PL3656764T3 - Sposoby przygotowania związków pirymidynylocyklopentanu - Google Patents

Sposoby przygotowania związków pirymidynylocyklopentanu

Info

Publication number
PL3656764T3
PL3656764T3 PL19204562.3T PL19204562T PL3656764T3 PL 3656764 T3 PL3656764 T3 PL 3656764T3 PL 19204562 T PL19204562 T PL 19204562T PL 3656764 T3 PL3656764 T3 PL 3656764T3
Authority
PL
Poland
Prior art keywords
processes
preparation
pyrimidinylcyclopentane
compounds
pyrimidinylcyclopentane compounds
Prior art date
Application number
PL19204562.3T
Other languages
English (en)
Inventor
Hans Iding
Reinhard Reents
Michelangelo Scalone
Francis Gosselin
Original Assignee
F. Hoffmann-La Roche Ag
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag, Genentech, Inc. filed Critical F. Hoffmann-La Roche Ag
Publication of PL3656764T3 publication Critical patent/PL3656764T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/02Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165Heterorings having nitrogen atoms as the only ring heteroatoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
PL19204562.3T 2013-11-15 2014-11-13 Sposoby przygotowania związków pirymidynylocyklopentanu PL3656764T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13193030 2013-11-15

Publications (1)

Publication Number Publication Date
PL3656764T3 true PL3656764T3 (pl) 2024-01-22

Family

ID=49582648

Family Applications (2)

Application Number Title Priority Date Filing Date
PL14863015T PL3068770T3 (pl) 2013-11-15 2014-11-13 Sposoby przygotowania związków pirymidynylocyklopentanu
PL19204562.3T PL3656764T3 (pl) 2013-11-15 2014-11-13 Sposoby przygotowania związków pirymidynylocyklopentanu

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL14863015T PL3068770T3 (pl) 2013-11-15 2014-11-13 Sposoby przygotowania związków pirymidynylocyklopentanu

Country Status (21)

Country Link
US (3) US9862689B2 (pl)
EP (3) EP3656764B1 (pl)
JP (4) JP6374503B2 (pl)
KR (2) KR102493603B1 (pl)
CN (3) CN112898210B (pl)
AR (1) AR098427A1 (pl)
AU (5) AU2014348570B2 (pl)
CA (2) CA3207199A1 (pl)
ES (2) ES2765511T3 (pl)
HR (2) HRP20231100T1 (pl)
HU (1) HUE063095T2 (pl)
IL (3) IL245636B (pl)
MX (3) MX385726B (pl)
MY (2) MY174153A (pl)
NZ (1) NZ720805A (pl)
PL (2) PL3068770T3 (pl)
RU (1) RU2702355C1 (pl)
SG (1) SG10201901578UA (pl)
SI (1) SI3068770T1 (pl)
WO (1) WO2015073739A1 (pl)
ZA (2) ZA201603434B (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3068770T1 (sl) * 2013-11-15 2020-02-28 F. Hoffmann-La Roche Ag Postopki za pripravo pirimidinilciklopentanskih spojin
RU2732404C2 (ru) 2014-09-26 2020-09-16 Ф. Хоффманн-Ля Рош Аг СПОСОБЫ ПОЛУЧЕНИЯ (ЦИКЛОПЕНТИЛ[d]ПИРИМИДИН-4-ИЛ)ПИПЕРАЗИНОВЫХ СОЕДИНЕНИЙ
BR112019002007B1 (pt) 2016-08-10 2024-01-16 F. Hoffmann-La Roche Ag Composição farmacêutica e uso de uma composição farmacêutica
GB201802383D0 (en) * 2018-02-14 2018-03-28 Givaudan Sa Process

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US6545165B1 (en) 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
ATE407126T1 (de) * 2005-05-24 2008-09-15 Hoffmann La Roche Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on
CN101198594A (zh) * 2005-06-22 2008-06-11 尼科梅德有限责任公司 用于制备生产三环苯并咪唑类的中间体的方法
ATE523499T1 (de) * 2006-07-06 2011-09-15 Array Biopharma Inc Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA95641C2 (xx) 2006-07-06 2011-08-25 Эррей Биофарма Инк. Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス, インコーポレイテッド (r)−3−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
ES2422733T3 (es) * 2008-01-09 2013-09-13 Array Biopharma Inc Pirimidilciclopentanos hidroxilados como inhibidores de proteínas cinasas AKT
EP2240455B1 (en) 2008-01-09 2012-12-26 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
AR070176A1 (es) * 2008-01-17 2010-03-17 Novartis Ag Procesos de sintesis de inhibidores de nep, compuestos intermediarios y uso de los mismos en la sintesis
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
US20110054174A1 (en) * 2009-08-28 2011-03-03 Stephan Bachmann Process for the preparation of a glucokinase activator compound
WO2011130654A1 (en) * 2010-04-16 2011-10-20 Genentech, Inc. Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy
WO2012135781A1 (en) * 2011-04-01 2012-10-04 Genentech, Inc. Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use
KR102678074B1 (ko) * 2012-05-17 2024-06-26 제넨테크, 인크. 무정형 형태의 akt 저해성 피리미디닐 - 사이클로펜탄 화합물, 조성물 및 이들의 방법
ES2588878T3 (es) 2012-05-17 2016-11-07 Array Biopharma, Inc. Proceso para preparar compuestos de ciclopentilpirimidina hidroxilada
EP2850200A1 (en) * 2012-05-17 2015-03-25 Genentech, Inc. Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
US9416110B2 (en) 2012-05-17 2016-08-16 Array Biopharma Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
HRP20180948T1 (hr) 2012-05-17 2018-08-10 Genentech, Inc. Postupak za proizvodnju aminokiselinskih spojeva
SI3068770T1 (sl) 2013-11-15 2020-02-28 F. Hoffmann-La Roche Ag Postopki za pripravo pirimidinilciklopentanskih spojin
RU2732404C2 (ru) 2014-09-26 2020-09-16 Ф. Хоффманн-Ля Рош Аг СПОСОБЫ ПОЛУЧЕНИЯ (ЦИКЛОПЕНТИЛ[d]ПИРИМИДИН-4-ИЛ)ПИПЕРАЗИНОВЫХ СОЕДИНЕНИЙ

Also Published As

Publication number Publication date
CA2930870A1 (en) 2015-05-21
EP4282973A3 (en) 2024-03-27
MX374852B (es) 2025-03-06
RU2702355C1 (ru) 2019-10-08
JP2018052966A (ja) 2018-04-05
JP2019218384A (ja) 2019-12-26
CN105899492B (zh) 2021-08-24
KR20160075816A (ko) 2016-06-29
AU2019202461B2 (en) 2021-01-14
AU2024205845A1 (en) 2024-09-05
EP3068770A4 (en) 2017-04-19
JP2016539939A (ja) 2016-12-22
IL245636A0 (en) 2016-06-30
CN112898210B (zh) 2025-02-21
CN105899492A (zh) 2016-08-24
KR20220139440A (ko) 2022-10-14
MX2019006959A (es) 2019-08-01
CN110590606A (zh) 2019-12-20
AU2014348570A1 (en) 2016-06-09
RU2016123365A (ru) 2017-12-18
SG10201901578UA (en) 2019-03-28
MX2020009462A (es) 2021-08-31
US20200062717A1 (en) 2020-02-27
HRP20192340T1 (hr) 2020-04-03
KR102698200B1 (ko) 2024-08-26
BR112016011048A8 (pt) 2020-04-22
AU2019202461A1 (en) 2019-05-02
CN112898210A (zh) 2021-06-04
CA2930870C (en) 2023-09-19
MY191759A (en) 2022-07-14
JP7377828B2 (ja) 2023-11-10
MY174153A (en) 2020-03-11
IL245636B (en) 2019-12-31
HK1223102A1 (zh) 2017-07-21
IL281072A (en) 2021-04-29
IL281072B (en) 2022-05-01
JP2021100953A (ja) 2021-07-08
EP3656764B1 (en) 2023-07-05
EP3068770A1 (en) 2016-09-21
AU2021202196A1 (en) 2021-05-06
HRP20231100T1 (hr) 2023-12-22
WO2015073739A1 (en) 2015-05-21
EP3068770B1 (en) 2019-10-23
MX2016006299A (es) 2017-02-22
AU2022275477A1 (en) 2023-01-05
NZ720805A (en) 2022-01-28
AR098427A1 (es) 2016-05-26
MX367620B (es) 2019-08-28
KR102493603B1 (ko) 2023-01-31
CA3207199A1 (en) 2015-05-21
JP6374503B2 (ja) 2018-08-15
US20160297773A1 (en) 2016-10-13
EP3656764A1 (en) 2020-05-27
US9862689B2 (en) 2018-01-09
JP6857219B2 (ja) 2021-04-14
IL271331A (en) 2020-01-30
BR112016011048A2 (pt) 2017-08-08
SI3068770T1 (sl) 2020-02-28
CN110590606B (zh) 2023-02-17
PL3068770T3 (pl) 2020-04-30
IL271331B (en) 2021-03-25
JP6634428B2 (ja) 2020-01-22
EP4282973A2 (en) 2023-11-29
HUE063095T2 (hu) 2023-12-28
ZA201603434B (en) 2020-08-26
ES2765511T3 (es) 2020-06-09
ZA202002611B (en) 2023-10-25
RU2019130505A (ru) 2020-02-18
US10858324B2 (en) 2020-12-08
EP3656764C0 (en) 2023-07-05
US10435378B2 (en) 2019-10-08
US20180086722A1 (en) 2018-03-29
MX385726B (es) 2025-03-18
AU2014348570B2 (en) 2019-02-28
ES2957314T3 (es) 2024-01-17

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