PL371913A1 - Sposoby syntezy beta-L-5-fluoro-2',3'-dideoksy-2',3'-didehydrocytydyny (beta-L-FD4C) - Google Patents
Sposoby syntezy beta-L-5-fluoro-2',3'-dideoksy-2',3'-didehydrocytydyny (beta-L-FD4C)Info
- Publication number
- PL371913A1 PL371913A1 PL03371913A PL37191303A PL371913A1 PL 371913 A1 PL371913 A1 PL 371913A1 PL 03371913 A PL03371913 A PL 03371913A PL 37191303 A PL37191303 A PL 37191303A PL 371913 A1 PL371913 A1 PL 371913A1
- Authority
- PL
- Poland
- Prior art keywords
- beta
- didehydcytidine
- fd4c
- dideoxy
- fluoro
- Prior art date
Links
- HSBKFSPNDWWPSL-VDTYLAMSSA-N 4-amino-5-fluoro-1-[(2s,5r)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one Chemical compound C1=C(F)C(N)=NC(=O)N1[C@@H]1C=C[C@H](CO)O1 HSBKFSPNDWWPSL-VDTYLAMSSA-N 0.000 title 1
- 230000002194 synthesizing effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37200602P | 2002-04-12 | 2002-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL371913A1 true PL371913A1 (pl) | 2005-07-11 |
Family
ID=29250776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL03371913A PL371913A1 (pl) | 2002-04-12 | 2003-04-11 | Sposoby syntezy beta-L-5-fluoro-2',3'-dideoksy-2',3'-didehydrocytydyny (beta-L-FD4C) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6897302B2 (pl) |
| EP (1) | EP1495040A4 (pl) |
| JP (1) | JP2005527589A (pl) |
| KR (1) | KR20050005442A (pl) |
| CN (1) | CN1329407C (pl) |
| AU (1) | AU2003234737B2 (pl) |
| BR (1) | BR0309111A (pl) |
| CA (1) | CA2481572A1 (pl) |
| MX (1) | MXPA04009986A (pl) |
| NO (1) | NO20044927L (pl) |
| PL (1) | PL371913A1 (pl) |
| RU (1) | RU2310661C2 (pl) |
| UA (1) | UA77291C2 (pl) |
| WO (1) | WO2003087119A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2183263E (pt) * | 2007-07-26 | 2012-01-11 | Lexicon Pharmaceuticals Inc | Processos e compostos úteis na preparação de inibidores do co-transportador 2 de glucose e sódio |
| EP2562163A1 (en) * | 2008-01-22 | 2013-02-27 | Dow AgroSciences LLC | 5-fluoro pyrimidine derivatives as fungicides |
| MX2014014323A (es) | 2012-05-25 | 2015-02-12 | Janssen R & D Ireland | Nucleosidos de espirooxetano de uracilo. |
| EP4619409A1 (en) * | 2022-11-15 | 2025-09-24 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for preparing an at least partially acetal-protected sugar |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| IL100965A (en) * | 1991-02-22 | 1999-12-31 | Univ Emory | 2-Hydroxymethyl-5-(5-fluorocytosin-l-yl)-1,3-oxathiolane its resolution and pharmaceutical compositions containing it |
| FI105556B (fi) * | 1991-09-30 | 2000-09-15 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta |
| US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
| TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
| US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
| US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
| US6005097A (en) * | 1996-06-14 | 1999-12-21 | Vion Pharmaceuticals, Inc. | Processes for high-yield diastereoselective synthesis of dideoxynucleosides |
| US6280940B1 (en) * | 1998-08-05 | 2001-08-28 | Agouron Pharmaceuticals, Inc. | Reporter gene system for use in cell-based assessment of inhibitors of the Hepatitis C virus protease |
| JP2002523408A (ja) * | 1998-08-25 | 2002-07-30 | イェール ユニバーシティ | ヘリオキサンチンおよびその類似体によるｂ型肝炎ウイルスおよびフラビウイルスの阻害および治療 |
| DE60119968T2 (de) * | 2000-11-20 | 2007-01-18 | Bristol-Myers Squibb Co. | Hepatitis c tripeptid inhibitoren |
| SK286630B6 (sk) * | 2001-01-22 | 2009-02-05 | Merck & Co., Inc. | Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| US6689559B2 (en) * | 2001-11-29 | 2004-02-10 | The Research Foundation Of The State University Of New York | Efficient hepatitis C virus replicon and its use in identifying antiviral compounds |
-
2003
- 2003-04-11 MX MXPA04009986A patent/MXPA04009986A/es active IP Right Grant
- 2003-04-11 AU AU2003234737A patent/AU2003234737B2/en not_active Ceased
- 2003-04-11 WO PCT/US2003/011445 patent/WO2003087119A1/en not_active Ceased
- 2003-04-11 PL PL03371913A patent/PL371913A1/pl not_active Application Discontinuation
- 2003-04-11 KR KR10-2004-7016211A patent/KR20050005442A/ko not_active Abandoned
- 2003-04-11 JP JP2003584075A patent/JP2005527589A/ja active Pending
- 2003-04-11 US US10/411,929 patent/US6897302B2/en not_active Expired - Lifetime
- 2003-04-11 CN CNB038113155A patent/CN1329407C/zh not_active Expired - Lifetime
- 2003-04-11 RU RU2004133062/04A patent/RU2310661C2/ru not_active IP Right Cessation
- 2003-04-11 BR BR0309111-2A patent/BR0309111A/pt not_active IP Right Cessation
- 2003-04-11 CA CA002481572A patent/CA2481572A1/en not_active Abandoned
- 2003-04-11 EP EP03728393A patent/EP1495040A4/en not_active Withdrawn
- 2003-11-04 UA UA20041109254A patent/UA77291C2/uk unknown
-
2004
- 2004-11-11 NO NO20044927A patent/NO20044927L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2310661C2 (ru) | 2007-11-20 |
| AU2003234737B2 (en) | 2009-08-27 |
| RU2004133062A (ru) | 2005-06-10 |
| EP1495040A1 (en) | 2005-01-12 |
| KR20050005442A (ko) | 2005-01-13 |
| CA2481572A1 (en) | 2003-10-23 |
| WO2003087119A1 (en) | 2003-10-23 |
| JP2005527589A (ja) | 2005-09-15 |
| US6897302B2 (en) | 2005-05-24 |
| AU2003234737A1 (en) | 2003-10-27 |
| UA77291C2 (en) | 2006-11-15 |
| MXPA04009986A (es) | 2005-08-16 |
| CN1329407C (zh) | 2007-08-01 |
| NO20044927L (no) | 2005-01-10 |
| BR0309111A (pt) | 2005-02-01 |
| EP1495040A4 (en) | 2006-01-25 |
| US20040147479A1 (en) | 2004-07-29 |
| CN1653078A (zh) | 2005-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |