PL3625339T3 - Modyfikacje w enzymówach dekarboksylazy lizynowej - Google Patents

Modyfikacje w enzymówach dekarboksylazy lizynowej

Info

Publication number
PL3625339T3
PL3625339T3 PL17910224.9T PL17910224T PL3625339T3 PL 3625339 T3 PL3625339 T3 PL 3625339T3 PL 17910224 T PL17910224 T PL 17910224T PL 3625339 T3 PL3625339 T3 PL 3625339T3
Authority
PL
Poland
Prior art keywords
modifications
lysine decarboxylase
decarboxylase enzymes
enzymes
lysine
Prior art date
Application number
PL17910224.9T
Other languages
English (en)
Inventor
Howard Chou
Wenqiang Lu
Ling Chen
Lijun Yu
Xiucai LIU
Original Assignee
Cathay Biotech Inc.
Cibt America Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cathay Biotech Inc., Cibt America Inc. filed Critical Cathay Biotech Inc.
Publication of PL3625339T3 publication Critical patent/PL3625339T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/001Amines; Imines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/01Carboxy-lyases (4.1.1)
    • C12Y401/01018Lysine decarboxylase (4.1.1.18)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
PL17910224.9T 2017-05-16 2017-05-16 Modyfikacje w enzymówach dekarboksylazy lizynowej PL3625339T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2017/084540 WO2018209563A1 (en) 2017-05-16 2017-05-16 Modifications to lysine decarboxylase enzymes

Publications (1)

Publication Number Publication Date
PL3625339T3 true PL3625339T3 (pl) 2026-01-19

Family

ID=64273117

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17910224.9T PL3625339T3 (pl) 2017-05-16 2017-05-16 Modyfikacje w enzymówach dekarboksylazy lizynowej

Country Status (6)

Country Link
US (1) US11512302B2 (pl)
EP (1) EP3625339B1 (pl)
CN (1) CN110546255B (pl)
ES (1) ES3053013T3 (pl)
PL (1) PL3625339T3 (pl)
WO (1) WO2018209563A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113881657B (zh) * 2020-07-02 2024-02-02 中国科学院过程工程研究所 一种用于合成戊二胺的赖氨酸脱羧酶及其应用
CN113881719A (zh) * 2020-07-02 2022-01-04 中国科学院过程工程研究所 一种全细胞催化合成1,5-戊二胺的方法
CN114621984B (zh) * 2020-12-14 2025-01-28 中国科学院过程工程研究所 一种离子液体强化赖氨酸脱羧酶合成1,5-戊二胺的方法
CN115125229B (zh) * 2021-03-25 2023-11-14 中国科学院过程工程研究所 一种用于合成戊二胺的赖氨酸脱羧酶突变体
CN116254253B (zh) * 2022-11-11 2024-06-28 浙大宁波理工学院 一种通过dna合成改组组合突变获得的谷氨酸脱羧酶突变体及应用
CN118516339A (zh) * 2023-02-18 2024-08-20 宁波酶赛生物工程有限公司 一种制备1,5-戊二胺的工程化赖氨酸脱羧酶

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4551433A (en) 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
EP2806026B1 (en) 2012-01-18 2018-12-26 Mitsui Chemicals, Inc. Method for producing 1,5-pentamethylenediamine, mutant lysine decarboxylase, method for producing 1,5-pentamethylene diisocyanate and method for producing polyisocyanate composition
CN103789292B (zh) 2013-12-26 2015-10-21 南京工业大学 一种赖氨酸脱羧酶、制备方法及其应用
CN104762336B (zh) 2014-01-06 2019-10-29 上海凯赛生物技术股份有限公司 1,5-戊二胺的制备方法
WO2015137418A1 (ja) 2014-03-11 2015-09-17 味の素株式会社 熱安定性向上リジン脱炭酸酵素変異体を用いる1,5-ペンタジアミンの製造方法
ES2881104T3 (es) * 2014-06-26 2021-11-26 Cathay Biotech Inc Expresión de polipéptidos implicados en descarboxilación de lisina, y métodos y aplicaciones de los mismos
EP3250583B1 (en) 2015-01-30 2021-03-03 Cathay Biotech Inc. Expression of klebsiella oxytoca polypeptides involved in lysine decarboxylation, and methods and applications thereof
KR101791837B1 (ko) 2015-08-06 2017-10-31 서울대학교산학협력단 라이신 디카르복실라아제의 변이주 개발 방법 및 그의 응용

Also Published As

Publication number Publication date
ES3053013T3 (en) 2026-01-16
EP3625339B1 (en) 2025-09-03
EP3625339A1 (en) 2020-03-25
WO2018209563A1 (en) 2018-11-22
EP3625339A4 (en) 2021-01-20
CN110546255A (zh) 2019-12-06
US11512302B2 (en) 2022-11-29
CN110546255B (zh) 2023-07-04
US20210155962A1 (en) 2021-05-27

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