PL3555074T3 - Aminopirazole jako selektywne inhibitory kinaz janusowych - Google Patents
Aminopirazole jako selektywne inhibitory kinaz janusowychInfo
- Publication number
- PL3555074T3 PL3555074T3 PL17821530.7T PL17821530T PL3555074T3 PL 3555074 T3 PL3555074 T3 PL 3555074T3 PL 17821530 T PL17821530 T PL 17821530T PL 3555074 T3 PL3555074 T3 PL 3555074T3
- Authority
- PL
- Poland
- Prior art keywords
- aminopyrazoles
- selective inhibitors
- janus kinases
- janus
- kinases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662434154P | 2016-12-14 | 2016-12-14 | |
| PCT/EP2017/082529 WO2018108969A1 (en) | 2016-12-14 | 2017-12-13 | Aminopyrazoles as selective janus kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3555074T3 true PL3555074T3 (pl) | 2022-11-07 |
Family
ID=60812050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17821530.7T PL3555074T3 (pl) | 2016-12-14 | 2017-12-13 | Aminopirazole jako selektywne inhibitory kinaz janusowych |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10875847B2 (pl) |
| EP (2) | EP4095135A1 (pl) |
| JP (1) | JP7116063B2 (pl) |
| CN (2) | CN117756789A (pl) |
| AU (1) | AU2017376398B2 (pl) |
| CA (1) | CA3045951A1 (pl) |
| DK (1) | DK3555074T3 (pl) |
| ES (1) | ES2926545T3 (pl) |
| FI (1) | FIC20253009I1 (pl) |
| FR (1) | FR25C1047I1 (pl) |
| NL (1) | NL301349I2 (pl) |
| PL (1) | PL3555074T3 (pl) |
| RU (1) | RU2757218C2 (pl) |
| WO (1) | WO2018108969A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019398756B2 (en) * | 2018-12-13 | 2023-01-05 | Intervet International B.V. | Crystalline forms of 1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl)amino]pyrazole-4-carboxamide |
| WO2020118597A1 (en) * | 2018-12-13 | 2020-06-18 | Intervet International B.V. | Process for making 1- [ (3r, 4s) -4-cyanotetrahydropyran-3-yl] -3- [ (2-fluoro-6-methoxy-4-pyridyl) amino] pyrazole-4-carboxamide |
| CN119350306A (zh) * | 2018-12-13 | 2025-01-24 | 英特维特国际股份有限公司 | 1-[(3r,4s)-4-氰基四氢吡喃-3-基]-3-[(2-氟-6-甲氧基-4-吡啶基)氨基]吡唑-4-甲酰胺制备方法 |
| US12281104B2 (en) | 2019-05-02 | 2025-04-22 | Intervet Inc. | Process for the production of ethyl 3-amino-1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]pyrazole-4-carboxylate through chiral separation of a racemic mixture |
| KR20220119023A (ko) * | 2019-12-20 | 2022-08-26 | 인터벳 인터내셔널 비.브이. | 중합체 매트릭스에 분산된 피라졸 화합물의 제약 조성물 |
| CA3161496A1 (en) | 2019-12-20 | 2021-06-24 | Mohamad Morsey | Bispecific caninized antibodies for treating atopic dermatitis |
| WO2021123108A1 (en) | 2019-12-20 | 2021-06-24 | Intervet International B.V. | A pyrazole pharmaceutical composition |
| EP4229083A1 (en) | 2020-10-15 | 2023-08-23 | Intervet International B.V. | Caninized antibodies to canine interleukin-31 receptor alpha |
| AU2021401834A1 (en) | 2020-12-18 | 2023-07-06 | Boehringer Ingelheim Animal Health USA Inc. | Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof |
| JP2024532159A (ja) | 2021-08-20 | 2024-09-05 | インターベット インターナショナル ベー． フェー． | アトピー性皮膚炎を治療するための融合タンパク質 |
| MX2024007089A (es) | 2021-12-16 | 2024-08-22 | Intervet Int Bv | Anticuerpos caninizados para el receptor alfa i de interleucina-31 canino. |
| MX2024007863A (es) | 2021-12-24 | 2024-08-30 | Intervet Int Bv | Uso de compuestos de aminopirazol. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| EP1087970B1 (en) | 1998-06-19 | 2004-04-28 | Pfizer Products Inc. | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS |
| CN101316843B (zh) * | 2005-11-03 | 2013-01-02 | 顶点医药品公司 | 用作激酶抑制剂的氨基嘧啶 |
| CA2733359C (en) | 2008-08-20 | 2014-08-05 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| JP6014148B2 (ja) * | 2011-09-22 | 2016-10-25 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ヤヌスキナーゼ阻害剤としてのシクロアルキルニトリルピラゾールカルボキサミド |
| WO2014146246A1 (en) | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
| WO2016170009A1 (en) * | 2015-04-21 | 2016-10-27 | Almirall, S.A. | Amino-substituted heterocyclic derivatives as sodium channel inhibitors |
-
2017
- 2017-12-13 AU AU2017376398A patent/AU2017376398B2/en active Active
- 2017-12-13 EP EP22178697.3A patent/EP4095135A1/en not_active Withdrawn
- 2017-12-13 WO PCT/EP2017/082529 patent/WO2018108969A1/en not_active Ceased
- 2017-12-13 JP JP2019531369A patent/JP7116063B2/ja active Active
- 2017-12-13 RU RU2019121667A patent/RU2757218C2/ru active
- 2017-12-13 CN CN202311769143.4A patent/CN117756789A/zh active Pending
- 2017-12-13 CN CN201780077566.6A patent/CN110062754B/zh active Active
- 2017-12-13 CA CA3045951A patent/CA3045951A1/en active Pending
- 2017-12-13 ES ES17821530T patent/ES2926545T3/es active Active
- 2017-12-13 PL PL17821530.7T patent/PL3555074T3/pl unknown
- 2017-12-13 US US16/468,548 patent/US10875847B2/en active Active
- 2017-12-13 EP EP17821530.7A patent/EP3555074B1/en active Active
- 2017-12-13 DK DK17821530.7T patent/DK3555074T3/da active
-
2025
- 2025-11-21 NL NL301349C patent/NL301349I2/nl unknown
- 2025-11-25 FI FIC20253009C patent/FIC20253009I1/fi unknown
- 2025-11-28 FR FR25C1047C patent/FR25C1047I1/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2757218C2 (ru) | 2021-10-12 |
| EP3555074B1 (en) | 2022-07-27 |
| DK3555074T3 (da) | 2022-10-03 |
| AU2017376398A1 (en) | 2019-05-30 |
| WO2018108969A1 (en) | 2018-06-21 |
| CN110062754B (zh) | 2024-01-02 |
| CN117756789A (zh) | 2024-03-26 |
| BR112019011835A2 (pt) | 2019-10-22 |
| JP2020503288A (ja) | 2020-01-30 |
| EP3555074A1 (en) | 2019-10-23 |
| EP4095135A1 (en) | 2022-11-30 |
| JP7116063B2 (ja) | 2022-08-09 |
| CN110062754A (zh) | 2019-07-26 |
| RU2019121667A3 (pl) | 2021-02-25 |
| NL301349I2 (nl) | 2026-03-02 |
| FIC20253009I1 (fi) | 2025-11-25 |
| RU2019121667A (ru) | 2021-01-15 |
| US20200115367A1 (en) | 2020-04-16 |
| US10875847B2 (en) | 2020-12-29 |
| FR25C1047I1 (fr) | 2026-01-02 |
| ES2926545T3 (es) | 2022-10-26 |
| CA3045951A1 (en) | 2018-06-21 |
| AU2017376398B2 (en) | 2021-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3555074T3 (pl) | Aminopirazole jako selektywne inhibitory kinaz janusowych | |
| CY2024003I1 (el) | Ενωσεις χρησιμες ως αναστολεις κινασης | |
| IL263586B (en) | Inhibitors of the menin-mll interaction | |
| HUE060078T2 (hu) | CDK7 gátlására alkalmas vegyületek | |
| ZA201904615B (en) | Small molecule inhibitors of the jak family of kinases | |
| PL3472153T3 (pl) | Pirymidyn-2-yloamino-1h-pirazole jako inhibitory lrrk2 do zastosowania w leczeniu zaburzeń neurodegeneracyjnych | |
| LT3464271T (lt) | Pirazolo dariniai kaip plazmos kalikreino inhibitoriai | |
| EP3347018A4 (en) | HEMMER OF CYCLINE-DEPENDENT KINASES | |
| EP3490564A4 (en) | MACRO CYCLE Kinase Inhibitors | |
| HUE063042T2 (hu) | Az aktivin receptorszerû kináz inhibitorai | |
| EP3438094A4 (en) | SELECTIVE C-KIT KINASE INHIBITOR | |
| EP3247692A4 (en) | INHIBITORS OF TRKA KINASE | |
| PL3209656T3 (pl) | Związki indolo-karboksyamidu użyteczne jako inhibitory kinazy | |
| EP3414234A4 (en) | BRUTON TYROSINE KINASE HEMMER | |
| HUE050842T2 (hu) | Janus-kináz inhibitor | |
| EP3310776A4 (en) | BRUTON TYROSINE KINASE HEMMER | |
| EP3273966A4 (en) | Inhibitors of cyclin-dependent kinases | |
| DK3303334T3 (da) | Tyrosinkinasehæmmere | |
| PL3567037T3 (pl) | Związki n-((het)arylometylo-heteroarylo-karboksyamidowe jako inhibitory kalikreiny osoczowej | |
| IL247915A0 (en) | Inhibitors of cyclin-dependent kinase 7 (cdk7) | |
| EP3386590A4 (en) | BICYCLIC INHIBITORS OF PAD4 | |
| DK3290418T3 (da) | Janus Kinase (JAK)-hæmmere | |
| EP3405192A4 (en) | BRUTON TYROSINE KINASE HEMMER | |
| HUE063541T2 (hu) | Eljárások piruvát-kináz aktivátorok alkalmazására | |
| EP3356447A4 (en) | INHIBITORS OF MENACHINONE BIOSYNTHESIS |