PL3572412T3 - Pochodna pirydyny jako inhibitor ask1 oraz sposób jej wytwarzania oraz zastosowanie - Google Patents

Pochodna pirydyny jako inhibitor ask1 oraz sposób jej wytwarzania oraz zastosowanie

Info

Publication number
PL3572412T3
PL3572412T3 PL18741136T PL18741136T PL3572412T3 PL 3572412 T3 PL3572412 T3 PL 3572412T3 PL 18741136 T PL18741136 T PL 18741136T PL 18741136 T PL18741136 T PL 18741136T PL 3572412 T3 PL3572412 T3 PL 3572412T3
Authority
PL
Poland
Prior art keywords
preparation
pyridine derivative
ask1 inhibitor
ask1
inhibitor
Prior art date
Application number
PL18741136T
Other languages
English (en)
Inventor
Chengde Wu
Tao Yu
Ning Li
Shuhui Chen
Original Assignee
Fujian Cosunter Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujian Cosunter Pharmaceutical Co., Ltd. filed Critical Fujian Cosunter Pharmaceutical Co., Ltd.
Publication of PL3572412T3 publication Critical patent/PL3572412T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL18741136T 2017-01-22 2018-01-22 Pochodna pirydyny jako inhibitor ask1 oraz sposób jej wytwarzania oraz zastosowanie PL3572412T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710054224 2017-01-22
PCT/CN2018/073640 WO2018133866A1 (zh) 2017-01-22 2018-01-22 作为ask1抑制剂的吡啶衍生物及其制备方法和应用
EP18741136.8A EP3572412B1 (en) 2017-01-22 2018-01-22 Pyridine derivative as ask1 inhibitor and preparation method and use thereof

Publications (1)

Publication Number Publication Date
PL3572412T3 true PL3572412T3 (pl) 2021-09-27

Family

ID=62907792

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18741136T PL3572412T3 (pl) 2017-01-22 2018-01-22 Pochodna pirydyny jako inhibitor ask1 oraz sposób jej wytwarzania oraz zastosowanie

Country Status (18)

Country Link
US (1) US11040968B2 (pl)
EP (1) EP3572412B1 (pl)
JP (1) JP6650552B2 (pl)
KR (1) KR102089234B1 (pl)
CN (1) CN109071538B (pl)
AU (1) AU2018209574B2 (pl)
BR (1) BR112019014756B1 (pl)
CA (1) CA3050346C (pl)
DK (1) DK3572412T3 (pl)
EA (1) EA037005B1 (pl)
ES (1) ES2870524T3 (pl)
MX (1) MX376618B (pl)
MY (1) MY174821A (pl)
PH (1) PH12019501688B1 (pl)
PL (1) PL3572412T3 (pl)
SG (1) SG11201906579UA (pl)
WO (1) WO2018133866A1 (pl)
ZA (1) ZA201904737B (pl)

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CN115504986B (zh) * 2017-03-03 2024-05-14 江苏豪森药业集团有限公司 凋亡信号调节激酶抑制剂及其制备方法和应用
JOP20190221A1 (ar) 2017-04-05 2019-09-23 Seal Rock Therapeutics Inc مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها
CN110869017B (zh) 2017-05-12 2023-05-05 英安塔制药有限公司 细胞凋亡信号调节激酶1抑制剂及其使用方法
US10253018B2 (en) 2017-05-25 2019-04-09 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2018218044A2 (en) 2017-05-25 2018-11-29 Enanta Pharmaceuticals Inc Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2018218051A1 (en) 2017-05-25 2018-11-29 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN109400625B (zh) * 2017-08-17 2021-11-12 广东东阳光药业有限公司 稠合双环类化合物及其在药物中的应用
WO2019046186A1 (en) 2017-08-28 2019-03-07 Enanta Pharmaceuticals, Inc. INHIBITORS OF KINASE 1 REGULATING THE APOPTOTIC SIGNAL CONTAINING TETRAZOLES AND METHODS OF USE THEREOF
CN111801314B (zh) 2018-01-02 2023-10-31 西尔洛克治疗公司 Ask1抑制剂化合物及其用途
WO2019213239A1 (en) 2018-05-02 2019-11-07 Enanta Pharmaceuticals Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
EP3787621B1 (en) 2018-05-02 2024-12-18 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN112638912B (zh) * 2018-07-20 2022-04-26 福建广生中霖生物科技有限公司 作为ask1抑制剂的晶型及其制备方法和应用
CN111107848B (zh) * 2018-08-10 2023-05-23 江苏豪森药业集团有限公司 一种含有酰胺类衍生物的药物组合物及其制备方法和应用
WO2020034988A1 (zh) * 2018-08-14 2020-02-20 江苏豪森药业集团有限公司 凋亡信号调节激酶1抑制剂的盐及其晶型
US10968199B2 (en) 2018-08-22 2021-04-06 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
CN110922407B (zh) * 2018-09-19 2021-11-12 广东东阳光药业有限公司 苯甲酰氨基吡啶衍生物的晶型及其用途
WO2020106707A1 (en) 2018-11-19 2020-05-28 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
JP7331116B2 (ja) * 2019-01-24 2023-08-22 チアンスー アオサイカン ファーマシューティカル カンパニー，リミティド ＴＧＦ－βＲ１キナーゼ阻害剤としての５－（４－ピリジルオキシ）ピラゾール類化合物
US11466033B2 (en) 2019-03-25 2022-10-11 Enanta Pharmaceuticals, Inc. Substituted pyridines as apoptosis signal-regulating kinase 1 inhibitors
CN110577534B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN110577535B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN110577536B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN110577541B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN110577537B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN110577540B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN110577539B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN110577538B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN110577533B (zh) * 2019-07-16 2021-07-23 广州安岩仁医药科技有限公司 苯甲酰氨基吡啶衍生物的盐及其在药物中的应用
CN113831323B (zh) * 2020-06-24 2025-08-29 武汉人福创新药物研发中心有限公司 芳杂环酰胺类化合物及其用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI491606B (zh) * 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
UY34573A (es) * 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
CN103570625A (zh) * 2012-07-19 2014-02-12 南京英派药业有限公司 N-(3-杂芳基芳基)-4-芳基芳基甲酰胺和类似物作为Hedgehog通路抑制剂及其应用
PE20160859A1 (es) * 2013-12-20 2016-09-18 Gilead Sciences Inc Inhibidores de la quinasa reguladora de la senal de apoptosis

Also Published As

Publication number Publication date
AU2018209574B2 (en) 2021-04-08
EA037005B1 (ru) 2021-01-26
BR112019014756A2 (pt) 2020-03-03
EP3572412A1 (en) 2019-11-27
CA3050346A1 (en) 2018-07-26
US11040968B2 (en) 2021-06-22
MX376618B (es) 2025-03-07
EP3572412A4 (en) 2019-11-27
AU2018209574A1 (en) 2019-09-05
ZA201904737B (en) 2020-05-27
CN109071538A (zh) 2018-12-21
US20200031823A1 (en) 2020-01-30
CN109071538B (zh) 2020-03-17
BR112019014756B1 (pt) 2021-08-10
JP6650552B2 (ja) 2020-02-19
KR102089234B1 (ko) 2020-05-15
PH12019501688B1 (en) 2023-08-04
DK3572412T3 (da) 2021-05-25
JP2020504166A (ja) 2020-02-06
WO2018133866A1 (zh) 2018-07-26
CA3050346C (en) 2020-07-14
PH12019501688A1 (en) 2020-03-09
KR20190110103A (ko) 2019-09-27
EP3572412B1 (en) 2021-03-03
MY174821A (en) 2020-05-18
EA201991693A1 (ru) 2019-12-30
ES2870524T3 (es) 2021-10-27
MX2019008698A (es) 2019-09-18
SG11201906579UA (en) 2019-08-27

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