PL344467A1 - Substituted indolinones, the production thereof and their use as medicaments - Google Patents

Substituted indolinones, the production thereof and their use as medicaments

Info

Publication number
PL344467A1
PL344467A1 PL99344467A PL34446799A PL344467A1 PL 344467 A1 PL344467 A1 PL 344467A1 PL 99344467 A PL99344467 A PL 99344467A PL 34446799 A PL34446799 A PL 34446799A PL 344467 A1 PL344467 A1 PL 344467A1
Authority
PL
Poland
Prior art keywords
medicaments
production
substituted indolinones
indolinones
substituted
Prior art date
Application number
PL99344467A
Inventor
Armin Heckel
Rainer Walter
Wolfgang Grell
Mell Jacobus C A Van
Norbert Rodemann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PL344467A1 publication Critical patent/PL344467A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL99344467A 1998-06-04 1999-05-28 Substituted indolinones, the production thereof and their use as medicaments PL344467A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (en) 1998-06-04 1998-06-04 Novel substituted indolinones, their preparation and their use as pharmaceuticals
PCT/EP1999/003692 WO1999062882A1 (en) 1998-06-04 1999-05-28 Substituted indolinones, the production thereof and their use as medicaments

Publications (1)

Publication Number Publication Date
PL344467A1 true PL344467A1 (en) 2001-11-05

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
PL99344467A PL344467A1 (en) 1998-06-04 1999-05-28 Substituted indolinones, the production thereof and their use as medicaments

Country Status (23)

Country Link
EP (1) EP1100779A1 (en)
JP (1) JP2002516906A (en)
KR (1) KR20010043973A (en)
CN (1) CN1303374A (en)
AU (1) AU764782B2 (en)
BG (1) BG104938A (en)
BR (1) BR9910898A (en)
CA (1) CA2328291A1 (en)
CO (1) CO5050294A1 (en)
DE (1) DE19824922A1 (en)
EA (1) EA003514B1 (en)
EE (1) EE200000723A (en)
HR (1) HRP20000831A2 (en)
HU (1) HUP0102210A3 (en)
ID (1) ID27035A (en)
IL (1) IL138702A0 (en)
NO (1) NO20006138L (en)
PL (1) PL344467A1 (en)
SK (1) SK18222000A3 (en)
TR (1) TR200003515T2 (en)
WO (1) WO1999062882A1 (en)
YU (1) YU73900A (en)
ZA (1) ZA200005435B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (en) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Novel substituted indolinones, their preparation and their use as pharmaceuticals
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
UA75054C2 (en) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Substituted in position 6 indolinones, producing and use thereof as medicament
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
EP1317446A1 (en) * 2000-09-01 2003-06-11 Glaxo Group Limited Oxindole derivatives
AU2001288374A1 (en) 2000-09-01 2002-03-22 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
DE10117204A1 (en) 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma Indolinones substituted in the 6-position, their preparation and their use as medicaments
JP2004537542A (en) * 2001-06-29 2004-12-16 アブ サイエンス Use of a tyrosine kinase inhibitor for treating inflammatory bowel disease (IBD)
ES2274993T3 (en) 2001-06-29 2007-06-01 Ab Science USE OF THYROSINE KINASE INHIBITORS FOR THE TREATMENT OF ALLERGIC DISEASES.
ES2266553T3 (en) 2001-06-29 2007-03-01 Ab Science USE OF N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES TO TREAT INFLAMMATORY DISEASES.
WO2003002109A2 (en) * 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitors for treating autoimmune diseases
WO2003003006A2 (en) 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
AU2002341881B2 (en) 2001-09-27 2008-05-08 Allergan, Inc. 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (en) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド Kinase inhibitors for the treatment of diseases
DE102004012070A1 (en) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments
PE20060777A1 (en) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
CN101547892B (en) * 2006-12-05 2014-08-20 艾尼纳制药公司 Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof
GB0706072D0 (en) * 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (en) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 Method for producing 4-N, N-dimethylamino methylaniline
CN103102352B (en) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 Tyrosine kinase inhibitor indolinone derivative
CN103130775B (en) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 As the dihydroindole ketone derivate of tyrosine kinase inhibitor
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (en) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 The full ketone derivatives of substituted indole as tyrosine kinase inhibitor
US11518758B2 (en) 2019-05-10 2022-12-06 Deciphera Pharmaceuticals, Llc Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
PE20220597A1 (en) 2019-05-10 2022-04-22 Deciphera Pharmaceuticals Llc PHENYLAMINOPYRIMIDINE AMIDE INHIBITORS OF AUTOPHAGY AND METHODS OF USE OF SUCH
PE20221083A1 (en) 2019-06-17 2022-07-05 Deciphera Pharmaceuticals Llc AMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND THEIR METHODS OF USE
JP2025530775A (en) * 2022-09-02 2025-09-17 デシフェラ・ファーマシューティカルズ，エルエルシー ULK inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (en) * 1976-02-16 1976-06-16 3-HYDROXYMETHYLENE-2-INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
DE69734521T9 (en) * 1996-08-23 2006-12-07 Sugen, Inc., South San Francisco COMBINATIVE INDOLINO LIBRARIES AND RELATED PRODUCTS AND METHOD FOR THE TREATMENT OF DISEASES
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
IL138702A0 (en) 2001-10-31
WO1999062882A1 (en) 1999-12-09
EE200000723A (en) 2002-04-15
BR9910898A (en) 2001-02-13
DE19824922A1 (en) 1999-12-09
CO5050294A1 (en) 2001-06-27
JP2002516906A (en) 2002-06-11
AU4370799A (en) 1999-12-20
NO20006138L (en) 2001-02-01
YU73900A (en) 2003-04-30
NO20006138D0 (en) 2000-12-01
HUP0102210A2 (en) 2001-11-28
HRP20000831A2 (en) 2001-12-31
EA003514B1 (en) 2003-06-26
ZA200005435B (en) 2002-01-07
CA2328291A1 (en) 1999-12-09
AU764782B2 (en) 2003-08-28
HUP0102210A3 (en) 2002-12-28
CN1303374A (en) 2001-07-11
EP1100779A1 (en) 2001-05-23
SK18222000A3 (en) 2001-08-06
EA200100001A1 (en) 2001-08-27
BG104938A (en) 2001-06-29
TR200003515T2 (en) 2001-06-21
ID27035A (en) 2001-02-22
KR20010043973A (en) 2001-05-25

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