PL3687400T3 - Sposoby i systemy do aktualizowania parametrów opóźnienia - Google Patents

Sposoby i systemy do aktualizowania parametrów opóźnienia

Info

Publication number
PL3687400T3
PL3687400T3 PL18863514.8T PL18863514T PL3687400T3 PL 3687400 T3 PL3687400 T3 PL 3687400T3 PL 18863514 T PL18863514 T PL 18863514T PL 3687400 T3 PL3687400 T3 PL 3687400T3
Authority
PL
Poland
Prior art keywords
systems
methods
delay parameters
updating delay
updating
Prior art date
Application number
PL18863514.8T
Other languages
English (en)
Inventor
Xiaoxiao Chen
Ravi Rastogi
Andrew Dehennis
Patricia Sanchez
Original Assignee
Senseonics, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senseonics, Incorporated filed Critical Senseonics, Incorporated
Publication of PL3687400T3 publication Critical patent/PL3687400T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1495Calibrating or testing of in-vivo probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031Implanted circuitry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/076Permanent implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271Specific aspects of physiological measurement analysis
    • A61B5/7275Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271Specific aspects of physiological measurement analysis
    • A61B5/7278Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient; User input means
    • A61B5/742Details of notification to user or communication with user or patient; User input means using visual displays
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0204Operational features of power management
    • A61B2560/0214Operational features of power management of power generation or supply
    • A61B2560/0219Operational features of power management of power generation or supply of externally powered implanted units
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0223Operational features of calibration, e.g. protocols for calibrating sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4866Evaluating metabolism
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Epidemiology (AREA)
PL18863514.8T 2017-09-26 2018-09-26 Sposoby i systemy do aktualizowania parametrów opóźnienia PL3687400T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762563240P 2017-09-26 2017-09-26
US201762566846P 2017-10-02 2017-10-02
US201862649329P 2018-03-28 2018-03-28
PCT/US2018/052834 WO2019067525A1 (en) 2017-09-26 2018-09-26 METHODS AND SYSTEMS FOR WEIGHING CALIBRATION POINTS AND UPDATING DELAY PARAMETERS

Publications (1)

Publication Number Publication Date
PL3687400T3 true PL3687400T3 (pl) 2024-05-20

Family

ID=65806299

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18863514.8T PL3687400T3 (pl) 2017-09-26 2018-09-26 Sposoby i systemy do aktualizowania parametrów opóźnienia

Country Status (5)

Country Link
US (4) US11185264B2 (pl)
EP (5) EP3687400B1 (pl)
ES (2) ES3063062T3 (pl)
PL (1) PL3687400T3 (pl)
WO (1) WO2019067525A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114727781B (zh) * 2019-11-13 2026-02-03 传感技术股份有限公司 分析物监测系统中的干扰检测
US12478297B2 (en) 2019-11-27 2025-11-25 Senseonics, Incorporated Methods and systems for reducing difference between calculated and measured analyte levels
WO2021108610A1 (en) * 2019-11-27 2021-06-03 Senseonics, Incorporated Methods and systems for reducing difference between calculated and measured analyte levels
IL273038B (en) 2020-03-03 2022-02-01 Ben Zion Karmon bone graft
CN111735970B (zh) * 2020-07-23 2020-12-01 南京岚煜生物科技有限公司 一种凝血分析系统进行凝血分析的方法
CN116507270A (zh) * 2020-09-08 2023-07-28 全球先进临床解决方案有限公司 用于利用统计学分析和人工智能分析进行癫痫发作检测的系统和方法
AU2022249389A1 (en) * 2021-04-02 2023-11-02 Dexcom, Inc. Personalized modeling of blood glucose concentration impacted by individualized sensor characteristics and individualized physiological characteristics
WO2024010827A1 (en) 2022-07-05 2024-01-11 Biolinq Incorporated Sensor assembly of a microneedle array-based continuous analyte monitoring device
US20240011923A1 (en) * 2022-07-07 2024-01-11 Know Labs, Inc. Systems and methods for analyte sensing of multiple analytes
WO2025221985A1 (en) * 2024-04-19 2025-10-23 Senseonics, Incorporated Analyte monitoring system including dynamic stream selection

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088608A (en) 1997-10-20 2000-07-11 Alfred E. Mann Foundation Electrochemical sensor and integrity tests therefor
US6835175B1 (en) 1998-04-10 2004-12-28 Proactive Metabolics Co. Medical devices for contemporaneous decision support in metabolic control
US6895263B2 (en) 2000-02-23 2005-05-17 Medtronic Minimed, Inc. Real time self-adjusting calibration algorithm
US8282549B2 (en) 2003-12-09 2012-10-09 Dexcom, Inc. Signal processing for continuous analyte sensor
US7651596B2 (en) 2005-04-08 2010-01-26 Dexcom, Inc. Cellulosic-based interference domain for an analyte sensor
US8060173B2 (en) 2003-08-01 2011-11-15 Dexcom, Inc. System and methods for processing analyte sensor data
US7519408B2 (en) 2003-11-19 2009-04-14 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US20100168657A1 (en) * 2003-08-01 2010-07-01 Dexcom, Inc. System and methods for processing analyte sensor data
US7986986B2 (en) 2003-08-01 2011-07-26 Dexcom, Inc. System and methods for processing analyte sensor data
US20070208245A1 (en) 2003-08-01 2007-09-06 Brauker James H Transcutaneous analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
DE10343863A1 (de) 2003-09-23 2005-04-14 Roche Diagnostics Gmbh Verfahren und Gerät zur laufenden Überwachung der Konzentration eines Analyten
EP3524142B1 (en) 2004-07-13 2021-04-28 Dexcom, Inc. Transcutaneous analyte sensor
US8989833B2 (en) * 2004-07-13 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US8073548B2 (en) 2004-08-24 2011-12-06 Sensors For Medicine And Science, Inc. Wristband or other type of band having an adjustable antenna for use with a sensor reader
CA2620586A1 (en) 2005-08-31 2007-03-08 Boris P. Kovatchev Improving the accuracy of continuous glucose sensors
US7885698B2 (en) * 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US8374668B1 (en) 2007-10-23 2013-02-12 Abbott Diabetes Care Inc. Analyte sensor with lag compensation
US8219173B2 (en) 2008-09-30 2012-07-10 Abbott Diabetes Care Inc. Optimizing analyte sensor calibration
US9675290B2 (en) * 2012-10-30 2017-06-13 Abbott Diabetes Care Inc. Sensitivity calibration of in vivo sensors used to measure analyte concentration
US7618369B2 (en) 2006-10-02 2009-11-17 Abbott Diabetes Care Inc. Method and system for dynamically updating calibration parameters for an analyte sensor
US9176141B2 (en) 2006-05-15 2015-11-03 Cercacor Laboratories, Inc. Physiological monitor calibration system
US20080234943A1 (en) * 2007-03-20 2008-09-25 Pinaki Ray Computer program for diabetes management
US9089292B2 (en) 2010-03-26 2015-07-28 Medtronic Minimed, Inc. Calibration of glucose monitoring sensor and/or insulin delivery system
US10092229B2 (en) 2010-06-29 2018-10-09 Abbott Diabetes Care Inc. Calibration of analyte measurement system
WO2013003735A1 (en) 2011-06-30 2013-01-03 Abbott Diabetes Care Inc. Methods for generating hybrid analyte level output, and devices and systems related thereto
WO2013033357A1 (en) 2011-08-30 2013-03-07 Abbott Diabetes Care Inc. Methods for positioning an analyte sensing device
EP2766887B1 (en) 2011-10-11 2019-12-18 Senseonics, Incorporated Electrodynamic field strength triggering system
US8870763B2 (en) 2011-10-26 2014-10-28 Medtronic Minimed, Inc. Method and/or system for multicompartment analyte monitoring
US9907491B2 (en) 2011-10-25 2018-03-06 Medtronic Minimed, Inc. Method and/or system for multicompartment analyte monitoring
US9693714B2 (en) 2012-02-10 2017-07-04 Senseonics, Incorporated Digital ASIC sensor platform
US9414775B2 (en) 2012-03-29 2016-08-16 Senseonics, Incorporated Purification of glucose concentration signal in an implantable fluorescence based glucose sensor
US9462970B2 (en) * 2012-04-24 2016-10-11 Abbott Diabetes Care Inc. Methods of lag-compensation for analyte measurements, and devices related thereto
EP2901153A4 (en) * 2012-09-26 2016-04-27 Abbott Diabetes Care Inc METHOD AND DEVICE FOR IMPROVING DELAY CORRECTION FUNCTION DURING IN VIVO MEASUREMENT OF ANALYZ CONCENTRATION WITH ANALYZ CONCENTRATION VARIABILITY AND RANGE DATA
EP4603003A3 (en) * 2013-02-20 2025-10-29 DexCom, Inc. Retrospective retrofitting method to generate a continuous glucose concentration profile
US9788354B2 (en) 2013-03-14 2017-10-10 Dexcom, Inc. Systems and methods for processing and transmitting sensor data
US9249751B2 (en) 2013-05-23 2016-02-02 Ford Global Technologies, Llc Exhaust gas sensor controls adaptation for asymmetric degradation responses
US8922366B1 (en) 2013-06-28 2014-12-30 Google Inc. Reader communication with contact lens sensors and display device
CA2935565C (en) * 2013-12-31 2024-04-16 Senseonics, Incorporated Continuous analyte monitoring system
US20160270740A1 (en) * 2013-12-31 2016-09-22 Senseonics, Incorporated Wireless analyte monitoring
US10201657B2 (en) * 2015-08-21 2019-02-12 Medtronic Minimed, Inc. Methods for providing sensor site rotation feedback and related infusion devices and systems
US9571578B1 (en) 2015-11-20 2017-02-14 International Business Machines Corporation Utilization based multi-buffer self-calibrated dynamic adjustment management

Also Published As

Publication number Publication date
EP4706526A2 (en) 2026-03-11
EP4292533A2 (en) 2023-12-20
US11185264B2 (en) 2021-11-30
EP4437949A1 (en) 2024-10-02
EP4699530A2 (en) 2026-02-25
EP4699530A3 (en) 2026-04-29
EP3687400A1 (en) 2020-08-05
EP4292533B1 (en) 2026-01-14
US20190090790A1 (en) 2019-03-28
WO2019067525A1 (en) 2019-04-04
US20190094231A1 (en) 2019-03-28
ES3063062T3 (en) 2026-04-15
US12059255B2 (en) 2024-08-13
US20190094232A1 (en) 2019-03-28
US11672450B2 (en) 2023-06-13
ES2962311T3 (es) 2024-03-18
EP4292533A3 (en) 2024-05-01
EP3687400A4 (en) 2021-10-20
US11259726B2 (en) 2022-03-01
US20190094233A1 (en) 2019-03-28
EP3687400B1 (en) 2023-10-04

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