PL3606929T3 - Nukleotydy estru beta-nikotynianowego i sposoby ich wytwarzania - Google Patents

Nukleotydy estru beta-nikotynianowego i sposoby ich wytwarzania

Info

Publication number
PL3606929T3
PL3606929T3 PL18781797T PL18781797T PL3606929T3 PL 3606929 T3 PL3606929 T3 PL 3606929T3 PL 18781797 T PL18781797 T PL 18781797T PL 18781797 T PL18781797 T PL 18781797T PL 3606929 T3 PL3606929 T3 PL 3606929T3
Authority
PL
Poland
Prior art keywords
beta
preparation
methods
nicotinate ester
nucleotides
Prior art date
Application number
PL18781797T
Other languages
English (en)
Inventor
Anthony A. Sauve
Original Assignee
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell University filed Critical Cornell University
Publication of PL3606929T3 publication Critical patent/PL3606929T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/58Pyridine rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • C07H1/02Phosphorylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048Pyridine radicals
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/316Foods, ingredients or supplements having a functional effect on health having an effect on regeneration or building of ligaments or muscles
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/322Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PL18781797T 2017-04-05 2018-04-05 Nukleotydy estru beta-nikotynianowego i sposoby ich wytwarzania PL3606929T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762481912P 2017-04-05 2017-04-05
EP18781797.8A EP3606929B1 (en) 2017-04-05 2018-04-05 Beta-nicotinate ester nucleotides and processes for preparing same
PCT/US2018/026209 WO2018187540A1 (en) 2017-04-05 2018-04-05 Beta-nicotinate ester nucleotides and processes for preparing same

Publications (1)

Publication Number Publication Date
PL3606929T3 true PL3606929T3 (pl) 2021-12-27

Family

ID=63712318

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18781797T PL3606929T3 (pl) 2017-04-05 2018-04-05 Nukleotydy estru beta-nikotynianowego i sposoby ich wytwarzania

Country Status (19)

Country Link
US (2) US10961268B2 (pl)
EP (1) EP3606929B1 (pl)
JP (1) JP7182289B2 (pl)
KR (1) KR102605369B1 (pl)
CN (1) CN110709406B (pl)
AU (2) AU2018250242B2 (pl)
CA (1) CA3059228C (pl)
CY (1) CY1124450T1 (pl)
DK (1) DK3606929T3 (pl)
ES (1) ES2887224T3 (pl)
HR (1) HRP20211296T1 (pl)
HU (1) HUE055521T2 (pl)
LT (1) LT3606929T (pl)
PL (1) PL3606929T3 (pl)
PT (1) PT3606929T (pl)
RS (1) RS62284B1 (pl)
SI (1) SI3606929T1 (pl)
SM (1) SMT202100496T1 (pl)
WO (1) WO2018187540A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2670927T3 (es) 2005-11-18 2018-06-04 Cornell Research Foundation, Inc. Composiciones de nicotinoil ribósido y métodos de uso
AU2016302005B2 (en) 2015-08-05 2021-03-04 Metro International Biotech, Llc Nicotinamide mononucleotide derivatives and their uses
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
JP7182289B2 (ja) 2017-04-05 2022-12-02 コーネル ユニヴァーシティー β-ニコチネートエステルヌクレオチドおよびその調製プロセス
US20210388018A1 (en) * 2018-10-01 2021-12-16 Cornell University Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof
KR102060374B1 (ko) * 2018-12-14 2019-12-30 주식회사 휴메딕스 지방알코올 컨쥬게이션된 니코틴아미드 리보사이드 유도체
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
IL308577A (en) 2021-05-27 2024-01-01 Metro Int Biotech Llc Crystalline solids of nicotinic acid mononucleotides and their esters and methods for their preparation and use
CN113527376A (zh) * 2021-08-06 2021-10-22 上海昶法新材料有限公司 β-烟酰胺单核苷酸的制备方法
WO2023122190A1 (en) * 2021-12-22 2023-06-29 Metro International Biotech, Llc Compositions for treatment of inflammation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3736314A (en) * 1967-06-02 1973-05-29 Syntex Corp Unsaturated nucleoside phosphonates phosphonic acids and phosphonic acid salts
ES2670927T3 (es) 2005-11-18 2018-06-04 Cornell Research Foundation, Inc. Composiciones de nicotinoil ribósido y métodos de uso
US9790252B2 (en) 2009-07-01 2017-10-17 Cornell University 2-fluorinated riboses and arabinoses and methods of use and synthesis
WO2011081942A1 (en) 2009-12-14 2011-07-07 Cornell University Activation and activators of sirt5
US9322049B2 (en) 2009-12-14 2016-04-26 Cornell University Activation and activators of SirT6
US9290791B2 (en) 2010-05-18 2016-03-22 Cornell University Reagents and methods for sirtuin capture
JP6289460B2 (ja) 2012-07-16 2018-03-07 コーネル ユニヴァーシティー 難聴を治療するためのニコチンアミドリボシド
RU2016149767A (ru) * 2014-06-06 2018-07-16 Глэксосмитклайн Интеллекчуал Проперти (Но.2) Лимитед Аналоги никотинамидрибозида и фармацевтические композиции и их применение
US20160035539A1 (en) 2014-07-30 2016-02-04 Lauri SAINIEMI Microfabrication
US10525070B2 (en) 2015-02-10 2020-01-07 Duke University Method of treating heart failure
WO2016160524A1 (en) 2015-03-27 2016-10-06 Cornell University Efficient synthesis of nicotinamide mononucleotide
CA2987986A1 (en) 2015-06-04 2016-12-08 Chromadex, Inc. Selective solvent free phosphorylation
US10392414B2 (en) 2015-07-15 2019-08-27 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
JP7182289B2 (ja) 2017-04-05 2022-12-02 コーネル ユニヴァーシティー β-ニコチネートエステルヌクレオチドおよびその調製プロセス
US20210388018A1 (en) 2018-10-01 2021-12-16 Cornell University Methyl and ethyl nicotinate-riboside-5-phosphates, preparation thereof and methods of use thereof

Also Published As

Publication number Publication date
US10961268B2 (en) 2021-03-30
PT3606929T (pt) 2021-09-02
HUE055521T2 (hu) 2021-11-29
ES2887224T3 (es) 2021-12-22
AU2021250984B2 (en) 2022-09-01
KR20190137133A (ko) 2019-12-10
US20210214386A1 (en) 2021-07-15
KR102605369B1 (ko) 2023-11-24
LT3606929T (lt) 2021-10-25
AU2018250242A1 (en) 2019-10-31
CA3059228A1 (en) 2018-10-11
CY1124450T1 (el) 2022-07-22
EP3606929B1 (en) 2021-06-02
RS62284B1 (sr) 2021-09-30
JP2020516619A (ja) 2020-06-11
AU2018250242B2 (en) 2021-07-15
US20200031860A1 (en) 2020-01-30
SI3606929T1 (sl) 2021-11-30
SMT202100496T1 (it) 2021-11-12
CA3059228C (en) 2025-03-18
DK3606929T3 (da) 2021-08-23
AU2021250984A1 (en) 2021-11-18
EP3606929A1 (en) 2020-02-12
HRP20211296T1 (hr) 2021-11-12
JP7182289B2 (ja) 2022-12-02
EP3606929A4 (en) 2020-05-06
US11530233B2 (en) 2022-12-20
WO2018187540A1 (en) 2018-10-11
CN110709406A (zh) 2020-01-17
CN110709406B (zh) 2022-11-08

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