PL359459A1 - Method used for transforming the carbonyl function in position 4'' of a cladinose unit of an aza macrolide into an amine derivative - Google Patents
Method used for transforming the carbonyl function in position 4'' of a cladinose unit of an aza macrolide into an amine derivativeInfo
- Publication number
- PL359459A1 PL359459A1 PL01359459A PL35945901A PL359459A1 PL 359459 A1 PL359459 A1 PL 359459A1 PL 01359459 A PL01359459 A PL 01359459A PL 35945901 A PL35945901 A PL 35945901A PL 359459 A1 PL359459 A1 PL 359459A1
- Authority
- PL
- Poland
- Prior art keywords
- transforming
- method used
- amine derivative
- carbonyl function
- cladinose
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000001131 transforming effect Effects 0.000 title abstract 2
- 150000001412 amines Chemical class 0.000 title 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 title 1
- AJSDVNKVGFVAQU-BIIVOSGPSA-N cladinose Chemical group O=CC[C@@](C)(OC)[C@@H](O)[C@H](C)O AJSDVNKVGFVAQU-BIIVOSGPSA-N 0.000 title 1
- 239000003120 macrolide antibiotic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 238000005576 amination reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Surface Treatment Of Glass Fibres Or Filaments (AREA)
- Glass Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention concerns a method for preparing a compound of general formula (I) by reducing amination of a corresponding (4'')-carbonyl derivative. The invention is characterised in that it consists in: bringing said (4'')-carbonyl derivative into the presence of at least a nitrogenous reagent and a Lewis acid in conditions suited for transforming the cabonyl 4'' function; reducing the resulting mixture using a reducing agent; and optionally deprotecting the hydroxide function in position 2', to lead to the expected compound of general formula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0006942A FR2809728B1 (en) | 2000-05-30 | 2000-05-30 | USEFUL PROCESS FOR TRANSFORMING THE CARBONYL FUNCTION TO THE 4 "POSITION OF THE CLADINOSE PATTERN FROM A MACROLIDE AZA TO AN AMINATED DERIVATIVE |
| PCT/FR2001/001398 WO2001092281A1 (en) | 2000-05-30 | 2001-05-09 | Method used for transforming the carbonyl function in position 4'' of a cladinose unit of an aza macrolide into an amine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL359459A1 true PL359459A1 (en) | 2004-08-23 |
| PL206682B1 PL206682B1 (en) | 2010-09-30 |
Family
ID=8850803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL359459A PL206682B1 (en) | 2000-05-30 | 2001-05-09 | Method used for transforming the carbonyl function in position 4'' of a cladinose unit of an aza macrolide into an amine derivative |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1284983B1 (en) |
| JP (1) | JP2003535101A (en) |
| CN (1) | CN1232527C (en) |
| AT (1) | ATE310743T1 (en) |
| AU (2) | AU2001258518B8 (en) |
| BR (1) | BR0111293A (en) |
| CA (1) | CA2410745C (en) |
| DE (1) | DE60115229T2 (en) |
| DK (1) | DK1284983T3 (en) |
| ES (1) | ES2256233T3 (en) |
| FR (1) | FR2809728B1 (en) |
| NZ (1) | NZ522818A (en) |
| PL (1) | PL206682B1 (en) |
| WO (1) | WO2001092281A1 (en) |
| ZA (1) | ZA200209956B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4879894B2 (en) | 2004-07-14 | 2012-02-22 | スリーエム イノベイティブ プロパティズ カンパニー | Dental composition containing carbosilane polymer |
| AU2005275246B2 (en) | 2004-07-14 | 2011-10-06 | 3M Deutschland Gmbh | Dental compositions containing carbosilane monomers |
| CN110482548A (en) * | 2019-09-04 | 2019-11-22 | 中国科学院山西煤炭化学研究所 | A method of removing super capacitor active carbon oxygen-containing functional group |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2064634C (en) * | 1991-04-04 | 1998-08-04 | James V. Heck | 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions |
-
2000
- 2000-05-30 FR FR0006942A patent/FR2809728B1/en not_active Expired - Lifetime
-
2001
- 2001-05-09 DE DE60115229T patent/DE60115229T2/en not_active Expired - Lifetime
- 2001-05-09 PL PL359459A patent/PL206682B1/en unknown
- 2001-05-09 CN CNB018114156A patent/CN1232527C/en not_active Expired - Lifetime
- 2001-05-09 CA CA002410745A patent/CA2410745C/en not_active Expired - Lifetime
- 2001-05-09 AU AU2001258518A patent/AU2001258518B8/en not_active Expired
- 2001-05-09 EP EP01931825A patent/EP1284983B1/en not_active Expired - Lifetime
- 2001-05-09 DK DK01931825T patent/DK1284983T3/en active
- 2001-05-09 BR BR0111293-7A patent/BR0111293A/en not_active Application Discontinuation
- 2001-05-09 WO PCT/FR2001/001398 patent/WO2001092281A1/en not_active Ceased
- 2001-05-09 ES ES01931825T patent/ES2256233T3/en not_active Expired - Lifetime
- 2001-05-09 AT AT01931825T patent/ATE310743T1/en active
- 2001-05-09 NZ NZ522818A patent/NZ522818A/en not_active IP Right Cessation
- 2001-05-09 JP JP2002500894A patent/JP2003535101A/en active Pending
- 2001-05-09 AU AU5851801A patent/AU5851801A/en active Pending
-
2002
- 2002-12-09 ZA ZA200209956A patent/ZA200209956B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60115229D1 (en) | 2005-12-29 |
| ZA200209956B (en) | 2003-12-09 |
| WO2001092281A1 (en) | 2001-12-06 |
| EP1284983B1 (en) | 2005-11-23 |
| DK1284983T3 (en) | 2006-04-03 |
| CN1232527C (en) | 2005-12-21 |
| FR2809728B1 (en) | 2003-02-28 |
| BR0111293A (en) | 2003-06-10 |
| CA2410745C (en) | 2006-04-25 |
| ES2256233T3 (en) | 2006-07-16 |
| AU2001258518B2 (en) | 2005-09-29 |
| AU5851801A (en) | 2001-12-11 |
| FR2809728A1 (en) | 2001-12-07 |
| CA2410745A1 (en) | 2001-12-06 |
| EP1284983A1 (en) | 2003-02-26 |
| CN1437609A (en) | 2003-08-20 |
| ATE310743T1 (en) | 2005-12-15 |
| AU2001258518B8 (en) | 2005-10-13 |
| PL206682B1 (en) | 2010-09-30 |
| JP2003535101A (en) | 2003-11-25 |
| DE60115229T2 (en) | 2006-08-03 |
| NZ522818A (en) | 2005-07-29 |
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