PL369678A1 - Zamknięty, automatyczny system terapii tkankowej,dawkowanie i sposób podawania przy jego zastosowaniu - Google Patents

Zamknięty, automatyczny system terapii tkankowej,dawkowanie i sposób podawania przy jego zastosowaniu

Info

Publication number
PL369678A1
PL369678A1 PL02369678A PL36967802A PL369678A1 PL 369678 A1 PL369678 A1 PL 369678A1 PL 02369678 A PL02369678 A PL 02369678A PL 36967802 A PL36967802 A PL 36967802A PL 369678 A1 PL369678 A1 PL 369678A1
Authority
PL
Poland
Prior art keywords
graft
production
produced
skin
skin graft
Prior art date
Application number
PL02369678A
Other languages
English (en)
Inventor
Stephen F. Bellomo
Andrew L. Pearlman
Guillermo A. Piva
Lior Rosenberg
Itzhak Lippin
Mordechay Bukhman
Menachem D. Shavitt
Niv Sher
Original Assignee
Medgenics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medgenics, Inc. filed Critical Medgenics, Inc.
Publication of PL369678A1 publication Critical patent/PL369678A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M45/00—Means for pre-treatment of biological substances
    • C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A61B2017/3225—Skin grafting apparatus with processing of harvested tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
PL02369678A 2001-11-05 2002-11-05 Zamknięty, automatyczny system terapii tkankowej,dawkowanie i sposób podawania przy jego zastosowaniu PL369678A1 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33095901P 2001-11-05 2001-11-05
US39374502P 2002-07-08 2002-07-08
US39374602P 2002-07-08 2002-07-08

Publications (1)

Publication Number Publication Date
PL369678A1 true PL369678A1 (pl) 2005-05-02

Family

ID=28678904

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02369678A PL369678A1 (pl) 2001-11-05 2002-11-05 Zamknięty, automatyczny system terapii tkankowej,dawkowanie i sposób podawania przy jego zastosowaniu

Country Status (12)

Country Link
US (2) US20070183974A1 (pl)
EP (2) EP1451571B1 (pl)
JP (2) JP4447916B2 (pl)
KR (2) KR100969344B1 (pl)
CN (2) CN100374085C (pl)
AU (4) AU2002347577A1 (pl)
BR (1) BR0214065A (pl)
CA (1) CA2466244C (pl)
IL (1) IL161746A0 (pl)
MX (1) MXPA04004387A (pl)
PL (1) PL369678A1 (pl)
WO (4) WO2003049783A2 (pl)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666192B2 (en) * 2001-02-16 2010-02-23 Kci Licensing, Inc. Skin grafting devices and methods
US7468242B2 (en) 2001-11-05 2008-12-23 Medgenics, Inc. Dermal micro organs, methods and apparatuses for producing and using the same
US8501396B2 (en) 2001-11-05 2013-08-06 Medgenics Medical Israel Ltd. Dermal micro-organs, methods and apparatuses for producing and using the same
US8088568B2 (en) 2001-11-05 2012-01-03 Medgentics, Inc. Dermal micro-organs, methods and apparatuses for producing and using the same
US20070183974A1 (en) * 2001-11-05 2007-08-09 Pearlman Andrew L Method and apparatus for production of a skin graft and the graft produced thereby
CN100515354C (zh) 2003-02-27 2009-07-22 应用纸巾技术有限公司 用于处理皮肤组织的方法和设备
US7708746B2 (en) 2003-02-27 2010-05-04 Wright Medical Technology, Inc. Method and apparatus for processing dermal tissue
CA2788000C (en) * 2003-05-01 2016-03-15 Medgenics Inc. Apparatus for harvesting a dermal micro-organ
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
JP2010504909A (ja) * 2006-09-14 2010-02-18 メドジェニクス・メディカル・イスラエル・リミテッド 長期持続性の医薬製剤
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
KR101642821B1 (ko) * 2008-09-24 2016-07-26 더 제너럴 하스피탈 코포레이션 피부 조직의 이식 방법 및 장치
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
AU2011268458B2 (en) 2010-06-15 2014-06-12 Medgenics Medical Israel Ltd. Long lasting drug formulations
US8926631B2 (en) 2010-08-06 2015-01-06 MoMelan Technologies, Inc. Methods for preparing a skin graft without culturing or use of biologics
US9173674B2 (en) 2010-08-06 2015-11-03 MoMelan Technologies, Inc. Devices for harvesting a skin graft
US8978234B2 (en) 2011-12-07 2015-03-17 MoMelan Technologies, Inc. Methods of manufacturing devices for generating skin grafts
US8617181B2 (en) 2010-08-06 2013-12-31 MoMelan Technologies, Inc. Methods for preparing a skin graft
US9610093B2 (en) 2010-08-06 2017-04-04 Kci Licensing, Inc. Microblister skin grafting
US8562626B2 (en) 2010-08-06 2013-10-22 MoMelan Technologies, Inc. Devices for harvesting a skin graft
US9597111B2 (en) 2010-08-06 2017-03-21 Kci Licensing, Inc. Methods for applying a skin graft
DE102011002193B4 (de) * 2011-04-20 2018-11-29 Leica Biosystems Nussloch Gmbh Gewebeproben-Handhabungsvorrichtung
US9468459B2 (en) 2011-04-20 2016-10-18 Kci Licensing, Inc. Skin graft devices and methods
CN102783991B (zh) * 2011-05-19 2014-09-03 常州菲胜图自动化仪器有限公司 精密微皮移植机
AU2012315744B2 (en) * 2011-09-29 2015-09-24 The University Of Miami Ultra-rapid diagnostic tissue preparation as an alternative to frozen section
CN104114111A (zh) * 2012-02-09 2014-10-22 迈德詹尼克斯医疗以色列有限公司 获取、改造和再植入真皮微器官的方法和装置
WO2013184527A1 (en) 2012-06-05 2013-12-12 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
EP2862949B1 (en) 2012-06-13 2021-03-10 JFE Steel Corporation Method for manufacturing sintered ore
DK2870072T3 (en) 2012-07-05 2017-12-04 P C O A Devices Ltd medicine dispensers
EP2879974B1 (en) 2012-07-30 2017-08-23 P.C.O.A. Devices Ltd. A receptacle for containing and dispensing solid medicinal pills
EP3563859B1 (en) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Cardiosphere-derived exosomes for tissue regeneration
CN102871708B (zh) * 2012-10-26 2015-02-18 元文勇 一种可调式微型取皮植皮机
CN103070719A (zh) * 2012-12-31 2013-05-01 陈金西 皮肤组织细胞提取分离专用梅花刀片
JP6491188B2 (ja) 2013-03-14 2019-03-27 ケーシーアイ ライセンシング インコーポレイテッド 皮膚移植片採取用の吸収性基材
TR201807063T4 (tr) * 2013-03-15 2018-06-21 Kci Licensing Inc Mikroblister deri greftleme.
US10001313B2 (en) 2013-09-09 2018-06-19 Inovatzia, Inc. Reusable cryogenic carrying case for biological materials
EP3089681B1 (en) * 2013-12-31 2021-09-08 3M Innovative Properties Company Fluid-assisted skin graft harvesting
US9993261B2 (en) 2013-12-31 2018-06-12 Kci Licensing, Inc. Sensor systems for skin graft harvesting
IL233295B (en) 2014-06-22 2019-11-28 Ilan Paz A control pill dispensing system
CN107105639A (zh) * 2014-09-02 2017-08-29 联合治疗学有限公司 自动生物反应器系统,自动实施器官去细胞方案系统,和废物净化系统
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
WO2016164890A1 (en) 2015-04-09 2016-10-13 Kci Licensing, Inc. Soft-tack, porous substrates for harvesting skin grafts
IL238387B (en) 2015-04-20 2019-01-31 Paz Ilan Drug dispenser release mechanism
US20180333148A1 (en) * 2015-10-15 2018-11-22 Indiana University Research and Technology Corpora tion System and method for quantifiable shave biopsy
EP3362030B1 (en) 2015-10-15 2023-09-06 Dosentrx Ltd. Image recognition-based dosage form dispensers
WO2017077529A1 (en) 2015-11-02 2017-05-11 P.C.O.A. Lockable advanceable oral dosage form dispenser containers
EP3370630B1 (en) 2015-11-03 2021-06-16 3M Innovative Properties Company Device for creating an epidermal graft sheet
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
US10105862B1 (en) * 2017-03-31 2018-10-23 Biocut, Llc Fenestrated graft press cutting die assembly
EP3612191B1 (en) 2017-04-19 2026-03-11 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
MX2021014694A (es) * 2019-06-04 2022-03-11 Cutiss Ag Portador para biopsia.
CN110575205B (zh) * 2019-09-04 2022-03-22 陕西中医药大学 一种公共卫生与预防医学用的皮肤取样装置
IL293019B2 (en) 2019-11-22 2026-02-01 Cutiss Ag Methods and systems for manufacturing skin grafts
CN110771600B (zh) * 2019-11-25 2021-06-08 深圳科学之门生物工程有限公司 一种用于干细胞冻存的转移架
JP7408133B2 (ja) * 2019-12-10 2024-01-05 Orbray株式会社 生体組織の採取方法
WO2021157950A1 (ko) 2020-02-06 2021-08-12 삼성전자 주식회사 디스플레이 구동 방법 및 이를 지원하는 전자 장치
WO2022126005A1 (en) * 2020-12-11 2022-06-16 3D Systems, Inc. Carrier matrix for facilitating transfer of skin cores from donor site to wound site
CN116448479B (zh) * 2023-04-14 2024-01-16 中国人民解放军总医院第三医学中心 一种病理活检大体取材自动切片装置

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1516071A (en) * 1921-11-02 1924-11-18 Stanley L Apolant Method of performing skin-grafting operations and surgical instrument used therefor
US3076461A (en) * 1956-12-31 1963-02-05 Meek Cicero Parker Microdermatome
US3470782A (en) * 1966-01-03 1969-10-07 Eric O Acker Slitting machine
US3613242A (en) * 1966-12-29 1971-10-19 Michigan Research Corp Skin graft cutter
US3515128A (en) * 1967-12-11 1970-06-02 Bernard F Mcevoy Skin biopsy punch
CA992255A (en) * 1971-01-25 1976-07-06 Cutter Laboratories Prosthesis for spinal repair
DE7235643U (de) * 1972-09-28 1974-06-27 Fischer A Hüftgelenkkopfprothese
US4115346A (en) * 1974-02-12 1978-09-19 Kulzer & Co. Gmbh Hydroxy group containing diesters of acrylic acids and their use in dental material
DE2939057C3 (de) * 1979-09-27 1982-02-25 Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen Schneidvorrichtung zum Einbringen von Schnitten in die Haut
SE420009B (sv) * 1979-12-21 1981-09-07 Ericsson Telefon Ab L M Expanderskruv for fastsettning i en halighet
DE3247387C2 (de) * 1982-12-22 1984-11-22 Rolf Prof. Dr.med. 7400 Tübingen Hettich Verfahren zur Herstellung eines Transplantats und Vorrichtung zur Durchführung des Verfahrens
DE3432897C2 (de) * 1984-09-07 1986-07-03 Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen Hautnetz-Dermatom
US5532341A (en) * 1985-03-28 1996-07-02 Sloan-Kettering Institute For Cancer Research Human pluripotent hematopoietic colony stimulating factor
US4966849A (en) * 1985-09-20 1990-10-30 President And Fellows Of Harvard College CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4951684A (en) * 1987-05-15 1990-08-28 Syntex (U.S.A.) Inc. Device for collecting biological material
US5487739A (en) * 1987-11-17 1996-01-30 Brown University Research Foundation Implantable therapy systems and methods
US5024841A (en) * 1988-06-30 1991-06-18 Collagen Corporation Collagen wound healing matrices and process for their production
US4973301A (en) * 1989-07-11 1990-11-27 Israel Nissenkorn Catheter and method of using same
WO1991002049A1 (en) * 1989-08-04 1991-02-21 Peter Grandics An integrated cell culture-protein purification system for the automated production and purification of cell culture products
JPH0390237A (ja) * 1989-08-31 1991-04-16 Matsutani Seisakusho Co Ltd アイレス縫合針の加工方法
DE3936703A1 (de) * 1989-11-03 1991-05-08 Lutz Biedermann Knochenschraube
US5059193A (en) * 1989-11-20 1991-10-22 Spine-Tech, Inc. Expandable spinal implant and surgical method
CH680564A5 (pl) * 1989-12-07 1992-09-30 Experimentelle Chirurgie Schwe
US5236445A (en) * 1990-07-02 1993-08-17 American Cyanamid Company Expandable bone anchor and method of anchoring a suture to a bone
US5725529A (en) * 1990-09-25 1998-03-10 Innovasive Devices, Inc. Bone fastener
CA2092400A1 (en) * 1990-09-25 1992-03-26 James E. Nicholson Bone fastener
US5550316A (en) * 1991-01-02 1996-08-27 Fox Chase Cancer Center Transgenic animal model system for human cutaneous melanoma
US5720753A (en) * 1991-03-22 1998-02-24 United States Surgical Corporation Orthopedic fastener
SG47470A1 (en) * 1991-04-25 1998-04-17 Univ Brown Res Found Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products
GB9112898D0 (en) * 1991-06-14 1991-07-31 Digital Equipment Int Communication networks
US5958764A (en) * 1992-04-30 1999-09-28 Baylor College Of Medicine Specific expression vectors and methods of use
JP2660641B2 (ja) * 1992-07-22 1997-10-08 株式会社東洋設計 ロール混練機の材料巻込み機構
DE9213656U1 (de) * 1992-10-09 1992-12-03 Angiomed AG, 7500 Karlsruhe Stent-Set
US5888720A (en) 1992-10-27 1999-03-30 Yissum Research And Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs
CN1045530C (zh) * 1993-02-23 1999-10-13 王诚 负压自动取皮机
US5423330A (en) * 1993-03-10 1995-06-13 The University Of Miami Capsule suction punch instrument and method of use
US5480400A (en) * 1993-10-01 1996-01-02 Berger; J. Lee Method and device for internal fixation of bone fractures
US5423850A (en) * 1993-10-01 1995-06-13 Berger; J. Lee Balloon compressor for internal fixation of bone fractures
JP3333211B2 (ja) * 1994-01-26 2002-10-15 レイリー,マーク・エイ 骨の治療に関する外科的方法で使用される、改良に係る拡張可能な装置
US6248110B1 (en) * 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
ATE265191T1 (de) * 1994-03-14 2004-05-15 Cryolife Inc Herstellungsverfahren von gewebe zur implantation
US6001647A (en) * 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US20030157074A1 (en) * 1994-11-16 2003-08-21 Mitrani Eduardo N. Vitro micro-organs, and uses related thereto
US6472200B1 (en) * 1999-07-23 2002-10-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Device and method for performing a biological modification of a fluid
US5578035A (en) * 1995-05-16 1996-11-26 Lin; Chih-I Expandable bone marrow cavity fixation device
US5782851A (en) * 1996-04-10 1998-07-21 Rassman; William R. Hair transplantation system
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US5985653A (en) * 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
US5857982A (en) * 1995-09-08 1999-01-12 United States Surgical Corporation Apparatus and method for removing tissue
US5782830A (en) * 1995-10-16 1998-07-21 Sdgi Holdings, Inc. Implant insertion device
US6071284A (en) * 1995-10-30 2000-06-06 Biomedical Enterprises, Inc. Materials collection system and uses thereof
DE19607517C1 (de) * 1996-02-28 1997-04-10 Lutz Biedermann Knochenschraube
US5763267A (en) * 1996-04-16 1998-06-09 Advanced Tissue Sciences Apparatus for the large scale growth and packaging of cell suspensions and three-dimensional tissue cultures
GB2314343B (en) * 1996-06-18 2000-08-23 Liau Ming Yi Method and apparatus for cultivating anchorage dependent monolayer cells
NL1004276C2 (nl) 1996-10-15 1998-04-20 Willem Marie Ysebaert Werkwijzen voor het vervaardigen van huideilandjes, voor het verplaatsen van huid of huideilandjes, voor het spreiden van huideilandjes en het aanbrengen hiervan op een brandwond, alsmede een houder, snijraam, snijtafel, contradrager, klemorgaan, membraan, transportorgaan en spreidingsorgaan om te worden toegepast voor dergelijke werkwijzen.
US5980887A (en) * 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
EP1181355A4 (en) 1997-01-16 2005-05-04 Yissum Res Dev Co METHOD AND DEVICE FOR REALIZING A BIOLOGICAL MODIFICATION OF A FLUID
US5972015A (en) * 1997-08-15 1999-10-26 Kyphon Inc. Expandable, asymetric structures for deployment in interior body regions
US6171812B1 (en) * 1997-07-15 2001-01-09 The National Institute Of Biogerontology, Inc. Combined perfusion and mechanical loading system for explanted bone
EP1014859A4 (en) 1997-08-19 2007-05-02 Philipp Lang MEASUREMENT OF INTERSTITIAL CAPILLARY FLUID BY MEANS OF ULTRASONIC METHOD AND DEVICES
AU1114699A (en) * 1997-10-24 1999-05-17 Children's Medical Center Corporation Methods for promoting cell transfection (in vivo)
US7687057B2 (en) * 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US6331166B1 (en) * 1998-03-03 2001-12-18 Senorx, Inc. Breast biopsy system and method
EP1064353B1 (en) * 1998-03-18 2002-11-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
AU756969B2 (en) * 1998-06-01 2003-01-30 Kyphon Sarl Expandable preformed structures for deployment in interior body regions
US6264659B1 (en) * 1999-02-22 2001-07-24 Anthony C. Ross Method of treating an intervertebral disk
US6245101B1 (en) * 1999-05-03 2001-06-12 William J. Drasler Intravascular hinge stent
US20030152562A1 (en) * 2001-10-23 2003-08-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Vitro micro-organs, and uses related thereto
CA2377541A1 (en) * 1999-06-25 2001-01-04 Eduardo N. Mitrani Method of inducing angiogenesis by micro-organs
US6155989A (en) * 1999-06-25 2000-12-05 The United States Of America As Represented By The United States Department Of Energy Vacuum enhanced cutaneous biopsy instrument
IL139259A0 (en) 2000-10-25 2001-11-25 Geus Inc Method and system for remote image reconstitution and processing and imaging data collectors communicating with the system
US20020154114A1 (en) * 2000-11-30 2002-10-24 Christensen Thomas Kragh Method and system for customising build-to-order products
US20070183974A1 (en) * 2001-11-05 2007-08-09 Pearlman Andrew L Method and apparatus for production of a skin graft and the graft produced thereby
JP4600373B2 (ja) * 2006-09-12 2010-12-15 株式会社デンソー 車両用交流発電機

Also Published As

Publication number Publication date
WO2003040686A3 (en) 2003-10-09
CN100374085C (zh) 2008-03-12
HK1126953A1 (en) 2009-09-18
CN1612717A (zh) 2005-05-04
AU2002341378A1 (en) 2003-06-23
KR20040060973A (ko) 2004-07-06
EP1451571A2 (en) 2004-09-01
CA2466244C (en) 2012-04-24
WO2003049783A3 (en) 2003-10-30
JP4447916B2 (ja) 2010-04-07
CA2466244A1 (en) 2003-06-19
US20070183974A1 (en) 2007-08-09
WO2003039382A2 (en) 2003-05-15
MXPA04004387A (es) 2005-07-05
JP2010054513A (ja) 2010-03-11
KR20090125158A (ko) 2009-12-03
BR0214065A (pt) 2004-12-07
WO2003039382A3 (en) 2004-01-08
WO2003049626A1 (en) 2003-06-19
AU2002347577A1 (en) 2003-05-19
KR100954987B1 (ko) 2010-04-29
AU2002347575A1 (en) 2003-05-19
AU2002341378B2 (en) 2008-04-17
CN101352365B (zh) 2010-09-08
CN101352365A (zh) 2009-01-28
IL161746A0 (en) 2005-11-20
WO2003040686A2 (en) 2003-05-15
AU2002347576A8 (en) 2003-06-23
KR100969344B1 (ko) 2010-07-09
AU2002347576A1 (en) 2003-06-23
JP2005511709A (ja) 2005-04-28
US20110201115A1 (en) 2011-08-18
EP1451571B1 (en) 2013-08-21
EP1441656A1 (en) 2004-08-04
WO2003049783A2 (en) 2003-06-19
EP1451571A4 (en) 2008-10-08

Similar Documents

Publication Publication Date Title
GB2380380B (en) Speech synthesis apparatus and method
GB2376394B (en) Speech synthesis apparatus and selection method
PL371669A1 (pl) Sposób i urządzenie do znakowania artykułów
AU2003297484A8 (en) Apparatus and method for making a forming structure
AU2002236036A1 (en) A method and apparatus for producing a prototype
GB2380381B (en) Speech synthesis apparatus and method
SG118122A1 (en) Waveform production method and apparatus
HUP0400298A3 (en) Photosensitiser and method for production thereof
EP1506014A4 (en) PROCESS FOR THE PRODUCTION AND ACTIVATION OF CORRESPONDING SUBSTANCES AND MEANS OF PRODUCTION
EP1367153A4 (en) ARTICAN HAIR AND METHOD FOR THE PRODUCTION THEREOF
PT2476526E (pt) Processo e dispositivo para a produção de uma placa fabricada a partir de fibras ou aparas
EP1439264A4 (en) FIBERGROW PRODUCT AND METHOD AND DEVICE FOR ITS MANUFACTURE
GB0124762D0 (en) Apparatus and method for forming a body
GB0118729D0 (en) Apparatus and method for forming a body
GB0107559D0 (en) Apparatus and method for forming a body
GB0101244D0 (en) Process and apparatus
PL368868A1 (pl) Świeca żarowa ogrzewana elektrycznie i sposób wytwarzania świecy żarowej ogrzewanej elektrycznie
EP1549469A4 (en) DEVICE AND METHOD FOR PRODUCING A PRODUCT WITH OVAL FORM
ZA200504493B (en) Method and apparatus for producing mechanical fibers
GB0107561D0 (en) Apparatus and method for forming a body
GB0313893D0 (en) A method and apparatus for the production of pizza
GB0210093D0 (en) Confectionery manufacture apparatus and method
HU0303170D0 (en) Method for the production of 2-coumarone and substituted 2-coumarones
GB9904762D0 (en) Apparatus and method for the production of disinfectant
GB0208052D0 (en) Method and apparatus for producing a publication

Legal Events

Date Code Title Description
DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)