PL370306A1 - Selekcja komórek zdolnych do ekspresji heteromerycznych polipeptydów - Google Patents

Selekcja komórek zdolnych do ekspresji heteromerycznych polipeptydów

Info

Publication number
PL370306A1
PL370306A1 PL02370306A PL37030602A PL370306A1 PL 370306 A1 PL370306 A1 PL 370306A1 PL 02370306 A PL02370306 A PL 02370306A PL 37030602 A PL37030602 A PL 37030602A PL 370306 A1 PL370306 A1 PL 370306A1
Authority
PL
Poland
Prior art keywords
selection
cells expressing
polypeptides
heteromeric polypeptides
expressing heteromeric
Prior art date
Application number
PL02370306A
Other languages
English (en)
Other versions
PL232477B1 (pl
Inventor
Jeffrey T. McGrew
Allison A. Bianchi
Original Assignee
Immunex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corporation filed Critical Immunex Corporation
Publication of PL370306A1 publication Critical patent/PL370306A1/pl
Publication of PL232477B1 publication Critical patent/PL232477B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL370306A 2001-09-20 2002-09-20 System ekspresji gospodarza i sposób wytwarzania heteromerycznego kompleksu PL232477B1 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32395401P 2001-09-20 2001-09-20
US60/323,954 2001-09-20
PCT/US2002/029985 WO2003035887A1 (en) 2001-09-20 2002-09-20 Selection of cells expressing heteromeric polypeptides

Publications (2)

Publication Number Publication Date
PL370306A1 true PL370306A1 (pl) 2005-05-16
PL232477B1 PL232477B1 (pl) 2019-06-28

Family

ID=23261429

Family Applications (1)

Application Number Title Priority Date Filing Date
PL370306A PL232477B1 (pl) 2001-09-20 2002-09-20 System ekspresji gospodarza i sposób wytwarzania heteromerycznego kompleksu

Country Status (12)

Country Link
US (3) US7691605B2 (pl)
EP (3) EP1434871B1 (pl)
JP (1) JP4266825B2 (pl)
CA (1) CA2458811C (pl)
CY (1) CY1118782T1 (pl)
DK (1) DK1434871T3 (pl)
ES (2) ES2711161T3 (pl)
LT (1) LT1434871T (pl)
MX (1) MXPA04002489A (pl)
PL (1) PL232477B1 (pl)
PT (1) PT1434871T (pl)
WO (1) WO2003035887A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035887A1 (en) * 2001-09-20 2003-05-01 Immunex Corporation Selection of cells expressing heteromeric polypeptides
US7906625B2 (en) * 2005-01-24 2011-03-15 Amgen Inc. Humanized anti-amyloid antibody
TWI395754B (zh) 2006-04-24 2013-05-11 Amgen Inc 人類化之ｃ-ｋｉｔ抗體
EP2235058A2 (en) 2007-12-21 2010-10-06 Amgen, Inc Anti-amyloid antibodies and uses thereof
KR101272817B1 (ko) * 2010-04-29 2013-06-10 한국생명공학연구원 항체 생산 세포주 선별 방법 및 선별 키트
CN103261220B (zh) * 2010-08-16 2016-06-15 诺夫免疫股份有限公司 用于生成多特异性和多价抗体的方法
WO2015134440A1 (en) * 2014-03-03 2015-09-11 Novogy, Inc. Reducing horizontal gene transfer of functional proteins
JP6972022B2 (ja) * 2016-05-11 2021-11-24 アムジエン・インコーポレーテツド グルタミンシンセターゼ遺伝子内相補ベクターを用いた高レベルのヘテロマータンパク質発現細胞の直接選択
JP7535310B2 (ja) * 2018-09-14 2024-08-16 ノースウェスタン ユニバーシティ Ｄｎａとのタンパク質重合のプログラミング
US12421524B2 (en) * 2018-09-24 2025-09-23 Merck Sharp & Dohme Llc Expression vectors for eukaryotic expression systems
AU2020269597A1 (en) * 2019-05-07 2021-09-23 Amgen Inc. Vectors and expression systems for producing recombinant proteins

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545503A (en) 1980-06-25 1996-08-13 Semiconductor Energy Laboratory Co., Ltd. Method of making printing member for electrostatic photocopying
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
AU643427B2 (en) 1988-10-31 1993-11-18 Immunex Corporation Interleukin-4 receptors
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
US5624818A (en) 1991-09-09 1997-04-29 Fred Hutchinson Cancer Research Center Nucleic acids encoding regulatory proteins that dimerize with Mad or Max
ES2198025T3 (es) 1991-10-25 2004-01-16 Immunex Corporation Anticuerpos contra cd40-l.
US6129914A (en) * 1992-03-27 2000-10-10 Protein Design Labs, Inc. Bispecific antibody effective to treat B-cell lymphoma and cell line
US5928904A (en) 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5573925A (en) 1994-11-28 1996-11-12 The Wistar Institute Of Anatomy And Biology P53 proteins with altered tetramerization domains
IL122174A (en) 1995-06-07 2004-07-25 Immunex Corp Dna encoding a cd40l mutein and a cd40l polypeptide encoded by said dna
CA2236867A1 (en) 1996-09-27 1998-04-02 Icos Corporation Method to identify compounds for disrupting protein/protein interactions
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
US6294330B1 (en) 1997-01-31 2001-09-25 Odyssey Pharmaceuticals Inc. Protein fragment complementation assays for the detection of biological or drug interactions
US6342345B1 (en) 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
US6632637B1 (en) * 1999-10-13 2003-10-14 Immunex Corporation Vectors and methods for recombinant protein expression
AUPQ422399A0 (en) 1999-11-24 1999-12-16 University Of New South Wales, The Method of screening transformed or transfected cells
WO2003035887A1 (en) * 2001-09-20 2003-05-01 Immunex Corporation Selection of cells expressing heteromeric polypeptides

Also Published As

Publication number Publication date
LT1434871T (lt) 2017-04-10
ES2711161T3 (es) 2019-04-30
ES2620410T3 (es) 2017-06-28
PT1434871T (pt) 2017-04-05
DK1434871T3 (en) 2017-04-18
US20100055794A1 (en) 2010-03-04
EP3187592A1 (en) 2017-07-05
EP1434871A1 (en) 2004-07-07
EP3467117B1 (en) 2020-07-15
PL232477B1 (pl) 2019-06-28
US20070031422A1 (en) 2007-02-08
EP1434871B1 (en) 2017-01-18
JP2005511031A (ja) 2005-04-28
US7691605B2 (en) 2010-04-06
EP3467117A1 (en) 2019-04-10
MXPA04002489A (es) 2004-11-22
WO2003035887A1 (en) 2003-05-01
CA2458811C (en) 2011-05-10
US7968313B2 (en) 2011-06-28
US20030082735A1 (en) 2003-05-01
CA2458811A1 (en) 2003-05-01
JP4266825B2 (ja) 2009-05-20
EP1434871A4 (en) 2004-11-03
EP3187592B1 (en) 2018-12-12
CY1118782T1 (el) 2017-07-12

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