PL3691692T3 - Anti-cd71 activatable antibody drug conjugates and methods of use thereof - Google Patents

Anti-cd71 activatable antibody drug conjugates and methods of use thereof

Info

Publication number: PL3691692T3
Authority: PL; Poland
Prior art keywords: methods; drug conjugates; antibody drug; activatable antibody; activatable
Prior art date: 2017-10-14

Application number

PL18797311T

Other languages

Polish (pl)

Inventor

Shweta SINGH

Jennifer Hope RICHARDSON

Laura Patterson SERWER

Jonathan Alexander Terrett

Susan E. Morgan-Lappe

Tracy HENRIQUES

Sherry L. RALSTON

Marvin Robert Leanna

Ilaria BADAGNANI

Sahana Bose

Original Assignee

Abbvie Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-10-14

Filing date

2018-10-12

Publication date

2021-07-19

2018-10-12 Application filed by Abbvie Inc. filed Critical Abbvie Inc.

2021-07-19 Publication of PL3691692T3 publication Critical patent/PL3691692T3/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Cell Biology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL18797311T 2017-10-14 2018-10-12 Anti-cd71 activatable antibody drug conjugates and methods of use thereof PL3691692T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201762572467P	2017-10-14	2017-10-14
PCT/US2018/055733 WO2019075417A1 (en)	2017-10-14	2018-10-12	Anti-cd71 activatable antibody drug conjugates and methods of use thereof
EP18797311.0A EP3691692B8 (en)	2017-10-14	2018-10-12	Anti-cd71 activatable antibody drug conjugates and methods of use thereof

Publications (1)

Publication Number	Publication Date
PL3691692T3 true PL3691692T3 (en)	2021-07-19

Family

ID=64110112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL18797311T PL3691692T3 (en)	2017-10-14	2018-10-12	Anti-cd71 activatable antibody drug conjugates and methods of use thereof

Country Status (36)

Country	Link
US (3)	US20190111150A1 (en)
EP (2)	EP3691692B8 (en)
JP (2)	JP7374891B2 (en)
KR (4)	KR102385495B1 (en)
CN (1)	CN111278467B (en)
AR (1)	AR115178A1 (en)
AU (1)	AU2018346969A1 (en)
BR (1)	BR112020007302B1 (en)
CA (1)	CA3077730A1 (en)
CL (1)	CL2020000977A1 (en)
CO (1)	CO2020005685A2 (en)
CR (1)	CR20200206A (en)
CY (1)	CY1123968T1 (en)
DK (1)	DK3691692T3 (en)
DO (1)	DOP2023000150A (en)
EC (1)	ECSP20025198A (en)
ES (1)	ES2864013T3 (en)
HR (1)	HRP20210436T8 (en)
HU (1)	HUE054037T2 (en)
IL (1)	IL273586A (en)
LT (1)	LT3691692T (en)
MA (1)	MA50752B1 (en)
MD (1)	MD3691692T2 (en)
MX (1)	MX2020003723A (en)
PE (1)	PE20210125A1 (en)
PH (1)	PH12020550417A1 (en)
PL (1)	PL3691692T3 (en)
PT (1)	PT3691692T (en)
RS (1)	RS61596B1 (en)
RU (2)	RU2022111211A (en)
SG (1)	SG11202003378WA (en)
SI (1)	SI3691692T1 (en)
SM (1)	SMT202100184T1 (en)
TW (2)	TWI780237B (en)
UY (1)	UY37931A (en)
WO (1)	WO2019075417A1 (en)

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IL310251A (en) *	2015-05-04	2024-03-01	Cytomx Therapeutics Inc	Anti-CD71 antibodies, activatable anti-71CD antibodies, preparations containing them and their uses
ES3065816T3 (en)	2017-06-07	2026-05-08	Regeneron Pharma	Compositions and methods for internalizing enzymes
BR112020007302B1 (en) *	2017-10-14	2023-01-31	Abbvie Inc.	ACTIVATIVE CONJUGATE ANTI-CD71 ANTIBODIES, METHOD FOR MANUFACTURING THEM, PHARMACEUTICAL COMPOSITION AND KIT COMPRISING THE SAME, USES OF SAID ANTIBODIES, AS WELL AS IN VITRO METHOD TO DETECT THE PRESENCE OR ABSENCE OF THE CLEAVAGE AGENT IN THE SAMPLE
CN112040985A (en)	2018-02-07	2020-12-04	瑞泽恩制药公司	Methods and compositions for delivery of therapeutic proteins
WO2019183633A1 (en)	2018-03-23	2019-09-26	Case Western Reserve Univeristy	Psma targeted conjugate compounds and uses thereof
BR112020023145A2 (en)	2018-05-17	2021-02-02	Regeneron Pharmaceuticals, Inc.	anti-cd63 antibody or antigen-binding fragment thereof, bispecific antigen-binding molecule, therapeutic protein of multiple domains, polynucleotide pharmaceutical composition, and, compound
EP4132589A4 (en) *	2020-04-08	2024-05-08	Aliada Therapeutics, Inc.	COMPOSITIONS AND METHODS FOR DELIVERY OF THE BLOOD-BRAIN BARRIER
CA3174665A1 (en)	2020-04-09	2021-10-14	Cytomx Therapeutics, Inc.	Compositions containing activatable antibodies
AU2021313058A1 (en) *	2020-07-23	2023-03-30	Dyne Therapeutics, Inc.	Muscle-targeting complexes and uses thereof
US20240382513A1 (en) *	2021-07-09	2024-11-21	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for modulation of genes associated with muscle health
CA3237590A1 (en)	2021-11-09	2023-05-08	James Basilion	Psma targeted conjugate compounds and uses thereof
KR20250054842A (en) *	2022-07-29	2025-04-23	리제너론 파마슈티칼스 인코포레이티드	Compositions and methods for transferrin receptor (TFR)-mediated delivery to brain and muscle
KR20260044219A (en)	2023-07-21	2026-04-01	매로우 테라퓨틱스, 인크.	Hematopoietic cell targeting conjugate and related methods
WO2025133132A1 (en) *	2023-12-20	2025-06-26	Institut National De La Sante Et De La Recherche Medicale	Novel anti-tfr1 (cd71) antibodies for cancer treatment

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2018
- 2018-10-12 BR BR112020007302-4A patent/BR112020007302B1/en active IP Right Grant
- 2018-10-12 KR KR1020207013706A patent/KR102385495B1/en not_active Expired - Fee Related
- 2018-10-12 CA CA3077730A patent/CA3077730A1/en active Pending
- 2018-10-12 SG SG11202003378WA patent/SG11202003378WA/en unknown
- 2018-10-12 PT PT187973110T patent/PT3691692T/en unknown
- 2018-10-12 AR ARP180102966A patent/AR115178A1/en not_active Application Discontinuation
- 2018-10-12 KR KR1020227011264A patent/KR20220045088A/en not_active Ceased
- 2018-10-12 US US16/159,559 patent/US20190111150A1/en not_active Abandoned
- 2018-10-12 TW TW107136020A patent/TWI780237B/en not_active IP Right Cessation
- 2018-10-12 HR HRP20210436TT patent/HRP20210436T8/en unknown
- 2018-10-12 SI SI201830233T patent/SI3691692T1/en unknown
- 2018-10-12 PL PL18797311T patent/PL3691692T3/en unknown
- 2018-10-12 AU AU2018346969A patent/AU2018346969A1/en not_active Abandoned
- 2018-10-12 DK DK18797311.0T patent/DK3691692T3/en active
- 2018-10-12 TW TW111137633A patent/TW202330039A/en unknown
- 2018-10-12 EP EP18797311.0A patent/EP3691692B8/en active Active
- 2018-10-12 KR KR1020227044475A patent/KR102529359B1/en active Active
- 2018-10-12 WO PCT/US2018/055733 patent/WO2019075417A1/en not_active Ceased
- 2018-10-12 LT LTEP18797311.0T patent/LT3691692T/en unknown
- 2018-10-12 RS RS20210341A patent/RS61596B1/en unknown
- 2018-10-12 JP JP2020520804A patent/JP7374891B2/en active Active
- 2018-10-12 ES ES18797311T patent/ES2864013T3/en active Active
- 2018-10-12 MD MDE20200822T patent/MD3691692T2/en unknown
- 2018-10-12 HU HUE18797311A patent/HUE054037T2/en unknown
- 2018-10-12 SM SM20210184T patent/SMT202100184T1/en unknown
- 2018-10-12 MA MA50752A patent/MA50752B1/en unknown
- 2018-10-12 PE PE2020000380A patent/PE20210125A1/en unknown
- 2018-10-12 RU RU2022111211A patent/RU2022111211A/en unknown
- 2018-10-12 KR KR1020237014403A patent/KR20230070046A/en not_active Withdrawn
- 2018-10-12 PH PH1/2020/550417A patent/PH12020550417A1/en unknown
- 2018-10-12 CR CR20200206A patent/CR20200206A/en unknown
- 2018-10-12 MX MX2020003723A patent/MX2020003723A/en unknown
- 2018-10-12 UY UY0001037931A patent/UY37931A/en not_active Application Discontinuation
- 2018-10-12 CN CN201880069577.4A patent/CN111278467B/en active Active
- 2018-10-12 EP EP20209320.9A patent/EP3834846A1/en not_active Withdrawn
- 2018-10-12 RU RU2020115713A patent/RU2771292C2/en active
2020
- 2020-03-25 IL IL273586A patent/IL273586A/en unknown
- 2020-04-09 CL CL2020000977A patent/CL2020000977A1/en unknown
- 2020-05-07 CO CONC2020/0005685A patent/CO2020005685A2/en unknown
- 2020-05-13 EC ECSENADI202025198A patent/ECSP20025198A/en unknown
- 2020-11-25 US US17/105,402 patent/US20210145978A1/en not_active Abandoned
2021
- 2021-03-22 CY CY20211100239T patent/CY1123968T1/en unknown
2023
- 2023-05-19 US US18/320,869 patent/US20240115724A1/en not_active Abandoned
- 2023-07-27 DO DO2023000150A patent/DOP2023000150A/en unknown
- 2023-10-25 JP JP2023183034A patent/JP2024012366A/en active Pending

Also Published As

Publication number	Publication date
KR102529359B1 (en)	2023-05-09
SI3691692T1 (en)	2021-04-30
US20240115724A1 (en)	2024-04-11
DOP2023000150A (en)	2023-08-31
KR20200070324A (en)	2020-06-17
AU2018346969A1 (en)	2020-04-23
MD3691692T2 (en)	2021-05-31
RU2020115713A (en)	2021-11-16
TW201927815A (en)	2019-07-16
EP3691692A1 (en)	2020-08-12
KR102385495B1 (en)	2022-04-15
US20190111150A1 (en)	2019-04-18
KR20220045088A (en)	2022-04-12
US20210145978A1 (en)	2021-05-20
HRP20210436T8 (en)	2022-01-07
PE20210125A1 (en)	2021-01-19
CR20200206A (en)	2021-02-18
AR115178A1 (en)	2020-12-09
KR20230070046A (en)	2023-05-19
HRP20210436T1 (en)	2021-04-30
TWI780237B (en)	2022-10-11
MA50752A (en)	2020-08-12
SMT202100184T1 (en)	2021-05-07
RS61596B1 (en)	2021-04-29
EP3691692B1 (en)	2020-12-30
PH12020550417A1 (en)	2021-04-12
CO2020005685A2 (en)	2020-05-15
EP3691692B8 (en)	2021-05-26
JP2020537649A (en)	2020-12-24
UY37931A (en)	2019-04-30
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