PL345577A1 - Inhibitors of transcription factor nf-κb - Google Patents

Inhibitors of transcription factor nf-κb

Info

Publication number: PL345577A1
Authority: PL; Poland
Prior art keywords: inhibitors; transcription factor; transcription; factor
Prior art date: 1998-06-19

Application number

PL99345577A

Other languages

English (en)

Inventor

James F Callahan

Marie C Chabot-Fletcher

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-19

Filing date

1999-06-18

Publication date

2001-12-17

1999-06-18 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2001-12-17 Publication of PL345577A1 publication Critical patent/PL345577A1/xx

Links

102000040945 Transcription factor Human genes 0.000 title 1
108091023040 Transcription factor Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Oncology (AREA)
Toxicology (AREA)

PL99345577A 1998-06-19 1999-06-18 Inhibitors of transcription factor nf-κb PL345577A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9001698P	1998-06-19	1998-06-19
PCT/US1999/013897 WO1999065495A1 (en)	1998-06-19	1999-06-18	INHIBITORS OF TRANSCRIPTION FACTOR NF-λB

Publications (1)

Publication Number	Publication Date
PL345577A1 true PL345577A1 (en)	2001-12-17

Family

ID=22220761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL99345577A PL345577A1 (en)	1998-06-19	1999-06-18	Inhibitors of transcription factor nf-κb

Country Status (17)

Country	Link
EP (1)	EP1085872A4 (no)
JP (1)	JP2002518333A (no)
KR (1)	KR20010052990A (no)
CN (1)	CN1306428A (no)
AR (1)	AR019871A1 (no)
AU (1)	AU4699699A (no)
BR (1)	BR9911151A (no)
CA (1)	CA2335293A1 (no)
CO (1)	CO5080752A1 (no)
CZ (1)	CZ20004760A3 (no)
HU (1)	HUP0102492A2 (no)
IL (1)	IL140324A0 (no)
NO (1)	NO20006452L (no)
PL (1)	PL345577A1 (no)
TR (1)	TR200003779T2 (no)
WO (1)	WO1999065495A1 (no)
ZA (1)	ZA200007448B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU713471C (en)	1996-12-23	2002-04-18	Immunex Corporation	Ligand for receptor activator of NF-kappa B, ligand is member of TNF superfamily
US6316408B1 (en)	1997-04-16	2001-11-13	Amgen Inc.	Methods of use for osetoprotegerin binding protein receptors
DK2009025T3 (da)	1998-05-14	2011-11-14	Immunex Corp	Fremgangsmåde til hæmning af osteoklast-aktivitet
PT1782800E (pt) *	2000-01-24	2014-03-25	Genzyme Corp	Métodos para detectar inibidores de jak3
US20060148732A1 (en) *	2000-11-17	2006-07-06	Gutterman Jordan U	Inhibition of NF-kappaB by triterpene compositions
NZ530765A (en)	2001-06-26	2006-11-30	Amgen Fremont Inc	Antibodies that bind OPGL and compositions and methods for the treatment of bone diseases
US7425580B2 (en)	2004-05-19	2008-09-16	Wyeth	(Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands
WO2007097981A2 (en)	2006-02-16	2007-08-30	Millennium Pharmaceuticals, Inc.	Alpha carbolines and uses thereof
BRPI0919282A2 (pt)	2008-10-02	2017-03-28	Asahi Kasei Pharma Corp	composto, composição farmacêutica, inibidor de ikkb, método para inibir ikkb, métodos para prevenir e/ou tratar uma doença ou sintoma associado com nf-kb, uma doença ou sintoma associado com ikkb, e uma doença ou sintoma associado com reação inflamatória aguda ou crônica em mamíferos
WO2010108058A2 (en) *	2009-03-20	2010-09-23	University Of Pittsburgh-Of The Commonwealth System Of Higher Education	Small molecule inhibitors of dusp6 and uses therefor
US9186365B2 (en) *	2009-07-31	2015-11-17	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Antiangiogenic small molecules and methods of use
WO2012109527A2 (en)	2011-02-10	2012-08-16	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Class of hdac inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
WO2014071000A1 (en)	2012-10-31	2014-05-08	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Class of hdac inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury

1998
- 1998-06-18 HU HU0102492A patent/HUP0102492A2/hu unknown
1999
- 1999-06-17 CO CO99037918A patent/CO5080752A1/es unknown
- 1999-06-18 AR ARP990102952A patent/AR019871A1/es unknown
- 1999-06-18 WO PCT/US1999/013897 patent/WO1999065495A1/en not_active Ceased
- 1999-06-18 CN CN99807572A patent/CN1306428A/zh active Pending
- 1999-06-18 KR KR1020007014385A patent/KR20010052990A/ko not_active Withdrawn
- 1999-06-18 BR BR9911151-9A patent/BR9911151A/pt not_active Application Discontinuation
- 1999-06-18 TR TR2000/03779T patent/TR200003779T2/xx unknown
- 1999-06-18 CZ CZ20004760A patent/CZ20004760A3/cs unknown
- 1999-06-18 JP JP2000554375A patent/JP2002518333A/ja not_active Withdrawn
- 1999-06-18 AU AU46996/99A patent/AU4699699A/en not_active Abandoned
- 1999-06-18 IL IL14032499A patent/IL140324A0/xx unknown
- 1999-06-18 CA CA002335293A patent/CA2335293A1/en not_active Abandoned
- 1999-06-18 PL PL99345577A patent/PL345577A1/xx not_active Application Discontinuation
- 1999-06-18 EP EP99930459A patent/EP1085872A4/en not_active Withdrawn
2000
- 2000-12-13 ZA ZA200007448A patent/ZA200007448B/en unknown
- 2000-12-18 NO NO20006452A patent/NO20006452L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP1085872A4 (en)	2003-04-16
HUP0102492A2 (hu)	2001-11-28
NO20006452D0 (no)	2000-12-18
CZ20004760A3 (cs)	2001-08-15
IL140324A0 (en)	2002-02-10
BR9911151A (pt)	2001-03-06
CO5080752A1 (es)	2001-09-25
ZA200007448B (en)	2001-12-12
TR200003779T2 (tr)	2001-06-21
AR019871A1 (es)	2002-03-20
NO20006452L (no)	2001-02-16
WO1999065495A1 (en)	1999-12-23
AU4699699A (en)	2000-01-05
CN1306428A (zh)	2001-08-01
EP1085872A1 (en)	2001-03-28
JP2002518333A (ja)	2002-06-25
CA2335293A1 (en)	1999-12-23
KR20010052990A (ko)	2001-06-25

Legal Events

Date	Code	Title	Description
2007-03-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
PL348969A1 (en)	2002-06-17	Inhibitors of transcription factor nf-κb
PL327569A1 (en)	1998-12-21	Promedications of thrombosin inhibitors
PL334846A1 (en)	2000-03-27	Sulphamidic inhibitors of metaloproteases
HU9602516D0 (en)	1996-11-28	Isoprenyl transferase inhibitors
PL331338A1 (en)	1999-07-05	Thiosulphonamidic metaloprotease inhibitors
GB9611422D0 (en)	1996-08-07	Coated scale inhibitors
PL333918A1 (en)	2000-01-31	Derivatives of 6-phenylpyryidil-2-amine useful as nos inhibitors
IL137540A0 (en)	2001-07-24	Inhibitors of phospholipase a2
HU9700602D0 (en)	1997-05-28	New inhibitors of bone-resorption and vitronectine-receptor-antagonists
AU6229699A (en)	2000-05-15	Beta-amyloid formation inhibitors
IL143535A0 (en)	2002-04-21	Inhibitors of multidrug transporters
PL331920A1 (en)	1999-08-16	Spirocyclic inhibitors of metaloproteases
PL331803A1 (en)	1999-08-02	Bidonoric metaloprotease inhibitors
AU5599598A (en)	1998-07-03	Inhibitors of glycosyltransferases
PL345577A1 (en)	2001-12-17	Inhibitors of transcription factor nf-κb
AU692123B2 (en)	1998-05-28	5alpha-reductase inhibitors
AU2277597A (en)	1997-09-10	New inhibitors of sh2-mediated processes
AU5673099A (en)	2000-03-06	Inhibitors of amyloid formation
ZA9710989B (en)	1999-05-25	Polyprolyl inhibitors of cyclophilin
AU6678398A (en)	1998-09-18	Inhibitors of isoprenyl transferase
IL134210A0 (en)	2001-04-30	Use of transcription factor brn-3a
AU5126298A (en)	1998-06-03	Inhibition of crib-biting
HK1035668A (en)	2001-12-07	INHIBITORS OF TRANSCRIPTION FACTOR NF-κB
HK1035667A (en)	2001-12-07	INHIBITORS OF TRANSCRIPTION FACTOR NF-κB
AU4021700A (en)	2000-10-09	Methods of use of beta1-integrin inhibitors