PL370137A1 - 3-Cyjanochinoliny jako inhibitory kinaz EGF-R i HER2 - Google Patents

3-Cyjanochinoliny jako inhibitory kinaz EGF-R i HER2

Info

Publication number
PL370137A1
PL370137A1 PL02370137A PL37013702A PL370137A1 PL 370137 A1 PL370137 A1 PL 370137A1 PL 02370137 A PL02370137 A PL 02370137A PL 37013702 A PL37013702 A PL 37013702A PL 370137 A1 PL370137 A1 PL 370137A1
Authority
PL
Poland
Prior art keywords
cyanoquinolines
egf
inhibitors
her2 kinases
her2
Prior art date
Application number
PL02370137A
Other languages
English (en)
Inventor
Allan Wissner
Hwei-Ru Tsou
Middleton Brawner Floyd Jr.
Bernard Dean Johnson
Elsebe Geraldine Overbeek-Klumpers
Original Assignee
Wyeth Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings Corporation filed Critical Wyeth Holdings Corporation
Publication of PL370137A1 publication Critical patent/PL370137A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL02370137A 2001-11-27 2002-11-26 3-Cyjanochinoliny jako inhibitory kinaz EGF-R i HER2 PL370137A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33356801P 2001-11-27 2001-11-27

Publications (1)

Publication Number Publication Date
PL370137A1 true PL370137A1 (pl) 2005-05-16

Family

ID=23303345

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02370137A PL370137A1 (pl) 2001-11-27 2002-11-26 3-Cyjanochinoliny jako inhibitory kinaz EGF-R i HER2

Country Status (24)

Country Link
US (1) US6821988B2 (pl)
EP (1) EP1448531B1 (pl)
JP (1) JP2005514384A (pl)
KR (1) KR20050044599A (pl)
CN (1) CN1659145A (pl)
AR (1) AR037438A1 (pl)
AT (1) ATE370123T1 (pl)
AU (1) AU2002359489B2 (pl)
BR (1) BR0214485A (pl)
CA (1) CA2467573A1 (pl)
CO (1) CO5580828A2 (pl)
DE (1) DE60221886D1 (pl)
EC (1) ECSP045122A (pl)
HU (1) HUP0402228A2 (pl)
IL (1) IL161921A0 (pl)
MX (1) MXPA04004969A (pl)
NO (1) NO20042634L (pl)
NZ (1) NZ533118A (pl)
PL (1) PL370137A1 (pl)
RU (1) RU2309150C2 (pl)
TW (1) TW200300348A (pl)
UA (1) UA77469C2 (pl)
WO (1) WO2003050090A1 (pl)
ZA (1) ZA200405025B (pl)

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MX2008015802A (es) * 2006-06-13 2009-01-09 Wyeth Corp 3-cianopiridinas sustituidas como inhibidores de proteina quinasa.
JP5368096B2 (ja) 2006-08-28 2013-12-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 未分化型胃癌に対する抗腫瘍剤
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TW201920110A (zh) 2009-01-16 2019-06-01 美商艾克塞里克斯公司 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
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EP2498751B1 (en) 2009-11-09 2019-04-03 Wyeth LLC Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
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Also Published As

Publication number Publication date
KR20050044599A (ko) 2005-05-12
ECSP045122A (es) 2004-07-23
US6821988B2 (en) 2004-11-23
NO20042634L (no) 2004-06-23
DE60221886D1 (de) 2007-09-27
UA77469C2 (en) 2006-12-15
HUP0402228A2 (hu) 2005-02-28
WO2003050090A1 (en) 2003-06-19
RU2004119414A (ru) 2006-02-27
US20030149056A1 (en) 2003-08-07
AU2002359489A1 (en) 2003-06-23
CN1659145A (zh) 2005-08-24
CO5580828A2 (es) 2005-11-30
NZ533118A (en) 2006-07-28
AR037438A1 (es) 2004-11-10
RU2309150C2 (ru) 2007-10-27
MXPA04004969A (es) 2004-08-11
EP1448531B1 (en) 2007-08-15
TW200300348A (en) 2003-06-01
BR0214485A (pt) 2004-09-14
EP1448531A1 (en) 2004-08-25
ZA200405025B (en) 2006-12-27
IL161921A0 (en) 2005-11-20
ATE370123T1 (de) 2007-09-15
JP2005514384A (ja) 2005-05-19
AU2002359489B2 (en) 2008-10-30
CA2467573A1 (en) 2003-06-19

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