PL371629A1 - Sposób wytwarzania kombrestatyn - Google Patents
Sposób wytwarzania kombrestatynInfo
- Publication number
- PL371629A1 PL371629A1 PL03371629A PL37162903A PL371629A1 PL 371629 A1 PL371629 A1 PL 371629A1 PL 03371629 A PL03371629 A PL 03371629A PL 37162903 A PL37162903 A PL 37162903A PL 371629 A1 PL371629 A1 PL 371629A1
- Authority
- PL
- Poland
- Prior art keywords
- combrestinates
- production method
- production
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Detergent Compositions (AREA)
- Magnetic Ceramics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0204499A FR2838437B1 (fr) | 2002-04-11 | 2002-04-11 | Procedes de preparation de combretastatines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL371629A1 true PL371629A1 (pl) | 2005-06-27 |
| PL213708B1 PL213708B1 (pl) | 2013-04-30 |
Family
ID=28459732
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL394820A PL213967B1 (pl) | 2002-04-11 | 2003-04-09 | Sposób wytwarzania kombrestatyn oraz zwiazek posredni |
| PL394821A PL214129B1 (pl) | 2002-04-11 | 2003-04-09 | Sposób wytwarzania kombrestatyn |
| PL371629A PL213708B1 (pl) | 2002-04-11 | 2003-04-09 | Sposób wytwarzania kombrestatyn |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL394820A PL213967B1 (pl) | 2002-04-11 | 2003-04-09 | Sposób wytwarzania kombrestatyn oraz zwiazek posredni |
| PL394821A PL214129B1 (pl) | 2002-04-11 | 2003-04-09 | Sposób wytwarzania kombrestatyn |
Country Status (27)
| Country | Link |
|---|---|
| EP (3) | EP2354118A1 (pl) |
| JP (1) | JP4299677B2 (pl) |
| KR (1) | KR101018983B1 (pl) |
| CN (1) | CN1291970C (pl) |
| AR (2) | AR039198A1 (pl) |
| AU (1) | AU2003260026B2 (pl) |
| BR (1) | BR0309087A (pl) |
| CA (1) | CA2481742C (pl) |
| CR (1) | CR7481A (pl) |
| EA (1) | EA007965B1 (pl) |
| EC (1) | ECSP045348A (pl) |
| FR (1) | FR2838437B1 (pl) |
| HR (1) | HRP20040935A2 (pl) |
| IL (1) | IL164247A0 (pl) |
| MA (1) | MA26407A1 (pl) |
| ME (1) | MEP91508A (pl) |
| MX (1) | MXPA04009112A (pl) |
| NO (2) | NO329701B1 (pl) |
| NZ (1) | NZ535318A (pl) |
| OA (1) | OA12804A (pl) |
| PL (3) | PL213967B1 (pl) |
| RS (3) | RS52331B (pl) |
| TN (1) | TNSN04201A1 (pl) |
| TW (1) | TWI262179B (pl) |
| UA (1) | UA76079C2 (pl) |
| WO (1) | WO2003084919A2 (pl) |
| ZA (1) | ZA200407417B (pl) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235688B1 (en) | 2004-11-04 | 2007-06-26 | University Of Notre Dame Du Lac | Process for preparing histone deacetylase inhibitors and intermediates thereof |
| FR2928148B1 (fr) * | 2008-02-28 | 2013-01-18 | Sanofi Aventis | Procede de preparation de combretastatine |
| FR2939665B1 (fr) | 2008-12-12 | 2011-10-07 | Sanofi Aventis | Combinaison antitumorale associant l'ave8062a et le docetaxel |
| FR2945210B1 (fr) | 2009-05-07 | 2011-07-01 | Sanofi Aventis | Combinaison antitumorale comprenant l'ave8062 et le sorafenib |
| FR2953518B1 (fr) | 2009-12-03 | 2012-01-20 | Sanofi Aventis | Procede de preparation d'un derive de combretastatine |
| EP2481404A1 (en) | 2010-11-15 | 2012-08-01 | Sanofi | An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative |
| BR112012031917A2 (pt) | 2010-06-18 | 2017-11-28 | Sanofi Sa | combinação antitumoral compreendendo ombrabulina, um derivado de taxano e um derivado de platina |
| EP2397135A1 (en) | 2010-06-18 | 2011-12-21 | Sanofi | An antitumoral combination comprising ombrabulin, a taxane derivative and a platinum derivative |
| EP2407161A1 (en) | 2010-07-13 | 2012-01-18 | Sanofi | An antitumoral combination comprising ombrabulin and bevacizumab |
| FR2968557A1 (fr) | 2010-12-09 | 2012-06-15 | Sanofi Aventis | Combinaison antitumorale comprenant un derive de la famille des combretastatines et le cetuximab |
| FR2978662A1 (fr) | 2011-08-01 | 2013-02-08 | Sanofi Sa | Combinaison antitumorale comprenant l'ombrabuline et le cisplatine, associee a la radiotherapie |
| FR2978663A1 (fr) | 2011-08-01 | 2013-02-08 | Sanofi Sa | Combinaison antitumorale comprenant l'ombrabuline et le cetuximab, associee a la radiotherapie |
| CN103012248B (zh) * | 2013-01-11 | 2014-11-05 | 浙江大德药业集团有限公司 | 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用 |
| EP3184095A1 (en) | 2013-05-23 | 2017-06-28 | IP Gesellschaft für Management mbH | Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide |
| EP4079327A1 (en) | 2021-04-22 | 2022-10-26 | Centaurus Polytherapeutics | Payloads for drug-conjugates and their use for treating cancer |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4996237A (en) | 1987-01-06 | 1991-02-26 | Arizona Board Of Regents | Combretastatin A-4 |
| UA19045A (uk) * | 1988-02-24 | 1997-12-25 | Ф.Хофманн - Ля Рош Аг | Спосіб одержаhhя похідhих стильбеhу |
| NZ232897A (en) * | 1989-04-03 | 1992-12-23 | Squibb & Sons Inc | Interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogues, preparation and pharmaceutical compositions thereof |
| TW325458B (en) | 1993-09-08 | 1998-01-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer |
| US5731353A (en) * | 1993-09-08 | 1998-03-24 | Ajinomoto Co., Inc. | Stilbene derivatives and pharmaceutical compositions containing them |
| DK0754682T3 (da) * | 1994-04-06 | 2002-02-04 | Western Therapeutics Inst D | Aminostilbazolderivat og lægemiddel |
| TW334418B (en) * | 1995-03-07 | 1998-06-21 | Ajinomoto Kk | Stilbene derivatives and pharmaceutical compositions |
| JP4551514B2 (ja) * | 1999-07-23 | 2010-09-29 | 住友化学株式会社 | 不飽和炭化水素残基置換アニリン類の製造方法 |
| GB9918912D0 (en) | 1999-08-12 | 1999-10-13 | Angiogene Pharm Ltd | New stilbenes with vascular damaging activity |
-
2002
- 2002-04-11 FR FR0204499A patent/FR2838437B1/fr not_active Expired - Fee Related
-
2003
- 2003-03-28 AR ARP030101111A patent/AR039198A1/es active IP Right Grant
- 2003-04-09 PL PL394820A patent/PL213967B1/pl not_active IP Right Cessation
- 2003-04-09 NZ NZ535318A patent/NZ535318A/en not_active IP Right Cessation
- 2003-04-09 PL PL394821A patent/PL214129B1/pl not_active IP Right Cessation
- 2003-04-09 EP EP10183135A patent/EP2354118A1/fr not_active Withdrawn
- 2003-04-09 HR HR20040935A patent/HRP20040935A2/hr not_active Application Discontinuation
- 2003-04-09 EP EP03740582A patent/EP1497255A2/fr not_active Withdrawn
- 2003-04-09 BR BR0309087-6A patent/BR0309087A/pt not_active IP Right Cessation
- 2003-04-09 KR KR1020047016132A patent/KR101018983B1/ko not_active Expired - Fee Related
- 2003-04-09 JP JP2003582118A patent/JP4299677B2/ja not_active Expired - Fee Related
- 2003-04-09 AU AU2003260026A patent/AU2003260026B2/en not_active Ceased
- 2003-04-09 OA OA1200400275A patent/OA12804A/fr unknown
- 2003-04-09 EA EA200401350A patent/EA007965B1/ru not_active IP Right Cessation
- 2003-04-09 MX MXPA04009112A patent/MXPA04009112A/es active IP Right Grant
- 2003-04-09 ME MEP-915/08A patent/MEP91508A/xx unknown
- 2003-04-09 CA CA2481742A patent/CA2481742C/fr not_active Expired - Fee Related
- 2003-04-09 CN CNB038075660A patent/CN1291970C/zh not_active Expired - Fee Related
- 2003-04-09 PL PL371629A patent/PL213708B1/pl not_active IP Right Cessation
- 2003-04-09 RS YU86504A patent/RS52331B/sr unknown
- 2003-04-09 RS RS20110561A patent/RS20110561A3/en unknown
- 2003-04-09 IL IL16424703A patent/IL164247A0/xx not_active IP Right Cessation
- 2003-04-09 EP EP10183123A patent/EP2348012A1/fr not_active Withdrawn
- 2003-04-09 RS RS20110562A patent/RS20110562A3/en unknown
- 2003-04-09 WO PCT/FR2003/001117 patent/WO2003084919A2/fr not_active Ceased
- 2003-04-10 TW TW092108184A patent/TWI262179B/zh not_active IP Right Cessation
- 2003-09-04 UA UA20041109227A patent/UA76079C2/uk unknown
-
2004
- 2004-09-14 CR CR7481A patent/CR7481A/es unknown
- 2004-09-15 ZA ZA200407417A patent/ZA200407417B/en unknown
- 2004-09-20 MA MA27868A patent/MA26407A1/fr unknown
- 2004-10-08 EC EC2004005348A patent/ECSP045348A/es unknown
- 2004-10-08 TN TNP2004000201A patent/TNSN04201A1/fr unknown
- 2004-11-05 NO NO20044814A patent/NO329701B1/no not_active IP Right Cessation
-
2010
- 2010-09-01 NO NO20101215A patent/NO331372B1/no not_active IP Right Cessation
-
2011
- 2011-08-05 AR ARP110102854A patent/AR082581A2/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20140409 |