PL3704143T3 - Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1 - Google Patents
Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1Info
- Publication number
- PL3704143T3 PL3704143T3 PL19709061.6T PL19709061T PL3704143T3 PL 3704143 T3 PL3704143 T3 PL 3704143T3 PL 19709061 T PL19709061 T PL 19709061T PL 3704143 T3 PL3704143 T3 PL 3704143T3
- Authority
- PL
- Poland
- Prior art keywords
- semaglutide
- liraglutide
- chemo
- glp
- enzymatic synthesis
- Prior art date
Links
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
- YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 title 1
- 108010019598 Liraglutide Proteins 0.000 title 1
- DLSWIYLPEUIQAV-UHFFFAOYSA-N Semaglutide Chemical compound CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(O)=O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(C)(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O DLSWIYLPEUIQAV-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960002701 liraglutide Drugs 0.000 title 1
- 229950011186 semaglutide Drugs 0.000 title 1
- 108010060325 semaglutide Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18161084 | 2018-03-09 | ||
| PCT/EP2019/056046 WO2019170918A1 (en) | 2018-03-09 | 2019-03-11 | Chemo-enzymatic synthesis of liraglutide, semaglutide and glp-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3704143T3 true PL3704143T3 (pl) | 2024-04-15 |
Family
ID=61800262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19709061.6T PL3704143T3 (pl) | 2018-03-09 | 2019-03-11 | Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10883132B2 (pl) |
| EP (1) | EP3704143B1 (pl) |
| JP (2) | JP2021516556A (pl) |
| KR (1) | KR102829589B1 (pl) |
| CN (2) | CN111819191B (pl) |
| CA (1) | CA3093221A1 (pl) |
| ES (1) | ES2962666T3 (pl) |
| PL (1) | PL3704143T3 (pl) |
| WO (1) | WO2019170918A1 (pl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3679131B1 (de) * | 2017-09-05 | 2024-09-04 | Henkel AG & Co. KGaA | Leistungsverbesserte proteasevarianten ii |
| ES2980707T3 (es) | 2018-04-05 | 2024-10-02 | Sun Pharmaceutical Ind Ltd | Nuevos análogos de GLP-1 |
| CN110590934B (zh) * | 2019-09-25 | 2020-12-08 | 北京乐普医药科技有限公司 | 一种glp-1化合物 |
| WO2021224938A1 (en) * | 2020-05-05 | 2021-11-11 | Neuland Laboratories Limited | Improved process for the preparation of semaglutide |
| EP4281464A4 (en) | 2021-01-20 | 2025-01-01 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| WO2022171667A1 (en) | 2021-02-12 | 2022-08-18 | Fresenius Kabi Ipsum S.R.L. | Subtilisin variants and their use |
| JP7642830B2 (ja) | 2021-09-15 | 2025-03-10 | バイキング・セラピューティクス・インコーポレイテッド | 代謝及び肝臓障害の処置のための組成物及び方法 |
| WO2024133313A1 (en) | 2022-12-19 | 2024-06-27 | Enzypep B.V. | Thermostable subtilisin variants and their use |
| WO2024163600A1 (en) * | 2023-02-01 | 2024-08-08 | Danisco Us Inc. | Subtilisin variants and methods of use |
| EP4658776A1 (en) * | 2023-02-01 | 2025-12-10 | Danisco US Inc. | Subtilisin variants and methods of use |
| WO2025190304A1 (zh) * | 2024-03-14 | 2025-09-18 | 博瑞生物医药（苏州）股份有限公司 | 包含glp-1和gip双受体激动剂的药物组合物及其用途 |
| WO2025262181A1 (en) | 2024-06-19 | 2025-12-26 | Fresenius Kabi Ipsum S.R.L. | Method to improve the producibility of a peptiligase enzyme |
| WO2026002733A1 (en) * | 2024-06-24 | 2026-01-02 | Fresenius Kabi Ipsum S.R.L. | Method for the synthesis of a peptide with amino acids having basic side-chains |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0542931T3 (da) | 1990-08-09 | 2000-05-22 | Genentech Inc | Serinproteasevarianter med peptidligaseaktivitet |
| US5567601A (en) * | 1993-06-01 | 1996-10-22 | University Of Maryland | Subtilisin mutants lacking a primary calcium binding site |
| US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
| US6541235B1 (en) | 2000-09-29 | 2003-04-01 | University Of Maryland Biotechnology Institute | Calcium free subtilisin mutants |
| WO2005081619A2 (en) * | 2003-11-20 | 2005-09-09 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| NZ573093A (en) * | 2006-06-23 | 2012-01-12 | Hoffmann La Roche | Insulinotropic peptide synthesis |
| WO2014199397A2 (en) | 2013-06-11 | 2014-12-18 | Mylan Laboratories Ltd | Process for the preparation of liraglutide |
| GR20140100479A (el) | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
| US10138268B2 (en) * | 2014-10-10 | 2018-11-27 | Enzypep B.V. | Peptide fragment condensation and cyclisation using a subtilisin variant with improved synthesis over hydrolysis ratio |
| WO2017007324A1 (en) * | 2015-07-09 | 2017-01-12 | Enzypep B.V. | Designing an enzymatic peptide fragment condensation strategy |
| WO2018032521A1 (zh) | 2016-08-19 | 2018-02-22 | 深圳市健元医药科技有限公司 | 一种利拉鲁肽的合成方法 |
-
2019
- 2019-03-11 PL PL19709061.6T patent/PL3704143T3/pl unknown
- 2019-03-11 KR KR1020207028592A patent/KR102829589B1/ko active Active
- 2019-03-11 US US16/463,471 patent/US10883132B2/en active Active
- 2019-03-11 CA CA3093221A patent/CA3093221A1/en active Pending
- 2019-03-11 JP JP2020570646A patent/JP2021516556A/ja active Pending
- 2019-03-11 WO PCT/EP2019/056046 patent/WO2019170918A1/en not_active Ceased
- 2019-03-11 ES ES19709061T patent/ES2962666T3/es active Active
- 2019-03-11 CN CN201980018036.3A patent/CN111819191B/zh active Active
- 2019-03-11 CN CN202411044016.2A patent/CN119060201A/zh active Pending
- 2019-03-11 EP EP19709061.6A patent/EP3704143B1/en active Active
-
2020
- 2020-02-06 US US16/783,570 patent/US10920258B2/en active Active
-
2023
- 2023-11-09 JP JP2023191845A patent/JP2024010221A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3704143C0 (en) | 2023-10-18 |
| KR20200130712A (ko) | 2020-11-19 |
| CN111819191B (zh) | 2024-08-20 |
| EP3704143B1 (en) | 2023-10-18 |
| JP2024010221A (ja) | 2024-01-23 |
| US10883132B2 (en) | 2021-01-05 |
| CN119060201A (zh) | 2024-12-03 |
| WO2019170918A1 (en) | 2019-09-12 |
| US20190345529A1 (en) | 2019-11-14 |
| CA3093221A1 (en) | 2019-09-12 |
| JP2021516556A (ja) | 2021-07-08 |
| ES2962666T3 (es) | 2024-03-20 |
| CN111819191A (zh) | 2020-10-23 |
| KR102829589B1 (ko) | 2025-07-04 |
| US20200347427A1 (en) | 2020-11-05 |
| EP3704143A1 (en) | 2020-09-09 |
| US10920258B2 (en) | 2021-02-16 |
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