PL3682000T3 - gRNA ukierunkowany na HPK1 i sposób edycji genu HPK1 - Google Patents

gRNA ukierunkowany na HPK1 i sposób edycji genu HPK1

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Publication number
PL3682000T3
PL3682000T3 PL18859478.2T PL18859478T PL3682000T3 PL 3682000 T3 PL3682000 T3 PL 3682000T3 PL 18859478 T PL18859478 T PL 18859478T PL 3682000 T3 PL3682000 T3 PL 3682000T3
Authority
PL
Poland
Prior art keywords
hpk1
gene editing
editing method
grna targeting
grna
Prior art date
Application number
PL18859478.2T
Other languages
English (en)
Inventor
Xuebin Liao
Jingwen SI
Original Assignee
Beijing Synthetic Vaccine Biosciences Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Synthetic Vaccine Biosciences Co., Ltd filed Critical Beijing Synthetic Vaccine Biosciences Co., Ltd
Publication of PL3682000T3 publication Critical patent/PL3682000T3/pl

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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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PL18859478.2T 2017-09-20 2018-09-20 gRNA ukierunkowany na HPK1 i sposób edycji genu HPK1 PL3682000T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710853090.2A CN109517820B (zh) 2017-09-20 2017-09-20 一种靶向HPK1的gRNA以及HPK1基因编辑方法
PCT/CN2018/106636 WO2019057102A1 (en) 2017-09-20 2018-09-20 HPK1 TARGETING ARNG AND HPK1 GENE EDITING METHOD

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Publication Number Publication Date
PL3682000T3 true PL3682000T3 (pl) 2023-08-07

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PL18859478.2T PL3682000T3 (pl) 2017-09-20 2018-09-20 gRNA ukierunkowany na HPK1 i sposób edycji genu HPK1

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Country Link
US (1) US11786550B2 (pl)
EP (1) EP3682000B8 (pl)
JP (1) JP7412666B2 (pl)
KR (1) KR102547477B1 (pl)
CN (2) CN109517820B (pl)
AU (1) AU2018336522B2 (pl)
BR (1) BR112020008517A2 (pl)
ES (1) ES2946332T3 (pl)
PL (1) PL3682000T3 (pl)
WO (1) WO2019057102A1 (pl)

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US20190284553A1 (en) 2018-03-15 2019-09-19 KSQ Therapeutics, Inc. Gene-regulating compositions and methods for improved immunotherapy
DK3873903T3 (da) 2018-10-31 2024-04-02 Gilead Sciences Inc Substituerede 6-azabenzimidazolforbindelser som hpk1-hæmmere
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
WO2021064655A1 (en) * 2019-10-02 2021-04-08 Massachusetts Institute Of Technology High-throughput genetic screening
CN114107292B (zh) * 2020-08-27 2024-03-12 阿思科力(苏州)生物科技有限公司 用于外源基因定点插入的基因编辑系统和方法
KR102874084B1 (ko) * 2021-11-24 2025-10-22 재단법인 아산사회복지재단 조혈전구 인산화효소 1 조절에 의한 nk세포 활성증진 방법
CN116893265A (zh) * 2023-09-08 2023-10-17 军科正源（北京）药物研究有限责任公司 检测pbmc中蛋白磷酸化的方法和试剂盒以及相关应用
WO2025082418A1 (zh) * 2023-10-18 2025-04-24 苏州沙砾生物科技有限公司 一种鉴定靶标的方法及其应用

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AU2018336522A1 (en) 2020-04-30
CN109517820B (zh) 2021-09-24
BR112020008517A2 (pt) 2021-01-26
CA3076095A1 (en) 2019-03-28
CN111263808B (zh) 2023-10-20
EP3682000A1 (en) 2020-07-22
CN109517820A (zh) 2019-03-26
CN111263808A (zh) 2020-06-09
AU2018336522B2 (en) 2025-03-27
EP3682000B1 (en) 2023-04-05
WO2019057102A1 (en) 2019-03-28
KR20200051805A (ko) 2020-05-13
EP3682000B8 (en) 2023-05-24
KR102547477B1 (ko) 2023-06-27
US11786550B2 (en) 2023-10-17
ES2946332T3 (es) 2023-07-17
JP7412666B2 (ja) 2024-01-15
JP2020536514A (ja) 2020-12-17
US20220023340A1 (en) 2022-01-27

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