PL363245A1 - Związki specyficzne względem receptorów adenozynyA1, A2A i A3 i ich zastosowanie - Google Patents

Związki specyficzne względem receptorów adenozynyA1, A2A i A3 i ich zastosowanie

Info

Publication number: PL363245A1
Authority: PL; Poland
Prior art keywords: adenosine; compounds specific; compounds; specific
Prior art date: 2000-12-01

Application number

PL01363245A

Other languages

English (en)

Inventor

Arlindo L. Castelhano

Bryan Mckibben

David J. Witter

Original Assignee

Osi Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-01

Filing date

2001-11-30

Publication date

2004-11-15

2000-12-01 Priority claimed from US09/728,316 external-priority patent/US6680322B2/en

2000-12-01 Priority claimed from US09/728,616 external-priority patent/US7160890B2/en

2000-12-01 Priority claimed from US09/728,607 external-priority patent/US6664252B2/en

2001-11-30 Application filed by Osi Pharmaceuticals, Inc. filed Critical Osi Pharmaceuticals, Inc.

2004-11-15 Publication of PL363245A1 publication Critical patent/PL363245A1/pl

Links

OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
239000002126 C01EB10 - Adenosine Substances 0.000 title 1
229960005305 adenosine Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Psychology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Hematology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL01363245A 2000-12-01 2001-11-30 Związki specyficzne względem receptorów adenozynyA1, A2A i A3 i ich zastosowanie PL363245A1 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US09/728,316 US6680322B2 (en)	1999-12-02	2000-12-01	Compounds specific to adenosine A1 receptors and uses thereof
US09/728,616 US7160890B2 (en)	1999-12-02	2000-12-01	Compounds specific to adenosine A3 receptor and uses thereof
US09/728,607 US6664252B2 (en)	1999-12-02	2000-12-01	4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
PCT/US2001/045280 WO2002057267A1 (en)	2000-12-01	2001-11-30	Compounds specific to adenosine a1, a2a, and a3 receptor and uses thereof

Publications (1)

Publication Number	Publication Date
PL363245A1 true PL363245A1 (pl)	2004-11-15

Family

ID=27419112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL01363245A PL363245A1 (pl)	2000-12-01	2001-11-30	Związki specyficzne względem receptorów adenozynyA1, A2A i A3 i ich zastosowanie

Country Status (20)

Country	Link
EP (1)	EP1347980A4 (pl)
JP (1)	JP4579497B2 (pl)
CN (1)	CN1263757C (pl)
AP (1)	AP1893A (pl)
AU (1)	AU2002248151B2 (pl)
BR (1)	BR0115847A (pl)
CA (1)	CA2430577A1 (pl)
CZ (1)	CZ20031831A3 (pl)
EA (1)	EA007254B1 (pl)
HU (1)	HUP0400692A3 (pl)
IL (1)	IL155962A0 (pl)
ME (1)	MEP35308A (pl)
MX (1)	MXPA03004717A (pl)
NO (1)	NO327207B1 (pl)
NZ (1)	NZ525885A (pl)
OA (1)	OA13295A (pl)
PL (1)	PL363245A1 (pl)
WO (1)	WO2002057267A1 (pl)
YU (1)	YU42703A (pl)
ZA (1)	ZA200303729B (pl)

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US6680324B2 (en)	2000-12-01	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
DE10148883A1 (de) *	2001-10-04	2003-04-10	Merck Patent Gmbh	Pyrimidinderivate
DK1450811T3 (da)	2001-11-30	2010-02-15	Osi Pharm Inc	Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf
ATE466581T1 (de) *	2001-12-07	2010-05-15	Vertex Pharma	Verbindungen auf pyrimidin-basis als gsk-3-hemmer
US20030229067A1 (en)	2001-12-20	2003-12-11	Arlindo Castelhano	Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
CN1620294A (zh)	2001-12-20	2005-05-25	Osi药物公司	嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
WO2004041285A1 (en) *	2002-10-31	2004-05-21	Amgen Inc.	Antiinflammation agents
HUP0203976A3 (en) *	2002-11-15	2004-08-30	Sanofi Aventis	Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
MY179032A (en)	2004-10-25	2020-10-26	Cancer Research Tech Ltd	Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
UY29177A1 (es)	2004-10-25	2006-05-31	Astex Therapeutics Ltd	Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
ES2344800T3 (es) *	2005-02-18	2010-09-07	Solvay Pharmaceuticals Gmbh	Composiciones farmaceuticas que comprenden inhibidores de nep, inhibidores del sistema productor de endotelina endogena y diureticos.
DK3421471T3 (da)	2006-04-25	2021-06-14	Astex Therapeutics Ltd	Purin- og deazapurinderivater som farmaceutiske forbindelser
US20070260203A1 (en) *	2006-05-04	2007-11-08	Allergan, Inc.	Vasoactive agent intraocular implant
TW200808819A (en) *	2006-06-19	2008-02-16	Solvay Pharm Gmbh	Use of adenosine A1 antagonists in radiocontrast media induced nephrophaty
PL2201012T3 (pl)	2007-10-11	2014-11-28	Astrazeneca Ab	Pochodne pirolo[2,3-d]pirymidyny jako inhibitory kinazy białkowej b
EP2247596A2 (en)	2008-01-11	2010-11-10	Natco Pharma Limited	Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents
AR070127A1 (es)	2008-01-11	2010-03-17	Novartis Ag	Pirrolo - pirimidinas y pirrolo -piridinas
EA027506B1 (ru)	2011-04-01	2017-08-31	Астразенека Аб	Способ лечения рака молочной железы
HRP20191982T4 (hr)	2011-11-30	2023-01-06	Astrazeneca Ab	Kombinacijsko liječenje raka
AU2013204533B2 (en)	2012-04-17	2017-02-02	Astrazeneca Ab	Crystalline forms
CN104350056A (zh) *	2012-06-07	2015-02-11	霍夫曼-拉罗奇有限公司	端锚聚合酶的吡咯并嘧啶酮和吡咯并吡啶酮抑制剂
SI3010503T1 (sl)	2013-06-21	2020-07-31	Zenith Epigenetics Ltd.	Novi biciklični inhibitorji bromodomene
JP6461118B2 (ja) *	2013-06-21	2019-01-30	ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈＥｐｉｇｅｎｅｔｉｃｓＬｔｄ．	ブロモドメイン阻害剤としての新規の置換された二環式化合物
JP6542212B2 (ja)	2013-07-31	2019-07-10	ゼニス・エピジェネティクス・リミテッドＺｅｎｉｔｈＥｐｉｇｅｎｅｔｉｃｓＬｔｄ．	ブロモドメイン阻害剤としての新規キナゾリノン
US10710992B2 (en)	2014-12-01	2020-07-14	Zenith Epigenetics Ltd.	Substituted pyridinones as bromodomain inhibitors
US10179125B2 (en)	2014-12-01	2019-01-15	Zenith Epigenetics Ltd.	Substituted pyridines as bromodomain inhibitors
WO2016092375A1 (en)	2014-12-11	2016-06-16	Zenith Epigenetics Corp.	Substituted heterocycles as bromodomain inhibitors
CA2966450A1 (en)	2014-12-17	2016-06-23	Olesya KHARENKO	Inhibitors of bromodomains
EA036122B1 (ru) *	2015-01-20	2020-09-30	Уси Форчун Фармасьютикал Ко., Лтд	Ингибитор jak
AU2016254385B2 (en)	2015-04-29	2018-05-10	Wuxi Fortune Pharmaceutical Co., Ltd	JAK inhibitors
KR102081272B1 (ko)	2015-05-29	2020-02-25	우시 포춘 파마슈티컬 컴퍼니 리미티드	Janus 키나아제 억제제
CN105771672B (zh) *	2016-04-18	2018-03-02	天津工业大学	一种抗污染抗菌芳香聚酰胺反渗透复合膜及制备方法
EP3594216B1 (en) *	2017-03-07	2022-04-06	Guangzhou Maxinovel Pharmaceuticals Co., Ltd.	Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof
CN108017584B (zh) *	2017-06-20	2021-03-23	南开大学	A3腺苷受体的小分子拮抗剂
CA3100923A1 (en) *	2018-06-04	2019-12-12	Exscientia Ltd	Pyrazolopyrimidine compounds as adenosine receptor antagonists
CN110128316B (zh) *	2019-05-22	2021-08-31	北京大学深圳研究生院	5位取代的β-脯氨酸及其衍生物的制备方法
CN110272373B (zh) *	2019-07-02	2022-07-29	天津国际生物医药联合研究院	一种具有选择性的腺苷a1受体拮抗剂及其应用
CN114085178A (zh) *	2021-12-29	2022-02-25	苏州楚凯药业有限公司	一种4-甲基-1-丙基-2-氨基-1h-吡咯-3-腈的制备方法

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KR19990067704A (ko) *	1992-12-17	1999-08-25	디. 제이. 우드, 스피겔 알렌 제이	부신피질자극호르몬 유리인자 길항제로서의 피롤로피리미딘을함유하는 약학 조성물
US5780450A (en) *	1995-11-21	1998-07-14	Alcon Laboratories, Inc.	Use of adenosine uptake inhibitors for treating retinal or optic nerve head damage
JP4611524B2 (ja) *	1998-06-02	2011-01-12	オーエスアイ・ファーマスーティカルズ・インコーポレーテッド	ピロロ［２，３ｄ］ピリミジン組成物およびその使用
HK1050319B (en) *	1999-12-02	2007-04-04	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine a1, a2a, and a3 receptor and uses thereof
DK1450811T3 (da) *	2001-11-30	2010-02-15	Osi Pharm Inc	Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf

2001
- 2001-11-30 CA CA002430577A patent/CA2430577A1/en not_active Abandoned
- 2001-11-30 NZ NZ525885A patent/NZ525885A/en active IP Right Revival
- 2001-11-30 WO PCT/US2001/045280 patent/WO2002057267A1/en not_active Ceased
- 2001-11-30 EA EA200300628A patent/EA007254B1/ru not_active IP Right Cessation
- 2001-11-30 CZ CZ20031831A patent/CZ20031831A3/cs unknown
- 2001-11-30 IL IL15596201A patent/IL155962A0/xx unknown
- 2001-11-30 PL PL01363245A patent/PL363245A1/pl not_active Application Discontinuation
- 2001-11-30 YU YU42703A patent/YU42703A/sh unknown
- 2001-11-30 AP APAP/P/2003/002807A patent/AP1893A/en active
- 2001-11-30 EP EP01997029A patent/EP1347980A4/en not_active Ceased
- 2001-11-30 OA OA1200300148A patent/OA13295A/en unknown
- 2001-11-30 AU AU2002248151A patent/AU2002248151B2/en not_active Ceased
- 2001-11-30 MX MXPA03004717A patent/MXPA03004717A/es active IP Right Grant
- 2001-11-30 HU HU0400692A patent/HUP0400692A3/hu unknown
- 2001-11-30 JP JP2002557944A patent/JP4579497B2/ja not_active Expired - Fee Related
- 2001-11-30 CN CNB018224601A patent/CN1263757C/zh not_active Expired - Fee Related
- 2001-11-30 ME MEP-353/08A patent/MEP35308A/xx unknown
- 2001-11-30 BR BR0115847-3A patent/BR0115847A/pt not_active Application Discontinuation
2003
- 2003-05-14 ZA ZA200303729A patent/ZA200303729B/en unknown
- 2003-06-02 NO NO20032482A patent/NO327207B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
MEP35308A (en)	2011-02-10
CN1263757C (zh)	2006-07-12
OA13295A (en)	2007-04-13
EA200300628A1 (ru)	2003-12-25
AP1893A (en)	2008-09-23
JP4579497B2 (ja)	2010-11-10
NO20032482L (no)	2003-07-28
WO2002057267A1 (en)	2002-07-25
EA007254B1 (ru)	2006-08-25
MXPA03004717A (es)	2004-06-30
AP2003002807A0 (en)	2003-06-30
HUP0400692A3 (en)	2007-09-28
EP1347980A4 (en)	2005-02-09
EP1347980A1 (en)	2003-10-01
JP2004517896A (ja)	2004-06-17
CA2430577A1 (en)	2002-07-25
AU2002248151B2 (en)	2008-02-21
CN1489590A (zh)	2004-04-14
NO20032482D0 (no)	2003-06-02
ZA200303729B (en)	2004-05-14
NO327207B1 (no)	2009-05-11
CZ20031831A3 (cs)	2004-05-12
BR0115847A (pt)	2004-02-25
YU42703A (sh)	2006-03-03
IL155962A0 (en)	2003-12-23
HUP0400692A2 (hu)	2004-07-28
NZ525885A (en)	2005-01-28

Legal Events

Date	Code	Title	Description
2011-09-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
PL363245A1 (pl)	2004-11-15	Związki specyficzne względem receptorów adenozynyA1, A2A i A3 i ich zastosowanie
GB0022370D0 (en)	2000-10-25	Improvements to televisionn system
EP1287154A4 (en)	2010-12-15	NUCLEOTIDES WITH CHARGE SWITCHING
GB0006513D0 (en)	2000-05-10	Improvements relating to converters
GB0006247D0 (en)	2000-05-03	Improvements in or relating to organic compounds
GB0021404D0 (en)	2000-10-18	Improvement in or to organic compounds
GB2360322B (en)	2003-08-06	Improvements relating to fasteners
GB2364338B (en)	2004-01-28	Improvements relating to construction
GB0028814D0 (en)	2001-01-10	Improvements relating to biosorbtion
GB0025524D0 (en)	2000-11-29	Improvements relating to screenboxes
GB2363331B (en)	2003-02-05	Supplement to enhance fertility
GB0121137D0 (en)	2001-10-24	Improvements to motorbility vehicles
GB2388346B (en)	2004-01-21	Improvements relating to vehicles
GB0013038D0 (en)	2000-07-19	Improvements relating to bicycles
GB2359528B (en)	2004-01-21	Improvements relating to vehicles
GB0029842D0 (en)	2001-01-24	Improvements relating to thermometers
GB0017107D0 (en)	2000-08-30	Improvements to velodromes
GB0025715D0 (en)	2000-12-06	Improvements relating to haribrushes
HRPK20000423B1 (en)	2002-06-30	Novel nucleosides
GB0022811D0 (en)	2000-11-01	Improvements relating to supports
GB0007565D0 (en)	2000-05-17	Improvements relating to radiators
GB0029608D0 (en)	2001-01-17	Improvements relating to lamp-holder
GB9906671D0 (en)	1999-05-19	Improvements relating to forms
GB0008226D0 (en)	2000-05-24	Improvements relating to spanners
GB9903159D0 (en)	1999-04-07	Improvements relating to window-walls