PL364921A1 - N-[5-[[[ 5-alkilo-2-oksazolilo] metylo] tio]-2-tiazolilo]-karboksyamidowe inhibitory zależnych od cyklin kinaz - Google Patents

N-[5-[[[ 5-alkilo-2-oksazolilo] metylo] tio]-2-tiazolilo]-karboksyamidowe inhibitory zależnych od cyklin kinaz

Info

Publication number: PL364921A1
Authority: PL; Poland
Prior art keywords: oxazolyl; thiazolyl; thio; alkyl; methyl
Prior art date: 1999-12-15

Application number

PL00364921A

Other languages

English (en)

Inventor

Raj N. Misra

Hai-Yun Xiao

Original Assignee

Bristol-Myers Squibb Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-15

Filing date

2000-12-07

Publication date

2004-12-27

1999-12-15 Priority claimed from US09/464,511 external-priority patent/US6262096B1/en

2000-12-07 Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.

2004-12-27 Publication of PL364921A1 publication Critical patent/PL364921A1/pl

Links

108091007914 CDKs Proteins 0.000 title 1
102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
125000000446 sulfanediyl group Chemical group *S* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL00364921A 1999-12-15 2000-12-07 N-[5-[[[ 5-alkilo-2-oksazolilo] metylo] tio]-2-tiazolilo]-karboksyamidowe inhibitory zależnych od cyklin kinaz PL364921A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/464,511 US6262096B1 (en)	1997-11-12	1999-12-15	Aminothiazole inhibitors of cyclin dependent kinases
US61662700A	2000-07-26	2000-07-26

Publications (1)

Publication Number	Publication Date
PL364921A1 true PL364921A1 (pl)	2004-12-27

Family

ID=27041008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL00364921A PL364921A1 (pl)	1999-12-15	2000-12-07	N-[5-[[[ 5-alkilo-2-oksazolilo] metylo] tio]-2-tiazolilo]-karboksyamidowe inhibitory zależnych od cyklin kinaz

Country Status (29)

Country	Link
EP (1)	EP1240166B1 (pl)
JP (1)	JP2003516987A (pl)
KR (1)	KR100738132B1 (pl)
CN (1)	CN1433416A (pl)
AR (1)	AR026974A1 (pl)
AT (1)	ATE289306T1 (pl)
AU (1)	AU783719B2 (pl)
BR (1)	BR0016424A (pl)
CA (1)	CA2394552A1 (pl)
CO (1)	CO5261565A1 (pl)
CZ (1)	CZ20022015A3 (pl)
DE (1)	DE60018205T2 (pl)
DK (1)	DK1240166T3 (pl)
EG (1)	EG24168A (pl)
ES (1)	ES2236034T3 (pl)
HK (1)	HK1049661B (pl)
HU (1)	HUP0301032A3 (pl)
IL (2)	IL149755A0 (pl)
MX (1)	MXPA02005870A (pl)
MY (1)	MY125768A (pl)
NO (1)	NO323726B1 (pl)
NZ (1)	NZ519120A (pl)
PE (1)	PE20011026A1 (pl)
PL (1)	PL364921A1 (pl)
PT (1)	PT1240166E (pl)
RU (1)	RU2002119016A (pl)
TW (1)	TWI273103B (pl)
UY (1)	UY26481A1 (pl)
WO (1)	WO2001044242A1 (pl)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6262096B1 (en)	1997-11-12	2001-07-17	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) *	1998-10-21	2002-07-02	Bristol-Myers Squibb Company	Process for preparing azacycloalkanoylaminothiazoles
US6515004B1 (en)	1999-12-15	2003-02-04	Bristol-Myers Squibb Company	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6392053B2 (en)	1999-12-15	2002-05-21	Bristol-Myers Squibb Company	Process for preparing arylacetylaminothiazoles
WO2002010162A1 (en) *	2000-07-26	2002-02-07	Bristol-Myers Squibb Company	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases
AU2001290912A1 (en)	2000-09-15	2002-03-26	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en)	2000-09-15	2009-01-06	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en)	2000-09-15	2003-12-09	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
BR0116493A (pt)	2000-12-21	2003-09-30	Vertex Pharma	Compostos de pirazol úteis como inibidores de proteìna cinase
MY141867A (en)	2002-06-20	2010-07-16	Vertex Pharma	Substituted pyrimidines useful as protein kinase inhibitors
MXPA05001367A (es)	2002-08-02	2005-04-28	Vertex Pharma	Composiciones de pirazol utiles como inhibidores de gsk-3.
US7392929B1 (en)	2004-07-26	2008-07-01	Zephyros, Inc.	Weldable synthetic material
EP1845973B1 (en)	2005-01-21	2015-08-12	Astex Therapeutics Limited	Pharmaceutical compounds
DE102005008310A1 (de) *	2005-02-17	2006-08-24	Schering Ag	Verwendung von CDKII Inhibitoren zur Fertilitätskontrolle
JP5249770B2 (ja)	2005-11-03	2013-07-31	バーテックスファーマシューティカルズインコーポレイテッド	キナーゼインヒビターとして有用なアミノピリジン
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
US8236128B2 (en)	2006-10-26	2012-08-07	Zephyros, Inc.	Adhesive materials, adhesive parts formed therewith and their uses
US20100247552A1 (en) *	2006-11-10	2010-09-30	Massachusetts Institute Of Technology	Pak modulators
WO2010033045A1 (en) *	2008-09-16	2010-03-25	Igor Anatolievich Pomytkin	Compositions and methods for prevention or treatment of beta amyloid deposition
EP2937345B1 (en)	2009-12-29	2018-03-21	Dana-Farber Cancer Institute, Inc.	Type ii raf kinase inhibitors
US10870651B2 (en)	2014-12-23	2020-12-22	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (CDK7)
CN107427521B (zh)	2015-03-27	2021-08-03	达纳-法伯癌症研究所股份有限公司	细胞周期蛋白依赖性激酶的抑制剂
WO2017044858A2 (en)	2015-09-09	2017-03-16	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
EP3810132A4 (en)	2018-06-25	2022-06-22	Dana-Farber Cancer Institute, Inc.	TAIRE FAMILY KINASE INHIBITORS AND RELATED USES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6040321A (en) *	1997-11-12	2000-03-21	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases

2000
- 2000-11-16 MY MYPI20005385A patent/MY125768A/en unknown
- 2000-12-07 NZ NZ519120A patent/NZ519120A/en unknown
- 2000-12-07 AT AT00990204T patent/ATE289306T1/de not_active IP Right Cessation
- 2000-12-07 EP EP00990204A patent/EP1240166B1/en not_active Expired - Lifetime
- 2000-12-07 BR BR0016424-0A patent/BR0016424A/pt not_active Application Discontinuation
- 2000-12-07 MX MXPA02005870A patent/MXPA02005870A/es active IP Right Grant
- 2000-12-07 HU HU0301032A patent/HUP0301032A3/hu unknown
- 2000-12-07 CZ CZ20022015A patent/CZ20022015A3/cs unknown
- 2000-12-07 JP JP2001544732A patent/JP2003516987A/ja not_active Withdrawn
- 2000-12-07 CN CN00818900A patent/CN1433416A/zh active Pending
- 2000-12-07 KR KR1020027007615A patent/KR100738132B1/ko not_active Expired - Fee Related
- 2000-12-07 HK HK03100935.5A patent/HK1049661B/en not_active IP Right Cessation
- 2000-12-07 RU RU2002119016/04A patent/RU2002119016A/ru unknown
- 2000-12-07 CA CA002394552A patent/CA2394552A1/en not_active Abandoned
- 2000-12-07 DK DK00990204T patent/DK1240166T3/da active
- 2000-12-07 DE DE60018205T patent/DE60018205T2/de not_active Expired - Fee Related
- 2000-12-07 AU AU27264/01A patent/AU783719B2/en not_active Ceased
- 2000-12-07 IL IL14975500A patent/IL149755A0/xx unknown
- 2000-12-07 PL PL00364921A patent/PL364921A1/pl not_active Application Discontinuation
- 2000-12-07 PT PT00990204T patent/PT1240166E/pt unknown
- 2000-12-07 WO PCT/US2000/033501 patent/WO2001044242A1/en not_active Ceased
- 2000-12-07 ES ES00990204T patent/ES2236034T3/es not_active Expired - Lifetime
- 2000-12-09 EG EG20001523A patent/EG24168A/xx active
- 2000-12-14 UY UY26481A patent/UY26481A1/es not_active Application Discontinuation
- 2000-12-14 CO CO00095237A patent/CO5261565A1/es not_active Application Discontinuation
- 2000-12-14 TW TW089126788A patent/TWI273103B/zh not_active IP Right Cessation
- 2000-12-15 PE PE2000001347A patent/PE20011026A1/es not_active Application Discontinuation
- 2000-12-15 AR ARP000106680A patent/AR026974A1/es unknown
2002
- 2002-05-20 IL IL149755A patent/IL149755A/en active IP Right Grant
- 2002-06-13 NO NO20022817A patent/NO323726B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO20022817L (no)	2002-08-14
DK1240166T3 (da)	2005-06-20
CA2394552A1 (en)	2001-06-21
EP1240166A1 (en)	2002-09-18
PE20011026A1 (es)	2001-12-02
NZ519120A (en)	2004-03-26
PT1240166E (pt)	2005-07-29
MXPA02005870A (es)	2003-01-28
IL149755A (en)	2009-09-22
KR20020067546A (ko)	2002-08-22
AR026974A1 (es)	2003-03-05
ATE289306T1 (de)	2005-03-15
AU2726401A (en)	2001-06-25
EP1240166B1 (en)	2005-02-16
DE60018205D1 (en)	2005-03-24
WO2001044242A9 (en)	2001-11-08
RU2002119016A (ru)	2004-01-10
JP2003516987A (ja)	2003-05-20
NO20022817D0 (no)	2002-06-13
DE60018205T2 (de)	2006-02-16
UY26481A1 (es)	2001-07-31
HUP0301032A3 (en)	2009-03-30
WO2001044242A1 (en)	2001-06-21
KR100738132B1 (ko)	2007-07-10
ES2236034T3 (es)	2005-07-16
TWI273103B (en)	2007-02-11
HUP0301032A2 (hu)	2003-08-28
HK1049661A1 (en)	2003-05-23
CO5261565A1 (es)	2003-03-31
EG24168A (en)	2008-09-10
HK1049661B (en)	2005-10-07
IL149755A0 (en)	2002-12-01
BR0016424A (pt)	2002-08-20
AU783719B2 (en)	2005-12-01
NO323726B1 (no)	2007-07-02
CZ20022015A3 (cs)	2003-02-12
CN1433416A (zh)	2003-07-30
MY125768A (en)	2006-08-30

Legal Events

Date	Code	Title	Description
2010-09-30	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
EG24409A (en)	2009-05-20	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases
EG24168A (en)	2008-09-10	N-[5-iii5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
PL364890A1 (pl)	2004-12-27	Aminotiazolowe inhibitory kinaz zależnych od cyklin
HUP0300974A3 (en)	2009-03-30	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases, pharmaceutical compositions containing them and their use
EG24028A (en)	2008-03-26	Aminothiazole inhibitors of cyclin dependent kinases
EP1087951A4 (en)	2002-08-14	CARBON SUBSTITUTED AMINOTHIAZOLE, CYCLINE DEPENDENT KINASE INHIBITORS
EP1178797A4 (en)	2003-05-02	IMPDH ENZYME INHIBITORS
PL355147A1 (pl)	2004-04-05	5-Członowe pochodne heterocykliczne, ich wytwarzanie oraz ich zastosowanie jako leków
AU2002213485A1 (en)	2002-04-22	Inhibitors of protein kinases
PL352282A1 (en)	2003-08-11	Derivatives of thiazoles and pharmaceutical compositions containing these derivatives
IL149118A0 (en)	2002-11-10	Inhibitors of neuraminidases
IL140244A0 (en)	2002-02-10	Heterocyclic compounds as inhibitors of rotamase enzymes
AU6111000A (en)	2001-02-13	Inhibitors of viral helcase
AU5553801A (en)	2001-11-07	Heterocycles that are inhibitors of impdh enzyme
IL137929A0 (en)	2001-10-31	Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
AU2001259990A1 (en)	2001-12-03	Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes
AU2002358874A1 (en)	2003-07-24	2-amino-4-heteroarylethyl thiazoline derivatives and their use an inhibitors of inducible no-synthase
AU3636201A (en)	2001-05-08	Antisense modulation of protein kinase c-theta expression
IL152792A0 (en)	2003-06-24	Heterocycle derivatives and methods of use
AU2002214038A1 (en)	2002-05-15	Inhibitors of transglutaminases
HK1052930A (en)	2003-10-03	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases
HUP0202819A3 (en)	2004-03-01	Process for the preparation of thiazole derivatives and the new intermediates
FI963882A7 (fi)	1996-09-27	Bentsotiatsolijohdannaiset 5-lipoksigenaasibiosynteesin estoaineina
AU4021700A (en)	2000-10-09	Methods of use of beta1-integrin inhibitors
PL342280A1 (en)	2001-03-12	Method of obtaining tetrahydro-4-[3-(4-fluorophenyl)-thio]phenyl-2h-pyrane-4-carboxamide and method of obtaining heterocyclic inhibitors of 5-lipoxygenase