PL3611174T3 - Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a - Google Patents

Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a

Info

Publication number
PL3611174T3
PL3611174T3 PL18781739.0T PL18781739T PL3611174T3 PL 3611174 T3 PL3611174 T3 PL 3611174T3 PL 18781739 T PL18781739 T PL 18781739T PL 3611174 T3 PL3611174 T3 PL 3611174T3
Authority
PL
Poland
Prior art keywords
triazolo
receptor inhibitor
pyrimidine derivative
pyrimidine
derivative
Prior art date
Application number
PL18781739.0T
Other languages
English (en)
Inventor
Kevin X Chen
Yanxin YU
Xinde CHEN
Li Zhang
Zhaoguo CHEN
Cheng Xie
Xiaofei Wang
Linghui Wu
Guoping Hu
Jian Li
Shuhui Chen
Original Assignee
Medshine Discovery Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medshine Discovery Inc. filed Critical Medshine Discovery Inc.
Publication of PL3611174T3 publication Critical patent/PL3611174T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL18781739.0T 2017-04-07 2018-04-08 Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a PL3611174T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201710224553 2017-04-07
CN201710737871 2017-08-24
CN201810129208 2018-02-08
PCT/CN2018/082119 WO2018184590A1 (zh) 2017-04-07 2018-04-08 作为A 2A受体抑制剂的[1,2,4]三唑并[1,5-c]嘧啶衍生物

Publications (1)

Publication Number Publication Date
PL3611174T3 true PL3611174T3 (pl) 2022-08-08

Family

ID=63712048

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18781739.0T PL3611174T3 (pl) 2017-04-07 2018-04-08 Pochodne [1,2,4]triazolo[1,5-c]pirymidyny jako inhibitor receptora a2a

Country Status (9)

Country Link
US (1) US11117899B2 (pl)
EP (1) EP3611174B1 (pl)
JP (1) JP7065113B2 (pl)
CN (1) CN110446712B (pl)
DK (1) DK3611174T3 (pl)
ES (1) ES2919474T3 (pl)
PL (1) PL3611174T3 (pl)
PT (1) PT3611174T (pl)
WO (1) WO2018184590A1 (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109535161B (zh) * 2017-09-22 2021-09-03 江苏恒瑞医药股份有限公司 三唑并嘧啶类衍生物、其制备方法及其在医药上的应用
TWI877770B (zh) * 2018-02-27 2025-03-21 美商英塞特公司 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶
PL3766884T3 (pl) * 2018-04-28 2022-07-18 Medshine Discovery Inc. Postać krystaliczna i rodzaj soli związku triazolopirymidynowego oraz sposób jej wytwarzania
EP3810610A1 (en) * 2018-05-18 2021-04-28 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
WO2020010197A1 (en) * 2018-07-05 2020-01-09 Incyte Corporation Fused pyrazine derivatives as a2a / a2b inhibitors
AR116315A1 (es) * 2018-09-12 2021-04-21 Dizal Jiangsu Pharmaceutical Co Ltd Compuestos de triazolo-pirimidina y usos de los mismos
AU2019383948A1 (en) 2018-11-20 2021-05-20 Merck Sharp & Dohme Llc Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
US12414952B2 (en) 2018-11-20 2025-09-16 Merck Sharp & Dohme Llc Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
WO2020112700A1 (en) 2018-11-30 2020-06-04 Merck Sharp & Dohme Corp. 9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
EP3889153A4 (en) * 2018-11-30 2022-09-07 Tuojie Biotech (Shanghai) Co., Ltd. PYRIMIDINE AND FIVE-MEMBERED HETEROCYCLIC NITROGEN DERIVATIVE, METHOD OF MANUFACTURE THEREOF AND MEDICAL USES THEREOF
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
EP3950064A4 (en) * 2019-04-03 2023-01-04 Tera Stone Co., Ltd THYMINE NUCLEOBASE BASED TRIAZOLOPYRIMIDINES AND PROCESS FOR THEIR PRODUCTION
CN111848625B (zh) * 2019-04-24 2022-07-26 江苏恒瑞医药股份有限公司 一种杂芳基并[4,3-c]嘧啶-5-胺类化合物的制备方法及中间体
PE20230372A1 (es) * 2019-08-26 2023-03-06 Incyte Corp Triazolopirimidinas como inhibidores de a2a/a2b
WO2021156439A1 (en) 2020-02-06 2021-08-12 Astrazeneca Ab Triazole compounds as adenosine receptor antagonists
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
KR20250133471A (ko) 2020-02-18 2025-09-05 길리애드 사이언시즈, 인코포레이티드 항바이러스 화합물
TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
KR20230049580A (ko) 2020-03-26 2023-04-13 헵테얼즈 테라퓨틱스 리미티드 트리아졸론 화합물
CA3216162A1 (en) 2021-04-16 2022-10-20 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides
AU2022328698B2 (en) 2021-08-18 2025-02-20 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
CN120022278A (zh) * 2023-11-22 2025-05-23 英诺湖医药(杭州)有限公司 用于治疗癌症的化合物
WO2025257365A1 (en) 2024-06-14 2025-12-18 Institut National de la Santé et de la Recherche Médicale Adenosine a2a antagonists for the treatment of endometriosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69820866T2 (de) 1997-03-24 2004-12-30 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
TWI330183B (pl) 2001-10-22 2010-09-11 Eisai R&D Man Co Ltd
AR038366A1 (es) 2001-11-30 2005-01-12 Schering Corp Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion
WO2004029056A1 (ja) * 2002-09-24 2004-04-08 Kyowa Hakko Kogyo Co., Ltd. [１，２，４]トリアゾロ[１，５−ｃ]ピリミジン誘導体
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
CN109535161B (zh) * 2017-09-22 2021-09-03 江苏恒瑞医药股份有限公司 三唑并嘧啶类衍生物、其制备方法及其在医药上的应用
TWI877770B (zh) * 2018-02-27 2025-03-21 美商英塞特公司 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶
CN109535162B (zh) 2018-12-13 2020-03-24 浙江圣达生物药业股份有限公司 一种n-对氨基苯甲酰谷氨酰叶酸的制备方法

Also Published As

Publication number Publication date
EP3611174A4 (en) 2020-09-09
PT3611174T (pt) 2022-07-07
WO2018184590A1 (zh) 2018-10-11
CN110446712A (zh) 2019-11-12
JP2020516606A (ja) 2020-06-11
EP3611174A1 (en) 2020-02-19
DK3611174T3 (da) 2022-07-04
CN110446712B (zh) 2021-09-14
US11117899B2 (en) 2021-09-14
US20200131184A1 (en) 2020-04-30
EP3611174B1 (en) 2022-06-08
ES2919474T3 (es) 2022-07-26
JP7065113B2 (ja) 2022-05-11

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