PL347721A1 - Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists - Google Patents

Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Info

Publication number: PL347721A1
Authority: PL; Poland
Prior art keywords: quinoline; receptor antagonists; carboxamide derivatives; carboxamide; derivatives
Prior art date: 1998-11-20

Application number

PL99347721A

Inventor

Carlo Farina

Giuseppe Giardina

Mario Grugni

Marcel Morvan

Guy Margueritte Marie G Nadler

Luca Francesco Raveglia

Original Assignee

Smithkline Beecham Spa

Smithkline Beecham Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-20

Filing date

1999-11-19

Publication date

2002-04-22

1998-11-20 Priority claimed from GBGB9825552.4A external-priority patent/GB9825552D0/en

1998-11-20 Priority claimed from GBGB9825553.2A external-priority patent/GB9825553D0/en

1999-11-19 Application filed by Smithkline Beecham Spa, Smithkline Beecham Lab filed Critical Smithkline Beecham Spa

2002-04-22 Publication of PL347721A1 publication Critical patent/PL347721A1/en

Links

108010040722 Neurokinin-2 Receptors Proteins 0.000 title 1
108010040716 Neurokinin-3 Receptors Proteins 0.000 title 1
102100029409 Neuromedin-K receptor Human genes 0.000 title 1
102100037342 Substance-K receptor Human genes 0.000 title 1
LEWDKQKVAFOMPI-UHFFFAOYSA-N quinoline-4-carboxamide Chemical class C1=CC=C2C(C(=O)N)=CC=NC2=C1 LEWDKQKVAFOMPI-UHFFFAOYSA-N 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Transplantation (AREA)
Nutrition Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL99347721A 1998-11-20 1999-11-19 Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists PL347721A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9825552.4A GB9825552D0 (en)	1998-11-20	1998-11-20	Novel compounds
GBGB9825553.2A GB9825553D0 (en)	1998-11-20	1998-11-20	Novel Compounds

Publications (1)

Publication Number	Publication Date
PL347721A1 true PL347721A1 (en)	2002-04-22

Family

ID=26314705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL99347721A PL347721A1 (en)	1998-11-20	1999-11-19	Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

Country Status (18)

Country	Link
EP (1)	EP1131295A1 (en)
JP (1)	JP2002530377A (en)
KR (1)	KR20010075726A (en)
CN (1)	CN1406225A (en)
AR (2)	AR021355A1 (en)
AU (1)	AU768708B2 (en)
BR (1)	BR9915475A (en)
CA (1)	CA2351865A1 (en)
CO (1)	CO5150149A1 (en)
HK (1)	HK1041257A1 (en)
HU (1)	HUP0104959A3 (en)
IL (1)	IL143137A0 (en)
MX (1)	MXPA01005095A (en)
NO (1)	NO20012473L (en)
NZ (1)	NZ511777A (en)
PL (1)	PL347721A1 (en)
TR (1)	TR200101412T2 (en)
WO (1)	WO2000031037A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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US7037922B1 (en)	2000-03-10	2006-05-02	Neurogen Corporation	Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
GB0027701D0 (en) *	2000-11-13	2000-12-27	Smithkline Beecham Spa	Novel compounds
EP1334089A1 (en) *	2000-11-13	2003-08-13	GlaxoSmithKline S.p.A.	Quinoline derivatives as nk-3 and nk-2 antagonists
EP1337253A1 (en) *	2000-11-28	2003-08-27	GlaxoSmithKline S.p.A.	Novel compounds
WO2002044165A1 (en) *	2000-11-28	2002-06-06	Glaxosmithkline Spa	Quinoline derivatives as nk-3 antagonists
GB0028964D0 (en) *	2000-11-28	2001-01-10	Smithkline Beecham Spa	Novel compounds
MXPA03009239A (en)	2001-04-10	2004-11-12	Johnson & Johnson	1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders.
EP1385839B1 (en) *	2001-04-11	2006-02-22	GlaxoSmithKline S.p.A.	3-substituted quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists
GB0109122D0 (en) *	2001-04-11	2001-05-30	Smithkline Beecham Spa	Novel compounds
MY134211A (en) *	2001-05-18	2007-11-30	Smithkline Beecham Corp	Novel use
EP1541149A1 (en) *	2002-06-26	2005-06-15	Kyowa Hakko Kogyo Co., Ltd.	Phosphodiesterase inhibitor
AU2003268512A1 (en)	2002-09-09	2004-03-29	Janssen Pharmaceutica N.V.	Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
GB0303086D0 (en) *	2003-02-11	2003-03-19	Merck Sharp & Dohme	New compounds
EP1635834A4 (en) *	2003-06-25	2009-12-02	Smithkline Beecham Corp	NEW COMPOUNDS
GB0419192D0 (en)	2004-08-27	2004-09-29	Merck Sharp & Dohme	Therapeutic agents
GB0425076D0 (en) *	2004-11-12	2004-12-15	Smithkline Beecham Corp	Novel compounds
GB0509405D0 (en) *	2005-05-10	2005-06-15	Merck Sharp & Dohme	Therapeutic compounds
CA2611060A1 (en) *	2005-06-03	2006-12-07	R. Thomas Simpson	Quinoline derivatives as nk3 antagonists
GB0515580D0 (en)	2005-07-29	2005-09-07	Merck Sharp & Dohme	Therapeutic compounds
AR057130A1 (en)	2005-09-21	2007-11-14	Astrazeneca Ab	ALKYL SULFOXIDE QUINOLINS AND A PHARMACEUTICAL COMPOSITION
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1999
- 1999-11-19 JP JP2000583865A patent/JP2002530377A/en active Pending
- 1999-11-19 AR ARP990105927A patent/AR021355A1/en not_active Application Discontinuation
- 1999-11-19 KR KR1020017006343A patent/KR20010075726A/en not_active Withdrawn
- 1999-11-19 MX MXPA01005095A patent/MXPA01005095A/en unknown
- 1999-11-19 WO PCT/EP1999/009115 patent/WO2000031037A1/en not_active Ceased
- 1999-11-19 CO CO99072805A patent/CO5150149A1/en unknown
- 1999-11-19 AR ARP990105926A patent/AR021354A1/en unknown
- 1999-11-19 AU AU17770/00A patent/AU768708B2/en not_active Ceased
- 1999-11-19 BR BR9915475-7A patent/BR9915475A/en not_active IP Right Cessation
- 1999-11-19 PL PL99347721A patent/PL347721A1/en unknown
- 1999-11-19 HK HK02101024.6A patent/HK1041257A1/en unknown
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- 1999-11-19 CA CA002351865A patent/CA2351865A1/en not_active Abandoned
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2001
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Also Published As

Publication number	Publication date
NZ511777A (en)	2003-12-19
MXPA01005095A (en)	2002-04-24
KR20010075726A (en)	2001-08-09
NO20012473D0 (en)	2001-05-18
AU1777000A (en)	2000-06-13
CN1406225A (en)	2003-03-26
HK1041257A1 (en)	2002-07-05
HUP0104959A3 (en)	2003-01-28
TR200101412T2 (en)	2001-10-22
NO20012473L (en)	2001-07-18
AU768708B2 (en)	2004-01-08
AR021355A1 (en)	2002-07-17
CO5150149A1 (en)	2002-04-29
AR021354A1 (en)	2002-07-17
BR9915475A (en)	2001-12-18
HUP0104959A2 (en)	2002-04-29
IL143137A0 (en)	2002-04-21
JP2002530377A (en)	2002-09-17
EP1131295A1 (en)	2001-09-12
CA2351865A1 (en)	2000-06-02
WO2000031037A1 (en)	2000-06-02

Publication	Publication Date	Title
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