PL356802A1 - Pirydo [2,3-d] pirymidyno-2,7-diaminy jako inhibitory kinaz - Google Patents

Pirydo [2,3-d] pirymidyno-2,7-diaminy jako inhibitory kinaz

Info

Publication number: PL356802A1
Authority: PL; Poland
Prior art keywords: pyrido; pyrimidine; diamine; kinase inhibitors; kinase
Prior art date: 2000-01-25

Application number

PL01356802A

Other languages

English (en)

Inventor

Richard John Booth

Ellen Myra Dobrusin

Vara Prasad Venkata Nagendra Josyula

Dennis Joseph Mcnamara

Peter Laurence Toogood

Original Assignee

Warner-Lambert Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2004-07-12

2001-01-23 Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company

2004-07-12 Publication of PL356802A1 publication Critical patent/PL356802A1/pl

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
QRRCMVPZJCHBLQ-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine-2,7-diamine Chemical compound C1=NC(N)=NC2=NC(N)=CC=C21 QRRCMVPZJCHBLQ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

PL01356802A 2000-01-25 2001-01-23 Pirydo [2,3-d] pirymidyno-2,7-diaminy jako inhibitory kinaz PL356802A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
PCT/IB2001/000069 WO2001055147A1 (en)	2000-01-25	2001-01-23	PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS

Publications (1)

Publication Number	Publication Date
PL356802A1 true PL356802A1 (pl)	2004-07-12

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL01356802A PL356802A1 (pl)	2000-01-25	2001-01-23	Pirydo [2,3-d] pirymidyno-2,7-diaminy jako inhibitory kinaz

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (pl)
JP (1)	JP4047010B2 (pl)
KR (1)	KR20020065939A (pl)
CN (1)	CN1395578A (pl)
AP (1)	AP2002002586A0 (pl)
AR (1)	AR030044A1 (pl)
AU (1)	AU2542501A (pl)
BG (1)	BG106850A (pl)
BR (1)	BR0107751A (pl)
CA (1)	CA2397961C (pl)
CO (1)	CO5261549A1 (pl)
CR (1)	CR6706A (pl)
CZ (1)	CZ20022475A3 (pl)
DZ (1)	DZ3266A1 (pl)
EA (1)	EA200200643A1 (pl)
EE (1)	EE200200405A (pl)
GT (1)	GT200100016A (pl)
HN (1)	HN2001000013A (pl)
HU (1)	HUP0204141A3 (pl)
IL (1)	IL150545A0 (pl)
IS (1)	IS6443A (pl)
MA (1)	MA26868A1 (pl)
MX (1)	MXPA02007221A (pl)
NO (1)	NO20023527L (pl)
OA (1)	OA12161A (pl)
PA (1)	PA8510701A1 (pl)
PE (1)	PE20011066A1 (pl)
PL (1)	PL356802A1 (pl)
SK (1)	SK10632002A3 (pl)
SV (1)	SV2002000294A (pl)
TN (1)	TNSN01014A1 (pl)
WO (1)	WO2001055147A1 (pl)
YU (1)	YU50402A (pl)
ZA (1)	ZA200205879B (pl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
JP4524072B2 (ja)	2000-10-23	2010-08-11	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	新規化合物
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
MXPA04010267A (es)	2002-04-19	2005-02-03	Smithkline Beecham Corp	Compuestos novedosos.
EA200500721A1 (ru) *	2002-11-28	2005-12-29	Шеринг Акциенгезельшафт	Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en)	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
JP2008518883A (ja) *	2004-09-21	2008-06-05	エフ．ホフマン−ラロシュアーゲー	タンパク質キナーゼ阻害剤として有用な６−（２−アルキル−フェニル）−ピリド［２，３−ｄ］ピリミジン
MY145343A (en)	2005-03-25	2012-01-31	Glaxo Group Ltd	Novel compounds
US20090137550A1 (en)	2005-03-25	2009-05-28	Glaxo Group Limited	Novel Compounds
PE20061193A1 (es)	2005-03-25	2006-12-02	Glaxo Group Ltd	DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
US20080096905A1 (en)	2005-03-25	2008-04-24	Glaxo Group Limited	Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives
FR2887882B1 (fr) *	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
ATE449097T1 (de) *	2005-07-21	2009-12-15	Hoffmann La Roche	Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
ES2351939T3 (es)	2005-08-09	2011-02-14	Irm Llc	Compuestos y composiciones como inhibidores de proteínas cinasas.
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (en)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr)	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (en)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Improved raf inhibitors
AU2009321867B2 (en) *	2008-12-01	2015-12-10	Merck Patent Gmbh	2,5-Diamino-substituted pyrido[4,3-d]pyrimidines as autotaxin inhibitors against cancer
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
ES2817448T3 (es)	2013-03-14	2021-04-07	Icahn School Med Mount Sinai	Compuestos de pirimidina como inhibidores de quinasas
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2191188C2 (ru) *	1994-11-14	2002-10-20	Варнер-Ламберт Компани	Производные 6-арилпиридо[2,3-d]-пиримидины и -нафтиридины, фармацевтическая композиция, обладающая ингибирующим действием клеточной пролиферации, вызываемой протеиновой тирозинкиназой, и способ ингибирования клеточной пролиферации
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
EE200000706A (et) *	1998-05-26	2002-06-17	Warner-Lambert Company	Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid

2001
- 2001-01-23 CA CA002397961A patent/CA2397961C/en not_active Expired - Fee Related
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/en not_active Ceased
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 PL PL01356802A patent/PL356802A1/pl not_active Application Discontinuation
- 2001-01-23 EP EP01900591A patent/EP1254137A1/en not_active Withdrawn
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Ceased
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20023527D0 (no)	2002-07-24
PE20011066A1 (es)	2001-10-22
NO20023527L (no)	2002-09-10
BR0107751A (pt)	2002-11-12
JP4047010B2 (ja)	2008-02-13
DZ3266A1 (fr)	2001-08-02
GT200100016A (es)	2001-10-19
EE200200405A (et)	2003-12-15
AP2002002586A0 (en)	2002-09-30
TNSN01014A1 (fr)	2005-11-10
CR6706A (es)	2005-04-04
MA26868A1 (fr)	2004-12-20
JP2003523357A (ja)	2003-08-05
EA200200643A1 (ru)	2002-12-26
KR20020065939A (ko)	2002-08-14
SK10632002A3 (sk)	2003-06-03
EP1254137A1 (en)	2002-11-06
CN1395578A (zh)	2003-02-05
BG106850A (bg)	2003-02-28
IL150545A0 (en)	2003-02-12
CA2397961C (en)	2008-08-26
HN2001000013A (es)	2001-06-18
CA2397961A1 (en)	2001-08-02
ZA200205879B (en)	2003-09-29
PA8510701A1 (es)	2002-12-11
CZ20022475A3 (cs)	2003-03-12
YU50402A (sh)	2005-11-28
AR030044A1 (es)	2003-08-13
CO5261549A1 (es)	2003-03-31
HUP0204141A2 (hu)	2003-04-28
HUP0204141A3 (en)	2005-03-29
MXPA02007221A (es)	2002-11-29
SV2002000294A (es)	2002-07-16
OA12161A (en)	2006-05-08
AU2542501A (en)	2001-08-07
WO2001055147A1 (en)	2001-08-02
IS6443A (is)	2002-06-25

Legal Events

Date	Code	Title	Description
2008-09-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
IL150545A0 (en)	2003-02-12	PYRIDO [2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
HRP20020798A2 (en)	2004-02-29	5-ALKYLPYRIDO[2,3-d]PYRIMIDINES TYROZINE KINASE INHIBITORS
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
PL357536A1 (pl)	2004-07-26	Farmaceutycznie czynne związki
IL181957A0 (en)	2009-02-11	Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
IL153754A0 (en)	2003-07-06	Pyrimidine derivatives
IL158697A0 (en)	2004-05-12	4-amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-d) pyrimidine derivatives
HUP0202713A3 (en)	2005-02-28	Pteridinones as kinase inhibitors
AU1041802A (en)	2002-01-30	Tetrahydro-heterocycloazepinyl pyrimidine derivatives
ZA200204510B (en)	2003-11-26	Imidazopyridine derivatives used as phosphodiesterase VII inhibitors.
DE50001191D1 (de)	2003-03-06	Pyrazolo[4, 3-d]pyrimidine
PL358551A1 (pl)	2004-08-09	5-Aminoalkilopirazolo [4,3-D] pirymidyny
HRP20030362A2 (en)	2005-04-30	Pyrimidine derivatives
PL363077A1 (pl)	2004-11-15	Zastosowanie pirazolo [4,3-D] pirymidyn
PL361890A1 (pl)	2004-10-04	Zastosowanie pirazolo[4,3-d] pirymidyn
AU8578501A (en)	2002-01-08	2-aminoalkyl-thieno(2,3-d)pyrimidines
IL155380A0 (en)	2003-11-23	SUBSTITUTED 3,4-DIHYDRO-PYRIDO[1,2-a] PYRIMIDINES
ZA200206528B (en)	2003-03-13	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors.
SI1303496T1 (sl)	2007-12-31	Pirimidinski derivati