PL352834A1 - Prodrugs of thrombin inhibitors - Google Patents

Prodrugs of thrombin inhibitors

Info

Publication number: PL352834A1
Authority: PL; Poland
Prior art keywords: prodrugs; thrombin inhibitors; thrombin; inhibitors
Prior art date: 1999-04-09

Application number

PL00352834A

Other languages

Polish (pl)

Inventor

Dorit Baucke

Helmut Mack

Werner Seitz

Wilfried Hornberger

Gisela Backfisch

Jurgen Delzer

Original Assignee

Abbott Gmbh & Co.Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-09

Filing date

2000-04-05

Publication date

2003-09-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26004346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL352834(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-04-05 Application filed by Abbott Gmbh & Co.Kg filed Critical Abbott Gmbh & Co.Kg

2003-09-08 Publication of PL352834A1 publication Critical patent/PL352834A1/en

Links

229940122388 Thrombin inhibitor Drugs 0.000 title 1
229940002612 prodrug Drugs 0.000 title 1
239000000651 prodrug Substances 0.000 title 1
239000003868 thrombin inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Enzymes And Modification Thereof (AREA)

PL00352834A 1999-04-09 2000-04-05 Prodrugs of thrombin inhibitors PL352834A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19915930		1999-04-09
DE10006799		2000-02-15

Publications (1)

Publication Number	Publication Date
PL352834A1 true PL352834A1 (en)	2003-09-08

Family

ID=26004346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL00352834A PL352834A1 (en)	1999-04-09	2000-04-05	Prodrugs of thrombin inhibitors

Country Status (16)

Country	Link
EP (1)	EP1169318A1 (en)
JP (1)	JP2002541254A (en)
KR (1)	KR20020004995A (en)
CN (1)	CN1349526A (en)
AU (1)	AU3659200A (en)
BG (1)	BG105985A (en)
BR (1)	BR0009653A (en)
CA (1)	CA2368830A1 (en)
HK (1)	HK1045516A1 (en)
HU (1)	HUP0202431A3 (en)
IL (1)	IL145670A0 (en)
NO (1)	NO20014807L (en)
PL (1)	PL352834A1 (en)
SK (1)	SK14092001A3 (en)
TR (1)	TR200102914T2 (en)
WO (1)	WO2000061577A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10064797A1 (en) *	2000-12-22	2002-06-27	Knoll Ag	Combination pack useful for the treatment of e.g. deep vein thrombosis and post-operative thrombosis, containing oral and parenteral formulations of thrombin inhibitor prodrugs
EP1514870A4 (en) *	2002-06-14	2006-08-23	Takeda Pharmaceutical	PRODUCT AND METHOD FOR PRODUCING THE SAME
KR101299322B1 (en)	2004-08-23	2013-08-26	록코 시스템즈 피티이 리미티드	Supply mechanism for the chuck of an integrated circuit dicing device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4421052A1 (en) *	1994-06-17	1995-12-21	Basf Ag	New thrombin inhibitors, their production and use
FI973360L (en) *	1995-02-17	1997-08-15	Basf Ag	New dipeptide amidines as thrombin inhibitors
DE19631084A1 (en) *	1996-08-01	1998-02-05	Basf Ag	Use of (meth) acrylic acid copolymers to increase the permeability of the mucosa
DE19635674A1 (en) *	1996-09-03	1998-03-05	Basf Ag	Process for the preparation of amidines

2000
- 2000-04-05 PL PL00352834A patent/PL352834A1/en unknown
- 2000-04-05 TR TR2001/02914T patent/TR200102914T2/en unknown
- 2000-04-05 HU HU0202431A patent/HUP0202431A3/en unknown
- 2000-04-05 SK SK1409-2001A patent/SK14092001A3/en unknown
- 2000-04-05 CN CN00807009A patent/CN1349526A/en active Pending
- 2000-04-05 KR KR1020017012802A patent/KR20020004995A/en not_active Ceased
- 2000-04-05 WO PCT/EP2000/003008 patent/WO2000061577A1/en not_active Ceased
- 2000-04-05 EP EP00915197A patent/EP1169318A1/en not_active Ceased
- 2000-04-05 HK HK02107043.0A patent/HK1045516A1/en unknown
- 2000-04-05 AU AU36592/00A patent/AU3659200A/en not_active Abandoned
- 2000-04-05 CA CA002368830A patent/CA2368830A1/en not_active Abandoned
- 2000-04-05 BR BR0009653-9A patent/BR0009653A/en not_active IP Right Cessation
- 2000-04-05 JP JP2000610850A patent/JP2002541254A/en active Pending
- 2000-04-05 IL IL14567000A patent/IL145670A0/en unknown
2001
- 2001-10-03 NO NO20014807A patent/NO20014807L/en not_active Application Discontinuation
- 2001-10-05 BG BG105985A patent/BG105985A/en unknown

Also Published As

Publication number	Publication date
CN1349526A (en)	2002-05-15
EP1169318A1 (en)	2002-01-09
WO2000061577A1 (en)	2000-10-19
BG105985A (en)	2002-06-28
HUP0202431A2 (en)	2002-11-28
BR0009653A (en)	2002-01-08
KR20020004995A (en)	2002-01-16
SK14092001A3 (en)	2002-05-09
NO20014807L (en)	2001-12-04
CA2368830A1 (en)	2000-10-19
HK1045516A1 (en)	2002-11-29
NO20014807D0 (en)	2001-10-03
TR200102914T2 (en)	2002-01-21
AU3659200A (en)	2000-11-14
JP2002541254A (en)	2002-12-03
HUP0202431A3 (en)	2003-03-28
IL145670A0 (en)	2002-06-30

Publication	Publication Date	Title
GB9912961D0 (en)	1999-08-04	Metalloprotease inhibitors
IL149118A0 (en)	2002-11-10	Inhibitors of neuraminidases
GB9900416D0 (en)	1999-02-24	Inhibitors
IL156064A0 (en)	2003-12-23	Vla-4 inhibitors
GB9930659D0 (en)	2000-02-16	Inhibitors of complement activation
IL145772A0 (en)	2002-07-25	Prodrugs of thrombin inhibitors
IL145085A0 (en)	2002-06-30	Dihetero-substituted metalloprotease inhibitors
AU2002222627A1 (en)	2002-06-24	Tak1 inhibitors
IL136139A0 (en)	2001-05-20	Thrombin inhibitors
GB0030284D0 (en)	2001-01-24	Enzyme inhibitors
EP1235577A4 (en)	2003-04-09	Protease inhibitors
EP1153022A4 (en)	2002-03-27	Prothease inhibitors
GB9924522D0 (en)	1999-12-15	Enzyme inhibitors
EP1232155A4 (en)	2002-11-20	Protease inhibitors
EP1229914A4 (en)	2004-06-23	Protease inhibitors
EP1229912A4 (en)	2003-05-07	Protease inhibitors
EP1229915A4 (en)	2003-05-14	Protease inhibitors
EP1231921A4 (en)	2004-06-23	Protease inhibitors
EP1161237A4 (en)	2002-03-27	Protease inhibitors
EP1351930A4 (en)	2004-09-15	Protease inhibitors
EP1173429A4 (en)	2002-06-19	Protease inhibitors
EP1229911A4 (en)	2003-05-07	Protease inhibitors
EP1233771A4 (en)	2003-05-14	Protease inhibitors
EP1231923A4 (en)	2003-05-14	Protease inhibitors
HUP0202431A3 (en)	2003-03-28	Prodrugs of thrombin inhibitors