PL369855A1 - 4-arylochinazoliny i ich zastosowanie jako inhibitorów NHE-3 - Google Patents

4-arylochinazoliny i ich zastosowanie jako inhibitorów NHE-3

Info

Publication number
PL369855A1
PL369855A1 PL02369855A PL36985502A PL369855A1 PL 369855 A1 PL369855 A1 PL 369855A1 PL 02369855 A PL02369855 A PL 02369855A PL 36985502 A PL36985502 A PL 36985502A PL 369855 A1 PL369855 A1 PL 369855A1
Authority
PL
Poland
Prior art keywords
arylquinazolines
nhe
inhibitors
Prior art date
Application number
PL02369855A
Other languages
English (en)
Inventor
Rolf Gericke
Norbert Beier
Claudia Wilm
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL369855A1 publication Critical patent/PL369855A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL02369855A 2001-12-24 2002-11-29 4-arylochinazoliny i ich zastosowanie jako inhibitorów NHE-3 PL369855A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10163992A DE10163992A1 (de) 2001-12-24 2001-12-24 4-Aryl-chinazoline

Publications (1)

Publication Number Publication Date
PL369855A1 true PL369855A1 (pl) 2005-05-02

Family

ID=7710890

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02369855A PL369855A1 (pl) 2001-12-24 2002-11-29 4-arylochinazoliny i ich zastosowanie jako inhibitorów NHE-3

Country Status (11)

Country Link
US (1) US20050020612A1 (pl)
EP (1) EP1458396A1 (pl)
KR (1) KR20040066856A (pl)
AR (1) AR037973A1 (pl)
AU (1) AU2002356762A1 (pl)
BR (1) BR0215294A (pl)
CA (1) CA2471524A1 (pl)
DE (1) DE10163992A1 (pl)
MX (1) MXPA04006193A (pl)
PL (1) PL369855A1 (pl)
WO (1) WO2003055490A1 (pl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10043667A1 (de) * 2000-09-05 2002-03-14 Merck Patent Gmbh 2-Guanidino-4-aryl-chinazoline
US7629967B2 (en) * 2003-02-14 2009-12-08 Next Holdings Limited Touch screen signal processing
US8508508B2 (en) 2003-02-14 2013-08-13 Next Holdings Limited Touch screen signal processing with single-point calibration
US8456447B2 (en) 2003-02-14 2013-06-04 Next Holdings Limited Touch screen signal processing
US7241775B2 (en) 2003-03-24 2007-07-10 Sanofi-Aventis Deutschland Gmbh Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines
DE10312963A1 (de) * 2003-03-24 2004-10-07 Aventis Pharma Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
US7538759B2 (en) 2004-05-07 2009-05-26 Next Holdings Limited Touch panel display system with illumination and detection provided from a single edge
GB0526515D0 (en) * 2005-12-28 2006-02-08 Merck Sharp & Dohme Modulation of signalling pathways
WO2008094706A2 (en) * 2007-02-01 2008-08-07 Cook Incorporated Closure device and method of closing a bodily opening
EP2135155B1 (en) * 2007-04-11 2013-09-18 Next Holdings, Inc. Touch screen system with hover and click input methods
KR20100075460A (ko) 2007-08-30 2010-07-02 넥스트 홀딩스 인코포레이티드 저 프로파일 터치 패널 시스템
US8432377B2 (en) * 2007-08-30 2013-04-30 Next Holdings Limited Optical touchscreen with improved illumination
US8405636B2 (en) 2008-01-07 2013-03-26 Next Holdings Limited Optical position sensing system and optical position sensor assembly
US20090207144A1 (en) * 2008-01-07 2009-08-20 Next Holdings Limited Position Sensing System With Edge Positioning Enhancement
US20090213093A1 (en) * 2008-01-07 2009-08-27 Next Holdings Limited Optical position sensor using retroreflection
WO2010039663A2 (en) * 2008-10-02 2010-04-08 Next Holdings, Inc. Stereo optical sensors for resolving multi-touch in a touch detection system
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CA2748607A1 (en) 2008-12-31 2010-07-08 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives
CN102713794A (zh) * 2009-11-24 2012-10-03 奈克斯特控股公司 用于手势识别模式控制的方法和装置
US20110199387A1 (en) * 2009-11-24 2011-08-18 John David Newton Activating Features on an Imaging Device Based on Manipulations
EP2507683A1 (en) * 2009-12-04 2012-10-10 Next Holdings Limited Methods and systems for position detection using an interactive volume
US20110234542A1 (en) * 2010-03-26 2011-09-29 Paul Marson Methods and Systems Utilizing Multiple Wavelengths for Position Detection
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2014029983A1 (en) 2012-08-21 2014-02-27 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
ES2735992T3 (es) 2013-04-12 2019-12-23 Ardelyx Inc Compuestos de unión a NHE3 y procedimientos para inhibir el transporte de fosfatos
ME03311B (me) 2014-07-25 2019-10-20 Taisho Pharmaceutical Co Ltd Fenil teтrahidroizokvinolinsko jedinjenje supsтituisano heteroarilom
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
JP7292207B2 (ja) 2017-01-09 2023-06-16 アルデリックス， インコーポレイテッド 消化管障害を処置するために有用な化合物
CN118440135A (zh) 2017-08-04 2024-08-06 阿德利克斯股份有限公司 用于治疗高钾血症的甘草次酸衍生物
TWI861053B (zh) 2019-02-07 2024-11-11 美商阿德利克斯公司 用於治療高鉀血症之化合物及方法
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3131187A (en) * 1964-04-28 Certain z-guantoino-x-aryl-quinazolines
FR2460224A1 (fr) * 1979-06-29 1981-01-23 Renault Regulateur d'allure pour vehicule automobile
FR2685667B1 (fr) * 1991-12-26 1994-07-29 Landerretche Alain Dispositif d'assistance au controle de la puissance de vehicules equipes d'un moteur a combustion interne.
DE10019062A1 (de) * 2000-04-18 2001-10-25 Merck Patent Gmbh 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren
DE10043667A1 (de) * 2000-09-05 2002-03-14 Merck Patent Gmbh 2-Guanidino-4-aryl-chinazoline

Also Published As

Publication number Publication date
DE10163992A1 (de) 2003-07-03
EP1458396A1 (de) 2004-09-22
US20050020612A1 (en) 2005-01-27
CA2471524A1 (en) 2003-07-10
AR037973A1 (es) 2004-12-22
BR0215294A (pt) 2005-02-09
MXPA04006193A (es) 2004-12-06
AU2002356762A1 (en) 2003-07-15
WO2003055490A1 (de) 2003-07-10
KR20040066856A (ko) 2004-07-27

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Legal Events

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DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)