PL3492075T3 - Skojarzone postacie użytkowe neosaksytoksyny do znieczulenia miejscowego o przedłużonym działaniu - Google Patents

Skojarzone postacie użytkowe neosaksytoksyny do znieczulenia miejscowego o przedłużonym działaniu

Info

Publication number: PL3492075T3
Authority: PL; Poland
Prior art keywords: local anesthesia; combination formulations; prolonged local; neosaxitoxin; neosaxitoxin combination
Prior art date: 2013-03-15

Application number

PL18215029.2T

Other languages

English (en)

Inventor

Charles Berde

Daniel S. Kohane

Original Assignee

The Children's Medical Center Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-03-15

Filing date

2014-03-17

Publication date

2024-04-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50549480&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3492075(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-03-17 Application filed by The Children's Medical Center Corporation filed Critical The Children's Medical Center Corporation

2024-04-22 Publication of PL3492075T3 publication Critical patent/PL3492075T3/pl

Links

PPEKGEBBBBNZKS-UHFFFAOYSA-N Neosaxitoxin Natural products N=C1N(O)C(COC(=O)N)C2N=C(N)NC22C(O)(O)CCN21 PPEKGEBBBBNZKS-UHFFFAOYSA-N 0.000 title 1
238000009472 formulation Methods 0.000 title 1
238000002690 local anesthesia Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
PPEKGEBBBBNZKS-HGRQIUPRSA-N neosaxitoxin Chemical compound N=C1N(O)[C@@H](COC(=O)N)[C@@H]2NC(=N)N[C@@]22C(O)(O)CCN21 PPEKGEBBBBNZKS-HGRQIUPRSA-N 0.000 title 1
230000002035 prolonged effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Rheumatology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PL18215029.2T 2013-03-15 2014-03-17 Skojarzone postacie użytkowe neosaksytoksyny do znieczulenia miejscowego o przedłużonym działaniu PL3492075T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201361789054P	2013-03-15	2013-03-15

Publications (1)

Publication Number	Publication Date
PL3492075T3 true PL3492075T3 (pl)	2024-04-22

Family

ID=50549480

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL18215029.2T PL3492075T3 (pl)	2013-03-15	2014-03-17	Skojarzone postacie użytkowe neosaksytoksyny do znieczulenia miejscowego o przedłużonym działaniu
PL14719486T PL2968225T3 (pl)	2013-03-15	2014-03-17	Preparaty skojarzone neosaksytoksyny do przedłużonego znieczulenia miejscowego

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL14719486T PL2968225T3 (pl)	2013-03-15	2014-03-17	Preparaty skojarzone neosaksytoksyny do przedłużonego znieczulenia miejscowego

Country Status (25)

Country	Link
US (4)	US10314833B2 (pl)
EP (2)	EP2968225B1 (pl)
JP (1)	JP6313420B2 (pl)
KR (4)	KR102787826B1 (pl)
CN (1)	CN105142625B (pl)
AU (2)	AU2014232881B2 (pl)
CA (2)	CA2906851C (pl)
CL (1)	CL2015002534A1 (pl)
CY (1)	CY1121606T1 (pl)
DK (1)	DK2968225T3 (pl)
ES (2)	ES2727292T3 (pl)
HR (1)	HRP20190419T1 (pl)
HU (1)	HUE042711T2 (pl)
IL (1)	IL241346B (pl)
LT (1)	LT2968225T (pl)
MX (1)	MX390159B (pl)
NZ (1)	NZ710890A (pl)
PE (1)	PE20160011A1 (pl)
PL (2)	PL3492075T3 (pl)
PT (1)	PT2968225T (pl)
RS (1)	RS58750B1 (pl)
RU (2)	RU2015143665A (pl)
SI (1)	SI2968225T1 (pl)
TR (1)	TR201903411T4 (pl)
WO (1)	WO2014145580A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR102787826B1 (ko) *	2013-03-15	2025-03-31	더 칠드런스 메디칼 센터 코포레이션	지속성 국소 마취용 네오삭시톡신 조합 제형
US20170368176A1 (en)	2014-12-15	2017-12-28	The Children's Medical Center Corporation	Non-toxic topical anesthetic ophthalmic compositions
EP3359134B1 (en)	2015-10-08	2025-04-09	The Children's Medical Center Corporation	Compositions and compositions for use in on-demand high-efficiency triggerable anesthesia
US10117847B2 (en)	2015-12-04	2018-11-06	Ventis Pharma	Extended duration local anesthetic formulation
US10791651B2 (en)	2016-05-31	2020-09-29	Carbice Corporation	Carbon nanotube-based thermal interface materials and methods of making and using thereof
WO2019109065A1 (en) *	2017-12-01	2019-06-06	The Children's Medical Center Corporation	Covalent anesthetic-polymer conjugates for prolonged local anesthesia
SG11202102830SA (en) *	2018-09-21	2021-04-29	The Cawthron Inst Trust Board	Preparative scale conversion of gonyautoxins to neosaxitoxin
RU2701571C1 (ru) *	2019-02-13	2019-09-30	Федеральное государственное бюджетное образовательное учреждение высшего образования "Казанский Государственный медицинский университет" Министерства здравоохранения Российской Федерации	Способ профилактики болевого синдрома после вмешательств на коленном суставе
WO2021141956A1 (en) *	2020-01-06	2021-07-15	Pacira Pharmaceuticals, Inc,	Treatment of pain associated with cesarean section surgery with sustained-release liposomal anesthetic compositions
WO2021141959A1 (en)	2020-01-10	2021-07-15	Pacira Pharmaceuticals, Inc.	Treatment of pain by administration of sustained-release liposomal anesthetic compositions
WO2021141963A1 (en)	2020-01-10	2021-07-15	Pacira Pharmaceuticals, Inc.	Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions
EP4274573A4 (en)	2021-01-11	2024-12-11	Pacira Pharmaceuticals, Inc.	TREATMENT OF HIP PAIN WITH LIPOSOMAL SUSTAINED-RELEASE ANESTHESIA COMPOSITIONS
EP4308084A4 (en)	2021-03-19	2025-04-23	Pacira Pharmaceuticals, Inc.	TREATMENT OF PAIN IN PEDIATRIC PATIENTS BY ADMINISTRATION OF SUSTAINED-RELEASE LIPOSOMAL ANESTHETIC COMPOSITIONS
US11918565B1 (en)	2022-11-03	2024-03-05	Pacira Pharmaceuticals, Inc.	Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions
US12226610B2 (en)	2022-11-03	2025-02-18	Pacira Pharmaceuticals, Inc.	Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions
EP4648760A1 (en) *	2023-01-13	2025-11-19	Smilanich, Michael D.	Composition for local anesthesia and uses thereof
US11977085B1 (en)	2023-09-05	2024-05-07	Elan Ehrlich	Date rape drug detection device and method of using same

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3004894A (en)	1959-04-07	1961-10-17	Upjohn Co	Therapeutic composition comprising tetracycline and a dioxolane
US3328259A (en)	1964-01-08	1967-06-27	Parachem Corp	Dressing for a wound containing a hemostatic agent and method of treating a wound
US3374144A (en)	1965-10-07	1968-03-19	Miles Lab	Ophthalmic composition
SE391286B (sv)	1971-01-26	1977-02-14	Astra Pharma Prod	Forfarande for framstellning av en lokalanestetiskt verksam injektionslosning med forlengd varaktighet av verkan
US3957996A (en)	1971-12-08	1976-05-18	Astra Pharmaceutical Products, Inc.	Pharmaceutical local anesthetic compositions
US3966934A (en)	1971-12-08	1976-06-29	Astra Pharmaceutical Products, Inc.	Synergistic local anesthetic compositions
US4022899A (en)	1973-06-12	1977-05-10	Astra Pharmaceutical Products, Inc.	Synergistic local anesthetic compositions
US4029794A (en)	1973-06-12	1977-06-14	Astra Pharmaceutical Products, Inc.	Pharmaceutical local anesthetic composition
US4029793A (en)	1973-06-12	1977-06-14	Astra Pharmaceutical Products, Inc.	Synergistic local anesthetic compositions
US4001413A (en)	1973-06-12	1977-01-04	Astra Pharmaceutical Products, Inc.	Pharmaceutical local anesthetic composition employing saxitoxin
CA1165240A (en)	1980-07-09	1984-04-10	The Procter & Gamble Company	Penetrating topical pharmaceutical compositions
US4313958A (en)	1980-10-24	1982-02-02	The Procter & Gamble Company	Method of producing analgesia
US4443473A (en)	1981-06-30	1984-04-17	The Procter & Gamble Company	Carbamate derivatives
US4401663A (en)	1981-06-30	1983-08-30	The Procter & Gamble Company	Novel sulfonamide derivatives
US4460602A (en)	1981-06-30	1984-07-17	The Procter & Gamble Company	Urea derivatives
US4537776A (en)	1983-06-21	1985-08-27	The Procter & Gamble Company	Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
US4564633A (en)	1983-07-14	1986-01-14	The Procter & Gamble Company	Compositions and methods useful for producing analgesia
US4544669A (en)	1983-07-14	1985-10-01	The Procter & Gamble Company	Compounds and compositions useful for producing analgesia
US4493848A (en)	1983-07-14	1985-01-15	The Procter & Gamble Company	Compositions and methods useful for producing analgesia
US4544668A (en)	1983-07-14	1985-10-01	The Procter & Gamble Company	Compounds and compositions useful for producing analgesia
US4605670A (en)	1984-02-01	1986-08-12	Nitto Electric Industrial Co., Ltd.	Method for percutaneously administering metoclopramide
CA1274508A (en)	1984-05-31	1990-09-25	Imre Szilagyi	Primycin components and process for the separation of the antibiotic complex
US4654323A (en)	1984-11-13	1987-03-31	Bar Ilan University	Method and composition for the therapeutic and prophylactic treatment of trauma to the skin
US5013759A (en)	1985-06-10	1991-05-07	The Procter & Gamble Company	Compounds and compositions having anti-inflammatory and analgesic activity
US4863970A (en)	1986-11-14	1989-09-05	Theratech, Inc.	Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
US5006342A (en)	1986-12-22	1991-04-09	Cygnus Corporation	Resilient transdermal drug delivery device
US5045565A (en)	1987-03-09	1991-09-03	The Procter & Gamble Company	Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US5099030A (en)	1987-03-09	1992-03-24	The Procter & Gamble Company	Novel compounds, pharmaceutical compositions, and methods for treating inflammation and pain
US4820720A (en)	1987-08-24	1989-04-11	Alza Corporation	Transdermal drug composition with dual permeation enhancers
US5871472A (en)	1987-11-17	1999-02-16	Brown University Research Foundation	Planting devices for the focal release of neuroinhibitory compounds
US4997853A (en)	1988-12-02	1991-03-05	Galenpharma, Inc.	Method and compositions utilizing capsaicin as an external analgesic
US5134166A (en)	1988-12-02	1992-07-28	Genderm Corporation	Method for treating nasal disorders and headaches
US5008289A (en)	1988-12-02	1991-04-16	Galenpharma, Inc.	Composition for treating nasal disorders and headaches
US4973468A (en)	1989-03-22	1990-11-27	Cygnus Research Corporation	Skin permeation enhancer compositions
WO1993011798A1 (en)	1991-12-16	1993-06-24	Alza Corporation	Improved formulations with hydrophobic permeation enhancers
DE69331387T2 (de)	1992-09-10	2002-08-22	Childrens Medical Center	Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika
US5700485A (en)	1992-09-10	1997-12-23	Children's Medical Center Corporation	Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5576016A (en)	1993-05-18	1996-11-19	Pharmos Corporation	Solid fat nanoemulsions as drug delivery vehicles
AU1888195A (en)	1994-03-17	1995-10-03	Nanning Maple Leaf Pharmaceutical Co. Ltd.	The use of amino hydrogenated quinazoline compounds and derivatives thereof for abstaining from drug dependence
US5942241A (en)	1995-06-09	1999-08-24	Euro-Celtique, S.A.	Formulations and methods for providing prolonged local anesthesia
US5858397A (en)	1995-10-11	1999-01-12	University Of British Columbia	Liposomal formulations of mitoxantrone
US6030974A (en)	1997-04-02	2000-02-29	The Regents Of The University Of California	Method of anesthesia
AU7389098A (en) *	1997-05-16	1998-12-08	Brigham And Women's Hospital	Local anesthetic formulations
US7016870B1 (en)	1997-12-02	2006-03-21	Financial Engines	Identifying a recommended portfolio of financial products for an investor based upon financial products that are available to the investor
CA2388828A1 (en)	1999-10-22	2001-06-14	Transdermatech, Inc.	Topical anesthetic formulation
US6673363B2 (en)	1999-12-16	2004-01-06	Dermatrends, Inc.	Transdermal and topical administration of local anesthetic agents using basic enhancers
US6455066B1 (en)	2000-03-10	2002-09-24	Epicept Corporation	Intradermal-penetration agents for topical local anesthetic administration
CN1284536C (zh)	2000-09-18	2006-11-15	威克斯医药有限公司	河豚毒素或蛤蚌毒素及其类似物在制备用于全身镇痛的镇痛药中的应用
CN1236773C (zh)	2000-11-22	2006-01-18	南宁枫叶药业有限公司	用于镇痛、麻醉或治疗药物依赖性的制剂
US20030152637A1 (en) *	2001-01-25	2003-08-14	Mark Chasin	Local anesthetic, and method of use
CN1382443A (zh)	2001-04-25	2002-12-04	威克斯医疗仪器有限公司	钠离子通道阻断剂在制备用于局部神经麻醉或镇痛的药物中的应用
MXPA04004543A (es)	2001-11-15	2005-03-31	Micro Algae Corp	Composiciones farmaceuticas que contienen 3,4-propinoperhidropurinas y sus usos para el bloqueo de la transmision neuronal.
US20050202093A1 (en)	2002-12-02	2005-09-15	Kohane Daniel S.	Prolonged suppression of electrical activity in excitable tissues
US20040172354A1 (en)	2003-02-13	2004-09-02	Charnley James Allen	Calculator for illustrating investment performance for irregular time periods
WO2005079157A2 (en)	2004-02-19	2005-09-01	Dmitry Gorbatovsky	Portfolio optimization
US20050214325A1 (en)	2004-03-26	2005-09-29	Vvii Newco 2003, Inc.	Compositions and methods to increase the effect of a neurotoxin treatment
EP1796676B1 (en)	2004-05-07	2016-03-09	Phytotox Limited	Transdermal administration of phycotoxins
CN100367966C (zh)	2004-09-28	2008-02-13	黄致强	河鲀毒素油相制剂的制备方法
WO2006091719A2 (en)	2005-02-23	2006-08-31	Sontra Medical Corporation	Compositions and methods enhancing transdermal delivery of drugs and biologics
KR20090082507A (ko)	2006-11-20	2009-07-30	프레지던트 앤드 펠로우즈 오브 하바드 칼리지	통증 및 소양증 치료용 방법, 조성물 및 키트
WO2009143175A2 (en)	2008-05-19	2009-11-26	Children's Medical Center Corporation	Sensory-specific local anesthesia and prolonged duration local anesthesia
WO2009143174A2 (en)	2008-05-19	2009-11-26	Children's Medical Center Corporation	Chemical permeation enhancers enhance nerve blockade by toxins
WO2010041255A2 (en)	2008-10-07	2010-04-15	Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd.	Liposomal systems comprising sphingomyelin
CL2009000722A1 (es)	2009-03-24	2009-06-19	Proteus Sa	Metodo de obtención y producción masiva de una especie de cianobacteria aislada productora de ficotoxinas paralizantes, utilizando un medio de cultivo mla suplementado con arginina, metionina y ácido alantoico.
CL2009000723A1 (es)	2009-03-24	2009-06-19	Proteus Sa	Metodo de purificacion industrial de ficotoxinas biologicamente activas que comprende proporcionar una cantidad adecuada de una fuente de ficotoxinas como por ejemplo el cultivo de un clon de cianobacterias.
US20120034296A1 (en)	2009-04-08	2012-02-09	Massachusetts Institute Of Technology	Prolonged duration local anesthesia with minimal toxicity
CA2760946C (en)	2009-05-07	2019-06-25	The Board Of Trustees Of The Leland Stanford Junior University	Methods and compositions for studying, imaging, and treating pain
JP6112867B2 (ja) *	2010-02-10	2017-04-12	ファイトトックスリミテッドＰｈｙｔｏｔｏｘＬｉｍｉｔｅｄ	サキシトキシン誘導体での触覚の喪失の処置
KR102787826B1 (ko) *	2013-03-15	2025-03-31	더 칠드런스 메디칼 센터 코포레이션	지속성 국소 마취용 네오삭시톡신 조합 제형

2014
- 2014-03-17 KR KR1020247009397A patent/KR102787826B1/ko active Active
- 2014-03-17 DK DK14719486.4T patent/DK2968225T3/da active
- 2014-03-17 ES ES14719486T patent/ES2727292T3/es active Active
- 2014-03-17 PL PL18215029.2T patent/PL3492075T3/pl unknown
- 2014-03-17 MX MX2015012879A patent/MX390159B/es unknown
- 2014-03-17 KR KR1020157029781A patent/KR20150131330A/ko not_active Ceased
- 2014-03-17 ES ES18215029T patent/ES2972603T3/es active Active
- 2014-03-17 WO PCT/US2014/030372 patent/WO2014145580A1/en not_active Ceased
- 2014-03-17 HU HUE14719486A patent/HUE042711T2/hu unknown
- 2014-03-17 PT PT14719486T patent/PT2968225T/pt unknown
- 2014-03-17 RS RS20190594A patent/RS58750B1/sr unknown
- 2014-03-17 HR HRP20190419TT patent/HRP20190419T1/hr unknown
- 2014-03-17 LT LTEP14719486.4T patent/LT2968225T/lt unknown
- 2014-03-17 PL PL14719486T patent/PL2968225T3/pl unknown
- 2014-03-17 EP EP14719486.4A patent/EP2968225B1/en active Active
- 2014-03-17 SI SI201431117T patent/SI2968225T1/sl unknown
- 2014-03-17 CA CA2906851A patent/CA2906851C/en active Active
- 2014-03-17 JP JP2016503385A patent/JP6313420B2/ja active Active
- 2014-03-17 EP EP18215029.2A patent/EP3492075B1/en active Active
- 2014-03-17 KR KR1020227032390A patent/KR20220132666A/ko not_active Ceased
- 2014-03-17 US US14/216,252 patent/US10314833B2/en active Active
- 2014-03-17 NZ NZ710890A patent/NZ710890A/en unknown
- 2014-03-17 AU AU2014232881A patent/AU2014232881B2/en active Active
- 2014-03-17 PE PE2015002008A patent/PE20160011A1/es unknown
- 2014-03-17 CA CA3018668A patent/CA3018668C/en active Active
- 2014-03-17 CN CN201480015980.0A patent/CN105142625B/zh active Active
- 2014-03-17 RU RU2015143665A patent/RU2015143665A/ru not_active Application Discontinuation
- 2014-03-17 KR KR1020217012549A patent/KR20210062693A/ko not_active Ceased
- 2014-03-17 TR TR2019/03411T patent/TR201903411T4/tr unknown
- 2014-07-15 US US14/331,983 patent/US8975281B2/en active Active
- 2014-07-15 US US14/331,947 patent/US8975268B2/en active Active
2015
- 2015-09-09 CL CL2015002534A patent/CL2015002534A1/es unknown
- 2015-09-09 IL IL241346A patent/IL241346B/en active IP Right Grant
2017
- 2017-04-10 AU AU2017202343A patent/AU2017202343B2/en active Active
- 2017-11-24 RU RU2017141000A patent/RU2673081C1/ru active
2019
- 2019-04-16 CY CY20191100416T patent/CY1121606T1/el unknown
- 2019-04-26 US US16/396,071 patent/US10881647B2/en active Active

Also Published As

Publication number	Publication date
EP2968225B1 (en)	2019-02-20
EP3492075A1 (en)	2019-06-05
RU2673081C1 (ru)	2018-11-22
AU2017202343A1 (en)	2017-04-27
EP2968225A1 (en)	2016-01-20
KR20220132666A (ko)	2022-09-30
JP6313420B2 (ja)	2018-04-18
HK1218384A1 (zh)	2017-02-17
US10881647B2 (en)	2021-01-05
CA3018668C (en)	2021-04-13
SI2968225T1 (sl)	2019-05-31
RU2015143665A (ru)	2017-04-27
AU2014232881A1 (en)	2015-08-27
US8975281B2 (en)	2015-03-10
US10314833B2 (en)	2019-06-11
CA2906851A1 (en)	2014-09-18
CA3018668A1 (en)	2014-09-18
US20190247377A1 (en)	2019-08-15
ES2727292T3 (es)	2019-10-15
PL2968225T3 (pl)	2019-08-30
BR112015021380A2 (pt)	2018-05-08
KR102787826B1 (ko)	2025-03-31
IL241346B (en)	2018-07-31
AU2017202343B2 (en)	2019-02-07
US20140329861A1 (en)	2014-11-06
RS58750B1 (sr)	2019-06-28
NZ710890A (en)	2016-11-25
PT2968225T (pt)	2019-04-02
US20140288103A1 (en)	2014-09-25
ES2972603T3 (es)	2024-06-13
MX2015012879A (es)	2016-06-24
CY1121606T1 (el)	2020-05-29
KR20240042210A (ko)	2024-04-01
US8975268B2 (en)	2015-03-10
DK2968225T3 (da)	2019-05-27
TR201903411T4 (tr)	2019-04-22
CA2906851C (en)	2019-05-07
WO2014145580A1 (en)	2014-09-18
US20140329841A1 (en)	2014-11-06
AU2014232881B2 (en)	2017-04-27
CN105142625A (zh)	2015-12-09
CL2015002534A1 (es)	2016-09-16
EP3492075B1 (en)	2023-12-13
KR20150131330A (ko)	2015-11-24
CN105142625B (zh)	2019-09-06
JP2016514704A (ja)	2016-05-23
LT2968225T (lt)	2019-04-25
KR20210062693A (ko)	2021-05-31
HRP20190419T1 (hr)	2019-05-03
PE20160011A1 (es)	2016-02-10
HUE042711T2 (hu)	2019-07-29
IL241346A0 (en)	2015-11-30
MX390159B (es)	2025-03-20

Publication	Publication Date	Title
IL241346B (en)	2018-07-31	Neoscitoxin combination formulations for prolonged local anesthesia
GB201319791D0 (en)	2013-12-25	Formulations
IL240846A0 (en)	2015-10-29	drug combination
IL243080B (en)	2020-01-30	Alkhush helmet
HUE044430T2 (hu)	2019-10-28	Gyógyszerkombinációk
SG10201706406TA (en)	2017-09-28	Otoscope
AU353438S (en)	2014-01-23	Bed rail
GB201319792D0 (en)	2013-12-25	Formulations
EP3017727A4 (en)	2016-06-22	CUSHION FOR SHARED SLEEP
EP2910227A4 (en)	2016-01-20	REMOVABLE BED
IL245420A0 (en)	2016-06-30	New formulations
IL242493A0 (en)	2016-02-01	Pharmaceutical formulations relieve radioactivity
SG11201507957VA (en)	2015-10-29	Stabilized vitamin d formulations
GB2517922B (en)	2015-08-12	Train set
GB2583319B (en)	2021-03-10	Integrated nanospray system
PL2821061T3 (pl)	2018-05-30	Nowe preparaty do inhalacji
IL246393A0 (en)	2016-08-31	Prodrug compounds
GB2516706B (en)	2015-06-24	Railway points
PH32013000147S1 (en)	2017-07-27	DETACHABLE BED (Eurotop)
PH22013000360U1 (en)	2013-11-04	Detachable bed
GB201320093D0 (en)	2014-01-01	Tram
AU352342S (en)	2013-11-21	Fitting for furniture
AU352341S (en)	2013-11-21	Fitting for furniture
AU352351S (en)	2013-11-21	Locomotive
AU352352S (en)	2013-11-21	Locomotive