PL3440205T3 - Nieinwazyjna diagnostyka poprzez sekwencjonowanie 5-hydroksymetylowanego dna bezkomórkowego - Google Patents
Nieinwazyjna diagnostyka poprzez sekwencjonowanie 5-hydroksymetylowanego dna bezkomórkowegoInfo
- Publication number
- PL3440205T3 PL3440205T3 PL17779593T PL17779593T PL3440205T3 PL 3440205 T3 PL3440205 T3 PL 3440205T3 PL 17779593 T PL17779593 T PL 17779593T PL 17779593 T PL17779593 T PL 17779593T PL 3440205 T3 PL3440205 T3 PL 3440205T3
- Authority
- PL
- Poland
- Prior art keywords
- sequencing
- free dna
- hydroxymethylated
- cell
- noninvasive diagnostics
- Prior art date
Links
- 238000012163 sequencing technique Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/191—Modifications characterised by incorporating an adaptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319702P | 2016-04-07 | 2016-04-07 | |
| US201762444122P | 2017-01-09 | 2017-01-09 | |
| US201762461712P | 2017-02-21 | 2017-02-21 | |
| EP17779593.7A EP3440205B1 (en) | 2016-04-07 | 2017-04-03 | Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna |
| PCT/US2017/025735 WO2017176630A1 (en) | 2016-04-07 | 2017-04-03 | Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3440205T3 true PL3440205T3 (pl) | 2021-11-22 |
Family
ID=60000634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17779593T PL3440205T3 (pl) | 2016-04-07 | 2017-04-03 | Nieinwazyjna diagnostyka poprzez sekwencjonowanie 5-hydroksymetylowanego dna bezkomórkowego |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US10718010B2 (pl) |
| EP (2) | EP3929290A1 (pl) |
| JP (2) | JP7143221B2 (pl) |
| CN (1) | CN109312399B (pl) |
| AU (1) | AU2017246318B2 (pl) |
| DK (1) | DK3440205T3 (pl) |
| ES (1) | ES2882329T3 (pl) |
| MX (1) | MX391039B (pl) |
| PL (1) | PL3440205T3 (pl) |
| PT (1) | PT3440205T (pl) |
| RU (1) | RU2742355C2 (pl) |
| SG (1) | SG11201808775PA (pl) |
| WO (1) | WO2017176630A1 (pl) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| ES3018861T3 (en) | 2011-12-13 | 2025-05-19 | Univ Oslo Hf | Method for detection of hydroxymethylation status |
| US10563248B2 (en) | 2012-11-30 | 2020-02-18 | Cambridge Epigenetix Limited | Oxidizing agent for modified nucleotides |
| CA2912666A1 (en) | 2013-05-28 | 2014-12-04 | Ramot At Tel-Aviv University Ltd. | Detection of hydroxymethylcytosine bases |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3274440B1 (en) | 2015-03-27 | 2026-03-04 | Exact Sciences Corporation | Detecting esophageal disorders |
| US11459573B2 (en) | 2015-09-30 | 2022-10-04 | Trustees Of Boston University | Deadman and passcode microbial kill switches |
| US20170298422A1 (en) | 2016-04-18 | 2017-10-19 | The Board Of Trustees Of The Leland Stanford Junior University | Simultaneous single-molecule epigenetic imaging of dna methylation and hydroxymethylation |
| TWI833715B (zh) | 2017-10-27 | 2024-03-01 | 美商奇諾診療公司 | 用於超低體積液體生物檢體之裝置、系統及方法 |
| MA51633A (fr) | 2018-01-08 | 2020-11-18 | Ludwig Inst For Cancer Res Ltd | Identification par résolution de base sans bisulfite de modifications de cytosine |
| US11634748B2 (en) | 2018-02-14 | 2023-04-25 | Clearnote Health, Inc. | Methods for the epigenetic analysis of DNA, particularly cell-free DNA |
| JP2021514663A (ja) * | 2018-03-08 | 2021-06-17 | セント・ジョーンズ・ユニバーシティＳｔ． Ｊｏｈｎｓ Ｕｎｉｖｅｒｓｉｔｙ | 循環性血清無細胞ｄｎａバイオマーカー及び方法 |
| WO2019191319A1 (en) | 2018-03-30 | 2019-10-03 | Juno Diagnostics, Inc. | Deep learning-based methods, devices, and systems for prenatal testing |
| WO2019195268A2 (en) | 2018-04-02 | 2019-10-10 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| CN112534067A (zh) | 2018-06-22 | 2021-03-19 | 蓝星基因组股份有限公司 | 用于分配起源组织的无细胞核酸样品的羟甲基化分析及相关使用方法 |
| SG11202102421PA (en) * | 2018-09-19 | 2021-04-29 | Bluestar Genomics Inc | Cell-free dna hydroxymethylation profiles in the evaluation of pancreatic lesions |
| CA3111887A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| CN113166796A (zh) | 2018-10-04 | 2021-07-23 | 蓝星基因组股份有限公司 | 来自单个生物样品的蛋白质、核糖体和无细胞核酸的同时基于测序的分析 |
| WO2020080861A1 (ko) * | 2018-10-19 | 2020-04-23 | 한국생명공학연구원 | Syt11 억제제를 유효성분으로 포함하는 위암 치료용 조성물 |
| CN109321647A (zh) * | 2018-10-26 | 2019-02-12 | 苏州森苗生物科技有限公司 | 标记组合物及羟甲基化核酸文库的构建方法 |
| CA3127329A1 (en) | 2019-01-24 | 2020-07-30 | Mayo Foundation For Medical Education And Research | Detecting endometrial cancer |
| ES3013495T3 (en) | 2019-01-31 | 2025-04-14 | Guardant Health Inc | Method for isolating and sequencing cell-free dna |
| WO2020194057A1 (en) * | 2019-03-22 | 2020-10-01 | Cambridge Epigenetix Limited | Biomarkers for disease detection |
| WO2020198312A1 (en) * | 2019-03-27 | 2020-10-01 | Juno Diagnostics, Inc. | Optimized ultra-low volume liquid biopsy methods, systems, and devices |
| WO2020263978A1 (en) * | 2019-06-25 | 2020-12-30 | Accuragen Holdings Limited | Methods and systems for disease detection |
| WO2021005537A1 (en) | 2019-07-08 | 2021-01-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Bisulfite-free, whole genome methylation analysis |
| JP7475427B2 (ja) * | 2019-08-06 | 2024-04-26 | ヌーマ バイオ インコーポレイテッド | ナノ細孔デバイス内で特徴をマッピングするための強制移動ポリヌクレオチドスキャンニング |
| WO2021087275A1 (en) | 2019-10-31 | 2021-05-06 | Mayo Foundation For Medical Education And Research | Detecting ovarian cancer |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| WO2021198726A1 (en) * | 2020-03-30 | 2021-10-07 | Vilnius University | Methods and compositions for noninvasive prenatal diagnosis through targeted covalent labeling of genomic sites |
| CN115989551A (zh) * | 2020-06-10 | 2023-04-18 | 国家医疗保健研究所 | 用于评估器官组织学数据的方法和相关设备 |
| IL300238A (en) | 2020-07-30 | 2023-03-01 | Cambridge Epigenetix Ltd | Compositions and Methods for Nucleic Acid Analysis |
| CN116670299A (zh) | 2020-08-19 | 2023-08-29 | 梅约医学教育与研究基金会 | 检测非霍奇金淋巴瘤 |
| EP4251765A1 (en) * | 2020-11-30 | 2023-10-04 | Guardant Health, Inc. | Compositions and methods for enriching methylated polynucleotides |
| CN114613423A (zh) * | 2020-12-09 | 2022-06-10 | 上海易毕恩基因科技有限公司 | 用于弥漫大b细胞淋巴瘤化疗疗效预测的生物标志物 |
| CA3206781A1 (en) | 2021-01-29 | 2022-08-04 | John B. Kisiel | Detecting the presence or absence of multiple types of cancer |
| WO2023003851A1 (en) * | 2021-07-20 | 2023-01-26 | Freenome Holdings, Inc. | Compositions and methods for improved 5-hydroxymethylated cytosine resolution in nucleic acid sequencing |
| CN113528616A (zh) * | 2021-07-26 | 2021-10-22 | 深圳泰莱生物科技有限公司 | 一种捕获cfDNA5hmC片段的检测方法 |
| WO2023040997A1 (zh) * | 2021-09-17 | 2023-03-23 | 北京大学 | 一种单基因检测方法及其应用 |
| CA3233868A1 (en) * | 2021-10-08 | 2023-04-13 | Eddie Adams | Metaepigenomics-based disease diagnostics |
| CN115992203B (zh) * | 2022-07-26 | 2024-07-26 | 生工生物工程（上海）股份有限公司 | 一种全基因组羟甲基化捕获测序的文库构建方法 |
| CN115491414A (zh) * | 2022-09-21 | 2022-12-20 | 安徽中医药大学第一附属医院(安徽省中医院) | 类风湿关节炎全转录组m6A甲基化修饰差异表达的综合分析方法 |
| EP4655416A1 (en) | 2023-01-25 | 2025-12-03 | Guardant Health, Inc. | Nucleic acid methylation profiling method |
| EP4684035A1 (en) | 2023-03-22 | 2026-01-28 | ClearNote Health, Inc. | Cell-free dna analysis in the detection and monitoring of pancreatic cancer using a combination of features |
| WO2026024692A1 (en) | 2024-07-24 | 2026-01-29 | Guardant Health, Inc. | Direct methylation single-base resolution sequencing of enriched unmethylated dna |
| WO2026024956A1 (en) | 2024-07-24 | 2026-01-29 | Guardant Health, Inc. | Selecting low technical noise biomarkers for sensitive molecular diagnostics |
| WO2026043702A1 (en) | 2024-08-21 | 2026-02-26 | Guardant Health, Inc. | Methods and approaches for personalized identification and monitoring of extrachromosomal circular dna |
| WO2026050179A1 (en) | 2024-08-26 | 2026-03-05 | Guardant Health, Inc. | Tumor fraction (tf) is associated with real-world progression-free survival (rwpfs) in non-small-cell lung cancer (nsclc) patients treated with platinum-based chemotherapy (chemo) |
| WO2026050287A1 (en) | 2024-08-27 | 2026-03-05 | Guardant Health, Inc. | Methylation biomarkers for osimertinib treatment management |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712126A (en) | 1995-08-01 | 1998-01-27 | Yale University | Analysis of gene expression by display of 3-end restriction fragments of CDNA |
| US5948902A (en) | 1997-11-20 | 1999-09-07 | South Alabama Medical Science Foundation | Antisense oligonucleotides to human serine/threonine protein phosphatase genes |
| US6287825B1 (en) | 1998-09-18 | 2001-09-11 | Molecular Staging Inc. | Methods for reducing the complexity of DNA sequences |
| US20050233340A1 (en) | 2004-04-20 | 2005-10-20 | Barrett Michael T | Methods and compositions for assessing CpG methylation |
| US20100273151A1 (en) * | 2004-05-28 | 2010-10-28 | Fred Hutchinson Cancer Research Center | Genome-wide analysis of palindrome formation and dna methylation |
| MX2007015416A (es) * | 2005-06-08 | 2008-02-19 | Millennium Pharm Inc | Metodos para la identificacion, evaluacion y tratamiento de pacientes con terapia contra cancer. |
| WO2007087312A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Molecular counting |
| CA2689356A1 (en) | 2007-06-01 | 2008-12-11 | 454 Life Sciences Corporation | System and meth0d for identification of individual samples from a multiplex mixture |
| US20090093378A1 (en) | 2007-08-29 | 2009-04-09 | Helen Bignell | Method for sequencing a polynucleotide template |
| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| WO2010048337A2 (en) * | 2008-10-22 | 2010-04-29 | Illumina, Inc. | Preservation of information related to genomic dna methylation |
| US20100323348A1 (en) | 2009-01-31 | 2010-12-23 | The Regents Of The University Of Colorado, A Body Corporate | Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process |
| EP2765205B1 (en) * | 2009-04-01 | 2016-05-18 | DxTerity Diagnostics Incorporated | Chemical ligation dependent probe amplification (CLPA) |
| US9034597B2 (en) * | 2009-08-25 | 2015-05-19 | New England Biolabs, Inc. | Detection and quantification of hydroxymethylated nucleotides in a polynucleotide preparation |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US8969061B2 (en) * | 2010-01-20 | 2015-03-03 | New England Biolabs, Inc. | Compositions, methods and related uses for cleaving modified DNA |
| WO2011127136A1 (en) | 2010-04-06 | 2011-10-13 | University Of Chicago | Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc) |
| US20120034603A1 (en) * | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| ES2595433T3 (es) | 2010-09-21 | 2016-12-30 | Population Genetics Technologies Ltd. | Aumento de la confianza en las identificaciones de alelos con el recuento molecular |
| US20120122087A1 (en) | 2010-11-17 | 2012-05-17 | Weiwei Li | 5-Hydroxymethylcytosine as a biomarker for early detection, treatment and prognostic monitoring of cancer |
| EP2694686B2 (en) | 2011-04-06 | 2023-07-19 | The University of Chicago | COMPOSITION AND METHODS RELATED TO MODIFICATION OF 5-METHYLCYTOSINE (5mC) |
| EP3246416B1 (en) | 2011-04-15 | 2024-06-05 | The Johns Hopkins University | Safe sequencing system |
| US10011871B2 (en) | 2012-02-17 | 2018-07-03 | Fred Hutchinson Cancer Research Center | Compositions and methods for accurately identifying mutations |
| EP3744857A1 (en) | 2012-03-20 | 2020-12-02 | University Of Washington Through Its Center For Commercialization | Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing |
| US9732390B2 (en) * | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| CA3043574C (en) * | 2012-11-26 | 2023-09-19 | The University Of Toledo | Methods for standardized sequencing of nucleic acids and uses thereof |
| US11060145B2 (en) * | 2013-03-13 | 2021-07-13 | Sequenom, Inc. | Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus |
| US20160194696A1 (en) * | 2013-08-09 | 2016-07-07 | New England Biolabs, Inc. | Detecting, Sequencing and/or Mapping 5-Hydroxymethylcytosine and 5-Formylcytosine at Single-Base Resolution |
| CA2921619C (en) * | 2013-08-19 | 2021-05-25 | Abbott Molecular Inc. | Nucleotide analogs |
| US10260087B2 (en) * | 2014-01-07 | 2019-04-16 | Fundació Privada Institut De Medicina Predictiva I Personalitzada Del Cáncer | Method for generating double stranded DNA libraries and sequencing methods for the identification of methylated cytosines |
| CN106232833A (zh) * | 2014-01-30 | 2016-12-14 | 加利福尼亚大学董事会 | 用于非侵入性诊断的甲基化单体型分析(monod) |
| GB201405226D0 (en) * | 2014-03-24 | 2014-05-07 | Cambridge Entpr Ltd | Nucleic acid preparation method |
| EP4170044B1 (en) * | 2014-06-06 | 2026-03-11 | Cornell University | Method for identification and enumeration of nucleic acid sequence, expression, copy, or dna methylation changes, using combined nuclease, ligase, polymerase, and sequencing reactions |
| EP2975116B1 (en) * | 2014-07-16 | 2019-08-21 | Max-Delbrück-Centrum für Molekulare Medizin | Tgif2-induced reprogramming of hepatic cells to pancreatic progenitor cells and medical uses thereof |
| US20180046754A1 (en) * | 2015-03-24 | 2018-02-15 | Agency For Science, Technology And Research (A*Star) | Normalization methods for measuring gene copy number and expression |
| US11162139B2 (en) | 2016-03-02 | 2021-11-02 | Shanghai Epican Genetech Co. Ltd. | Method for genomic profiling of DNA 5-methylcytosine and 5-hydroxymethylcytosine |
-
2017
- 2017-04-03 PL PL17779593T patent/PL3440205T3/pl unknown
- 2017-04-03 MX MX2018012156A patent/MX391039B/es unknown
- 2017-04-03 AU AU2017246318A patent/AU2017246318B2/en active Active
- 2017-04-03 ES ES17779593T patent/ES2882329T3/es active Active
- 2017-04-03 CN CN201780031390.0A patent/CN109312399B/zh active Active
- 2017-04-03 EP EP21167021.1A patent/EP3929290A1/en not_active Withdrawn
- 2017-04-03 DK DK17779593.7T patent/DK3440205T3/da active
- 2017-04-03 EP EP17779593.7A patent/EP3440205B1/en active Active
- 2017-04-03 JP JP2018553116A patent/JP7143221B2/ja active Active
- 2017-04-03 SG SG11201808775PA patent/SG11201808775PA/en unknown
- 2017-04-03 WO PCT/US2017/025735 patent/WO2017176630A1/en not_active Ceased
- 2017-04-03 RU RU2018138848A patent/RU2742355C2/ru active
- 2017-04-03 PT PT177795937T patent/PT3440205T/pt unknown
-
2018
- 2018-09-28 US US16/146,807 patent/US10718010B2/en active Active
-
2020
- 2020-04-14 US US16/848,498 patent/US20200248248A1/en not_active Abandoned
- 2020-04-14 US US16/848,482 patent/US20200283838A1/en active Pending
- 2020-04-14 US US16/848,515 patent/US20200248249A1/en not_active Abandoned
- 2020-04-15 US US16/849,071 patent/US20200299760A1/en not_active Abandoned
- 2020-04-15 US US16/849,067 patent/US20200277667A1/en not_active Abandoned
- 2020-04-15 US US16/848,989 patent/US20200277666A1/en active Pending
-
2022
- 2022-06-07 JP JP2022092184A patent/JP2022120007A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017246318A1 (en) | 2018-11-08 |
| US20190017109A1 (en) | 2019-01-17 |
| RU2018138848A (ru) | 2020-05-12 |
| MX391039B (es) | 2025-03-21 |
| EP3440205A4 (en) | 2019-04-03 |
| US20200277667A1 (en) | 2020-09-03 |
| JP2019520791A (ja) | 2019-07-25 |
| CN109312399B (zh) | 2023-02-03 |
| EP3440205A1 (en) | 2019-02-13 |
| EP3440205B1 (en) | 2021-05-26 |
| US20200248248A1 (en) | 2020-08-06 |
| US20200299760A1 (en) | 2020-09-24 |
| WO2017176630A1 (en) | 2017-10-12 |
| ES2882329T3 (es) | 2021-12-01 |
| CN109312399A (zh) | 2019-02-05 |
| US20200283838A1 (en) | 2020-09-10 |
| DK3440205T3 (da) | 2021-08-16 |
| MX2018012156A (es) | 2019-02-07 |
| RU2018138848A3 (pl) | 2020-12-15 |
| JP2022120007A (ja) | 2022-08-17 |
| JP7143221B2 (ja) | 2022-09-28 |
| AU2017246318A2 (en) | 2018-11-08 |
| US20200248249A1 (en) | 2020-08-06 |
| US20200277666A1 (en) | 2020-09-03 |
| RU2742355C2 (ru) | 2021-02-05 |
| CA3019836A1 (en) | 2017-10-12 |
| US10718010B2 (en) | 2020-07-21 |
| SG11201808775PA (en) | 2018-11-29 |
| AU2017246318B2 (en) | 2023-07-27 |
| PT3440205T (pt) | 2021-08-06 |
| EP3929290A1 (en) | 2021-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3440205T3 (pl) | Nieinwazyjna diagnostyka poprzez sekwencjonowanie 5-hydroksymetylowanego dna bezkomórkowego | |
| ZA201802493B (en) | Representative diagnostics | |
| ZA201704231B (en) | Chimeric protein | |
| EP3288455C0 (en) | DIAGNOSTIC PROCEDURE | |
| EP3218519A4 (en) | Multi-pass sequencing | |
| EP3234128A4 (en) | Sequencing controls | |
| GB201614873D0 (en) | Autonomous driving certification generalizer | |
| SG11201609754QA (en) | Sequencing process | |
| GB201506223D0 (en) | Chimeric protein | |
| ES3059610T3 (en) | Diagnostic methods | |
| GB201511969D0 (en) | Biosensor | |
| SG10201404895XA (en) | Diagnosis | |
| PL3190964T3 (pl) | Spirometr | |
| GB201406485D0 (en) | Universal controls for sequencing assays | |
| ZA201702351B (en) | Revaprazan hydrochloride polymorphs and preparation method therefor. | |
| GB201508860D0 (en) | Diagnostic method | |
| GB201409851D0 (en) | Diagnostic method | |
| GB201615753D0 (en) | Diagnostic method | |
| PL3169295T3 (pl) | Krata boczna o ruchu współbieżnym | |
| GB201504297D0 (en) | Diagnosis | |
| GB201509658D0 (en) | Method of diagnosis | |
| GB201408875D0 (en) | Diagnostic method | |
| EP3535421C0 (en) | DIAGNOSTIC PROCEDURES | |
| GB201615330D0 (en) | Method of diagnosis | |
| GB201510033D0 (en) | Asymmetric addition reactions |