HRP20210328T1 (pl)
HU (1) HUE053554T2 (pl)
PL (1) PL3438096T3 (pl)
PT (1) PT3438096T (pl)
RS (1) RS61556B1 (pl)
SI (1) SI3438096T1 (pl)
WO (1) WO2017167251A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4185295A4 (en) * 2020-07-24 2024-07-24 Impact Therapeutics (Shanghai), Inc Combination therapy of parp inhibitors
WO2022099442A1 (zh) * 2020-11-10 2022-05-19 上海瑛派药业有限公司 5-氟-1-(4-氟-3-(4-(嘧啶-2-基)哌嗪-1-羰基)苄基)喹唑啉-2,4(1h,3h)-二酮的结晶形式及其制备
WO2022199697A1 (en) 2021-03-26 2022-09-29 Impact Therapeutics (Shanghai) , Inc Oral capsule of parp inhibitor and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100475793C (zh) * 2003-03-31 2009-04-08 大正制药株式会社 喹唑啉衍生物及其制备药物的用途
CN1980913B (zh) * 2004-06-30 2011-12-14 詹森药业有限公司 作为parp抑制剂的喹唑啉二酮衍生物
CN101068794B (zh) * 2004-09-02 2012-12-19 沃泰克斯药物股份有限公司 可用作离子通道调控剂的喹唑啉
CN101475537A (zh) * 2009-01-07 2009-07-08 太仓市浦源化工有限公司 一种2,4-二氯喹唑啉的制备方法
EP2686305B1 (en) * 2011-03-14 2020-09-16 Impact Therapeutics, Inc. Quinazolinediones and their use
TWI527800B (zh) * 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用
US9102631B2 (en) * 2011-11-01 2015-08-11 Impact Therapeutics, Inc. 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof
DK3278803T3 (da) * 2015-04-03 2022-08-29 Impact Therapeutics Shanghai Inc Fast farmaceutisk doseringsform af PARP-inhibitor, og anvendelse af fast farmaceutisk doseringsform af PARP-inhibitor
WO2017109722A1 (en) * 2015-12-21 2017-06-29 Idemitsu Kosan Co., Ltd. Nitrogen-containing heterocyclic compounds and organic electroluminescence devices containing them

Also Published As

Publication number Publication date
ES2859460T3 (es) 2021-10-04
CN109153652B (zh) 2021-07-27
PT3438096T (pt) 2021-03-03
RS61556B1 (sr) 2021-04-29
US10562889B2 (en) 2020-02-18
SI3438096T1 (sl) 2021-04-30
EP3438096B1 (en) 2020-12-02
EP3438096A1 (en) 2019-02-06
EP3438096A4 (en) 2019-08-21
US20190112298A1 (en) 2019-04-18
WO2017167251A1 (zh) 2017-10-05
DK3438096T3 (da) 2021-02-22
HUE053554T2 (hu) 2021-07-28
CY1123898T1 (el) 2022-05-27
HRP20210328T1 (hr) 2021-04-02
CN109153652A (zh) 2019-01-04

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