PL369599A1 - Antagoniści receptora chemokiny i sposoby ich zastosowania - Google Patents

Antagoniści receptora chemokiny i sposoby ich zastosowania

Info

Publication number: PL369599A1
Authority: PL; Poland
Prior art keywords: methods; receptor antagonists; chemokine receptor; chemokine; antagonists
Prior art date: 2001-11-21

Application number

PL02369599A

Other languages

English (en)

Other versions

PL217918B1 (pl

Inventor

Yoshisuke Nakasato

Etsuo Ohshima

Geraldine C.B. Harriman

Kenneth G. Carson

Shomir Ghosh

Amy M. Elder

Karen M. Mattia

Jay R. Luly

Original Assignee

Millennium Pharmaceuticals, Inc.

Kyowa Hakko Kogyo Co, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-21

Filing date

2002-11-13

Publication date

2005-05-02

2001-11-21 Priority claimed from US09/989,086 external-priority patent/US20020169155A1/en

2002-11-13 Application filed by Millennium Pharmaceuticals, Inc., Kyowa Hakko Kogyo Co, Ltd. filed Critical Millennium Pharmaceuticals, Inc.

2005-05-02 Publication of PL369599A1 publication Critical patent/PL369599A1/pl

2014-09-30 Publication of PL217918B1 publication Critical patent/PL217918B1/pl

Links

229940122444 Chemokine receptor antagonist Drugs 0.000 title 1
239000002559 chemokine receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Obesity (AREA)
Tropical Medicine & Parasitology (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)

PL369599A 2001-11-21 2002-11-13 Związki, ich zastosowanie oraz kompozycja je zawierająca PL217918B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/989,086 US20020169155A1 (en)	1998-09-04	2001-11-21	Chemokine receptor anagonists and methods of use therefor

Publications (2)

Publication Number	Publication Date
PL369599A1 true PL369599A1 (pl)	2005-05-02
PL217918B1 PL217918B1 (pl)	2014-09-30

Family

ID=32713949

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL403800A PL403800A1 (pl)	2001-11-21	2002-11-13	Kompozycja farmaceutyczna
PL369599A PL217918B1 (pl)	2001-11-21	2002-11-13	Związki, ich zastosowanie oraz kompozycja je zawierająca

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL403800A PL403800A1 (pl)	2001-11-21	2002-11-13	Kompozycja farmaceutyczna

Country Status (23)

Country	Link
EP (3)	EP1688418B1 (pl)
JP (5)	JP4889920B2 (pl)
KR (3)	KR100919346B1 (pl)
CN (3)	CN1585772B (pl)
AR (2)	AR037394A1 (pl)
AT (1)	ATE320431T1 (pl)
AU (1)	AU2002352772B2 (pl)
BR (1)	BR0213633A (pl)
CA (1)	CA2467672C (pl)
CY (1)	CY1107243T1 (pl)
DE (2)	DE60209937D1 (pl)
DK (1)	DK1448566T5 (pl)
ES (2)	ES2260497T7 (pl)
IL (3)	IL161669A0 (pl)
MY (2)	MY142646A (pl)
NO (1)	NO328166B1 (pl)
NZ (3)	NZ532827A (pl)
PL (2)	PL403800A1 (pl)
PT (1)	PT1448566E (pl)
SG (2)	SG195393A1 (pl)
SI (1)	SI1448566T1 (pl)
TW (1)	TWI308568B (pl)
ZA (1)	ZA200403530B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2260497T7 (es) *	2001-11-21	2009-11-05	Millennium Pharmaceuticals, Inc.	Antagonistas de receptores de quimioquininas y metodos de uso de los mismos.
US7541365B2 (en)	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) *	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor
AU2008333272B2 (en) *	2007-12-03	2012-03-29	Novartis Ag	1,2-disubstituted-4-benzylamino-pyrrolidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperli pidemia or arteriosclerosis
TWI431010B (zh) *	2007-12-19	2014-03-21	Lilly Co Eli	礦皮質素受體拮抗劑及使用方法
CN104292142B (zh) *	2013-07-17	2019-05-14	天津大地康和医药技术有限公司	一种n-芳基杂环丁烷脱芳基方法
CN105237455A (zh) *	2015-10-14	2016-01-13	湖南华腾制药有限公司	一种3-取代氮杂环丁烷的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD80449A (pl) *
JPS5250634B2 (pl)	1971-08-23	1977-12-26
JPS61152673A (ja)	1984-12-26	1986-07-11	Kyowa Hakko Kogyo Co Ltd	ジベンズ〔ｂ，ｅ〕オキセピン誘導体の製造法
US5089496A (en)	1986-10-31	1992-02-18	Schering Corporation	Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
JPH0678315B2 (ja)	1988-04-28	1994-10-05	シェリング・コーポレーション	新規なベンゾピリド‐ピペリジン、ピペリジリデンおよびピペラジン化合物、組成物、製造法および利用法
AU2028892A (en)	1991-05-23	1992-12-30	Schering Corporation	Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
EP0524784A1 (en)	1991-07-23	1993-01-27	Schering Corporation	Benzopyrido piperidylidene compounds as PAF antagonists
JP3664176B2 (ja)	1992-11-10	2005-06-22	ジェネンテック・インコーポレーテッド	Ｃ−ｃｃｋｒ−１，ｃ−ｃケモカインレセプター
WO1996031469A1 (en) *	1995-04-07	1996-10-10	Novo Nordisk A/S	N-substituted azaheterocyclic carboxylic acids and esters thereof
JP3048067B2 (ja) *	1995-12-15	2000-06-05	ノボノルディスクアクティーゼルスカブ	新規方法
US6509346B2 (en) *	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
DK1049700T3 (da) *	1998-01-21	2006-02-20	Millennium Pharm Inc	Kemokinreceptorantagonister og fremgangsmåder til anvendelse deraf
EP1109815A1 (en) *	1998-09-04	2001-06-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
AU6503900A (en) *	1999-07-28	2001-02-19	Kyowa Hakko Kogyo Co. Ltd.	Chemokine receptor antagonists and methods of use therefor
WO2001029133A1 (en)	1999-10-20	2001-04-26	Kingspan Industrial Insulation Limited	Cellular plastic material based on phenolic resin
TW503427B (en)	2000-07-25	2002-09-21	Koninkl Philips Electronics Nv	Display tube comprising a mask with vibration damping means
ES2260497T7 (es) *	2001-11-21	2009-11-05	Millennium Pharmaceuticals, Inc.	Antagonistas de receptores de quimioquininas y metodos de uso de los mismos.
DE102011084910A1 (de)	2011-10-20	2013-04-25	Wobben Properties Gmbh	Verfahren und Vorrichtung zum Einspeisen elektrischen Stroms in ein elektrisches Netz

2002
- 2002-11-13 ES ES02789725T patent/ES2260497T7/es active Active
- 2002-11-13 ES ES10012138T patent/ES2396186T3/es not_active Expired - Lifetime
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- 2002-11-13 BR BR0213633-3A patent/BR0213633A/pt not_active Application Discontinuation
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- 2002-11-13 CN CN201410171050.6A patent/CN104031054A/zh active Pending
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2010
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2014
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Also Published As

Publication number	Publication date
EP1448566B3 (en)	2009-04-08
EP1448566A2 (en)	2004-08-25
NO328166B1 (no)	2009-12-21
PL403800A1 (pl)	2013-08-19
ATE320431T1 (de)	2006-04-15
NZ585746A (en)	2011-12-22
JP2010229136A (ja)	2010-10-14
CA2467672C (en)	2011-06-28
CN1585772B (zh)	2014-06-04
KR20040064283A (ko)	2004-07-16
JP5936669B2 (ja)	2016-06-22
CY1107243T1 (el)	2012-11-21
AU2002352772A1 (en)	2003-06-10
AR090829A2 (es)	2014-12-10
EP2286811B1 (en)	2012-09-05
KR20070118146A (ko)	2007-12-13
DK1448566T3 (da)	2006-07-31
IL161669A0 (en)	2004-09-27
EP1688418A3 (en)	2008-05-14
JP2016138122A (ja)	2016-08-04
JP4889920B2 (ja)	2012-03-07
DK1448566T5 (da)	2009-08-03
PL217918B1 (pl)	2014-09-30
NZ532827A (en)	2007-09-28
ES2260497T7 (es)	2009-11-05
ES2396186T3 (es)	2013-02-19
TW200303197A (en)	2003-09-01
SI1448566T1 (sl)	2006-08-31
BR0213633A (pt)	2004-08-24
PT1448566E (pt)	2006-08-31
DE60209937D1 (de)	2006-05-11
IL181191A (en)	2012-10-31
NO20042500L (no)	2004-06-15
EP2286811A1 (en)	2011-02-23
EP1448566B1 (en)	2006-03-15
JP2005510565A (ja)	2005-04-21
KR100919346B1 (ko)	2009-09-25
TWI308568B (en)	2009-04-11
CN1585772A (zh)	2005-02-23
MY146601A (en)	2012-08-30
IL161669A (en)	2010-12-30
JP2015083577A (ja)	2015-04-30
MY142646A (en)	2010-12-15
EP1688418A2 (en)	2006-08-09
SG165152A1 (en)	2010-10-28
AU2002352772B2 (en)	2006-10-26
DE60209937T2 (de)	2006-11-30
SG195393A1 (en)	2013-12-30
KR101001092B1 (ko)	2010-12-14
AR037394A1 (es)	2004-11-10
CA2467672A1 (en)	2003-06-05
HK1154504A1 (en)	2012-04-27
KR100952767B1 (ko)	2010-04-14
DE60209937T4 (de)	2009-10-29
HK1063789A1 (en)	2005-01-14
IL181191A0 (en)	2007-07-04
CN104031054A (zh)	2014-09-10
CN1911930A (zh)	2007-02-14
ES2260497T3 (es)	2006-11-01
JP2013209393A (ja)	2013-10-10
NZ596484A (en)	2013-05-31
KR20100010952A (ko)	2010-02-02
JP5878494B2 (ja)	2016-03-08
EP1688418B1 (en)	2017-03-15
ZA200403530B (en)	2005-07-28

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