PL362870A1 - Zmodyfikowany interferon beta o obniżonej immunogeniczności - Google Patents

Zmodyfikowany interferon beta o obniżonej immunogeniczności

Info

Publication number
PL362870A1
PL362870A1 PL02362870A PL36287002A PL362870A1 PL 362870 A1 PL362870 A1 PL 362870A1 PL 02362870 A PL02362870 A PL 02362870A PL 36287002 A PL36287002 A PL 36287002A PL 362870 A1 PL362870 A1 PL 362870A1
Authority
PL
Poland
Prior art keywords
interferon beta
reduced immunogenicity
modified interferon
modified
immunogenicity
Prior art date
Application number
PL02362870A
Other languages
English (en)
Inventor
Francis J. Carr
Graham Carter
Tim Jones
John Watkins
Matthew Baker
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL362870A1 publication Critical patent/PL362870A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL02362870A 2001-03-15 2002-03-15 Zmodyfikowany interferon beta o obniżonej immunogeniczności PL362870A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01106539 2001-03-15
PCT/EP2002/002925 WO2002074783A2 (en) 2001-03-15 2002-03-15 Modified interferon beta with reduced immunogenicity

Publications (1)

Publication Number Publication Date
PL362870A1 true PL362870A1 (pl) 2004-11-02

Family

ID=8176796

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02362870A PL362870A1 (pl) 2001-03-15 2002-03-15 Zmodyfikowany interferon beta o obniżonej immunogeniczności

Country Status (13)

Country Link
US (2) US7381795B2 (pl)
EP (1) EP1368377A2 (pl)
JP (1) JP2004529633A (pl)
KR (1) KR20030084992A (pl)
CN (1) CN1496369A (pl)
BR (1) BR0208041A (pl)
CA (1) CA2441095A1 (pl)
HU (1) HUP0303534A3 (pl)
MX (1) MXPA03008310A (pl)
PL (1) PL362870A1 (pl)
RU (1) RU2003129072A (pl)
WO (1) WO2002074783A2 (pl)
ZA (1) ZA200307992B (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001010912A1 (en) 1999-08-09 2001-02-15 Lexigen Pharmaceuticals Corp. Multiple cytokine-antibody complexes
DK1366067T3 (da) 2001-03-07 2012-10-22 Merck Patent Gmbh Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed
PL362870A1 (pl) * 2001-03-15 2004-11-02 Merck Patent Gmbh Zmodyfikowany interferon beta o obniżonej immunogeniczności
BR0209177A (pt) 2001-05-03 2004-10-05 Merck Patent Gmbh Anticorpo especìfico a tumor recombinante e uso do mesmo
US20030198624A1 (en) * 2002-03-02 2003-10-23 Mohapatra Shyam S. Method of treating allergic disease and asthma by recombinant adenovirus- and adeno-associated virus- mediated IFN-gamma gene transfer
US7354908B2 (en) * 2002-04-30 2008-04-08 University Of South Florida Materials and methods for prevention and treatment of RNA viral diseases
DK1578772T3 (da) * 2002-05-01 2010-08-16 Danisco Us Inc Cytokiner og cytokinreceptorer med reduceret immunogenicitet
US7595303B1 (en) * 2002-09-05 2009-09-29 University Of South Florida Genetic adjuvants for immunotherapy
WO2004022593A2 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
ATE471946T1 (de) 2002-12-17 2010-07-15 Merck Patent Gmbh Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2
CA2516188C (en) * 2003-02-14 2012-04-17 University Of South Florida Chitosan-derivatives for gene delivery and expression
EP1636256A2 (en) * 2003-06-10 2006-03-22 Xencor, Inc. Interferon variants with improved properties
US20050266093A1 (en) * 2004-04-27 2005-12-01 Mohapatra Shyam S Nanogene therapy for cell proliferation disorders
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
US20080038224A1 (en) * 2006-03-28 2008-02-14 Thierry Guyon Modified interferon-beta (IFN-beta) polypeptides
EP2423220B1 (en) 2007-01-30 2015-04-29 Epivax, Inc. Regulatory t cell epitopes, compositions and uses thereof
CN101675071B (zh) 2007-05-02 2014-06-18 Ambrx公司 经修饰干扰素β多肽和其用途
US20090010966A1 (en) * 2007-06-21 2009-01-08 Angelica Therapeutics, Inc. Modified diphtheria toxins
EP2268297A4 (en) * 2008-02-29 2011-11-16 Angelica Therapeutics Inc MODIFIED TOXINS
AU2010238858A1 (en) * 2009-04-22 2011-12-08 Merck Patent Gmbh Antibody fusion proteins with modified FcRn binding sites
IN2014CN02982A (pl) 2011-10-01 2015-07-03 Glytech Inc
EP2968450A4 (en) 2013-03-15 2016-10-26 Angelica Therapeutics Inc MODIFIED TOXINS
AU2014245917B2 (en) 2013-03-29 2017-09-28 Glytech, Inc. Polypeptide having sialylated sugar chains attached thereto

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
EP0983303B1 (en) * 1997-05-21 2006-03-08 Biovation Limited Method for the production of non-immunogenic proteins
AU766190B2 (en) * 1998-10-16 2003-10-09 Biogen Idec Ma Inc. Interferon-beta fusion proteins and uses
AU776910B2 (en) * 1998-12-08 2004-09-23 Merck Patent Gesellschaft Mit Beschrankter Haftung Modifying protein immunogenicity
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
PL362870A1 (pl) * 2001-03-15 2004-11-02 Merck Patent Gmbh Zmodyfikowany interferon beta o obniżonej immunogeniczności

Also Published As

Publication number Publication date
HUP0303534A2 (hu) 2004-01-28
HUP0303534A3 (en) 2005-12-28
CA2441095A1 (en) 2002-09-26
EP1368377A2 (en) 2003-12-10
WO2002074783A3 (en) 2003-08-28
ZA200307992B (en) 2005-01-14
JP2004529633A (ja) 2004-09-30
US20050054052A1 (en) 2005-03-10
US7381795B2 (en) 2008-06-03
US20090043076A1 (en) 2009-02-12
MXPA03008310A (es) 2003-12-11
BR0208041A (pt) 2004-02-25
RU2003129072A (ru) 2005-04-20
US7615615B2 (en) 2009-11-10
WO2002074783A2 (en) 2002-09-26
KR20030084992A (ko) 2003-11-01
CN1496369A (zh) 2004-05-12

Similar Documents

Publication Publication Date Title
HUP0303534A3 (en) Modified interferon beta with reduced immunogenicity
GB0118651D0 (en) Flat-plate
PT1361893E (pt) Anticorpos anti-rfce modificados com imunogenicidade reduzida
MXPA03007323A (es) Proteinas artificiales con inmunogenicidad reducida.
HUP0400466A3 (en) G-csf conjugates
GB9912350D0 (en) Modified cytokine
EP1455859A4 (en) RETRACTABLE HYPODERMAL SYRINGE
HUP0402259A3 (en) Vaccines
GB2391571B (en) Sintered wellscreen
EP1581631A4 (en) INTERFERON VARIANTS HAVING IMPROVED PROPERTIES
PL363181A1 (pl) Zmodyfikowany interferon alfa o obniżonej immunogeniczności
IL155788A0 (en) Stabilized interferon compositions
PL362375A1 (pl) Zmodyfikowana leptyna o obniżonej immunogeniczności
GB2393372B (en) Multi-power heaters
HUP0303430A3 (en) Modified protamine with reduced immunogenicity
HUP0401121A3 (en) Modified thrombopoietin with reduced immunogenicity
HUP0303523A3 (en) Modified insulin with reduced immunogenicity
GB0105238D0 (en) Vaccines
AU2003276846A8 (en) Thrombopoiesis-stimulating proteins having reduced immunogenicity
GB2383044B (en) Alstroem syndrome gene
GB2372248B (en) Kiln furniture
GB2412555B (en) Multi-power heaters
TW538729U (en) Chair with heating function
GB0130194D0 (en) Jetlift with downward thrust
MXPA03008086A (es) Protamina modificada con inmunogenicidad reducida.

Legal Events

Date Code Title Description
DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)