PL3478719T3 - Stosowanie przeciwciał przeciw sklerostynie w leczeniu wrodzonej łamliwości kości - Google Patents

Stosowanie przeciwciał przeciw sklerostynie w leczeniu wrodzonej łamliwości kości

Info

Publication number
PL3478719T3
PL3478719T3 PL17823190T PL17823190T PL3478719T3 PL 3478719 T3 PL3478719 T3 PL 3478719T3 PL 17823190 T PL17823190 T PL 17823190T PL 17823190 T PL17823190 T PL 17823190T PL 3478719 T3 PL3478719 T3 PL 3478719T3
Authority
PL
Poland
Prior art keywords
treatment
antibodies against
bone fragility
congenital bone
against sclerostin
Prior art date
Application number
PL17823190T
Other languages
English (en)
Other versions
PL3478719T6 (pl
Inventor
Uwe Junker
Michaela Kneissel
Anthony Kent HALL
Rena Joy EUDY
Matthew Manning RIGGS
Original Assignee
Mereo Biopharma 3 Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mereo Biopharma 3 Limited filed Critical Mereo Biopharma 3 Limited
Publication of PL3478719T3 publication Critical patent/PL3478719T3/pl
Publication of PL3478719T6 publication Critical patent/PL3478719T6/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL17823190.8T 2016-12-21 2017-12-21 Stosowanie przeciwciał przeciw sklerostynie w leczeniu wrodzonej łamliwości kości PL3478719T6 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662437353P 2016-12-21 2016-12-21
PCT/GB2017/053850 WO2018115880A1 (en) 2016-12-21 2017-12-21 Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
EP17823190.8A EP3478719B3 (en) 2016-12-21 2017-12-21 Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta

Publications (2)

Publication Number Publication Date
PL3478719T3 true PL3478719T3 (pl) 2021-10-25
PL3478719T6 PL3478719T6 (pl) 2025-01-27

Family

ID=60915566

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17823190.8T PL3478719T6 (pl) 2016-12-21 2017-12-21 Stosowanie przeciwciał przeciw sklerostynie w leczeniu wrodzonej łamliwości kości

Country Status (22)

Country Link
US (5) US20200179509A1 (pl)
EP (2) EP3868780A1 (pl)
JP (3) JP7050335B2 (pl)
KR (3) KR20190096409A (pl)
CN (2) CN110325548B (pl)
AU (1) AU2017381433B2 (pl)
BR (1) BR112019012731A2 (pl)
CL (1) CL2019001749A1 (pl)
CY (1) CY1124238T1 (pl)
DK (1) DK3478719T6 (pl)
ES (1) ES2862922T7 (pl)
FI (1) FI3478719T6 (pl)
HR (1) HRP20210207T4 (pl)
HU (1) HUE053436T2 (pl)
IL (1) IL267430B2 (pl)
LT (1) LT3478719T (pl)
MX (1) MX2019007161A (pl)
NZ (1) NZ754676A (pl)
PL (1) PL3478719T6 (pl)
PT (1) PT3478719T (pl)
SI (1) SI3478719T2 (pl)
WO (1) WO2018115880A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10961305B2 (en) 2016-12-21 2021-03-30 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為malt1抑制劑之吡唑衍生物
AU2017381433B2 (en) * 2016-12-21 2024-11-14 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
EP3774879B1 (en) 2018-03-30 2026-01-28 Amgen Inc. C-terminal antibody variants
EA202190055A1 (ru) 2018-06-18 2021-04-23 Янссен Фармацевтика Нв Производные пиразола в качестве ингибиторов malt1
US12404260B2 (en) 2019-04-11 2025-09-02 Janssen Pharmaceutica Nv Pyridine rings containing derivatives as MALT1 inhibitors
KR102472582B1 (ko) * 2020-08-20 2022-11-30 한림대학교 산학협력단 인공관절 마모편에 의한 활막염과 골용해의 진단 및 치료 방법
PH12023550779A1 (en) 2020-09-28 2023-11-20 Angitia Biomedicines Ltd Anti-sclerostin constructs and uses thereof
EP4408884A4 (en) * 2021-09-30 2025-04-23 Mereo Biopharma 3 Limited Method for using anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
WO2025212547A1 (en) * 2024-04-05 2025-10-09 Amgen Inc. Methods of treating osteogenesis imperfecta

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
ES2639020T3 (es) 1998-11-27 2017-10-25 Ucb Pharma S.A. Composiciones y métodos para incrementar la mineralización de la substancia ósea
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
CN1835974A (zh) 2003-06-16 2006-09-20 细胞技术研究与发展公司 对硬化素特异的抗体和用于增加骨矿化的方法
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) * 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US20100036091A1 (en) 2006-11-10 2010-02-11 Amgen Inc. Antibody-based diagnostics and therapeutics
EP2131860B1 (en) * 2007-03-20 2013-12-18 Eli Lilly & Company Anti-sclerostin antibodies
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
AR068767A1 (es) * 2007-10-12 2009-12-02 Novartis Ag Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
WO2010100200A2 (en) * 2009-03-05 2010-09-10 Novartis Ag Lyophilised antibody formulation
EP2558106A1 (en) * 2010-04-16 2013-02-20 Novartis AG Methods and compositions for improving implant osseointegration
CN105859889B (zh) * 2010-11-17 2020-01-07 中外制药株式会社 具有代替凝血因子viii的功能的功能的多特异性抗原结合分子
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
MA41142A (fr) * 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
AU2017381433B2 (en) * 2016-12-21 2024-11-14 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta
US10961305B2 (en) * 2016-12-21 2021-03-30 Mereo Biopharma 3 Limited Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta

Also Published As

Publication number Publication date
CN117442720A (zh) 2024-01-26
HRP20210207T1 (hr) 2021-03-19
SI3478719T2 (sl) 2025-07-31
HRP20210207T4 (hr) 2025-01-31
HUE053436T2 (hu) 2021-06-28
IL267430B1 (en) 2025-09-01
FI3478719T6 (fi) 2025-01-20
WO2018115880A1 (en) 2018-06-28
KR20220051269A (ko) 2022-04-26
AU2017381433A1 (en) 2019-07-04
EP3478719B3 (en) 2024-12-18
CA3047221A1 (en) 2018-06-28
NZ754676A (en) 2023-06-30
US20230365669A1 (en) 2023-11-16
JP2025020150A (ja) 2025-02-12
DK3478719T6 (da) 2025-01-20
SI3478719T1 (sl) 2021-09-30
JP7050335B2 (ja) 2022-04-08
CN110325548B (zh) 2023-11-17
IL267430B2 (en) 2026-01-01
ES2862922T3 (es) 2021-10-08
BR112019012731A2 (pt) 2019-11-26
US20200123242A1 (en) 2020-04-23
KR20190096409A (ko) 2019-08-19
US20240400666A1 (en) 2024-12-05
KR20240113615A (ko) 2024-07-22
ES2862922T7 (en) 2025-02-26
RU2019118719A3 (pl) 2021-06-01
CL2019001749A1 (es) 2019-12-27
JP2020502219A (ja) 2020-01-23
DK3478719T3 (da) 2021-03-01
US20200179509A1 (en) 2020-06-11
CN110325548A (zh) 2019-10-11
IL267430A (en) 2019-08-29
EP3478719B1 (en) 2021-01-20
CY1124238T1 (el) 2022-07-22
US20210253684A1 (en) 2021-08-19
JP2022046529A (ja) 2022-03-23
MX2019007161A (es) 2020-02-12
EP3478719A1 (en) 2019-05-08
AU2017381433B2 (en) 2024-11-14
PT3478719T (pt) 2021-03-18
RU2019118719A (ru) 2021-01-22
PL3478719T6 (pl) 2025-01-27
EP3868780A1 (en) 2021-08-25
LT3478719T (lt) 2021-04-12

Similar Documents

Publication Publication Date Title
CY2025027I1 (el) Ελαφιμπρανορη για χρηση στην αντιμετωπιση πρωτοπαθους χολικης χολαγγειiτιδας
IL269371A (en) Treatment methods
DK3504187T3 (da) Anvendelse af pridopidin til behandling af funktionel tilbagegang
LT3661514T (lt) Mavakamtenas, skirtas naudoti gydant hipertrofinę kardiomiopatiją
PT3785717T (pt) Métodos para o tratamento de infeções por coronaviridae
PT3562486T (pt) Uso de dexmedetomidina sublingual para o tratamento da agitação
KR20180084817A (ko) 항-siglec-9 항체 및 이의 이용 방법
PL3265053T3 (pl) Sposoby leczenia skóry
PL3503890T3 (pl) Stosowanie pridopidyny w leczeniu dystonii
DK3481846T3 (da) 11-substituerede 24-hydroxysteroler til anvendelse til behandling af nmda-relaterede tilstande
PL3519142T3 (pl) Sposób obróbki powierzchniowej przedmiotu
PL3493812T3 (pl) Połączenia imetelstatu i wenetoklaksu do leczenia ostrej białaczki szpikowej
DK3570940T3 (da) Pridopidin til anvendelse i behandling af fragilt x-syndrom
DK3710000T3 (da) Tradipitant til anvendelse til behandling af gastroparese
PL3236960T3 (pl) Fluralaner do zastosowania w leczeniu demodekozy
SI3478719T1 (sl) Uporaba protiteles proti sklerostinu pri zdravljenju osteogenesis imperfecte
PL3592355T3 (pl) Kx2-391/kx-01 do zastosowania w leczeniu rogowacenia słonecznego
PL3432872T3 (pl) Eflornityna do zastosowania w leczeniu nawracającego/opornego na leczenie temozolomidem gwiaździaka anaplastycznego
DK3576738T3 (da) Gaboxadolmonohydrat i behandling af tinnitus
PL3732294T3 (pl) Tymohydrochinon do stosowania w leczeniu hiperglikemii
HUE063528T2 (hu) Anti-CD40 antitestek alkalmazása lupus nephritis kezelésére
IL260373B (en) Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy
EP3532063C0 (en) POLYTHERAPY FOR THE TREATMENT OF PULMONARY HYPERTENSION
IL289371A (en) Methylthioninium for use in the treatment of synaptopathies
CY2024037I1 (el) Χρηση delgocitinib για την θεραπεια χρονιουεκζεματος χεριων