PL371492A1 - Pochodne chinolinonu przeznaczone do leczenia chorób związanych z proliferacją komórek - Google Patents
Pochodne chinolinonu przeznaczone do leczenia chorób związanych z proliferacją komórekInfo
- Publication number
- PL371492A1 PL371492A1 PL03371492A PL37149203A PL371492A1 PL 371492 A1 PL371492 A1 PL 371492A1 PL 03371492 A PL03371492 A PL 03371492A PL 37149203 A PL37149203 A PL 37149203A PL 371492 A1 PL371492 A1 PL 371492A1
- Authority
- PL
- Poland
- Prior art keywords
- cell proliferation
- related disorders
- treating cell
- quinolinone derivatives
- proliferation related
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35531302P | 2002-02-07 | 2002-02-07 | |
| US10/360,226 US6822097B1 (en) | 2002-02-07 | 2003-02-06 | Compounds and methods of uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL371492A1 true PL371492A1 (pl) | 2005-06-13 |
Family
ID=27737493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL03371492A PL371492A1 (pl) | 2002-02-07 | 2003-02-07 | Pochodne chinolinonu przeznaczone do leczenia chorób związanych z proliferacją komórek |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6822097B1 (pl) |
| EP (1) | EP1478645A2 (pl) |
| JP (1) | JP2005526029A (pl) |
| AU (1) | AU2003209058A1 (pl) |
| CA (1) | CA2475637A1 (pl) |
| MX (1) | MXPA04007661A (pl) |
| PL (1) | PL371492A1 (pl) |
| WO (1) | WO2003066630A2 (pl) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040147561A1 (en) * | 2002-12-27 | 2004-07-29 | Wenge Zhong | Pyrid-2-one derivatives and methods of use |
| CA2533626A1 (en) * | 2003-07-22 | 2005-02-03 | Janssen Pharmaceutica, N.V. | Quinolinone derivatives as inhibitors of c-fms kinase |
| JP2007503388A (ja) * | 2003-08-22 | 2007-02-22 | アバニール・ファーマシューティカルズ | マクロファージ遊走阻止因子の阻害剤としての置換ナフチリジン誘導体、およびヒト疾患の治療におけるそれらの使用 |
| JP4823914B2 (ja) * | 2003-11-07 | 2011-11-24 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Fgfr3の阻害および多発性骨髄腫の治療 |
| NZ546991A (en) | 2003-11-20 | 2010-01-29 | Janssen Pharmaceutica Nv | 6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors |
| WO2005121132A1 (ja) * | 2004-06-11 | 2005-12-22 | Shionogi & Co., Ltd. | 抗hcv作用を有する縮合ヘテロ環化合物 |
| BRPI0515012A (pt) | 2004-08-13 | 2008-07-01 | Genentech Inc | substáncia quìmica, composição e formulação farmacêutica, método de tratamento, método de inibição de pelo menos uma enzima que utiliza atp e uso |
| US20060142312A1 (en) * | 2004-12-23 | 2006-06-29 | Pfizer Inc | C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones |
| US8206650B2 (en) * | 2005-04-12 | 2012-06-26 | Chromedx Inc. | Joint-diagnostic spectroscopic and biosensor meter |
| CA2517299A1 (en) * | 2005-08-26 | 2007-02-26 | Chromedx Inc. | Hollow needle assembly |
| CA2507323A1 (en) * | 2005-05-13 | 2006-11-13 | Chromedx Inc. | Diagnostic whole blood and plasma apparatus |
| US20100245803A1 (en) * | 2005-04-12 | 2010-09-30 | Chromedx Inc. | Blood sample holder for spectroscopic analysis |
| WO2006119148A2 (en) * | 2005-04-29 | 2006-11-09 | The Ohio State University Research Foundation | Keratinocyte growth factor receptor - tyrosine specific inhibitors for the prevention of cancer metastatis |
| HRP20130902T1 (hr) * | 2005-10-07 | 2013-11-08 | Exelixis Inc. | PIRIDOPIRIMIDINONSKI INHIBITORI PI3Kalfa |
| PT1940839E (pt) * | 2005-10-07 | 2013-10-10 | Exelixis Inc | Inibidores de piridopirimidinona pi3k alfa |
| GB0601031D0 (en) * | 2006-01-18 | 2006-03-01 | Novartis Ag | Organic compounds |
| PL2027123T3 (pl) * | 2006-05-11 | 2011-09-30 | Irm Llc | Związki i kompozycje jako inhibitory kinaz białkowych |
| US8138205B2 (en) | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
| US8080563B2 (en) | 2006-07-07 | 2011-12-20 | Kalypsys | Bicyclic heteroaryl inhibitors of PDE4 |
| EP1914234A1 (en) | 2006-10-16 | 2008-04-23 | GPC Biotech Inc. | Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors |
| JP5545955B2 (ja) | 2007-03-08 | 2014-07-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Parpおよびtank阻害剤としてのキノリノン誘導体 |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| WO2009053373A1 (en) * | 2007-10-26 | 2009-04-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as parp inhibitors |
| ES2330495B1 (es) * | 2007-11-07 | 2010-09-20 | Consejo Superior De Investigaciones Cientificas (Titular Al 51%) | Inhibidores de la enzima o6-alquilguanina-adn-metil-transferasa para el tratamiento del cancer. |
| EP2252612B1 (en) | 2008-02-22 | 2012-03-28 | Irm Llc | Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors |
| EP2112150B1 (en) | 2008-04-22 | 2013-10-16 | Forma Therapeutics, Inc. | Improved raf inhibitors |
| WO2010008843A1 (en) * | 2008-06-24 | 2010-01-21 | Takeda Pharmaceutical Company Limited | Apoptosis signal-regulating kinase 1 inhibitors |
| WO2011011312A1 (en) | 2009-07-22 | 2011-01-27 | Merck Sharp & Dohme Corp. | Quinolinone pde2 inhibitors |
| WO2011051212A1 (de) * | 2009-10-28 | 2011-05-05 | Basf Se | Verwendung heteroaromatischer verbindungen als herbizide |
| EP2332939A1 (en) * | 2009-11-26 | 2011-06-15 | Æterna Zentaris GmbH | Novel Naphthyridine derivatives and the use thereof as kinase inhibitors |
| US9815845B2 (en) | 2010-10-13 | 2017-11-14 | Trustees Of Boston University | Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics |
| US9802948B2 (en) | 2010-10-13 | 2017-10-31 | Trustees Of Boston Univeristy | Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics |
| CN103347520A (zh) * | 2010-10-13 | 2013-10-09 | 波士顿大学管理委员会 | 用作癌症化学治疗的晚期sv40因子(lsf)的抑制剂 |
| CA2817460A1 (en) | 2010-12-17 | 2012-06-21 | F. Hoffmann-La Roche Ag | Substituted 6,6-fused nitrogenous heterocyclic compounds and uses thereof |
| WO2012150550A1 (en) * | 2011-05-04 | 2012-11-08 | Basf Se | Novel pesticidal amino pyranone compounds |
| WO2012158913A2 (en) | 2011-05-17 | 2012-11-22 | Discoverybiomed Inc. | Treating protein folding disorders with small molecule cftr correctors |
| WO2012158691A1 (en) | 2011-05-19 | 2012-11-22 | The Board Of Trustees Of The Leland Stanford Junior University | Anti-proliferative compounds and methods for using the same |
| EP2727920B1 (en) * | 2011-07-29 | 2016-11-02 | FUJIFILM Corporation | 1,5-naphthyridine derivative or salt thereof |
| US9676779B2 (en) | 2012-11-20 | 2017-06-13 | Discoverybiomed, Inc. | Small molecule CFTR correctors |
| CA2891965A1 (en) | 2012-11-20 | 2014-05-30 | Discoverybiomed, Inc. | Small molecule bicyclic and tricyclic cftr correctors |
| WO2014107622A1 (en) | 2013-01-07 | 2014-07-10 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| US9353122B2 (en) | 2013-02-15 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| US9353123B2 (en) | 2013-02-20 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| CA2903103C (en) * | 2013-03-15 | 2020-06-09 | Discoverybiomed, Inc. | Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders |
| HK1218537A1 (zh) * | 2013-03-15 | 2017-02-24 | Discoverybiomed Inc. | 香豆素衍生物以及用於治疗过度增生性疾病的方法 |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| KR20160099084A (ko) | 2013-11-01 | 2016-08-19 | 칼라 파마슈티컬스, 인크. | 치료 화합물의 결정질 형태 및 그의 용도 |
| WO2015103489A1 (en) | 2014-01-03 | 2015-07-09 | University Of Southern California | Heteroatom containing deoxyuridine triphosphatase inhibitors |
| WO2016021742A1 (en) * | 2014-08-07 | 2016-02-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds as ep4 receptor antagonists |
| DK3319939T3 (da) | 2015-07-08 | 2025-02-24 | Cv6 Therapeutics Ni Ltd | Hydantoin indeholdende deoxyuridintriphosphatase-inhibitorer |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
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| US5801183A (en) | 1995-01-27 | 1998-09-01 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists |
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| AU742999B2 (en) | 1997-08-20 | 2002-01-17 | Warner-Lambert Company | Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation |
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| DE10100175A1 (de) * | 2001-01-04 | 2002-07-11 | Bayer Ag | Hetarylsubstituierte Homotetram-und Homotetronsäuren |
| US20030055263A1 (en) * | 2001-07-11 | 2003-03-20 | Boehringer Ingelheim Pharma Kg | Carboxylic acid derivatives, medicaments comprising these compounds, their use and processes for their production |
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- 2003-02-07 EP EP03707786A patent/EP1478645A2/en not_active Withdrawn
- 2003-02-07 AU AU2003209058A patent/AU2003209058A1/en not_active Abandoned
- 2003-02-07 CA CA002475637A patent/CA2475637A1/en not_active Abandoned
- 2003-02-07 WO PCT/US2003/003762 patent/WO2003066630A2/en not_active Ceased
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| WO2003066630A2 (en) | 2003-08-14 |
| US6822097B1 (en) | 2004-11-23 |
| JP2005526029A (ja) | 2005-09-02 |
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| WO2003066630A3 (en) | 2003-12-18 |
| CA2475637A1 (en) | 2003-08-14 |
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