PL3597649T3 - Kompozycje zawierające podstawione związki [1,2,4]triazolo[1,5-a]pirymidyn-7-ylowe jako inhibitory pde2 - Google Patents

Kompozycje zawierające podstawione związki [1,2,4]triazolo[1,5-a]pirymidyn-7-ylowe jako inhibitory pde2

Info

Publication number
PL3597649T3
PL3597649T3 PL19194930T PL19194930T PL3597649T3 PL 3597649 T3 PL3597649 T3 PL 3597649T3 PL 19194930 T PL19194930 T PL 19194930T PL 19194930 T PL19194930 T PL 19194930T PL 3597649 T3 PL3597649 T3 PL 3597649T3
Authority
PL
Poland
Prior art keywords
triazolo
pyrimidin
compounds
compositions containing
containing substituted
Prior art date
Application number
PL19194930T
Other languages
English (en)
Inventor
James Breitenbucher
Graeme Freestone
Laurent Gomez
Robert Lemus
Kiev Ly
Margaret MCCARRICK
William Vernier
Troy Vickers
Original Assignee
Dart Neuroscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dart Neuroscience Llc filed Critical Dart Neuroscience Llc
Publication of PL3597649T3 publication Critical patent/PL3597649T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/50—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving creatine phosphokinase

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL19194930T 2014-04-23 2015-04-22 Kompozycje zawierające podstawione związki [1,2,4]triazolo[1,5-a]pirymidyn-7-ylowe jako inhibitory pde2 PL3597649T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461983387P 2014-04-23 2014-04-23
EP19194930.4A EP3597649B8 (en) 2014-04-23 2015-04-22 Compositions containing substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors
PCT/US2015/027102 WO2015164508A1 (en) 2014-04-23 2015-04-22 Substituted [1,2,4] triazolo [1,5-a] pyrimidin-7-yl compounds as pde2 inhibitors
EP15721086.5A EP3134413B1 (en) 2014-04-23 2015-04-22 Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors

Publications (1)

Publication Number Publication Date
PL3597649T3 true PL3597649T3 (pl) 2022-04-04

Family

ID=53055118

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19194930T PL3597649T3 (pl) 2014-04-23 2015-04-22 Kompozycje zawierające podstawione związki [1,2,4]triazolo[1,5-a]pirymidyn-7-ylowe jako inhibitory pde2

Country Status (23)

Country Link
US (5) US9932345B2 (pl)
EP (2) EP3134413B1 (pl)
JP (1) JP6626449B2 (pl)
KR (1) KR102471058B1 (pl)
CN (2) CN110092788B (pl)
AU (2) AU2015249753B2 (pl)
BR (1) BR112016024713B1 (pl)
CA (1) CA2938294C (pl)
DK (2) DK3597649T3 (pl)
ES (2) ES2902806T3 (pl)
HR (1) HRP20212035T1 (pl)
HU (1) HUE057317T2 (pl)
IL (2) IL248292A (pl)
MA (1) MA50375A (pl)
MX (1) MX358004B (pl)
NZ (1) NZ725161A (pl)
PL (1) PL3597649T3 (pl)
PT (1) PT3597649T (pl)
RU (1) RU2659070C9 (pl)
SG (1) SG11201606216UA (pl)
SI (1) SI3597649T1 (pl)
TW (1) TWI664181B (pl)
WO (1) WO2015164508A1 (pl)

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CA3001768C (en) * 2015-11-02 2022-12-13 Janssen Pharmaceutica Nv [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
JP2019506430A (ja) 2016-02-25 2019-03-07 エースニューロン・ソシエテ・アノニム グリコシダーゼ阻害剤
JP6971999B2 (ja) 2016-02-25 2021-11-24 エースニューロン・ソシエテ・アノニム ピペラジン誘導体の酸付加塩
CN108884077A (zh) 2016-02-25 2018-11-23 阿森纽荣股份公司 糖苷酶抑制剂
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WO2018083103A1 (en) 2016-11-02 2018-05-11 Janssen Pharmaceutica Nv [1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors
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EP3134413B1 (en) 2014-04-23 2019-09-11 Dart NeuroScience (Cayman) Ltd. Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors
TWI568737B (zh) 2014-11-05 2017-02-01 達特神經科學（開曼）有限責任公司 作為ｐｄｅ２抑制劑之經取代的５－甲基－［１，２，４］三唑并［１，５－ａ］嘧啶－２－胺化合物

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TW201625625A (zh) 2016-07-16
IL248292A (en) 2017-09-28
AU2015249753A1 (en) 2016-11-03
MA50375A (fr) 2021-05-26
US12630556B2 (en) 2026-05-19
HUE057317T2 (hu) 2022-04-28
US20180179216A1 (en) 2018-06-28
US20230192698A1 (en) 2023-06-22
WO2015164508A4 (en) 2015-12-23
JP6626449B2 (ja) 2019-12-25
IL254224B (en) 2019-01-31
JP2017513808A (ja) 2017-06-01
SG11201606216UA (en) 2016-09-29
IL254224A0 (en) 2017-10-31
CA2938294C (en) 2023-02-21
ES2759246T3 (es) 2020-05-08
AU2019283994A1 (en) 2020-01-23
US11186582B2 (en) 2021-11-30
HRP20212035T1 (hr) 2022-04-01
CA2938294A1 (en) 2015-10-29
WO2015164508A1 (en) 2015-10-29
MX2016013860A (es) 2017-05-12
BR112016024713B1 (pt) 2023-05-02
CN106459062A (zh) 2017-02-22
KR20160145745A (ko) 2016-12-20
US20200095256A1 (en) 2020-03-26
AU2019283994C1 (en) 2021-12-09
NZ725161A (en) 2017-10-27
SI3597649T1 (sl) 2022-04-29
US9932345B2 (en) 2018-04-03
AU2019283994B2 (en) 2021-05-27
ES2902806T3 (es) 2022-03-29
EP3597649B8 (en) 2022-02-16
RU2016143387A3 (pl) 2018-05-23
US20250092047A1 (en) 2025-03-20
EP3134413A1 (en) 2017-03-01
AU2015249753B2 (en) 2019-10-10
RU2659070C2 (ru) 2018-06-28
BR112016024713A2 (pt) 2017-08-15
MX358004B (es) 2018-07-31
TWI664181B (zh) 2019-07-01
DK3597649T3 (da) 2022-01-10
EP3597649B1 (en) 2021-10-13
EP3134413B1 (en) 2019-09-11
CN110092788A (zh) 2019-08-06
US20170057967A1 (en) 2017-03-02
KR102471058B1 (ko) 2022-11-25
US10501465B2 (en) 2019-12-10
EP3597649A1 (en) 2020-01-22
RU2016143387A (ru) 2018-05-23
PT3597649T (pt) 2022-01-21
CN110092788B (zh) 2022-02-25
DK3134413T3 (da) 2019-10-14
RU2659070C9 (ru) 2018-08-24

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